Pharmacokinetics of dexmedetomidine in postsurgical pediatric intensive care unit patients: Preliminary study

Pediatric Critical Care Medicine

Volumn 8, Issue 5, 2007, Pages 419-424

  Díaz, Susan M ^a,d   Rodarte, Alexander ^b   Foley, Jennifer ^b   Capparelli, Edmund V ^c  

^a Presbyterian Healthcare Services   (United States)

^b RADY CHILDREN'S HOSPITAL   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d Presbyterian Hospital Albuquerque   (United States)

Author keywords

Artificial; Conscious sedation; Dexmedetomidine; Intensive care units; Intubation; Pediatric; Respiration; 2 adrenergic receptors

Indexed keywords

DEXMEDETOMIDINE; FENTANYL; MIDAZOLAM; MILRINONE; MORPHINE; PROPOFOL;

ARTICLE; ARTIFICIAL VENTILATION; BLOOD PRESSURE; BRADYCARDIA; CHILD; CLINICAL ARTICLE; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG DOSE REDUCTION; DRUG DOSE TITRATION; DRUG HALF LIFE; FEMALE; HUMAN; HYPOTENSION; INFANT; INTENSIVE CARE UNIT; MALE; OPERATING ROOM; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; TACHYCARDIA; VITAL SIGN;

EID: 34548670030     PISSN: 15297535     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.PCC.0000282046.66773.39     Document Type: Article

References (31)

1. Gertler R, Brown HC, Mitchell DH, et al: Dexmedetomidine: A novel sedative-analgesic agent. Proc (Bayl Univ Med Cent) 2001; 14:13-21
2. Dutta S, Karol MD, Cohen T, et al: Effect of dexmedetomidine on propofol requirements in healthy subjects. J Pharm Sci 2001; 90: 172-181
3. Mantz J: Dexmedetomidine. Drugs Today (Barc) 1999; 34:151-157
4. Venn RM, Bradshaw CJ, Spencer R, et al: Preliminary UK experience of dexmedetomidine, a novel agent for postoperative sedation in the intensive care unit. Anesthesia 1999; 54:116-142
5. Aho MS, Erkola OA, Scheinin H, et al: Effect of intravenously administered dexmedetomidine on pain after laparoscopic tubal ligation. Anesth Analg 1991; 73:112-118
6. Talke P, Richardson CA, Scheinin M, et al: Postoperative pharmacokinetics and sympatholytic effects of dexmedetomidine. Anesth Analg 1997; 85:1136-1142
7. Venn RM, Karol MD, Grounds RM: Pharmacokinetics of dexmedetomidine infusions for sedation of postoperative patients requiring intensive care. Br J Anaesth 2002; 88:669-675
8. Dyck JB, Schafer SL: Dexmedetomidine pharmacokinetics and pharmacodynamics. Anesth Pharmacol Rev 1993; 71:108-118
9. 2-adrenoceptor agonist - In healthy volunteers. Pain 1991; 46:281-285
10. Khan ZP, Munday IT, Jones RM, et al: Effects of dexmedetomidine on isoflurane requirements in healthy volunteers. 1: Pharmacodynamic and pharmacokinetic interactions. Br J Anaesth 1999; 83:372-380
11. Hsu YW, Cortinez LI, Roberson KM, et al: Dexmedetomidine pharmacodynamics. I: Crossover comparison of the respiratory effects of dexmedetomidine and remifentanil in healthy volunteers. Anesthesiology 2004; 101:1066-1076
12. Avitsian R, Lin J, Loto M, et al: Dexmedetomidine and awake fiberoptic intubation for possible cervical spine myelopathy: A clinical series. J Neurosurg Anesthesiol 2005; 17:97-99
13. Mack PF, Perrine K, Kobylarz E, et al: Dexmedetomidine and neurocognitive testing in awake craniotomy. J Neurosurg Anesthesiol 2004; 16:20-25
14. Baddigam K, Russo P, Russo J, et al: Dexmedetomidine in the treatment of withdrawal syndromes in cardiothoracic surgery patients. J Intensive Care Med 2005; 20: 118-123
15. Hospira, Inc.: Precedex®, dexmedetomidine hydrochloride injection. Reference EN-0049-R2, April 2004, pp 1-11
16. Munoz R, Berry D: Dexmedetomidine: Promising drug for pediatric sedation? Pediatr Crit Care Med 2005; 6:493-494
17. Ramsay M, Savage T, Simpson BRJ, et al: Controlled sedation with alphaxalone/aphadalone. BMJ 1974; 2:656-659
18. Ji QC, Zhou JY, Gonzales RJ, et al: Simultaneous quantitation of dexmedetomidine and glucuronide metabolites (G-Dex-1 and G-Dex-2) in human plasma utilizing liquid chromatography with tandem mass spectrometric detection. Rapid Commun Mass Spectrom 2004; 18:1753-1760
19. Tobias J: Pain control and sedation in the pediatric intensive care unit. In: Current Concepts in Pediatric Critical Care. Chicago, Society for Critical Care Medicine, 2001, pp 59-77
20. Maze M: Dexmedetomidine: A viewpoint by Professor Mervyn Maze. Drugs 2000; 59:269
21. Goodale D: MedWatch report. Food and Drug Administration Web site. Available at: http:// www.fda.gov/MEDWATCH/SAFETY/2001/ DIPRIVAN_DEARDOC.PDF. Accessed December 13, 2005
22. Tobias JD, Berkenbosch JW: Initial experience with dexmedetomidine in paediatric-aged patients. Paediatr Anaesth 2002; 12:171-175
23. Tobias JD, Berkenbosch JW: Sedation during mechanical ventilation in infants and children: Dexmedetomidine versus midazolam. South Med J 2004; 97:451-455
24. Ard J, Doyle W, Bekker A: Awake craniotomy with dexmedetomidine in pediatric patients. J Neurosurg Anesthesiol 2003; 15:263-266
25. Korogulu A, Demirbilek S, Teksan H, et al: Sedative, haemodynamic and respiratory effects of dexmedetomidine in children undergoing magnetic resonance imaging examination: Preliminary results. Br J Anaesth 2005; 94:821-824
26. Ramsay MA, Luterman DL: Dexmedetomidine as a total intravenous anesthetic agent. Anesthesiology 2004; 101:787-790
27. Hammer GB, Philip BM, Schroeder AR: Prolonged infusion of dexmedetomidine for sedation following tracheal resection. Paediatr Anaesth 2005; 15:616-620
28. Bekker AY, Basile J, Gold M, et al: Dexmedetomidine for awake carotid endarterectomy: efficacy, hemodynamic profile and side effects. J Neurosurg Anesthesiol 2004; 16: 126-135
29. Berkenbosch JW, Wankum PC, Tobias JD: Prospective evaluation of dexmedetomidine for noninvasive procedural sedation in children. Pediatr Crit Care Med 2005; 6:435-439
30. Knibbe CA, Zuideveld KP, Aarts LP, et al: Allometric relationships between the pharmacokinetics of propofol in rats, children and adults. Br J Clin Pharmacol 2005; 59: 705-711
31. Dutta S, Lal R, Karol MD, et al: Influence of cardiac output on dexmedetomidine pharmacokinetics. J Pharm Sci 2000; 89:519-527