Activation of alpha-2 adrenergic receptors inhibits norepinephrine release by a pertussis toxin-insensitive pathway independent of changes in cytosolic calcium in cultured rat sympathetic neurons

Journal of Pharmacology and Experimental Therapeutics

Volumn 282, Issue 1, 1997, Pages 248-255

  Schwartz, Dean D ^a  

^a AUBURN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 2 ADRENERGIC RECEPTOR; ALPHA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; BRIMONIDINE; CALCIUM CHANNEL; CALCIUM ION; IDAZOXAN; NORADRENALIN; OMEGA CONOTOXIN GVIA; OXYMETAZOLINE; PERTUSSIS TOXIN;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CONTROLLED STUDY; ELECTROSTIMULATION; NERVE POTENTIAL; NONHUMAN; NORADRENALIN RELEASE; PRIORITY JOURNAL; PROTEIN FAMILY; RAT; SUPERIOR CERVICAL GANGLION; SYMPATHETIC NERVE CELL;

ADRENERGIC ALPHA-AGONISTS; ANIMALS; CALCIUM; CELLS, CULTURED; CYCLIC AMP; NOREPINEPHRINE; OMEGA-CONOTOXIN GVIA; PEPTIDES; PERTUSSIS TOXIN; QUINOXALINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ADRENERGIC, ALPHA-2; SUPERIOR CERVICAL GANGLION; VIRULENCE FACTORS, BORDETELLA;

EID: 0030855907     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (42)

1. AGHAJANIAN, G. K. AND WANG, Y.-Y.: Pertussis toxin blocks the outward currents evoked by opiate and alpha-2-agonists in locus coeruleus neurons. Brain Res. 371: 390-394, 1986.
2. ALLGAIER, C., FEUERSTEIN, T. J., JACKISCH, R. AND HERTTING, G.: Islet-activating protein (pertussis toxin) diminishes alpha-2-adrenoceptor mediated effects on noradrenaline release. Naunyn-Schmiedeberg's Arch. Pharmacol. 331: 235-239, 1985.
3. AUGUSTINE, G. J., ADLER, E. M., CHARLTON, M. P. HANS, M., SWANDULLA, D. AND ZIPSER, Z.: Presynaptic calcium signals during neurotransmitter release: Detection with fluorescent indicators and other calcium chelators. J. Physiol. 86: 129-134, 1992.
4. BEECH, D. J., BERNHEIM, L. AND HILLE, B.: Pertussis toxin and voltage dependence distinguish multiple pathways modulating calcium channels of rat sympathetic neurons. Neuron 8: 97-106, 1992.
5. 3H-norepinephrine release by norepinephrine in cultured sympathetic neurons. Ann. NY Acad. Sci. 609: 188-196, 1990.
6. BIRNBAUMER, L., AERAMOWITZ, J. AND BROWN, A. M.: Receptor-effector coupling by G proteins. Biochim. Biophys. Acta 1031: 163-224, 1990.
7. BOEHM, D. J., HUCK, S., DROBNEY, H. AND SINGER, E. A.: Electrically evoked noradrenaline release from cultured chick sympathetic neurons: modulation via alpha-2-adrenoceptors and lack of autoinhibition. Naunyn-Schmiedeberg's Arch. Pharmacol. 344: 130-132, 1991.
8. 2+ currents and of noradrenaline via alpha-2-adrenoceptors in chick sympathetic neurons. Naunyn-Schmiedeberg's Arch. Pharmacol. 345: 606-609, 1992.
9. 2-adrenergic agonists. Life Sci. 33: 2627-2633, 1983.
10. CABLE, H. C., EL-MANSOURY, A. AND MORGAN, N. G.: Activation of alpha-2-adrenoceptors results in an increase in F-actin formation in HIT-T15 pancreatic B-cells. Biochem. J. 307: 169-174, 1995.
11. DOCHERTY, J. R.: Pertussis toxin and pre-junctional alpha-2-adrenoceptors in rat heart and vas deferens. J. Auto. Pharmacol. 8: 197-201, 1988.
12. DOCHERTY, J. R.: No effect of pertussis toxin on peripheral prejunctional alpha-2-adrenoceptor-mediated responses and on endothelium-dependent relaxations in the rat. Br. J. Pharmacol. 100: 348-352, 1990.
13. DOLEZAL, V., HELDT, R. AND HERTTING, G.: Presynaptic alpha-2 adrenoceptors inhibit calcium influx in terminals of chicken sympathetic neurons and noradrenaline release evoked by nicotinic stimulation. Neurosci. Lett. 180: 63-66, 1994.
14. GILON, P., SHEPERD, R. M. AND HENQUIN, J. C.: Oscillations of secretion driven by oscillations of cytoplasmic calcium as evidenced in single pancreatic islets. J. Biol. Chem 268: 22265-22268, 1993.
15. 2+ indicators with greatly improved fluorescence properties. J. Biol. Chem. 260: 3440-3450, 1985.
16. HILL, C. E., POWIS, D. A. AND HENDRY, I. A.: Involvement of pertussis toxin-sensitive and insensitive mechanisms in α-adrenoceptor modulation of noradrenaline release from rat sympathetic neurons in tissue culture. Br. J. Pharmacol. 110: 503-508, 1993.
17. 2+ channels in evoked release of norepinephrine from sympathetic neurons. Science 239: 57-61, 1988.
18. 2-adrenergic receptors decreases calcium influx to inhibit insulin secretion in a hamster beta-cell line: An action mediated by a guanosine triphosphate-binding protein. Endocrinology 128: 958-964, 1991.
19. IKEDA, S. R.: Double-pulse calcium channels current facilitation in adult rat sympathetic neurons. J. Physiol. 439: 181-214, 1991.
20. KATZ, B.: The Release of Neurotransmitter Substances, Liverpool University Press, Liverpool, England, 1969.
21. α subunits. EMBO J. 14: 3635-3644, 1995.
22. LIPSCOMBE, D., KONGSAMUT, S. AND TSEIN, R. W.: Alpha-adrenergic inhibition of sympathetic neurotransmitter release mediated by modulation of N-type calcium channel gating. Nature 340: 639-542, 1989.
23. 0, antagonize noradrenaline-induced calcium current inhibition in NG108-15 hybrid cells. Neuron 3: 177-182, 1989.
24. MURPHY, T. V. AND MAJEWSKI, H.: Modulation of noradrenaline release in slices of rat kidney cortex through alpha-1-and alpha-2-adrenoreceptors. Eur. J. Pharmacol. 169: 285-295, 1989.
25. 2-adrenoceptor-mediated inhibition of noradrenaline release in mouse atria. Naunyn-Schmiedeberg's Arch. Pharmacol 336: 280-286, 1987.
26. 0, in the mechanism of exocytosis in adrenal chromaffin cells. J. Neurochem. 68: 2275-2284, 1992.
27. PLUMMER, M. R., RITTENHOUSE, A., KANEVSKY, M. AND HESS, P.: Neurotransmitter modulation of calcium channels in rat sympathetic neurons. J. Neurosci. 11: 2339-2348, 1991.
28. 3H]noradrenaline release in chick sympathetic neurons. J. Physiol. 437: 201-220, 1991.
29. 2+ in cultured sympathetic neurons. Neuroscience 52: 973-986, 1993a.
30. i and transmitter release in sympathetic neurons. Eur. J. Pharmacol. Mol. Pharmacol. Sect. 247: 353-356, 1993b.
31. SCHOFIELD, G. G.: Norepinephrine blocks a calcium current of adult rat sympathetic neurons via an alpha-2-adrenoceptor. Eur. J. Pharmacol. 180: 37-47, 1990.
32. 2+ current in rat sympathetic neurons via a G-protein. Eur. J. Pharmacol. 207: 195-207, 1991.
33. SCHWARTZ, D. D. AND MALIK, K. U.: Mechanism of action of neurotransmitter release elicited by the preferential alpha-1 adrenergic receptor agonist phenylephrine in superfused superior cervical ganglion cells in culture. J. Neurochem. 57: 831-838, 1991.
34. SCHWARTZ, D. D. AND MALIK, K. U.: Angiotensin II - alpha-2 adrenergic receptor cross signaling in cultured sympathetic nerves. FASEB J. 7: A183, 1993a.
35. 3H]norepinephrine release by activation of alpha-2 adrenergic receptors in cultured rat ganglion cells. Neuroscience 52: 107-113, 1993b.
36. SONG, S.-Y., SAITO, K., NOGUCHI, K. AND KONISHI, S.: Different GTP-binding proteins mediate regulation of calcium channels by acetylcholine and noradrenaline in rat sympathetic neurons. Brain Res. 494: 383-386, 1989.
37. 2+ channels mediated by different GTP-binding proteins in rat sympathetic neurons. Pflugers Arch. 418: 592-600, 1991.
38. SONTAG, J.-M., THIERSE, D., ROUOT, B., AUNIS, D. AND BADER, M.-F.: A pertussistoxin-sensitive protein controls exocytosis in chromaffin cells at a step distal to the generation of second messengers. Biochem. J. 274: 339-347, 1991.
39. TRIFARO, J.-M. AND VITALE, M. L.: Cytoskeleton dynamics during neurotransmitter release. Trends Neurol. Sci. 16: 466-471, 1993.
40. UI, M.: The multiple biological activities of pertussis toxin. In Pathogenesis and Immunity in Pertussis, ed. by A. C. Wardlaw and R. Parton, pp. 121-145, John Wiley and Sons Ltd., New York, 1988.
41. VITALE, M. L., DELCASTILLO, A. R. AND TRIFARO, J. M.: Protein kinase C activation by phorbol essters induced chromaffin cell cortical filamentous actin disassembly and increases the initial rate of exocytosis in response to nicotinic receptor stimulation. Neuroscience 51: 463-474, 1992.
42. WOLLHEIM, C. B. AND SHARP, G. W.: Regulation of insulin release by calcium. Physiol. Rev. 61: 914-973, 1981.