Mapping of AF1 transactivation domains in duplicated rainbow trout glucocorticoid receptors

Journal of Molecular Endocrinology

Volumn 45, Issue 6, 2010, Pages 391-404

  Sturm, Armin ^a,b   Bron, James E ^b   Green, Darren M ^b   Bury, Nic R ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF STIRLING   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DEXAMETHASONE; GLUCOCORTICOID RECEPTOR; GLUCOCORTICOID RECEPTOR 1; GLUCOCORTICOID RECEPTOR 2; UNCLASSIFIED DRUG;

ACIDITY; ALPHA HELIX; AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BIOINFORMATICS; CONTROLLED STUDY; GENE DELETION; GENE EXPRESSION; GENE MAPPING; HYDROPHOBICITY; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN MOTIF; RAINBOW TROUT; RECEPTOR BINDING; SEQUENCE ALIGNMENT; TRANSACTIVATION; WILD TYPE;

ANIMALS; CERCOPITHECUS AETHIOPS; COMPUTATIONAL BIOLOGY; COS CELLS; FISH PROTEINS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; MICROSCOPY, CONFOCAL; ONCORHYNCHUS MYKISS; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, GLUCOCORTICOID; TRANSCRIPTIONAL ACTIVATION;

EID: 78650478144     PISSN: 09525041     EISSN: 14796813     Source Type: Journal    
DOI: 10.1677/JME-09-0152     Document Type: Article

References (62)

1. Alksnis M, Barkhem T, Stromstedt PE, Ahola H, Kutoh E, Gustafsson JA, Poellinger L & Nilsson S 1991 High level expression of functional full length and truncated glucocorticoid receptor in Chinese hamster ovary cells. Demonstration of ligand-induced down-regulation of expressed receptor mRNA and protein. Journal of Biological Chemistry 266 10078-10085.
2. Almlöf T, Wright APH & Gustafsson JA 1995 Role of acidic and phosphorylated residues in gene activation by the glucocorticoid receptor. Journal of Biological Chemistry 270 17535-17540. (doi:10. 1074/jbc.270.29.17535)
3. Almlöf T, Gustafsson JA & Wright APH 1997 Role of hydrophobic amino acid clusters in the transactivation activity of the human glucocorticoid receptor. Molecular and Cellular Biology 17 934-945.
4. Almlöf T, Wallberg AE, Gustafsson JA & Wright APH 1998 Role of important hydrophobic amino acids in the interaction between the glucocorticoid receptor tau 1-core activation domain and target factors. Biochemistry 37 9586-9594. (doi:10.1021/bi973029x)
5. Arriza JL, Weinberger C, Cerelli G, Glaser TM, Handelin BL, Housman DE & Evans RM 1987 Cloning of human mineralocorticoid receptor complementary DNA: structural and functional kinship with the glucocorticoid receptor. Science 237 268-275. (doi:10.1126/science.3037703)
6. Bain DL, Heneghan AF, Connaghan-Jones KD & Miura MT 2007 Nuclear receptor structure: implications for function. Annual Review of Physiology 69 201-220. (doi:10.1146/annurev. physiol.69. 031905.160308)
7. Bamberger CM, Schulte HM & Chrousos GP 1996 Molecular determinants of glucocorticoid receptor function and tissue sensitivity to glucocorticoids. Endocrine Reviews 17 245-261. (doi:10.1210/edrv-17-3-245)
8. Baskakov IV, Kumar R, Srinivasan G, Ji YS, Bolen DW & Thompson EB 1999 Trimethylamine N-oxide-induced cooperative folding of an intrinsically unfolded transcription-activating fragment of human glucocorticoid receptor. Journal of Biological Chemistry 274 10693-10696. (doi:10.1074/jbc.274.16.10693)
9. Becker H, Sturm A, Bron JE, Schirmer K & Bury NR 2008 The A/B domain of the teleost glucocorticoid receptors influences partial nuclear localization in the absence of hormone. Endocrinology 149 4567-4576. (doi:10.1210/en. 2007-1683)
10. Bland R & Hewison M 2001 Steroid hormone metabolites and hormone binding assays. In Steroid Receptor Methods, pp 145-162. Ed BA Lieberman. Totowa, NJ: Humana.
11. Bledsoe RK, Montana VG, Stanley TB, Delves CJ, Apolito CJ, McKee DD, Consler TG, Parks DJ, Stewart EL, Willson TM et al. 2002 Crystal structure of the glucocorticoid receptor ligand binding domain reveals a novel mode of receptor dimerization and coactivator recognition. Cell 110 93-105. (doi:10.1016/S0092-8674 (02) 00817-6)
12. Bridgham JT, Carroll SM & Thornton JW 2006 Evolution of hormone-receptor complexity by molecular exploitation. Science 312 97-101. (doi:10.1126/science.1123348)
13. Bury NR & Sturm A 2007 Evolution of the corticosteroid receptor signalling pathway in fish. General and Comparative Endocrinology 153 47-56. (doi:10.1016/j.ygcen. 2007.03.009)
14. Bury NR, Sturm A, Le Rouzic P, Lethimonier C, Ducouret B, Guigen Y, Robinson-Rechavi M, Laudet V & Prunet P 2003 Evidence for two distinct functional glucocorticoid receptors in teleost fish. Journal of Molecular Endocrinology 31 141-156. (doi:10.1677/jme.0.0310141)
15. Charmandari E, Tsigos C & Chrousos G 2005 Endocrinology of the stress response. Annual Review of Physiology 67 259-284. (doi:10. 1146/annurev. physiol.67.040403.120816)
16. Colombe L, Fostier A, Bury N, Pakdel F & Guigen Y 2000 A mineralocorticoid-like receptor in the rainbow trout, Oncorhynchus mykiss: cloning and characterization of its steroid binding domain. Steroids 65 319-328. (doi:10.1016/S0039-128X (00) 00090-8)
17. Combet C, Blanchet C, Geourjon C & Deleage G 2000 NPS@: network protein sequence analysis. Trends in Biochemical Sciences 25 147-150. (doi:10.1016/S0968-0004 (99) 01540-6)
18. Dahlman-Wright K, Almlof T, McEwan IJ, Gustafsson JA & Wright APH 1994 Delineation of a small region within the major transactivation domain of the human glucocorticoid receptor that mediates transactivation of gene-expression. PNAS 91 1619-1623. (doi:10. 1073/pnas.91.5.1619)
19. Dahlman-Wright K, Baumann H, McEwan IJ, Almlof T, Wright AP, Gustafsson JA & Hard T 1995 Structural characterization of a minimal functional transactivation domain from the human glucocorticoid receptor. PNAS 92 1699-1703. (doi:10.1073/pnas. 92.5.1699)
20. Danielian PS, White R, Lees JA & Parker MG 1992 Identification of a conserved region required for hormone dependent transcriptional activation by steroid-hormone receptors. EMBO Journal 11 1025-1033.
21. Ducouret B, Tujague M, Ashraf J, Mouchel N, Servel N, Valotaire Y & Thompson EB 1995 Cloning of a teleost fish glucocorticoid receptor shows that it contains a deoxyribonucleic acid-binding domain different from that of mammals. Endocrinology 136 3774-3783. (doi:10.1210/en. 136.9.3774)
22. Dunker AK, Brown CJ, Lawson JD, Iakoucheva LM & Obradovic Z 2002 Intrinsic disorder and protein function. Biochemistry 41 6573-6582. (doi:10.1021/bi012159+)
23. Escriva H, Safi R, Hanni C, Langlois MC, Saumitou-Laprade P
24. Stehelin D, Capron A, Pierce R & Laudet V 1997 Ligand binding was acquired during evolution of nuclear receptors. PNAS 94 6803-6808. (doi:10.1073/pnas.94.13.6803)
25. Giguere V, Hollenberg SM, Rosenfeld MG & Evans RM 1986 Functional domains of the human glucocorticoid receptor. Cell 46 645-652. (doi:10.1016/0092-8674 (86) 90339-9)
26. Godowski PJ, Picard D & Yamamoto KR 1988 Signal transduction and transcriptional regulation by glucocorticoid receptor-Lexa fusion proteins. Science 241 812-816. (doi:10.1126/science.3043662)
27. Gouilleux F, Sola B, Couette B & Richard-Foy H 1991 Cooperation between structural elements in hormono-regulated transcription from the mouse mammary tumor virus promoter. Nucleic Acids Research 19 1563-1569. (doi:10.1093/nar/19.7.1563)
28. Greenwood AK, Butler PC, White RB, DeMarco U, Pearce D & Fernald RD 2003 Multiple corticosteroid receptors in a teleost fish: distinct sequences, expression patterns, and transcriptional activities. Endocrinology 144 4226-4236. (doi:10.1210/en. 2003-0566)
29. Hard T, Kellenbach E, Boelens R, Maler BA, Dahlman K, Freedman LP, Carlstedt-Duke J, Yamamoto KR, Gustafsson JA & Kaptein R 1990 Solution structure of the glucocorticoid receptor DNA-binding domain. Science 249 157-160. (doi:10.1126/science.2115209)
30. Heery DM, Kalkhoven E, Hoare S & Parker MG 1997 A signature motif in transcriptional co-activators mediates binding to nuclear receptor. Nature 387 733-736. (doi:10.1038/42750)
31. Heitzer MD, Wolf IM, Sanchez ER, Witchel SF & DeFranco DB 2007 Glucocorticoid receptor physiology. Reviews in Endocrine and Metabolic Disorders 8 321-330. (doi:10.1007/s11154-007-9059-8)
32. Hollenberg SM & Evans RM 1988 Multiple and cooperative transactivation domains of the human glucocorticoid receptor. Cell 55 899-906. (doi:10.1016/0092-8674 (88) 90145-6)
33. Hollenberg SM, Weinberger C, Ong ES, Cerelli G & Oro A 1985 Primary structure and expression of a functional human glucocorticoid receptor cDNA. Nature 318 635-641. (doi:10.1038/318635a0)
34. Hollenberg SM, Giguere V, Segui P & Evans RM 1987 Colocalization of DNA-binding and transcriptional activation functions in the human glucocorticoid receptor. Cell 49 39-46. (doi:10.1016/0092-8674 (87) 90753-7)
35. Htun H, Barsony J, Renyi I, Gould DL & Hager GL 1996 Visualization of glucocorticoid receptor translocation and intranuclear organization in living cells with a green fluorescent protein chimera. PNAS 93 4845-4850. (doi:10.1073/pnas.93.10.4845)
36. Iniguez-Lluhi JA, Lou DY & Yamamoto KR 1997 Three amino acid substitutions selectively disrupt the activation but not the repression function of the glucocorticoid receptor N terminus. Journal of Biological Chemistry 272 4149-4156. (doi:10.1074/jbc.272. 7.4149)
37. Jaillon O, Aury JM, Brunet F, Petit JL, Stange-Thomann N, Mauceli E, Bouneau L, Fischer C, Ozouf-Costaz C, Bernot A et al. 2004 Genome duplication in the teleost fish Tetraodon nigroviridis reveals the early vertebrate proto-karyotype. Nature 431 946-957. (doi:10.1038/nature03025)
38. Jiang JQ, Young G, Kobayashi T & Nagahama Y 1998 Eel (Anguilla japonica) testis 11β-hydroxylase gene is expressed in interrenal tissue and its product lacks aldosterone synthesizing activity. Molecular and Cellular Endocrinology 146 207-211. (doi:10.1016/S0303-7207 (98) 00147-6)
39. Kucera T, Waltner-Law M, Scott DK, Prasad R & Granner DK 2002 A point mutation of the AF2 transactivation domain of the glucocorticoid receptor disrupts its interaction with steroid receptor coactivator 1. Journal of Biological Chemistry 277 26098-26102. (doi:10.1074/jbc. M204013200)
40. Kumar R, Baskakov IV, Srinivasan G, Bolen DW, Lee JC & Thompson EB 1999 Interdomain signaling in a two-domain fragment of the human glucocorticoid receptor. Journal of Biological Chemistry 274 24737-24741. (doi:10.1074/jbc.274. 35.24737)
41. Kumar R, Volk DE, Li JQ, Lee JC, Gorenstein DG & Thompson EB 2004 TATA box binding protein induces structure in the recombinant glucocorticoid receptor AF1 domain. PNAS 101 16425-16430. (doi:10.1073/pnas.0407160101)
42. Lavery DN & McEwan IJ 2005 Structure and function of steroid receptor AF1 transactivation domains: induction of active conformations. Biochemical Journal 391 449-464. (doi:10.1042/BJ20050872)
43. Mommsen TP, Vijayan MM & Moon TW 1999 Cortisol in teleosts: dynamics, mechanisms of action, and metabolic regulation. Reviews in Fish Biology and Fisheries 9 211-298. (doi:10.1023/A:1008924418720)
44. Moras D & Gronemeyer H 1998 The nuclear receptor ligand-binding domain: structure and function. Current Opinion in Cell Biology 10 384-391. (doi:10.1016/S0955-0674 (98) 80015-X)
45. Nelson DR 2003 Comparison of P450s from human and fugu: 420 million years of vertebrate P450 evolution. Archives of Biochemistry and Biophysics 409 18-24. (doi:10.1016/S0003-9861 (02) 00553-2)
46. Ortlund EA, Bridgham JT, Redinbo MR & Thornton JW 2007 Crystal structure of an ancient protein: evolution by conformational epistasis. Science 317 1544-1548. (doi:10.1126/science.1142819)
47. Pratt WB & Toft DO 1997 Steroid receptor interactions with heat shock protein and immunophilin chaperones. Endocrine Reviews 18 306-360. (doi:10.1210/er.18.3.306)
48. Rogatsky I, Wang JC, Derynck MK, Nonaka DF, Khodabakhsh DB, Haqq CM, Darimont BD, Garabedian MJ & Yamamoto KR 2003 Target-specific utilization of transcriptional regulatory surfaces by the glucocorticoid receptor. PNAS 100 13845-13850. (doi:10.1073/pnas.2336092100)
49. Sackey FNA, Hache RJG, Reich T, Kwast-Welfeld J & Lefebvre YA 1996 Determinants of subcellular distribution of the glucocorticoid receptor. Molecular Endocrinology 10 1191-1205. (doi:10.1210/me.10.10.1191)
50. Sambrook J & Russell DW 2001 Molecular Cloning. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press.
51. Schaaf MJM, Champagne D, van Laanen IHC, van Wijk D, Meijer AH, Meijer OC, Spaink HP & Richardson MK 2008 Discovery of a functional glucocorticoid receptor β-isoform in zebrafish. Endocrinology 149 1591-1599. (doi:10.1210/en. 2007-1364)
52. Schaaf MJM, Chatzopoulou A & Spaink HP 2009 The zebrafish as a model system for glucocorticoid receptor research. Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology 153 75-82. (doi:10.1016/j.cbpa.2008.12.014)
53. Schoneveld O, Gaemers IC & Lamers WH 2004 Mechanisms of glucocorticoid signalling. Biochimica et Biophysica Acta - Gene Structure and Expression 1680 114-128. (doi:10.1016/j.bbaexp. 2004.09.004)
54. Stolte EH, van Kemenade BM, Savelkoul HF & Flik G 2006 Evolution of glucocorticoid receptors with different glucocorticoid sensitivity. Journal of Endocrinology 190 17-28. (doi:10.1677/joe.1. 06703)
55. Stolte EH, de Mazon AF, Leon-Koosterziel KM, Jesiak M, Bury NR, Sturm A, Savelkoul HFJ, van Kemenade B & Flik G 2008a Corticosteroid receptors involved in stress regulation in common carp, Cyprinus carpio. Journal of Endocrinology 198 403-417. (doi:10. 1677/JOE-08-0100)
56. Stolte EH, Nabuurs SB, Bury NR, Sturm A, Flik G, Savelkoul HFJ & Kemenade B 2008b Stress and innate immunity in carp: corticosteroid receptors and pro-inflammatory cytokines. Molecular Immunology 46 70-79. (doi:10.1016/j.molimm.2008.07.022)
57. Sturm A, Bury N, Dengreville L, Fagart J, Flouriot G, Rafestin-Oblin ME & Prunet P 2005 11-Deoxycorticosterone is a potent agonist of the rainbow trout (Oncorhynchus mykiss) mineralocorticoid receptor. Endocrinology 146 47-55. (doi:10.1210/en. 2004-0128)
58. Walker D, Htun H & Hager GL 1999 Using inducible vectors to study intracellular trafficking of GFP-tagged steroid/nuclear receptors in living cells. Methods 19 386-393. (doi:10.1006/meth. 1999.0874)
59. Wärnmark A, Gustafsson JA & Wright APH 2000 Architectural principles for the structure and function of the glucocorticoid receptor tau 1 core activation domain. Journal of Biological Chemistry 275 15014-15018. (doi:10.1074/jbc. M001007200)
60. Wärnmark A, Treuter E, Wright APH & Gustafsson JA 2003 Activation functions 1 and 2 of nuclear receptors: molecular strategies for transcriptional activation. Molecular Endocrinology 17 1901-1909. (doi:10.1210/me.2002-0384)
61. Wurtz JM, Bourguet W, Renaud J-P, Vivat V, Chambon P, Moras D & Gronemeyer H 1996 A canonical structure for the ligand-binding domain of nuclear receptors. Nature Structural Biology 3 87-94. (doi:10.1038/nsb0196-87)
62. Ylikomi T, Bocquel MT, Berry M, Gronemeyer H & Chambon P 1992 Cooperation of protosignals for nuclear accumulation of estrogen and progesterone receptors. EMBO Journal 11 3681-3694.