Sedative, haemodynamic and respiratory effects of dexmedetomidine in children undergoing magnetic resonance imaging examination: Preliminary results

British Journal of Anaesthesia

Volumn 94, Issue 6, 2005, Pages 821-824

  Koroglu, A ^a   Demirbilek, S ^a   Teksan, H ^a   Sagir, O ^a   But, A K ^a   Ersoy, M O ^a  

^a INONU UNIVERSITY   (Turkey)

Author keywords

Brain, magnetic resonance imaging; Sedation, paediatrics; Sedative, dexmedetomidine

Indexed keywords

DEXMEDETOMIDINE; EMLA; MIDAZOLAM; MIDAZOLAM MALEATE;

ARTERIAL OXYGEN SATURATION; ARTICLE; BREATHING RATE; CHILD; CLINICAL TRIAL; CONTINUOUS INFUSION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG DOSE REGIMEN; DRUG MECHANISM; FEMALE; HEART RATE; HEMODYNAMIC MONITORING; HUMAN; IMAGE QUALITY; MAJOR CLINICAL STUDY; MALE; MEAN ARTERIAL PRESSURE; NUCLEAR MAGNETIC RESONANCE IMAGING; PATIENT MONITORING; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RESPIRATORY FUNCTION; SEDATION;

EID: 19944386258     PISSN: 00070912     EISSN: None     Source Type: Journal    
DOI: 10.1093/bja/aei119     Document Type: Article

References (26)

1. Lawson GR. Sedation of children for magnetic resonance imaging. Arch Dis Child 2000; 82: 150-2
2. Hasan RA, Shayevitz JR, Patel V. Deep sedation with propofol for children undergoing ambulatory magnetic resonance imaging of the brain: experience from a pediatric intensive care unit. Pediatr Crit Care Med. 2003; 4: 454-8
3. Malviya S, Voepel LT, Eldevik OP et al. Sedation and general anaesthesia in children undergoing MRI and CT: adverse events and outcomes. Br J Anaesth 2000; 84: 743-8
4. Bhana KNL, McClellan GJ, McClellan KJ. Dexmedetomidine. Drugs 2000; 59: 263-8
5. Shelly MP. Dexmedetomidine: a real innovation or more of the same? Br J Anaesth 2001; 87: 677-8
6. Nelson LE, Lu J, Guo T et al. The alpha2-adrenoceptor agonist dexmedetomidine converges on an endogenous sleep-promoting pathway to exert its sedative effects. Anesthesiology 2003; 98: 428-36
7. Hall JE, Uhrich TD, Barney JA et al. Sedative, amnestic and analgesic properties of small-dose dexmedetomidine infusions. Anesth Analg 2000; 90: 699-705
8. Venn M, Newman J, Grounds M. A phase II study to evaluate the efficacy of dexmedetomidine for sedation in the medical intensive care unit. Intensive Care Med 2003; 29: 201-7
9. Venn RM, Bradshaw CJ, Spencer R et al. Preliminary UK experience of dexmedetomidine, a novel agent for postoperative sedation in the intensive care unit. Anaesthesia 1999; 54: 1136-42
10. Ard J, Doyle W, Bekker A. Awake craniotomy with dexmedetomidine in pediatric patients. J Neurosurg Anesthesiol 2003; 15: 263-6
11. Tobias JD, Berkenbosch JW. Initial experience with dexmedetomidine in paediatric-aged patients. Paediatr Anaesth 2002; 12: 171-5
12. Tobias JD, Berkenbosch JW, Russo P. Additional experience with dexmedetomidine in pediatric patients. South Med J 2003; 96: 871-5
13. Schulte-Tamburen AM, Scheier J, Briegel J et al. Comparison of five sedation scoring systems by means of auditory evoked potentials. Intensive Care Med 1999; 25: 377-82
14. Voepel LT, Malviya S, Prochaska G, Tait RA. Sedation failures in children undergoing MRI and CT: is temperament a factor? Paediatr Anaesth 2000; 10: 319-23
15. Triltsch AE, Welte M, Von Homeyer P et al. Bispectral indexguided sedation with dexmedetomidine in intensive care: randomized, double blind, placebo-controlled phase II study. Crit Care Med 2002; 30: 1007-14
16. Dutta S, Karol MD, Cohen T et al. Effect of dexmedetomidine on propofol requirements in healthy subjects. J. Pharmacol Sci 2001; 90: 172-81
17. Rosen DA, Rosen KR. Intravenous conscious sedation with midazolam in pediatric patients. Int J Clin Pract 1998; 52: 46-50
18. Keengwe IN, Hegde S, Dearlove O, Wilson B, Yates RW, Sharples A. Structured sedation programme for magnetic resonance imaging examination in children. Anaesthesia 1999; 54: 1069-72
19. Arian SR, Ebert TJ. The efficacy, side effects, and recovery characteristics of dexmedetomidine versus propofol when used for intraoperative sedation. Anesth Analg 2002; 95: 461-6
20. Ebert TJ, Hall JE, Barney JA et al. The effects of increasing plasma concentrations of dexmedetomidine in humans. Anesthesiology 2000; 93: 382-94
21. Venn RM, Karol MD, Grounds RM. Pharmacokinetics of dexmedetomidine infusions for sedation of postoperative patients requiring intensive care. Br J Anaesth 2002; 88: 669-75
22. Kallio A, Scheinin M, Koulu M et al. Effects of dexmedetomidine, a selective alpha2-adrenoceptor agonist, on hemodynamic control mechanisms. Clin Pharmacol Ther 1989; 49: 33-42
23. Venn RM, Hell J, Grounds RM. Respiratory effects of dexmedetomidine in the surgical patient requiring intensive care. Crit Care 2000; 4: 302-8
24. Belleville JP, Wards DS, Bloor BC, Maze M. Effects of intravenous dexmedetomidine in human: sedation, ventilation and metabolic rate. Anesthesiology 1992; 77: 1125-33
25. Tramer MR, Moore RA, McQuay HJ. Propofol and bradycardia: causation, frequency and severity. Br J Anaesth 1997; 78: 642-51
26. Aun CS. New i.v. agents for paediatric patients. Br J Anaesth 1999; 83: 29-41