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Volumn 10, Issue 1, 2011, Pages 55-66

Dexmedetomidine: Pediatric pharmacology, clinical uses and safety

Author keywords

2 agonist; adverse effects; dexmedetomidine; indications; pediatrics; sedation

Indexed keywords

DEXMEDETOMIDINE; INTERLEUKIN 1; INTERLEUKIN 6; PLACEBO; TUMOR NECROSIS FACTOR ALPHA;

EID: 78650456887     PISSN: 14740338     EISSN: None     Source Type: Journal    
DOI: 10.1517/14740338.2010.512609     Document Type: Review
Times cited : (84)

References (83)
  • 1
    • 33847392052 scopus 로고    scopus 로고
    • Dexmedetomidine: An updated review
    • Gerlach AT, Dasta JF. Dexmedetomidine: an updated review. Ann Pharmacother 2007;41:245-54
    • (2007) Ann Pharmacother , vol.41 , pp. 245-254
    • Gerlach, A.T.1    Dasta, J.F.2
  • 2
    • 34147136551 scopus 로고    scopus 로고
    • Dexmedetomidine: Applications in pediatric critical care and pediatric anesthesiology
    • DOI 10.1097/01.PCC.0000257100.31779.41
    • Tobias JD. Dexmedetomidine: applications in pediatric critical care and pediatric anesthesiology. Pediatr Crit Care Med 2007;8:115-31 (Pubitemid 46568561)
    • (2007) Pediatric Critical Care Medicine , vol.8 , Issue.2 , pp. 115-131
    • Tobias, J.D.1
  • 3
    • 0023903938 scopus 로고
    • Characterization of the selectivity, specificity and potency of medetomidine as an alpha 2-adrenoceptor agonist
    • Virtanen R, Savola JM, Saano V, Nyman L. Characterization of the selectivity, specificity and potency of medetomidine as an alpha 2-adrenoceptor agonist. Eur J Pharmacol 1988;150:9-14
    • (1988) Eur J Pharmacol , vol.150 , pp. 9-14
    • Virtanen, R.1    Savola, J.M.2    Saano, V.3    Nyman, L.4
  • 4
    • 0021923603 scopus 로고
    • 2-adrenoceptors which increase potassium conductance in rat locus coeruleus neurones
    • DOI 10.1016/0306-4522(85)90166-6
    • Williams JT, Henderson G, North RA. Characterization of alpha 2-adrenoceptors which increase potassium conductance in rat locus coeruleus neurones. Neuroscience 1985;14:95-101 (Pubitemid 15124286)
    • (1985) Neuroscience , vol.14 , Issue.1 , pp. 95-101
    • Williams, J.T.1    Henderson, G.2    North, R.A.3
  • 5
    • 0030855907 scopus 로고    scopus 로고
    • Activation of alpha-2 adrenergic receptors inhibits norepinephrine release by a pertussis toxin-insensitive pathway independent of changes in cytosolic calcium in cultured rat sympathetic neurons
    • Schwartz DD. Activation of alpha-2 adrenergic receptors inhibits norepinephrine release by a pertussis toxin-insensitive pathway independent of changes in cytosolic calcium in cultured rat sympathetic neurons. J Pharmacol Exp Ther 1997;282:248-55
    • (1997) J Pharmacol Exp Ther , vol.282 , pp. 248-255
    • Schwartz, D.D.1
  • 6
    • 0026780486 scopus 로고
    • A hypnotic response to dexmedetomidine, an alpha 2 agonist, is mediated in the locus coeruleus in rats
    • Correa-Sales C, Rabin BC, Maze M. A hypnotic response to dexmedetomidine, an alpha 2 agonist, is mediated in the locus coeruleus in rats. Anesthesiology 1992;76:948-52
    • (1992) Anesthesiology , vol.76 , pp. 948-952
    • Correa-Sales, C.1    Rabin, B.C.2    Maze, M.3
  • 7
    • 0026445566 scopus 로고
    • Pertussis toxin-mediated ribosylation of G proteins blocks the hypnotic response to an alpha 2-agonist in the locus coeruleus of the rat
    • Correa-Sales C, Reid K, Maze M. Pertussis toxin-mediated ribosylation of G proteins blocks the hypnotic response to an alpha 2-agonist in the locus coeruleus of the rat. Pharmacol Biochem Behav 1992;43:723-7
    • (1992) Pharmacol Biochem Behav , vol.43 , pp. 723-727
    • Correa-Sales, C.1    Reid, K.2    Maze, M.3
  • 8
    • 0024365299 scopus 로고
    • Dexmedetomidine produces a hypnotic-anesthetic action in rats via activation of central alpha-2 adrenoceptors
    • Doze VA, Chen BX, Maze M. Dexmedetomidine produces a hypnotic-anesthetic action in rats via activation of central alpha-2 adrenoceptors. Anesthesiology 1989;71:75-9 (Pubitemid 19182469)
    • (1989) Anesthesiology , vol.71 , Issue.1 , pp. 75-79
    • Doze, A.1    Chen, B.-X.2    Maze, M.3
  • 9
    • 0028081752 scopus 로고
    • 2-adrenergic agonist dexmedetomidine in the locus coeruleus of the rat
    • DOI 10.1097/00000542-199412000-00029
    • Nacif-Coelho C, Correa-Sales C, Chang LL, Maze M. Perturbation of ion channel conductance alters the hypnotic response to the alpha 2-adrenergic agonist dexmedetomidine in the locus coeruleus of the rat. Anesthesiology 1994;81:1527-34 (Pubitemid 24381446)
    • (1994) Anesthesiology , vol.81 , Issue.6 , pp. 1527-1534
    • Nacif-Coelho, C.1    Correa-Sales, C.2    Chang, L.L.3    Maze, M.4
  • 10
    • 0037313063 scopus 로고    scopus 로고
    • 2-adrenoceptor agonist dexmedetomidine converges on an endogenous sleep-promoting pathway to exert its sedative effects
    • DOI 10.1097/00000542-200302000-00024
    • Nelson LE, Lu J, Guo T, et al. The alpha2-adrenoceptor agonist dexmedetomidine converges on an endogenous sleep-promoting pathway to exert its sedative effects. Anesthesiology 2003;98:428-36 (Pubitemid 36592812)
    • (2003) Anesthesiology , vol.98 , Issue.2 , pp. 428-436
    • Nelson, L.E.1    Lu, J.2    Guo, T.3    Saper, C.B.4    Franks, N.P.5    Maze, M.6
  • 11
    • 38149016800 scopus 로고    scopus 로고
    • Electroencephalogram spindle activity during dexmedetomidine sedation and physiological sleep
    • Huupponen E, Maksimow A, Lapinlampi P, et al. Electroencephalogram spindle activity during dexmedetomidine sedation and physiological sleep. Acta Anaesthesiol Scand 2008;52:289-94
    • (2008) Acta Anaesthesiol Scand , vol.52 , pp. 289-294
    • Huupponen, E.1    Maksimow, A.2    Lapinlampi, P.3
  • 12
    • 70450159841 scopus 로고    scopus 로고
    • Effects of dexmedetomidine sedation on the EEG in children
    • Mason KP, OMahony E, Zurakowski D, et al. Effects of dexmedetomidine sedation on the EEG in children. Pediatr Anesth 2009;19:1175-83
    • (2009) Pediatr Anesth , vol.19 , pp. 1175-1183
    • Mason, K.P.1    Omahony, E.2    Zurakowski, D.3
  • 13
    • 0030609171 scopus 로고    scopus 로고
    • Assessment of the role of alpha2-adrenoceptor subtypes in the antinociceptive, sedative and hypothermic action of dexmedetomidine in transgenic mice
    • Hunter JC, Fontana DJ, Hedley LR, et al. Assessment of the role of alpha2-adrenoceptor subtypes in the antinociceptive, sedative and hypothermic action of dexmedetomidine in transgenic mice. Br J Pharmacol 1997;122:1339-44
    • (1997) Br J Pharmacol , vol.122 , pp. 1339-1344
    • Hunter, J.C.1    Fontana, D.J.2    Hedley, L.R.3
  • 15
    • 0030611098 scopus 로고    scopus 로고
    • The alpha2a adrenergic receptor subtype mediates spinal analgesia evoked by alpha2 agonists and is necessary for spinal adrenergic-opioid synergy
    • Stone LS, MacMillan LB, Kitto KF, et al. The alpha2a adrenergic receptor subtype mediates spinal analgesia evoked by alpha2 agonists and is necessary for spinal adrenergic-opioid synergy. J Neurosci 1997;17:7157-65
    • (1997) J Neurosci , vol.17 , pp. 7157-7165
    • Stone, L.S.1    MacMillan, L.B.2    Kitto, K.F.3
  • 16
    • 0021966740 scopus 로고
    • Pharmacology of spinal adrenergic systems which modulate spinal nociceptive processing
    • Yaksh TL. Pharmacology of spinal adrenergic systems which modulate spinal nociceptive processing. Pharmacol Biochem Behav 1985;22:845-58
    • (1985) Pharmacol Biochem Behav , vol.22 , pp. 845-858
    • Yaksh, T.L.1
  • 19
    • 0029777474 scopus 로고    scopus 로고
    • Central hypotensive effects of the α(2a)-adrenergic receptor subtype
    • MacMillan LB, Hein L, Smith MS, et al. Central hypotensive effects of the alpha2a-adrenergic receptor subtype. Science 1996;273:801-3 (Pubitemid 26271526)
    • (1996) Science , vol.273 , Issue.5276 , pp. 801-803
    • MacMillan, L.B.1    Hein, L.2    Smith, M.S.3    Piascik, M.T.4    Limbird, L.E.5
  • 20
    • 77951729054 scopus 로고    scopus 로고
    • Population pharmacokinetics of dexmedetomidine in infants after open heart surgery
    • Su F, Nicolson SC, Gastonguay MR, et al. Population pharmacokinetics of dexmedetomidine in infants after open heart surgery. Anesth Analg 2010;110:1383-92
    • Anesth Analg , vol.2010 , Issue.110 , pp. 1383-1392
    • Su, F.1    Nicolson, S.C.2    Gastonguay, M.R.3
  • 21
    • 65749093661 scopus 로고    scopus 로고
    • Prolonged use of dexmedetomidine in the paediatric cardiothoracic intensive care unit
    • Bejian S, Valasek C, Nigro JJ, et al. Prolonged use of dexmedetomidine in the paediatric cardiothoracic intensive care unit. Cardiol Young 2009;19:98-104
    • (2009) Cardiol Young , vol.19 , pp. 98-104
    • Bejian, S.1    Valasek, C.2    Nigro, J.J.3
  • 22
    • 70349742451 scopus 로고    scopus 로고
    • Results of a pilot study on the effects of propofol and dexmedetomidine on inflammatory responses and intraabdominal pressure in severe sepsis
    • Tasdogan M, Memis D, Sut N, Yuksel M. Results of a pilot study on the effects of propofol and dexmedetomidine on inflammatory responses and intraabdominal pressure in severe sepsis. J Clin Anesth 2009;21:394-400
    • (2009) J Clin Anesth , vol.21 , pp. 394-400
    • Tasdogan, M.1    Memis, D.2    Sut, N.3    Yuksel, M.4
  • 23
    • 0035030213 scopus 로고    scopus 로고
    • Effects of dexmedetomidine on adrenocortical function, and the cardiovascular, endocrine and inflammatory responses in post-operative patients needing sedation in the intensive care unit
    • DOI 10.1093/bja/86.5.650
    • Venn RM, Bryant A, Hall GM, Grounds RM. Effects of dexmedetomidine on adrenocortical function, and the cardiovascular, endocrine and inflammatory responses in post-operative patients needing sedation in the intensive care unit. Br J Anaesth 2001;86:650-6 (Pubitemid 32409406)
    • (2001) British Journal of Anaesthesia , vol.86 , Issue.5 , pp. 650-656
    • Venn, R.M.1    Bryant, A.2    Hall, G.M.3    Grounds, R.M.4
  • 24
    • 0030609171 scopus 로고    scopus 로고
    • Assessment of the role of alpha2-adrenoceptor subtypes in the antinociceptive, sedative and hypothermic action of dexmedetomidine in transgenic mice
    • Hunter JC, Fontana DJ, Hedley LR, et al. Assessment of the role of alpha2-adrenoceptor subtypes in the antinociceptive, sedative and hypothermic action of dexmedetomidine in transgenic mice. Br J Pharmacol 1997;122:1339-44
    • (1997) Br J Pharmacol , vol.122 , pp. 1339-1344
    • Hunter, J.C.1    Fontana, D.J.2    Hedley, L.R.3
  • 25
    • 0034087475 scopus 로고    scopus 로고
    • In vivo gene modification elucidates subtype-specific functions of alpha2-adrenergic receptors
    • Kable JW, Murrin LC, Bylund DB. In vivo gene modification elucidates subtype-specific functions of alpha2-adrenergic receptors. J Pharmacol Exp Ther 2000;293:1-7
    • (2000) J Pharmacol Exp Ther , vol.293 , pp. 1-7
    • Kable, J.W.1    Murrin, L.C.2    Bylund, D.B.3
  • 26
    • 0033742791 scopus 로고    scopus 로고
    • Pharmacokinetics and interaction pharmacodynamics of dexmedetomidine in humans
    • Karol MD. Pharmacokinetics and interaction pharmacodynamics of dexmedetomidine in humans. Best Pract Res Clin Anaesthesiol 2000;14:261-9
    • (2000) Best Pract Res Clin Anaesthesiol , vol.14 , pp. 261-269
    • Karol, M.D.1
  • 27
    • 0001657955 scopus 로고    scopus 로고
    • Pharmacokinetics of dexmedetomidine in patients with hepatic failure [abstract]
    • Cunningham FE, Baughman VL, Tonkovich L, et al. Pharmacokinetics of dexmedetomidine in patients with hepatic failure [abstract]. Clin Pharmacol Ther 1999;65:128
    • (1999) Clin Pharmacol Ther , vol.65 , pp. 128
    • Cunningham, F.E.1    Baughman, V.L.2    Tonkovich, L.3
  • 29
    • 33751312459 scopus 로고    scopus 로고
    • A phase I, two-center study of the pharmacokinetics and pharmacodynamics of dexmedetomidine in children
    • DOI 10.1097/00000542-200612000-00009, PII 0000054220061200000009
    • Petroz GC, Sikich N, James M, et al. A phase I, two-center study of the pharmacokinetics and pharmacodynamics of dexmedetomidine in children. Anesthesiology 2006;105:1098-110 (Pubitemid 44808573)
    • (2006) Anesthesiology , vol.105 , Issue.6 , pp. 1098-1110
    • Petroz, G.C.1    Sikich, N.2    James, M.3    Van Dyk, H.4    Shafer, S.L.5    Schily, M.6    Lerman, J.7
  • 30
    • 34548670030 scopus 로고    scopus 로고
    • Pharmacokinetics of dexmedetomidine in postsurgical pediatric intensive care unit patients: Preliminary study
    • DOI 10.1097/01.PCC.0000282046.66773.39, PII 0013047820070900000001
    • Diaz SM, Rodarte A, Foley J, Capparelli EV. Pharmacokinetics of dexmedetomidine in postsurgical pediatric intensive care unit patients: preliminary study. Pediatr Crit Care Med 2007;8:419-24 (Pubitemid 47415293)
    • (2007) Pediatric Critical Care Medicine , vol.8 , Issue.5 , pp. 419-424
    • Diaz, S.M.1    Rodarte, A.2    Foley, J.3    Capparelli, E.V.4
  • 31
    • 47349104647 scopus 로고    scopus 로고
    • Dexmedetomidine disposition in children: A population analysis
    • Potts AL, Warman GR, Anderson BJ. Dexmedetomidine disposition in children: a population analysis. Pediatr Anesth 2008;18:722-30
    • (2008) Pediatr Anesth , vol.18 , pp. 722-730
    • Potts, A.L.1    Warman, G.R.2    Anderson, B.J.3
  • 33
    • 70350552006 scopus 로고    scopus 로고
    • Dexmedetomidine pharmacokinetics in pediatric intensive care - a pooled analysis
    • Potts AL, Anderson BJ, Warman GR, et al. Dexmedetomidine pharmacokinetics in pediatric intensive care - a pooled analysis. Pediatr Anesth 2009;19:1119-29
    • (2009) Pediatr Anesth , vol.19 , pp. 1119-1129
    • Potts, A.L.1    Anderson, B.J.2    Warman, G.R.3
  • 34
    • 2442584848 scopus 로고    scopus 로고
    • Sedation during mechanical ventilation in infants and children: Dexmedetomidine versus midazolam
    • Tobias JD, Berkenbosch JW. Sedation during mechanical ventilation in infants and children: dexmedetomidine versus midazolam. South Med J 2004;97:451-5
    • (2004) South Med J , vol.97 , pp. 451-455
    • Tobias, J.D.1    Berkenbosch, J.W.2
  • 35
    • 75149143531 scopus 로고    scopus 로고
    • Dexmedetomidine sedation in children after cardiac surgery
    • Hosokawa K, Shime N, Kato Y, et al. Dexmedetomidine sedation in children after cardiac surgery. Pediatr Crit Care Med 2010;11:39-43
    • Pediatr Crit Care Med , vol.2010 , Issue.11 , pp. 39-43
    • Hosokawa, K.1    Shime, N.2    Kato, Y.3
  • 36
    • 68849097671 scopus 로고    scopus 로고
    • The use of dexmedetomidine in critically ill children
    • Czaja AS, Zimmerman JJ. The use of dexmedetomidine in critically ill children. Pediatr Crit Care Med 2009;10:381-6
    • (2009) Pediatr Crit Care Med , vol.10 , pp. 381-386
    • Czaja, A.S.1    Zimmerman, J.J.2
  • 38
    • 33645553849 scopus 로고    scopus 로고
    • Use of dexmedetomidine in children after cardiac and thoracic surgery
    • Chrysostomou C, Di Filippo S, Manrique AM, et al. Use of dexmedetomidine in children after cardiac and thoracic surgery. Pediatr Crit Care Med 2006;7:126-31
    • (2006) Pediatr Crit Care Med , vol.7 , pp. 126-131
    • Chrysostomou, C.1    Di Filippo, S.2    Manrique, A.M.3
  • 40
    • 70349591446 scopus 로고    scopus 로고
    • Prolonged dexmedetomidine infusions in critically ill infants and children
    • Reiter PD, Pietras M, Dobyns EL. Prolonged dexmedetomidine infusions in critically ill infants and children. Indian Pediatr 2009;46:767-73
    • (2009) Indian Pediatr , vol.46 , pp. 767-773
    • Reiter, P.D.1    Pietras, M.2    Dobyns, E.L.3
  • 42
    • 19944386258 scopus 로고    scopus 로고
    • Sedative, haemodynamic and respiratory effects of dexmedetomidine in children undergoing magnetic resonance imaging examination: Preliminary results
    • DOI 10.1093/bja/aei119
    • Koroglu A, Demirbilek S, Teksan H, et al. Sedative haemodynamic and respiratory effects of dexmedetomidine in children undergoing magnetic resonance imaging examination: preliminary results. Br J Anaesth 2005;94:821-4 (Pubitemid 40754000)
    • (2005) British Journal of Anaesthesia , vol.94 , Issue.6 , pp. 821-824
    • Koroglu, A.1    Demirbilek, S.2    Teksan, H.3    Sagir, O.4    But, A.K.5    Ersoy, M.O.6
  • 43
    • 33745820883 scopus 로고    scopus 로고
    • A comparison of the sedative, hemodynamic, and respiratory effects of dexmedetomidine and propofol in children undergoing magnetic resonance imaging
    • DOI 10.1213/01.ANE.0000219592.82598.AA
    • Koroglu A, Teksan H, Sagir O, et al. A comparison of the sedative hemodynamic and respiratory effects of dexmedetomidine and propofol in children undergoing magnetic resonance imaging. Anesth Analg 2006;103:63-7 (Pubitemid 44036032)
    • (2006) Anesthesia and Analgesia , vol.103 , Issue.1 , pp. 63-67
    • Koroglu, A.1    Teksan, H.2    Sagir, O.3    Yucel, A.4    Toprak, H.I.5    Ersoy, O.M.6
  • 44
    • 58149295459 scopus 로고    scopus 로고
    • A comparison of dexmedetomidine-midazolam with propofol for maintenance of anesthesia in children undergoing magnetic resonance imaging
    • Heard C, Burrows F, Johnson K, et al. A comparison of dexmedetomidine-midazolam with propofol for maintenance of anesthesia in children undergoing magnetic resonance imaging. Anesth Analg 2008;107:1832-9
    • (2008) Anesth Analg , vol.107 , pp. 1832-1839
    • Heard, C.1    Burrows, F.2    Johnson, K.3
  • 45
    • 22144448567 scopus 로고    scopus 로고
    • Prospective evaluation of dexmedetomidine for noninvasive procedural sedation in children
    • Berkenbosch JW, Wankum PC, Tobias JD. Prospective evaluation of dexmedetomidine for noninvasive procedural sedation in children. Pediatr Crit Care Med 2005;6:435-9
    • (2005) Pediatr Crit Care Med , vol.6 , pp. 435-439
    • Berkenbosch, J.W.1    Wankum, P.C.2    Tobias, J.D.3
  • 46
    • 67649643517 scopus 로고    scopus 로고
    • Dexmedetomidine for procedural sedation in children with autism and other behavior disorders
    • Lubisch N, Roskos R, Berkenbosch JW. Dexmedetomidine for procedural sedation in children with autism and other behavior disorders. Pediatr Neurol 2009;41:88-94
    • (2009) Pediatr Neurol , vol.41 , pp. 88-94
    • Lubisch, N.1    Roskos, R.2    Berkenbosch, J.W.3
  • 47
    • 70149085027 scopus 로고    scopus 로고
    • A comparison of dexmedetomidine with propofol for magnetic resonance imaging sleep studies in children
    • Mahmoud M, Gunter J, Donnelly LF, et al. A comparison of dexmedetomidine with propofol for magnetic resonance imaging sleep studies in children. Anesth Analg 2009;109:745-53
    • (2009) Anesth Analg , vol.109 , pp. 745-753
    • Mahmoud, M.1    Gunter, J.2    Donnelly, L.F.3
  • 51
    • 50149097286 scopus 로고    scopus 로고
    • Dexmedetomidine for sedation during electroencephalographic analysis in children with autism pervasive developmental disorders and seizure disorders
    • Ray T, Tobias JD. Dexmedetomidine for sedation during electroencephalographic analysis in children with autism pervasive developmental disorders and seizure disorders. J Clin Anesth 2008;20:364-8
    • (2008) J Clin Anesth , vol.20 , pp. 364-368
    • Ray, T.1    Tobias, J.D.2
  • 52
    • 33746375052 scopus 로고    scopus 로고
    • Dexmedetomidine-Ketamine and Propofol-Ketamine Combinations for Anesthesia in Spontaneously Breathing Pediatric Patients Undergoing Cardiac Catheterization
    • DOI 10.1053/j.jvca.2005.07.018, PII S1053077005002946
    • Tosun Z, Akin A, Guler G, et al. Dexmedetomidine-ketamine and propofol-ketamine combinations for anesthesia in spontaneously breathing pediatric patients undergoing cardiac catheterization. J Cardiothorac Vasc Anesth 2006;20:515-19 (Pubitemid 44119260)
    • (2006) Journal of Cardiothoracic and Vascular Anesthesia , vol.20 , Issue.4 , pp. 515-519
    • Tosun, Z.1    Akin, A.2    Guler, G.3    Esmaoglu, A.4    Boyaci, A.5
  • 53
    • 33846130582 scopus 로고    scopus 로고
    • Initial experience with dexmedetomidine for diagnostic and interventional cardiac catheterization in children
    • Munro HM, Tirotta CF, Felix DE, et al. Initial experience with dexmedetomidine for diagnostic and interventional cardiac catheterization in children. Pediatr Anesth 2007;17:109-12
    • (2007) Pediatr Anesth , vol.17 , pp. 109-112
    • Munro, H.M.1    Tirotta, C.F.2    Felix, D.E.3
  • 54
    • 58849122266 scopus 로고    scopus 로고
    • Determination of the pharmacodynamic interaction of propofol and dexmedetomidine during esophagogastroduodenoscopy in children
    • Hammer GB, Sam WJ, Chen MI, et al. Determination of the pharmacodynamic interaction of propofol and dexmedetomidine during esophagogastroduodenoscopy in children. Pediatr Anesth 2009;19:138-44
    • (2009) Pediatr Anesth , vol.19 , pp. 138-144
    • Hammer, G.B.1    Sam, W.J.2    Chen, M.I.3
  • 55
    • 67649662245 scopus 로고    scopus 로고
    • The effects of dexmedetomidine and fentanyl on emergence characteristics after adenoidectomy in children
    • Erdil F, Demirbilek S, Begec Z, et al. The effects of dexmedetomidine and fentanyl on emergence characteristics after adenoidectomy in children. Anaesth Intensive Care 2009;37:571-6
    • (2009) Anaesth Intensive Care , vol.37 , pp. 571-576
    • Erdil, F.1    Demirbilek, S.2    Begec, Z.3
  • 56
    • 28044471360 scopus 로고    scopus 로고
    • Single-dose dexmedetomidine reduces agitation and provides smooth extubation after pediatric adenotonsillectomy
    • DOI 10.1111/j.1460-9592.2004.01541.x
    • Guler G, Akin A, Tosun Z, et al. Single-dose dexmedetomidine reduces agitation and provides smooth extubation after pediatric adenotonsillectomy. Pediatr Anesth 2005;15:762-6 (Pubitemid 43960893)
    • (2005) Paediatric Anaesthesia , vol.15 , Issue.9 , pp. 762-766
    • Guler, G.1    Akin, A.2    Tosun, Z.3    Ors, S.4    Esmaoglu, A.5    Boyaci, A.6
  • 57
    • 0347363666 scopus 로고    scopus 로고
    • Single-Dose Dexmedetomidine Reduces Agitation after Sevoflurane Anesthesia in Children
    • Ibacache ME, Munoz HR, Brandes V, Morales AL. Single-dose dexmedetomidine reduces agitation after sevoflurane anesthesia in children. Anesth Analg 2004;98:60-3 (Pubitemid 38029843)
    • (2004) Anesthesia and Analgesia , vol.98 , Issue.1 , pp. 60-63
    • Ibacache, M.E.1    Munoz, H.R.2    Brandes, V.3    Morales, A.L.4
  • 58
    • 33748341460 scopus 로고    scopus 로고
    • Dexmedetomidine decreases emergence agitation in pediatric patients after sevoflurane anesthesia without surgery
    • DOI 10.1111/j.1460-9592.2006.01845.x
    • Isik B, Arslan M, Tunga AD, Kurtipek O. Dexmedetomidine decreases emergence agitation in pediatric patients after sevoflurane anesthesia without surgery. Pediatr Anesth 2006;16:748-53 (Pubitemid 44365964)
    • (2006) Paediatric Anaesthesia , vol.16 , Issue.7 , pp. 748-753
    • Isik, B.1    Arslan, M.2    Tunga, A.D.3    Kurtipek, O.4
  • 60
    • 53349120526 scopus 로고    scopus 로고
    • Effects of dexmedetomidine on intraoperative motor and somatosensory evoked potential monitoring during spinal surgery in adolescents
    • Tobias JD, Goble TJ, Bates G, et al. Effects of dexmedetomidine on intraoperative motor and somatosensory evoked potential monitoring during spinal surgery in adolescents. Pediatr Anesth 2008;18:1082-8
    • (2008) Pediatr Anesth , vol.18 , pp. 1082-1088
    • Tobias, J.D.1    Goble, T.J.2    Bates, G.3
  • 61
    • 0037707400 scopus 로고    scopus 로고
    • Awake craniotomy with dexmedetomidine in pediatric patients
    • DOI 10.1097/00008506-200307000-00015
    • Ard J, Doyle W, Bekker A. Awake craniotomy with dexmedetomidine in pediatric patients. J Neurosurg Anesthesiol 2003;15:263-6 (Pubitemid 36807890)
    • (2003) Journal of Neurosurgical Anesthesiology , vol.15 , Issue.3 , pp. 263-266
    • Ard, J.1    Doyle, W.2    Bekker, A.3
  • 62
    • 33645325370 scopus 로고    scopus 로고
    • Use of dexmedetomidine in awake craniotomy in adolescents: Report of two cases
    • Everett LL, van Rooyen IF, Warner MH, et al. Use of dexmedetomidine in awake craniotomy in adolescents: report of two cases. Pediatr Anesth 2006;16:338-42
    • (2006) Pediatr Anesth , vol.16 , pp. 338-342
    • Everett, L.L.1    Van Rooyen, I.F.2    Warner, M.H.3
  • 63
    • 71649100529 scopus 로고    scopus 로고
    • Comparison of patient-controlled analgesia with and without dexmedetomidine following spine surgery in children
    • Sadhasivam S, Boat A, Mahmoud M. Comparison of patient-controlled analgesia with and without dexmedetomidine following spine surgery in children. J Clin Anesth 2009;21:493-501
    • (2009) J Clin Anesth , vol.21 , pp. 493-501
    • Sadhasivam, S.1    Boat, A.2    Mahmoud, M.3
  • 64
    • 33847632825 scopus 로고    scopus 로고
    • Dexmedetomidine for the treatment of postanesthesia shivering in children
    • Easley RB, Brady KM, Tobias JD. Dexmedetomidine for the treatment of postanesthesia shivering in children. Pediatr Anesth 2007;17:341-6
    • (2007) Pediatr Anesth , vol.17 , pp. 341-346
    • Easley, R.B.1    Brady, K.M.2    Tobias, J.D.3
  • 65
    • 56149094268 scopus 로고    scopus 로고
    • Dexmedetomidine: A novel drug for the treatment of atrial and junctional tachyarrhythmias during the perioperative period for congenital cardiac surgery: A preliminary study
    • Chrysostomou C, Beerman L, Shiderly D, et al. Dexmedetomidine: a novel drug for the treatment of atrial and junctional tachyarrhythmias during the perioperative period for congenital cardiac surgery: a preliminary study. Anesth Analg 2008;107:1514-22
    • (2008) Anesth Analg , vol.107 , pp. 1514-1522
    • Chrysostomou, C.1    Beerman, L.2    Shiderly, D.3
  • 66
    • 20644454903 scopus 로고    scopus 로고
    • Dexmedetomidine in the treatment of withdrawal syndromes in cardiothoracic surgery patients
    • DOI 10.1177/0885066604273481
    • Baddigam K, Russo P, Russo J, Tobias JD. Dexmedetomidine in the treatment of withdrawal syndromes in cardiothoracic surgery patients. J Intensive Care Med 2005;20:118-23 (Pubitemid 43093903)
    • (2005) Journal of Intensive Care Medicine , vol.20 , Issue.2 , pp. 118-123
    • Baddigam, K.1    Russo, P.2    Russo, J.3    Tobias, J.D.4
  • 67
    • 2442685706 scopus 로고    scopus 로고
    • The use of dexmedetomidine to facilitate opioid and benzodiazepine detoxification in an infant
    • Finkel JC, Elrefai A. The use of dexmedetomidine to facilitate opioid and benzodiazepine detoxification in an infant. Anesth Analg 2004;98:1658-9 (Pubitemid 38668910)
    • (2004) Anesthesia and Analgesia , vol.98 , Issue.6 , pp. 1658-1659
    • Finkel, J.C.1    Elrefai, A.2
  • 68
    • 24944552207 scopus 로고    scopus 로고
    • The use of dexmedetomidine to facilitate acute discontinuation of opioids after cardiac transplantation in children
    • Finkel JC, Johnson YJ, Quezado ZMN. The use of dexmedetomidine to facilitate acute discontinuation of opioids after cardiac transplantation in children. Crit Care Med 2005;33:2110-12
    • (2005) Crit Care Med , vol.33 , pp. 2110-2112
    • Finkel, J.C.1    Johnson, Y.J.2    Quezado, Z.M.N.3
  • 69
    • 0642335955 scopus 로고    scopus 로고
    • Additional Experience with Dexmedetomidine in Pediatric Patients
    • DOI 10.1097/01.SMJ.0000053557.75799.09
    • Tobias JD, Berkenbosch JW, Russo P. Additional experience with dexmedetomidine in pediatric patients. South Med J 2003;96:871-5 (Pubitemid 38279587)
    • (2003) Southern Medical Journal , vol.96 , Issue.9 , pp. 871-875
    • Tobias, J.D.1    Berkenbosch, J.W.2    Russo, P.3
  • 70
    • 33947209104 scopus 로고    scopus 로고
    • Dexmedetomidine to treat opioid withdrawal in infants following prolonged sedation in the pediatric ICU
    • Tobias JD. Dexmedetomidine to treat opioid withdrawal in infants following prolonged sedation in the pediatric ICU. J Opioid Manag 2006;2:201-5
    • (2006) J Opioid Manag , vol.2 , pp. 201-205
    • Tobias, J.D.1
  • 71
    • 78650480209 scopus 로고    scopus 로고
    • Hospira, Inc. Lake Forest, IL Available from [Last accessed 26 July 2010]
    • Precedex-(dexmedetomidine HCL injection) Product Label. Hospira, Inc. Lake Forest, IL 2008. Available from: www.precedex.com/safety/full-prescribing- information/[Last accessed 26 July 2010]
    • (2008) Precedex-(dexmedetomidine HCL Injection) Product Label
  • 73
    • 0032705173 scopus 로고    scopus 로고
    • Preliminary UK experience of dexmedetomidine a novel agent for postoperative sedation in the intensive care unit
    • Venn RM, Bradshaw CJ, Spencer R, et al. Preliminary UK experience of dexmedetomidine a novel agent for postoperative sedation in the intensive care unit. Anaesthesia 1999;54:1136-42
    • (1999) Anaesthesia , vol.54 , pp. 1136-1142
    • Venn, R.M.1    Bradshaw, C.J.2    Spencer, R.3
  • 74
    • 38549151951 scopus 로고    scopus 로고
    • Monitored anesthesia care with a combination of ketamine and dexmedetomidine during cardiac catheterization
    • DOI 10.1097/MJT.0b013e3180a72255, PII 0004539120080100000006
    • Mester R, Easley RB, Brady KM, et al. Monitored anesthesia care with a combination of ketamine and dexmedetomidine during cardiac catheterization. Am J Ther 2008;15:24-30 (Pubitemid 351161178)
    • (2008) American Journal of Therapeutics , vol.15 , Issue.1 , pp. 24-30
    • Mester, R.1    Easley, R.B.2    Brady, K.M.3    Chilson, K.4    Tobias, J.D.5
  • 75
    • 77950631996 scopus 로고    scopus 로고
    • Dexmedetomidine hemodynamics in children after cardiac surgery
    • Potts AL, Anderson BJ, Holford NHG, et al. Dexmedetomidine hemodynamics in children after cardiac surgery. Pediatr Anesth 2010;20:425-33
    • Pediatr Anesth , vol.2010 , Issue.20 , pp. 425-433
    • Potts, A.L.1    Anderson, B.J.2    Holford, N.H.G.3
  • 76
    • 37549071486 scopus 로고    scopus 로고
    • The effects of dexmedetomidine on cardiac electrophysiology in children
    • Hammer GB, Drover DR, Cao H, et al. The effects of dexmedetomidine on cardiac electrophysiology in children. Anesth Analg 2008;106:79-83
    • (2008) Anesth Analg , vol.106 , pp. 79-83
    • Hammer, G.B.1    Drover, D.R.2    Cao, H.3
  • 77
    • 77951204138 scopus 로고    scopus 로고
    • Electrocardiographic effects of dexmedetomidine in patients with congenital heart disease
    • Chrysostomou C, Komarlu R, Lichtenstein S, et al. Electrocardiographic effects of dexmedetomidine in patients with congenital heart disease. Intensive Care Med 2010;36:836-42
    • Intensive Care Med , vol.2010 , Issue.36 , pp. 836-842
    • Chrysostomou, C.1    Komarlu, R.2    Lichtenstein, S.3
  • 78
    • 68849118812 scopus 로고    scopus 로고
    • Dexmedetomidine sedation for pediatric post-Fontan procedure patients
    • Tokuhira N, Atagi K, Shimaoka H, et al. Dexmedetomidine sedation for pediatric post-Fontan procedure patients. Pediatr Crit Care Med 2009;10:207-12
    • (2009) Pediatr Crit Care Med , vol.10 , pp. 207-212
    • Tokuhira, N.1    Atagi, K.2    Shimaoka, H.3
  • 79
    • 65349184527 scopus 로고    scopus 로고
    • Postoperative intensive care unit drug fever caused by dexmedetomidine
    • Okabe T, Takeda S, Akada S, et al. Postoperative intensive care unit drug fever caused by dexmedetomidine. Anesth Analg 2009;108:1589-91
    • (2009) Anesth Analg , vol.108 , pp. 1589-1591
    • Okabe, T.1    Takeda, S.2    Akada, S.3
  • 80
    • 33745834806 scopus 로고    scopus 로고
    • Short duration large dose dexmedetomidine in a pediatric patient during procedural sedation
    • Rosen DA, Daume JT. Short duration large dose dexmedetomidine in a pediatric patient during procedural sedation. Anesth Analg 2006;103:68-9
    • (2006) Anesth Analg , vol.103 , pp. 68-69
    • Rosen, D.A.1    Daume, J.T.2
  • 82
    • 77957577533 scopus 로고    scopus 로고
    • Effect of dexmedetomidine on pulmonary artery pressure after congenital cardiac surgery: A pilot study
    • Lazol JP, Lichtenstein SE, Jooste EH, et al. Effect of dexmedetomidine on pulmonary artery pressure after congenital cardiac surgery: a pilot study. Pediatr Crit Care Med 2010;11:1-4
    • Pediatr Crit Care Med , vol.2010 , Issue.11 , pp. 1-4
    • Lazol, J.P.1    Lichtenstein, S.E.2    Jooste, E.H.3
  • 83
    • 70449500266 scopus 로고    scopus 로고
    • Successful use of dexmedetomidine for sedation in a 24-week gestational age neonate
    • OMara K, Gal P, Ransommd JL, et al. Successful use of dexmedetomidine for sedation in a 24-week gestational age neonate. Ann Pharmacother 2009;43:1707-13
    • (2009) Ann Pharmacother , vol.43 , pp. 1707-1713
    • Omara, K.1    Gal, P.2    Ransommd, J.L.3


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