Three amino acid substitutions selectively disrupt the activation but not the repression function of the glucocorticoid receptor N terminus

Journal of Biological Chemistry

Volumn 272, Issue 7, 1997, Pages 4149-4156

  Iñiguez Lluhí, Jorge A ^a   Lou, David Y ^a   Yamamoto, Keith R ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GALACTOSIDASE; GLUCOCORTICOID RECEPTOR;

AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CANCER CELL CULTURE; DNA TRANSFECTION; EMBRYO; ENZYME ASSAY; GENE LIBRARY; GENE REPRESSION; HYDROPHOBICITY; IMMUNOBLOTTING; MAMMAL CELL; MOUSE; NONHUMAN; PLASMID; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; TRANSCRIPTION REGULATION;

AMINO ACIDS; ANIMALS; MICE; MUTAGENESIS, SITE-DIRECTED; RATS; RECEPTORS, GLUCOCORTICOID; TRANSCRIPTION, GENETIC; TUMOR CELLS, CULTURED;

EID: 0031054799     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.272.7.4149     Document Type: Article

References (64)

1. Mangelsdorf, D. J., Thummel, C., Beato, M., Herrlich, P., Schütz, G., Umesono, K., Blumberg, B., Kastner, P., Mark, M., Chambon, P., and Evans, R. M. (1995) Cell 83, 835-839
2. Tsai, M.-J., and O'Malley, B. W. (1994) Annu. Rev. Biochem. 63, 451-486
3. Yamamoto, K. R. (1996) The Harvey Lectures, in press
4. Beato, M., Herrlich, P., and Schütz, G. (1995) Cell 83, 851-857
5. Yamamoto, K. R., Pearce, D., Thomas, J., and Miner, J. N. (1992) in Transcriptional Regulation (McKnight, S. L., and Yamamoto, K. R., eds) pp. 1169-1192, Cold Spring Harbor Press, Cold Spring Harbor, NY
6. Diamond, M. I., Miner, J. N., Yoshinaga, S. K., and Yamamoto, K. R. (1990) Science 249, 1266-1272
7. Jonat, C., Rahmsdorf, H. J., Herrlich, P., Park, K.-K, Cato, A. C. B., Gebel, S., Ponta, H., and Herrlich, P. (1990) Cell 62, 1189-1204
8. Miner, J. N., and Yamamoto, K. R. (1992) Genes Dev. 12, 2491-2501
9. Starr, D. B., Matsui, W., Thomas, J. R., and Yamamoto, K. R. (1996) Genes Dev. 10, 1271-1283
10. Lefstin, J. A., Thomas, J. R., and Yamamoto, K. R. (1994) Genes Dev. 8, 2842-2856
11. Segraves, W. A. (1991) Cell 67, 225-228
12. Detera-Wadleigh, S. D., and Fanning, T. G. (1994) Mol. Phylogenet. Evol. 3, 192-205
13. Godowski, P. J., Rusconi, S., Miesfeld, R., and Yamamoto, K. R. (1987) Nature 325, 365-368
14. Hollenberg, S. M., and Evans, R. M. (1988) Cell 55, 899-906
15. Giguère, V., Hollenberg, S. M., Rosenfeld, M. G., and Evans, R. M. (1986) Cell 46, 645-652
16. Godowski, P. J., Picard, D., and Yamamoto, K. R. (1988) Science 241, 812-816
17. Tasset, D., Tora, L., Fromental, C., Scheer, E., and Chambon, P. (1990) Cell 62, 1177-1187
18. Miesfeld, R., Sakai, D., Inoue, A., Schena, M., Godowski, P. J., and Yamamoto, K. R. (1988) in Steroid Hormone Action, UCLA Symposium on Molecular and Cellular Biology (Ringold, G., ed) Vol. 75, pp. 193-200, Alan R. Liss, Inc., New York
19. Miesfeld, R., Godowski, P. J., Maler, B. A., and Yamamoto, K. R. (1987) Science 236, 423-427
20. König, H., Ponta, H., Rahmsdorf, H. J., and Herrlich, P. 11992) EMBO J. 11, 2241-2246
21. Heck, S., Kullmann, M., Gast, A., Ponta, H., Rahmsdorf, H. J., Herrlich, p., and Cato, A. C. (1994) EMBO J. 13, 4087-4095
22. Pearce, D., and Yamamoto, K. R. (1992) Science 259, 1161-1165
23. Yoshinaga, S. K., Peterson, C. L., Herskowitz, I., and Yamamoto, K. R. (1992) Science 258, 1598-1604
24. Kingston, R. E., Bunker, C. A., and Imbalzano, A. N. (1996) Genes Dev. 10, 905-920
25. Muchardt, C., and Yaniv, M. (1993) EMBO J. 12, 4279-4290
26. Cairns, B. R., Levinson, R. S., Yamamoto, K. R., and Kornberg, R. D. (1996) Genes Dev. 10, 2131-2144
27. Freedman, L. P., Yoshinaga, S. K., Vanderbilt, J. N., and Yamamoto, K. R. (1989) Science 245, 298-301
28. Tjian, R., and Maniatis, T. (1994) Cell 77, 5-8
29. Zawel, L., and Reinberg, D. (1995) Annu. Rev. Biochem. 64, 533-561
30. Guarente, L. (1995) Trends Biochem. Sci. 20, 517-521
31. Hong, H., Kohli, K., Trivedi, A., Johnson, D. L., and Stallcup, M. R. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 4948-4952
32. Cavailles, V., Dauvois, S., L'Horset, F., Lopez, G., Hoare, S., Kushner, P. J., and Parker, M. G. (1995) EMBO J. 14, 3741-3751
33. Baniahmad, C., Nawaz, Z., Baniahmad, A., Gleeson, M. A., Tsai, M. J., and O'Malley, B. W. (1995) Mol. Endocrinol. 9, 34-43
34. Onate, S. A., Tsai, S. Y., Tsai, M. J., and O'Malley, B. W. (1995) Science 270, 1354-1357
35. Eggert, M., Mows, C. C., Tripier, D., Arnold, R., Michel, J., Nickel, J., Schmidt, S., Beato, M., and Renkawitz, R. (1995) J. Biol. Chem. 270, 30755-30759
36. Folkers, G. E., and van der Saag, P. T. (1995) Mol. Cell. Biol. 15, 5868-5878
37. Lee, J. W., Ryan, F., Swaffield, J. C., Johnston, S. A., and Moore, D. D. (1995) Nature 374, 91-94
38. Lee, J. W., Choi, H. S., Gyuris, J., Brent, R., and Moore, D. D. (1995) Mol. Endocrinol. 9, 243-254
39. vom Baur, E., Zechel, C., Heery, D., Heine, M. J. S., Garnier, J. M., Vivat, V., Le Douarin, B., Gronemeyer, H., Chambon, P., and Losson, R. (1996) EMBO J. 15, 110-124
40. Zeiner, M., and Gehring, U. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 11465-11469
41. LeDouarin, B., Zechel, C., Garnier, J. M., Lutz, Y., Tora, L., Pierrat, P., Heery, D., Gronemeyer, H., Chambon, P., and Losson, R. (1995) EMBO J. 14, 2020-2033
42. Courey, A. J., and Tjian, R. (1988) Cell 55, 887-898
43. Gill, G., Pascal, E., Tseng, Z. H., and Tjian, R. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 192-196
44. Triezenberg, S. J. (1995) Curr. Opin. Genet. Dev. 5, 190-196
45. Sherman, F. (1991) Methods Enzymol. 194, 3-21
46. Sikorski, R. S., and Hieter, P. (1989) Genetics 122, 19-27
47. Schena, M., and Yamamoto, K. R. (1988) Science 241, 965-967
48. Kralli, A., Bohen, S. P., and Yamamoto, K. R. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 4701-4705
49. Gametchu, B., and Harrison, R. W. (1984) Endocrinology 114, 274-279
50. Kunkel, T. A., Roberts, J. D., and Zakour, R. A. (1987) Methods Enzymol. 154, 367-382
51. Miller, J. H. (1972) Experiments in Molecular Genetics, pp. 352-355, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY
52. Jantzen, H. M., Strähle, U., Gloss, B., Stewart, F., Schmid, W., Boshart, M., Miksicek, R., and Schütz, G. (1987) Cell 49, 29-38
53. Baichwal, V. R., and Tjian, R. (1990) Cell 63, 815-825
54. Dahlman-Wright, K., Almlof, T., McEwan, I. J., Gustafsson, J. Å., and Wright, A. P. H. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 1619-1623
55. Regier, J. L., Shen, F., and Triezenberg, S. J. (1993) Proc. Natl. Acad. Sci. U. S. A. 90, 883-887
56. Lin, J., Chen, J., Elenbaas, B., and Levine, A. J. (1994) Genes Dev. 8, 1235-1246
57. Almlof, T., Wright, A. P. H., and Gustafsson, J. A. (1995) J. Biol. Chem. 270, 17535-17540
58. Whiteway, M., Clark, K. L., Leberer, E., Dignard, D., and Thomas, D. Y. (1994) Mol. Cell. Biol. 14, 3223-3229
59. Wall, M. A., Coleman, D. E., Lee, E., Iñiguez-Lluhí, J. A., Posner, B. A., Gilman, A. G., and Sprang, S. R. (1995) Cell 83, 1047-1058
60. Bodwell, J. E., Orti, E., Coull, J. M., Pappin, D. J. C., Smith, L. I., and Swift, F. (1991) J. Biol. Chem. 266, 7549-7555
61. Shen, F., Triezenberg, S. J., Hensley, P., Porter, D., and Knutson, J. R. (1996) J. Biol. Chem. 271, 4827-4837
62. Dahlman-Wright, K., Baumann, H., McEwan, I. J., Almlof, T., Wright, A. P., Gustafsson, J. Å., and Hard, T. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 1699-1703
63. Dahlman-Wright, K., and McEwan, I. J. (1996) Biochemistry 35, 1323-1327
64. Kamei, Y., Xu, L., Heinzel, T., Torchia, J., Kurokawa, R., Gloss, B., Lin, S. C., Heyman, R. A., Rose, D. W., Glass, C. K, and Rosenfeld, M. G. (1996) Cell 85, 403-414