The A/B domain of the teleost glucocorticoid receptors influences partial nuclear localization in the absence of hormone

Endocrinology

Volumn 149, Issue 9, 2008, Pages 4567-4576

  Becker, Heidi ^a,b   Sturm, Armin ^a,c   Bron, James E ^c   Schirmer, Kristin ^b,d   Bury, Nicolas R ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b HELMHOLTZ CENTRE FOR ENVIRONMENTAL RESEARCH UFZ   (Germany)

^c UNIVERSITY OF STIRLING   (United Kingdom)

^d SWISS FEDERAL INSTITUTE OF AQUATIC SCIENCE AND TECHNOLOGY   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOCORTICOID RECEPTOR; GREEN FLUORESCENT PROTEIN; MINERALOCORTICOID RECEPTOR;

ANIMAL CELL; ARTICLE; CELL NUCLEUS TRANSPLANTATION; CELLULAR DISTRIBUTION; CHIMERA; CONTROLLED STUDY; HORMONE RECEPTOR INTERACTION; HORMONE SENSITIVITY; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN STRUCTURE; RAINBOW TROUT; RECEPTOR BINDING; TELEOST; TRANSACTIVATION;

ANIMALS; CELL NUCLEUS; CELLS, CULTURED; CERCOPITHECUS AETHIOPS; CHO CELLS; COS CELLS; CRICETINAE; CRICETULUS; GLUCOCORTICOIDS; GREEN FLUORESCENT PROTEINS; ONCORHYNCHUS MYKISS; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; RATS; RECEPTORS, GLUCOCORTICOID; RECOMBINANT FUSION PROTEINS; TRANSFECTION;

EID: 50449091975     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2007-1683     Document Type: Article

References (38)

1. Charmandari E, Tsigos C, Chrousos G 2005 Endocrinology of the stress response. Annu Rev Physiol 67:259-284
2. Bamberger CM, Schulte HM, Chrousos GP 1996 Molecular determinants of glucocorticoid receptor function and tissue sensitivity to glucocorticoids. Endocr Rev 17:245-261
3. Glass CK, Rosenfeld MG 2000 The coregulator exchange in transcription of nuclear receptors. Genes Dev 14:121-141
4. Picard D, Yamamoto K 1987 Two signals mediate hormone-dependent nuclear localization of the glucocorticoid receptor. EMBO J 6:3333-3340
5. Htun H, Barsony J, Renyi I, Gould DL, Hager GL 1996 Visualization of glucocorticoid receptor translocation and intranuclear organization in living cells with a green fluorescent protein chimera. Proc Natl Acad Sci USA 93:4845-4850
6. Tissing, WJE, Meijerink JPP, den Boer ML, Brinkhof B, Pieters R 2005 mRNA expression levels of (co)chaperone molecules of the glucocorticoid receptor are not involved in glucocorticoid resistance in pediatric ALL. Leukemia 19:727-733
7. Pratt WB, Toft D 2003 Regulation of signaling protein function and trafficking by the hsp90/hsp70-based chaperone machinery. Exp Biol Med 228:111-133
8. Sackey FN, Haché RJ, Reich T, Kwast-Welfeld J, Lefebvre YA 1996 Determinants of subcellular distribution of the glucocorticoid receptor. Mol Endocrinol 10:1191-1205
9. Savory JG, Hsu B, Laquian IR, Giffin W, Reich T, Hache RJ, Lefebvre YA 1999 Discrimination between NL1- and NL2-mediated nuclear localization of the glucocorticoid receptor. Mol Cell Biol 19:1025-1037
10. Freedman ND, Yamamoto KR 2004 Importin 7 and importin α/importin β are nuclear import receptors for the glucocorticoid receptor. Mol Biol Cell 15:2276-2286
11. Black BE, Holaska JM, Rastinejad F, Paschal BM 2001 DNA binding domains in diverse nuclear receptors function as nuclear export signals. Curr Biol 11:1749-1758
12. Carrigan A, Walther RF, Salem HA, Wu D, Atlas E, Lefebvre YA, Hache RJ 2007 An active nuclear retention signal in the glucocorticoid receptor functions as a strong inducer of transcriptional activation. J Biol Chem 282:10963-10971
13. Evans RM 1988 The steroid and thyroid hormone receptor superfamily. Science 240:889-895
14. Picard D, Kumar V, Chambon P, Yamamoto KR 1990 Signal transduction by steroid hormones: nuclear localization is differentially regulated in estrogen and glucocorticoid receptors. Cell Regul 1:291-299
15. Simental JA, Sar M, Lane MV, French FS, Wilson EM 1991 Transcriptional activation and nuclear targeting signals of the human androgen receptor. J Biol Chem 266:510-518
16. Ylikomi T, Bocquel MY, Berry M, Gronemeyer H, Chambon P 1992 Cooperation of proto-signals for nuclear accumulation of estrogen and progesterone receptors. EMBO J 11:3681-3694
17. Thornton JW 2001 Evolution of vertebrate steroid receptors from an ancestral estrogen receptor by ligand exploitation and serial genome expansions. Proc Natl Acad Sci USA 98:5671-5676
18. Fejes-Toth G, Pearce D, Naray-Fejes-Toth A 1998 Subcellular localization of mineralocorticoid receptors in living cells: effects of receptor agonists and antagonists. Proc Natl Acad Sci USA 95:2973-2978
19. Wan Y, Coxe KK, Thackray VG, Housley PR, Nordeen SK 2001 Separable features of the ligand-binding domain determine the differential subcellular localization and ligand-binding specificity of glucocorticoid receptor and progesterone receptor. Mol Endocrinol 15:17-31
20. Bridgham JT, Carroll SE, Thornton JW 2006 Evolution of hormone-receptor complexity by molecular exploitation. Science 312:97-101
21. Ortlund EA, Bridgham JT, Redinbo MR, Thornton JW 2007 Crystal structure of an ancient protein: evolution by conformational epistasis. Science 317:1544-1548
22. Galigniana MD, Radanyi C, Renoir JM, Housley PR, Pratt WB 2001 Evidence that the peptidylprolyl isomerase domain of the hsp90-binding immunophilin FKBP52 is involved in both dynein interaction and glucocorticoid receptor movement to the nucleus. J Biol Chem 276:14884-14889
23. Her S, Patel PD, Schatzberg AF, Lyons DM 2005 Mutations in squirrel monkey glucocorticoid receptor impair nuclear translocation. J Steroid Biochem Mol Biol 94:319-326
24. Jaillon O, Aury JM, Brunet F, Petit JL, Stange-Thomann N, Mauceli E, Bouneau L, Fischer C, Ozouf-Costaz C, Bernot A, Nicaud S, Jaffe D, Fisher S, Lutfalla G, Dossat C, Segurens B, Dasilva C, Salanoubat M, Levy M, Boudet N, Castellano S, Anthouard V, Jubin C, Castelli V, Katinka M, et al. 2004 Genome duplication in the teleost fish Tetraodon nigroviridis reveals the early vertebrate proto-karyotype. Nature 431:946-957
25. Bury NR, Sturm A, Le Rouzic P, Lethimonier C, Ducouret B, Guiguen Y, Robinson-Rechavi M, Laudet V, Rafestin-Oblin ME, Prunet P 2003 Evidence for two distinct functional glucocorticoid receptors in teleost fish. J Mol Endocrinol 31:141-156
26. Greenwood AK, Butler PC, White RB, DeMarco U, Pearce D, Fernald RD 2003 Multiple corticosteroid receptors in a teleost fish: distinct sequences, expression patterns, and transcriptional activities. Endocrinology 144:4226-4236
27. Stolte EH, van Kemenade BM, Savelkoul HF, Flik G 2006 Evolution of glucocorticoid receptors with different glucocorticoid sensitivity. J Endocrinol 190:17-28
28. Bury NR, Sturm A 2007 Evolution of the corticosteroid receptor signalling pathway in fish. Gen Comp Endocrionol 153:47-56
29. Sambrook J, Russell DW 2001 Molecular cloning. 3rd ed. Cold Spring Harbor, NY: CSHL
30. Walther RF, Atlas E, Carrigan A, Rouleau Y, Edgecombe A, Visentin L, Lamprecht C, Addicks GC, Haché RJ, Lefebvre YA 2005 A serine/threonine-rich motif is one of three nuclear localization signals that determine unidirectional transport of the mineralocorticoid receptor to the nucleus. J Biol Chem 280:17549-17561
31. Sturm A, Bury N, Dengreville L, Fagart J, Flouriot G, Rafestin-Oblin ME, Prunet P 2005 11-Deoxycorticosterone is a potent agonist of the rainbow trout (Oncorhynchus mykiss) mineralocorticoid receptor. Endocrinology 146:47-55
32. Lee LE, Bols NC 1989 The corticosteroid receptor and the action of various steroids in rainbow trout fibroblasts. Gen Comp Endocrinol 74:85-95
33. Lim-Toi SS, Keightly M-C, Fuller PJ 1997 Determinants of specificity of transactivation by the mineralocorticoid or glucocorticoid receptor. Endocrinology 138:2537-2543
34. Fuller PJ, Lim-Toi SS, Brennan FE 2000 Specificity in mineralocorticoid verus glucocorticoid action. Kidney Int 57:1256-1264
35. Kucera T, Waltner-Law M, Scott DK, Prasad R, Granner DK 2002 A point mutation of the AF2 transactivation domain of the glucocorticoid receptor disrupts its interaction with steroid receptor coactivator 1. J Biol Chem 277:26098-26102
36. Wolff T, Unterstab G, Heins G, Richt JA, Kann M 2002 Characterization of an unusual importin α binding motif in the Borna disease virus p10 protein that directs nuclear import. J Biol Chem 277:12151-12157
37. Tang Y, Ramakrishnan C, Thomas J, DeFranco DB 1997 A role for HDJ-2/HSDJ in correcting subnuclear trafficking, transactivation, and transrepression defects of a glucocorticoid receptor zinc finger mutant. Mol Biol Cell 8:795-809
38. Ducouret B, Tujague M, Ashraf J, Mouchel N, Servel N, Valotaire Y, Thompson EB 1995 Cloning of a teleost fish glucocorticoid receptor shows that it contains a deoxyribonucleic acid-binding domain different from that of mammals. Endocrinology 136:3774-3783