Isolation and characterization of rufoxin, a novel protein exhibiting neurotoxicity from venom of the psammophiine, Rhamphiophis oxyrhynchus (Rufous beaked snake)

Neuropharmacology

Volumn 52, Issue 4, 2007, Pages 1065-1070

  Lumsden, Natalie G ^a   Banerjee, Yajnavalka ^b   Kini, R Manjunatha ^b   Kuruppu, Sanjaya ^c   Hodgson, Wayne C ^c  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b Faculty of Science   (Singapore)

^c MONASH UNIVERSITY   (Australia)

Author keywords

Colubrid venom; Neurotoxin; Skeletal muscle nicotinic receptor

Indexed keywords

CARBACHOL; NEUROTOXIN; NICOTINIC AGENT; NICOTINIC RECEPTOR; RUFOXIN; SNAKE VENOM; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL TISSUE; ARTICLE; COMPETITIVE INHIBITION; CONCENTRATION (PARAMETERS); CONCENTRATION RESPONSE; INHIBITION KINETICS; NEUROTOXICITY; NONHUMAN; PHYLOGENY; POSTSYNAPTIC POTENTIAL; PRIORITY JOURNAL; PROTEIN ISOLATION; PROTEIN MOTIF; PSAMMOPHIINE; RHAMPHIOPHIS OXYRHYNCHUS; SKELETAL MUSCLE; SNAKE;

ANALYSIS OF VARIANCE; ANIMALS; CHICKENS; CHOLINESTERASE INHIBITORS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COLUBRIDAE; DOSE-RESPONSE RELATIONSHIP, DRUG; MUSCLE CONTRACTION; NEOSTIGMINE; NEUROMUSCULAR JUNCTION; NEUROTOXINS; SNAKE VENOMS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TIME FACTORS;

EID: 33847255316     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2006.11.002     Document Type: Article

References (25)

1. Aird S.D. Ophidian envenomation strategies and the role of purines. Toxicon 40 (2002) 335-393
2. Assakura M.T., Salomao M.G., Puorto G., and Mandelbaum F.R. Hemorrhagic, fibrinogenolytic and edema-forming activities of the venom of the colubrid snake Philodryas olfersii (green snake). Toxicon 30 (1992) 427-438
3. Broaders M., Faro C., and Ryan M.F. Partial purification of acetylcholine receptor binding components from the Duvernoy's secretions of Blanding's tree snake (Boiga blandingi) and the Mangrove snake (Boiga dendrophila). J. Nat. Toxins 8 (1999) 155-166
4. Christopoulos A., Parsons A.M., Lew M.J., and El-Fakahany E.E. The assessment of antagonist potency under conditions of transient response kinetics. Eur. J. Pharmacol. 382 (1999) 217-227
5. Fry B.G. Structure-function properties of venom components from Australian elapids. Toxicon 37 (1999) 11-32
6. Fry B.G., Lumsden N.G., Wüster W., Wickramaratna J.C., Hodgson W.C., and Kini R.M. Isolation of a neurotoxin (α-colubritoxin) from a 'non-venomous' colubrid: evidence for early origin of venom in snakes. J. Mol. Evol. 57 (2003) 446-452
7. Fry B.G., Wüster W., Ramjan S.F., Jackson T., Martelli P., and Kini R.M. Analysis of Colubroidea snake venoms by liquid chromatography with mass spectrometry: evolutionary and toxinological implications. Rapid Commun. Mass Spectrom. 17 (2003) 1-16
8. Greene, H.W., 1997. Snakes: the evolution of mystery in nature. University of California Press, Berkeley, CA.
9. Harvey A.L., Barfaraz A., Thomson E., Faiz A., Preston S., and Harris J.B. Screening of snake venoms for neurotoxic and myotoxic effects using simple in vitro preparations from rodents and chicks. Toxicon 32 (1994) 257-265
10. Hodgson W.C., and Wickramaratna J.C. The in vitro neuromuscular activity of snake venoms. Clin. Exp. Pharmacol. Physiol. 29 (2002) 807-814
11. Hodgson, W.C., Wickramaratna, J.C., 2004. Pharmacological characterisation of toxins from Death Adder (Acanthophis) venoms. In: Symposium of the Pan American Section of the International Society on Toxinology, Angra dos Reis/Brazil, P225.
12. Kamiguti A.S., Theakston R.D., Sherman N., and Fox J.W. Mass spectrophotometric evidence for P-III/P-IV metalloproteinases in the venom of the Boomslang (Dispholidus typus). Toxicon 38 (2000) 1613-1620
13. Kraus F., and Brown W.M. Phylogenetic relationships of colubroid snakes based on mitochondrial DNA sequences. Zool. J. Linn. Soc. 122 (1998) 455-487
14. Lumsden, N.G., 2005. A pharmacological and biochemical examination of colubrid venoms. Doctoral dissertation, Monash University, Australia.
15. Lumsden N.G., Fry B.G., Kini R.M., and Hodgson W.C. In vitro neuromuscular activity of 'colubrid' venoms: clinical and evolutionary implications. Toxicon 43 (2004) 819-827
16. Lumsden N.G., Fry B.G., Ventura S., Kini R.M., and Hodgson W.C. Pharmacological characterisation of a neurotoxin from the venom of Boiga dendrophila (Mangrove catsnake). Toxicon 45 (2005) 329-334
17. Lumsden N.G., Ventura S., Dauer R.J., and Hodgson W.C. A biochemical and pharmacological examination of Rhamphiophis oxyrhynchus (Rufous beaked snake) venom. Toxicon 45 (2005) 219-231
18. Nirthanan S., Charpantier E., Gopalakrishnakone P., Gwee M., Khoo H., Cheah L., Bertrand D., and Kini M. Candoxin, a novel toxin from Bungarus candidus, is a reversible antagonist of muscle (αβγδ) but a poorly reversible antagonist of neuronal α7 nicotinic acetylcholine receptors. J. Biol. Chem. 277 (2002) 17811-17820
19. Nirthanan S., Gopalakrishnakone P., Gwee M., Khoo H., and Kini R. Non-conventional toxins from Elapid venoms. Toxicon 41 (2003) 397-407
20. Ogay A.Y., Rzhevsky D.I., Murashev A.N., Tsetlin V.I., and Utkin Y.N. Weak neurotoxin from Naja kaouthia cobra venom affects haemodynamic regulation by acting on acetylcholine receptors. Toxicon 45 (2005) 93-99
21. Pawlak J., Mackessy S.P., Fry B.G., Bhatia M., Mourier G., Fruchart-Gaillard C., Servent D., Menez R., Stura E., Menez A., and Kini R.M. Denmotoxin, a three-finger toxin from the colubrid snake Boiga dendrophila (Mangrove Catsnake) with bird-specific activity. J. Biol. Chem. 281 (2006) 29030-29041
22. Utkin Y.N., Kukhtina V.V., Kryukova E.V., Chiodini F., Bertrand D., Methfessel C., and Tsetlin V.I. 'Weak toxin' from Naja kaouthia is a nontoxic antagonist of α 7 and muscle-type nicotinic acetylcholine receptors. J. Biol. Chem. 276 (2001) 15810-15815
23. Wickramaratna, J.C., 2003. A pharmacological characterisation of death adder (Acanthophis Spp.) venoms and toxins. Doctoral dissertation. Monash University, Australia.
24. Wickramaratna J.C., Fry B.G., Loiacono R.E., Aguilar M.I., Alewood P.F., and Hodgson W.C. Isolation and characterisation at cholinergic nicotinic receptors of a neurotoxin from the venom of the Acanthophis sp. Seram death adder. Biochem. Pharmacol. 68 (2004) 383-394
25. Zamudio F., Wolf K., Martin B., Possani L.D., and Chiappinelli V. Two novel α-neurotoxins isolated from the Taipan Snake, Oxyuranus scutellatus, exhibit reduced affinity for nicotinic acetylcholine receptors in brain and skeletal muscle. Biochem. 35 (1996) 7910-7916