Isolation of a Neurotoxin (α-colubritoxin) from a Nonvenomous Colubrid: Evidence for Early Origin of Venom in Snakes

Journal of Molecular Evolution

Volumn 57, Issue 4, 2003, Pages 446-452

  Fry, Bryan G ^a,b   Lumsden, Natalie G ^c   Wüster, Wolfgang ^d   Wickramaratna, Janith C ^c   Hodgson, Wayne C ^c   Manjunatha Kini, R ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c MONASH UNIVERSITY   (Australia)

^d BANGOR UNIVERSITY   (United Kingdom)

Author keywords

Evolution; Multi gene; Neurotoxin; Snake; Three finger; Venom

Indexed keywords

ALPHA COLUBRITOXIN; NEUROTOXIN; NICOTINIC RECEPTOR; NICOTINIC RECEPTOR BLOCKING AGENT; POLYPEPTIDE; SNAKE VENOM; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EVOLUTIONARY HOMOLOGY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MOLECULAR WEIGHT; NONHUMAN; PHYLOGENETIC TREE; SEQUENCE HOMOLOGY;

AMINO ACID SEQUENCE; ANIMALS; CHICKENS; CHROMATOGRAPHY, LIQUID; COLUBRIDAE; EVOLUTION, MOLECULAR; MASS SPECTROMETRY; MOLECULAR SEQUENCE DATA; MUSCLES; NEUROTOXINS; PHYLOGENY; SEQUENCE HOMOLOGY, AMINO ACID; SNAKE VENOMS;

ANIMALIA; COELOGNATHUS; COELOGNATHUS RADIATUS; ELAPHE; SERPENTES; VIPERIDAE;

EID: 0142043933     PISSN: 00222844     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00239-003-2497-3     Document Type: Article

References (28)

1. Broaders M, Faro C, Ryan MF (1999) Partial purification of acetylcholine receptor binding components from the Duvernoy's secretions of Blanding's tree snake (Boiga blandingi) and the mangrove snake (Boiga dendrophila). J Nat Toxins 8:155-166.
2. Chang CC (1999) Looking back on the discovery of α-bungaro-toxin. J Biomed Sci 6:368-375
3. Chippaux JP, Williams V, White J (1991) Snake venom variability: Methods of study, results and interpretation. Toxicon 29:1279-1303
4. Endo T, Tamiya N (1987) Current view on the structure-function relationship of postsynaptic neurotoxins from snake venoms. Pharmacol Therapeut 34:405-512
5. Fleming TJ, Ohigin C, Malek TR (1993) Characterization of two novel Ly-6 genes. Protein sequence and potential structural similarity to α-bungarotoxin and other neurotoxins. J Immunol 150:5379-5390
6. Fry BG, Wüster W, Kini RM, Brusic V, Khan A, Venkataraman D, Rooney AP (2003) Molecular evolution and phylogeny of snake venom three-finger toxins. J Mol Evol 57:110-129
7. Greene HW (1997) Snakes: The evolution of mystery in nature. University of California Press, Brekely
8. Gumley TP, McKenzie IFC, Sandrin MS (1995) Tissue expression, structure and function of the murine Ly-6 family of molecules. Immunol Cell Biol 73:277-296
9. Harvey AL, Barfaraz A, Thomson E, Faiz A, Preston S, Harris JB (1994) Screening of snake venoms for neurotoxic and myotoxic effects using simple in vitro preparations from rodents and chicks. Toxicon 32:257-265
10. Helfenberger N (2001) Phylogenetic relationships of Old World ratsnakes based on visceral organ topography, osteology, and allozyme variation. Russ J Herpetol 8:S1-S62
11. Hill RE, Mackessy SP (1997) Venom yields from several species of colubrid snakes and differential effects of ketamine. Toxicon 35:671-678
12. Hill RE, Mackessy SP (2000) Characterization of venom (Duvernoy's secretion) from twelve species of colubrid snakes and partial sequence of four venom proteins. Toxicon 38:1663-1687
13. Huelsenbeck JP, Ronquist F (2001) MrBayes - Bayesian inference of phylogeny, version 3.0b4. Bioinformatics 17:754-755
14. Kamiguti AS, Theakston RD, Sherman N, Fox JW (2000) Mass spectrophotometric evidence for P-III/P-IV metalloproteinases in the venom of the Boomslang Toxicon 38:1613-1620
15. Kini RM (2002) Molecular folds with multiple missions: Functional sites in three-finger toxins. Clin Exp Pharmacol Physiol 29:815-822
16. Kraus F, Brown WM (1998) Phylogenetic relationships of colubroid snakes based on mitochondrial DNA sequences. Zoo J Linn Soc 122:455-487
17. Levinson SR, Evans MH, Groves F (1976) A neurotoxic component of the venom from Blanding's tree snake (Boiga blandingii) Toxicon 14:307-312
18. Mackessy SP (2002) Biochemistry and pharmacology of colubrid snake venoms. J Toxicol Toxin Rev 21:43-83
19. Ménez A (1998) Functional architectures of animal toxins: A clue to drug design? Toxicon 36:1557-1572
20. Miwa JM, Ibanez-Tallon I, Crabtree GW, Sanchez R, Sali A, Role LW, Heintz N (1999) lynx1, an endogenous toxin-like modulator of nicotinic acetylcholine receptors in the mammalian CNS. Neuron 23:105-114
21. Nirthanan S, Charpantier E, Gopalakrishnakone P, Gwee MC, Khoo HE, Cheah LS, et al. (2002) Candoxin, a novel toxin from Bungarus candidus, is a reversible antagonist of muscle (alphabetagammadelta) but a poorly reversible antagonist of neuronal alpha 7 nicotinic acetylcholine receptors. J Biol chem 277:17811-17820
22. Ronquist F, Huelsenbeck JP (2003) MrBayes3: Bayesian phylogenetic inference under mixed models. Bioinformatics, in press
23. Slowinski JB, Lawson R (2002) Snake phylogeny: Evidence from nuclear and mitochondrial genes. Mol Phylogenet Evol 24:194-202
24. Thompson JD, Gibson TJ, Plewniak F, Jeanmougin F, Higgins DG (1997) The CLUSTAL_X windows interface: Flexible strategies for multiple sequence alignment aided by quality analysis tools. Nucleic Acids Res 25:4876-4882
25. Utkin YN, Kukhtina VV, Kryukova EV, Chiodini F, Bertrand D, Methfessel C, Tsetlin VI (2001) "Weak toxin" from Naja kaouthia is a nontoxic antagonist of alpha 7 and muscle-type nicotinic acetylcholine receptors. J Biol Chem 276:15810-15815
26. Underwood G, Kochva E (1993) On the affinities of the burrowing asps Atractaspis (Serpentes: Atractaspididae). Zool J Linn Soc 107:3-64
27. Vidal N (2002) Colubroid systematics: Evidence for an early appearance of the venom apparatus followed by extensive evolutionary tinkering. J Toxicol Toxin Rev 21:21-41
28. Vidal N, Hedges SB (2002) Higher-level relationships of caenophidian snakes inferred from four nuclear and mitochondrial genes. C R Biologies 325:987-995