Dexmedetomidine sedation for pediatric post-Fontan procedure patients

Pediatric Critical Care Medicine

Volumn 10, Issue 2, 2009, Pages 207-212

  Tokuhira, Natusko ^a   Atagi, Kazuaki ^b   Shimaoka, Hideki ^a   Ujiro, Atsushi ^a   Otsuka, Yasunori ^a   Ramsay, Michael ^c  

^a OSAKA CITY GENERAL HOSPITAL   (Japan)

^b HYOGO COLLEGE OF MEDICINE   (Japan)

^c BAYLOR UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Alpha 2 agonists; Congenital heart surgery; Dexmedetomidine; Fontan procedure; Hemodynamics; Pediatric critical care; Postoperative sedation; Pulmonary vascular resistance

Indexed keywords

DEXMEDETOMIDINE; PROPOFOL; ALPHA ADRENERGIC RECEPTOR STIMULATING AGENT; HYPNOTIC SEDATIVE AGENT;

ARTERIAL CARBON DIOXIDE TENSION; ARTICLE; ARTIFICIAL HEART PACEMAKER; BRADYCARDIA; CHILD; CLINICAL ARTICLE; CONGENITAL HEART MALFORMATION; CONTROLLED STUDY; DRUG EFFICACY; FEMALE; FONTAN PROCEDURE; HEART OUTPUT; HEMODYNAMICS; HOSPITALIZED CHILD; HUMAN; INTENSIVE CARE UNIT; LUNG VASCULAR RESISTANCE; MALE; MEDICAL RECORD REVIEW; PEDIATRIC ANESTHESIA; POSTOPERATIVE ANALGESIA; POSTOPERATIVE PAIN; POSTOPERATIVE PERIOD; PRESCHOOL CHILD; PRIORITY JOURNAL; RESPIRATION DEPRESSION; RETROSPECTIVE STUDY; SCHOOL CHILD; SEDATION; TREATMENT OUTCOME; INFANT; PEDIATRICS;

ADRENERGIC ALPHA-AGONISTS; CHILD; CHILD, PRESCHOOL; DEXMEDETOMIDINE; FEMALE; FONTAN PROCEDURE; HUMANS; HYPNOTICS AND SEDATIVES; INFANT; MALE; PEDIATRICS; RETROSPECTIVE STUDIES;

EID: 68849118812     PISSN: 15297535     EISSN: None     Source Type: Journal    
DOI: 10.1097/PCC.0b013e31819a3a3e     Document Type: Article

References (26)

1. Gewillig M: The Fontan circulation. Heart 2005; 91:839-846
2. Deal BJ, Mavroudis C, Backer CL: Arrythmia management in the Fontan patient. Pediatr Cardiol 2007; 28:448-456
3. Redington AN, Penny, Shinebourne EA: Pulmonary blood flow after total cavopulmonary shunt. Br Heart J 1991; 65:213-217
4. Kamibayashi T, Maze M. Clinical uses of alpha 2-adrenergic agonists. Anesthesiology 2000; 93:1345-1349
5. Pandharipande P, Ely EW, Maze M: Alpha-2 agonists: Can they modify the outcomes in the postanesthesia care unit? Curr Drug Targets 2005; 6:749-754
6. Tobias J: Dexmedetomidine: Applications in pediatric critical care and pediatric anesthesiology. Pediatr Crit Care Med 2007; 8:115-131
7. Ramsay MA, Savege TM, Simpson BR, et al: Controlled sedation with alphaxalone-alphadolone. BMJ 1974; 2:656-659
8. Hammer GB: Con: Dexmedetomidine should not be used for infants and children during cardiac surgery. J Cardiothorac Vasc Anesth 2008; 22:152-154
9. Easley RB, Tobias JD: Pro: Dexmedetomidine should be used for infants and children undergoing cardiac surgery. J Cardiothorac Vasc Anesth 2008; 22:147-151
10. Buck ML, Willson DF: Use of dexmedetomi-dine in the pediatric intensive care unit. Pharmacotherapy 2008; 28:51-57
11. Nichols DG, Cameron DE, Greeley WJ: Critical Heart Disease in Infants and Children, 1st edition. St Louis, MO, Mosby-Year Book, 1995, pp 751-763
12. Chang AC, Hanley FL , Wernovsky G, et al: Pediatric Cardiac Intensive Care, 1st edition. Philadelphia, PA, Lippincott Williams & Wilkin, 1998, pp 497-516
13. Venn RM, Bradshaw CJ, Spencer R, et al: Preliminary UK experience of dexmedetomi-dine, a novel agent for postoperative sedation in the intensive care unit. Anaesthesia 1999; 54:1136-1142
14. Tobias JD, Berkenbosch JW: Sedation during mechanical ventilation in infants and children: Dexmedetomidine versus midazolam. South Med J 2004; 97:451-455
15. Tobias JD: Sedation and analgesia in the pediatric intensive care unit. Pediatric Ann 2005; 34:636-648
16. Koroglu A, Teksan H, Sagir O, et al: A comparison of the sedative, hemodynamic, and respiratory effects of dexmedetomidine and propofol in children undergoing magnetic resonance imaging. Anesth Analg 2006; 103:63-67
17. Mason KP, Zgleswski SE, Deaden JL, et al: Dexmedetomidine for pediatric sedation for computed tomography imaging studies. Anesth Analg 2006; 103:67-162
18. Berkenbosch JW, Wankum PC, Tobias JD: Prospective evaluation of dexmedetomidine for noninvasive procedural sedation in children. 2005; 6:435-439
19. Nichols DP, Berkenbosch JW, Tobias JD: Rescue sedation with dexmedetomidine for diag- nostic imaging: A preliminary report. Pediatr Anesth 2005; 15:199-203
20. Diaz S, Rodarte A, Foley J, et al: Pharma-cokinetics of dexmedetomidine in postsur-gical pediatric intensive care unit patients: Preliminary study. Pediatr Crit Care Med 2007; 8:419-424
21. Buck M, Willson D: Use of dexmedetomidine in the pediatric intensive care unit. Pharma-cotherapy 2008; 28:51-57
22. Chrysostomou C, Di Filippo S, Manrique AM, et al: Use of dexmedetomidine in children after cardiac and thoracic surgery. Pediatr Crit Care Med 2006; 7:126-131
23. Mukhtar AM, Obayah EM, Hassona AM: The use of dexmedetomidine in pediatric cardiac surgery. Anesth Analg 2006; 103:52-56
24. Herr DL, Sum-Ping ST, England M: ICU Sedation after coronary artery bypass graft surgery: Dexmedetomidine-based versus propo-fol-based sedation regimens. J Cardiothorac Vasc Anesth 2003; 17:576-584
25. Wijeysundera DN, Naik JS, Beattie WS: Alpha-2 adrenergic agonists to prevent perioperative cardiovascular complications: A meta-analysis. Am J Med 2003; 114:742-752
26. Hammer GB, Drover DR, Cao H, et al: The effects of dexmedetomidine on cardiac elec-trophysiology in children. Anesth Analg 2008; 106:79-83