Oxylepitoxin-1, a reversible neurotoxin from the venom of the inland taipan (Oxyuranus microlepidotus)

Peptides

Volumn 27, Issue 11, 2006, Pages 2655-2660

  Clarke, Carol ^a   Kuruppu, Sanjaya ^a   Reeve, Shane ^a   Ian Smith, A ^a   Hodgson, Wayne C ^a  

^a MONASH UNIVERSITY   (Australia)

Author keywords

Antivenom; Chromatography; Neurotoxin; Nicotinic receptor; Skeletal muscle; Snake venom

Indexed keywords

CARBACHOL; NEUROTOXIN; NICOTINIC RECEPTOR; OXYLEPITOXIN 1; PHOSPHOLIPASE A2; SNAKE VENOM; SNAKE VENOM ANTISERUM; TUBOCURARINE CHLORIDE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL TISSUE; ARTICLE; CHICK; CHRONOLOGY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVITY; INHIBITION KINETICS; MUSCLE INNERVATION; MUSCLE TWITCH; NEUROTOXICITY; NONHUMAN; OXYURANUS MICROLEPIDOTUS; PRIORITY JOURNAL; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SKELETAL MUSCLE; SNAKE; SYNAPSE; TOXICOLOGY;

AMINO ACID SEQUENCE; ANIMALS; ANTIVENINS; CARBACHOL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOSE-RESPONSE RELATIONSHIP, DRUG; ELAPID VENOMS; ELAPIDAE; MOLECULAR SEQUENCE DATA; NEUROTOXINS; SEQUENCE ALIGNMENT;

OXYURANUS MICROLEPIDOTUS; OXYURANUS SCUTELLATUS SCUTELLATUS;

EID: 33750056717     PISSN: 01969781     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.peptides.2006.06.003     Document Type: Article

References (20)

1. Broad A.J., Sutherland S.K., and Coulter A.R. The lethality in mice of dangerous Australian and other snake venoms. Toxicon 17 (1979) 661-664
2. Christopoulos A., Coles P., Lay L., Lew M.J., and Angus J.A. Pharmacological analysis of cannabinoid receptor activity in the rat vas deferens. Br J Pharmacol 132 (2001) 1281-1291
3. Christopoulos A., Parsons A.M., Lew M.J., and El-Fakahany E.E. The assessment of antagonist potency under conditions of transient response kinetics. Eur J Pharmacol 382 (1999) 217-227
4. Chiappinelli V.A. κ-Neurotoxins and α-neurotoxins: effects on neuronal nicotinic acetylcholine receptors. In: Harvey A.L. (Ed). Snake toxins (1991), Pergamon Press, New York 223-258
5. Chicheportiche R., Vincent J.P., Kopeyan C., Schweitz H., and Lazdunski M. Structure-function relationship in the binding of snake neurotoxins to the torpedo membrane receptor. Biochemistry 14 (1975) 2081-2091
6. Crachi M.T., Hammer L.W., and Hodgson W.C. The effects of antivenom on the in vitro neurotoxicity of venoms from the taipans, Oxyuranus scutellatus, Oxyuranus microlepidotus and Oxyuranus scutellatus canni. Toxicon 37 (1999) 1771-1778
7. Fohlman J. Comparison of two highly toxic Australian snake venoms: the taipan (Oxyuranus s. scutellatus) and fierce snake (Parademansia microlepidotus). Toxicon 17 (1979) 170-172
8. Fry B.G. Structure-function properties of venom components from Australian elapids. Toxicon 37 (1999) 11-32
9. Harris J.B. Phospholipases in snake venoms and their effects on nerve and muscle. In: Harvey A.L. (Ed). Snake toxins (1991), Pergamon Press, New York 91-129
10. Harvey A.L., Barfaraz A., Thomson E., Faiz A., Preston S., and Harris J.B. Screening of snake venoms for neurotoxic and myotoxic effects using simple in vitro preparations from rodents and chicks. Toxicon 32 (1994) 257-265
11. Kuruppu S., Reeve S., Smith A.I., and Hodgson W.C. Isolation and pharmacological characterization of papuantoxin-1, a postsynaptic neurotoxin from the venom of the Papuan black snake (Pseudechis papuanus). Biochem Pharmacol 70 (2005) 794-800
12. Lew M.J., and Angus J.A. Analysis of competitive agonist-antagonist interactions by nonlinear regression. Trends Pharmacol Sci 16 (1995) 328-337
13. Mirtschin P.J., Crowe G.R., and Thomas M.W. Envenomation by the inland taipan, Oxyuranus microlepidotus. Med J Aust 141 (1984) 850-851
14. Nirthanan S., Charpantier E., Gopalakrishnakone P., Gwee M.C., Khoo H.E., Cheah L.S., et al. Candoxin, a novel toxin from Bungarus candidus, is a reversible antagonist of muscle (αβγδ) but a poorly reversible antagonist of neuronal α7 nicotinic acetylcholine receptors. J Biol Chem 277 (2002) 17811-17820
15. Smith K. Envenomation by the small-scaled snake: the world's most venomous snake. Med J Aust 157 (1992) 140
16. Sutherland S.K., and Tibballs J. Australian animal toxins: the creatures, their toxins and care of the poisoned patient. 2nd ed. (2001), Oxford University Press, Melbourne
17. Tyler M.I., Retson-Yip K.V., Gibson M.K., Barnett D., Howe E., Stocklin R., et al. Isolation and amino acid sequence of a new long-chain neurotoxin with two chromatographic isoforms (Aa el and Ae e2) from the venom of the Australian death adder (Acanthophis antarcticus). Toxicon 35 (1997) 555-562
18. White J. CSL antivenom handbook (2001), CSL Ltd., Melbourne p. 69
19. Wickramaratna J.C., Fry B.G., Loiacono R.E., Aguilar M.I., Alewood P.F., and Hodgson W.C. Isolation and characterization at cholinergic nicotinic receptors of a neurotoxin from the venom of the Acanthophis sp. Seram death adder. Biochem Pharmacol 68 (2004) 383-394
20. Zamudio F., Wolf K.M., Martin B.M., Possani L.D., and Chiappinelli V.A. Two novel alpha-neurotoxins isolated from the taipan snake, Oxyuranus scutellatus, exhibit reduced affinity for nicotinic acetylcholine receptors in brain and skeletal muscle. Biochemistry 35 (1996) 7910-7916