Variations in the pharmacological profile of post-synaptic neurotoxins isolated from the venoms of the Papuan (Oxyuranus scutellatus canni) and coastal (Oxyuranus scutellatus scutellatus) taipans

NeuroToxicology

Volumn 31, Issue 2, 2010, Pages 239-243

  Kornhauser, Rachelle ^a   Hart, Andrew J ^a   Reeve, Shane ^a   Smith, A Ian ^a   Fry, Bryan G ^b   Hodgson, Wayne C ^a  

^a MONASH UNIVERSITY   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Competitive antagonism; Neurotoxin; Post synaptic; Pseudo irreversible; Snake; Taipan; Venom

Indexed keywords

ALPHA OXYTOXIN 1; ALPHA SCUTOXIN 1; CARBACHOL; NEUROTOXIN; POTASSIUM CHLORIDE; SNAKE VENOM; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANALYTIC METHOD; ANIMAL TISSUE; ARTICLE; CHICKEN; CONCENTRATION RESPONSE; CONTROLLED STUDY; NEUROTOXICITY; NONHUMAN; OXYURANUS SCUTELLATUS CANNI; OXYURANUS SCUTELLATUS SCUTELLATUS; POISONOUS SNAKE; POSTSYNAPTIC INHIBITION; PRIORITY JOURNAL; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SPECIES COMPARISON;

AMINO ACID SEQUENCE; ANIMALS; CARBACHOL; CHICKENS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELAPID VENOMS; ELAPIDAE; MOLECULAR SEQUENCE DATA; MUSCLE CONTRACTION; NEUROMUSCULAR JUNCTION; NEUROTOXINS; POTASSIUM CHLORIDE; SYNAPTIC TRANSMISSION;

MURINAE; OXYURANUS MICROLEPIDOTUS; OXYURANUS SCUTELLATUS; OXYURANUS SCUTELLATUS CANNI; OXYURANUS SCUTELLATUS SCUTELLATUS;

EID: 77649270454     PISSN: 0161813X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuro.2009.12.009     Document Type: Article

References (15)

1. Broad A.J., Sutherland S.K., and Coulter A.R. The lethality in mice of dangerous Australian and other snake venoms. Toxicon 17 (1979) 661-664
2. Chang C.C., Lee J.D., Eaker D., and Fohlman J. The presynaptic neuromuscular blocking action of taipoxin. A comparison with β-bungarotoxin and crotoxin. Toxicon 13 (1977) 371-376
3. Clarke C., Kuruppu S., Reeve S., Smith A.I., and Hodgson W.C. Oxylepitoxin-1, a reversible neurotoxin from the venom of the inland taipan (Oxyuranus microlepidotus). Peptides 27 (2006) 2655-2660
4. Crachi M.T., Hammer L.W., and Hodgson W.C. The effects of antivenom on the in vitro neurotoxicity of venoms from the taipans Oxyuranus scutellatus, Oxyuranus microlepidotus and Oxyuranus scutellatus canni. Toxicon 37 (1999) 1771-1778
5. Endo T., and Tamiya N. Current view on the structure function-relationship of post-synaptic neurotoxins from snake venoms. Pharmacol Ther 34 (1987) 403-451
6. Fohlman J. Comparison of two highly toxic Australian snake venoms: the taipan (Oxyuranus s. scutellatus) and the fierce snake (Parademansia microlepidotus). Toxicon 17 (1979) 170-172
7. Fry B.G. Structure function properties of venom components from Australian elapids. Toxicon 37 (1999) 11-32
8. Hodgson W.C., and Wickramaratna J.C. In vitro neuromuscular activity of snake venoms. Clin Exp Pharmacol Physiol 29 (2002) 807-814
9. Hodgson W.C., Dal Belo C.A., and Rowan E.G. The neuromuscular activity of paradoxin: a presynaptic neurotoxin from the venom of the inland taipan (Oxyuranus microlepidotus). Neuropharmacology 52 (2007) 1229-1236
10. Kuruppu S., Reeve S., Banjeree Y., Kini R.M., Smith A.I., and Hodgson W.C. Isolation and pharmacological characterisation of cannitoxin, a pre-synaptic neurotoxin from the venom of the Papuan taipan (Oxyuranus scutellatus canni). J Pharmacol Exp Ther 315 (2005) 1196-1202
11. Kuruppu S., Smith A.I., Isbister G.K., and Hodgson W.C. Neurotoxins from Australo-Papuan elapids: a biochemical and pharmacological perspective. Crit Rev Toxicol 38 (2008) 73-86
12. Sutherland S.K. Australian animal toxins. The creatures, their toxins, and care of the poisoned patient (1983), Oxford University Press, Melbourne p. 121-7
13. Trevett A.J., Lalloo D.G., Nwokolo N.C., Naraqi S., Kevau I.H., Theakston R.D.G., et al. Electrophysiological findings in patients envenomed following the bite of a Papuan taipan (Oxyuranus scutellatus canni). Trans R Soc Trop Med Hyg 89 (1995) 415-417
14. Trevett A.J., Lalloo D.G., Nwoloko N.C., Naraqi S., Kevau I.H., Theakston R.D.G., et al. The efficacy of antivenom in the treatment of bites by the Papuan taipan (Oxyuranus scutellatus canni). Trans R Soc Trop Med Hyg 89 (1995) 322-325
15. Zamudio F., Wolf K.M., Martin B.M., Possani L.D., and Chiappinelli V.A. Two novel alpha-neurotoxins isolated from the taipan snake, Oxyuranus scutellatus, exhibit reduced affinity for nicotinic acetylcholine receptors in brain and skeletal muscle. Biochemistry 35 (1996) 7910-7916