α-Elapitoxin-Aa2a, a long-chain snake α-neurotoxin with potent actions on muscle (α1)2βγδ nicotinic receptors, lacks the classical high affinity for neuronal α7 nicotinic receptors

Biochemical Pharmacology

Volumn 81, Issue 2, 2011, Pages 314-325

  Blacklow, Benjamin ^a   Kornhauser, Rachelle ^b   Hains, Peter G ^c,f   Loiacono, Richard ^b   Escoubas, Pierre ^d,g   Graudins, Andis ^b,e   Nicholson, Graham M ^a  

^a UNIVERSITY OF TECHNOLOGY SYDNEY   (Australia)

^b MONASH UNIVERSITY   (Australia)

^c UNIVERSITY OF SYDNEY   (Australia)

^d INSTITUT DE PHARMACOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

^e PRINCE OF WALES HOSPITAL   (Australia)

^f CHILDREN'S MEDICAL RESEARCH INSTITUTE   (Australia)

^g VenomeTech   (France)

Author keywords

Elapitoxin Aa2a; Acanthophis antarcticus; Long chain neurotoxin; Neuronal 7 receptor; Snake toxin

Indexed keywords

ALPHA BUNGAROTOXIN; ALPHA ELAPITOXIN AA2A; BUNGAROTOXIN RECEPTOR; CARBACHOL; NEUROMUSCULAR BLOCKING AGENT; NEUROTOXIN; NICOTINIC RECEPTOR; PHOSPHOLIPASE A2; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; DRUG RECEPTOR BINDING; ENZYME ACTIVITY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MUSCLE CONTRACTION; NEUROTOXICITY; NONHUMAN; POSTSYNAPTIC POTENTIAL; PRIORITY JOURNAL;

ANIMALS; CARBACHOL; DOSE-RESPONSE RELATIONSHIP, DRUG; ELAPID VENOMS; ELAPIDAE; FEMALE; MUSCLE, SKELETAL; NEURONS; NEUROTOXINS; PHOSPHOLIPASES A2; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, NICOTINIC;

EID: 78650179531     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2010.10.004     Document Type: Article

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