Isolation and pharmacological characterisation of papuantoxin-1, a postsynaptic neurotoxin from the venom of the Papuan black snake (Pseudechis papuanus)

Biochemical Pharmacology

Volumn 70, Issue 5, 2005, Pages 794-800

  Kuruppu, Sanjaya ^a   Reeve, Shane ^a   Smith, A Ian ^a   Hodgson, Wayne C ^a  

^a MONASH UNIVERSITY   (Australia)

Author keywords

Antivenom; Chick biventer; Neurotoxin; Skeletal muscle; Snake; Venom

Indexed keywords

CARBACHOL; NEUROTOXIN; NICOTINIC AGENT; NICOTINIC RECEPTOR; PAPUANTOXIN 1; SNAKE VENOM; UNCLASSIFIED DRUG; VENOM ANTISERUM;

ANIMAL TISSUE; ARTICLE; CHICKEN; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG EFFICACY; EXTRACTION; MALE; MUSCLE TISSUE; MUSCLE TWITCH; NONHUMAN; POSTSYNAPTIC POTENTIAL; PRIORITY JOURNAL; PURIFICATION; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SKELETAL MUSCLE; SNAKE; TOXICITY TESTING;

AMINO ACID SEQUENCE; ANIMALS; CHICKENS; ELAPID VENOMS; MOLECULAR WEIGHT; MUSCLE, SKELETAL; NEUROTOXINS; PHOSPHOLIPASES A; RECEPTORS, NICOTINIC;

EID: 23044516801     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2005.06.003     Document Type: Article

References (25)

1. C.H. Campbell The Papuan black snake (Pseudechis papuanus) and the effect of its bite Papua New Guinea Med J 10 1967 117 121
2. D. Lalloo, A. Trevett, J. Black, J. Mapao, S. Naraqi, and D. Owens Neurotoxicity and haemostatic disturbances in patients envenomed by the Papuan black snake (Pseudechis papuanus) Toxicon 32 1994 927 936
3. 2 platelet inhibitor Toxicon 32 1994 915 925
4. S. Ramasamy, G.K. Isbister, and W.C. Hodgson The efficacy of two antivenoms against the in vitro myotoxic effects of black snake (Pseudechis) venoms in the chick biventer cervicis nerve-muscle preparation Toxicon 44 2004 837 845
5. S. Ramasamy, B.G. Fry, and W.C. Hodgson Neurotoxic effects of venoms from seven species of Australian black snakes (Pseudechis): efficacy of black snake and tiger snake antivenoms Clin Exp Pharmacol Physiol 32 2005 7 12
6. 2 from the venom of the Papuan black snake (Pseudechis papuanus) Biochim Biophys Acta 1250 1995 137 143
7. J.C. Wickramaratna, B.G. Fry, R.E. Loiacono, M.I. Aguilar, P.F. Alewood, and W.C. Hodgson Isolation and characterization at cholinergic nicotinic receptors of a neurotoxin from the venom of the Acanthophis sp. seram death adder Biochem Pharmacol 68 2004 383 394
8. A.L. Harvey, A. Barfaraz, E. Thomson, A. Faiz, S. Preston, and J.B. Harris Screening of snake venoms for neurotoxic and myotoxic effects using simple in vitro preparations from rodents and chicks Toxicon 32 1994 257 265
9. M.T. Crachi, L.W. Hammer, and W.C. Hodgson A pharmacological examination of venom from the Papuan taipan (Oxyuranus scutellatus canni) Toxicon 37 1999 1721 1734
10. A. Barfaraz, and A.L. Harvey The use of the chick biventer cervicis preparation to assess the protective activity of six international reference antivenoms on the neuromuscular effects of snake venoms in vitro Toxicon 32 1994 267 272
11. A. Christopoulos, A.M. Parsons, M.J. Lew, and E.E. El-Fakahany The assessment of antagonist potency under conditions of transient response kinetics Eur J Pharmacol 382 1999 217 227
12. A. Christopoulos, P. Coles, L. Lay, M.J. Lew, and J.A. Angus Pharmacological analysis of cannabinoid receptor activity in the rat vas deferens Br J Pharmacol 132 2001 1281 1291
13. M.J. Lew, and J.A. Angus Analysis of competitive agonist-antagonist interactions by nonlinear regression Trends Pharmacol Sci 16 1995 328 337
14. F. Zamudio, K.M. Wolf, B.M. Martin, L.D. Possani, and V.A. Chiappinelli Two novel alpha-neurotoxins isolated from the taipan snake, Oxyuranus scutellatus, exhibit reduced affinity for nicotinic acetylcholine receptors in brain and skeletal muscle Biochemistry 35 1996 7910 7916
15. M.I. Tyler, K.V. Retson-Yip, M.K. Gibson, D. Barnett, E. Howe, and R. Stocklin Isolation and amino acid sequence of a new long-chain neurotoxin with two chromatographic isoforms (Aa el and Ae e2) from the venom of the Australian death adder (Acanthophis antarcticus) Toxicon 35 1997 555 562
16. B.G. Fry Structure-function properties of venom components from Australian elapids Toxicon 37 1999 11 32
17. C. Takasaki, and N. Tamiya Isolation and amino acid sequence of a short-chain neurotoxin from an Australian elapid snake Pseudechis australis Biochem J 232 1985 367 371
18. S. Nirthanan, R. Gao, P. Gopalakrishnakone, M.C. Gwee, H.E. Khoo, and L.S. Cheah Pharmacological characterization of mikatoxin, an α-neurotoxin isolated from the venom of the New-Guinean small-eyed snake Micropechis ikaheka Toxicon 40 2002 863 871
19. D.G. Lalloo, A.J. Trevett, J. Black, J. Mapao, A. Saweri, and S. Naraqi Neurotoxicity, anticoagulant activity and evidence of rhabdomyolysis in patients bitten by death adders (Acanthophis sp.) in southern Papua New Guinea Quaterly J Med (QJM) 89 1996 25 35
20. H.M. Doery, and J.E. Pearson Haemolysins in venoms of Australian snakes observations on the haemolysins of the venoms of some Australian snakes and the separation of phospholipase A from the venom of Pseudechis porphyriacus Biochem J 78 1961 820 827
21. R.M. Kini, and S. Iwanaga Structure-function relationships of phospholipases I: prediction of presynaptic neurotoxicity Toxicon 24 1986 527 541
22. 2 enzymes: structure function and mechanism 1997 Wiley Chichester 511
23. V.A. Chiappinelli κ-Neurotoxins and α-neurotoxins:effects on neuronal nicotinic acetylcholine receptors A.L. Harvey Snake toxins 1991 Pergamon Press New York 223 258
24. R. Chicheportiche, J.P. Vincent, C. Kopeyan, H. Schweitz, and M. Lazdunski Structure-function relationship in the binding of snake neurotoxins to the torpedo membrane receptor Biochemistry 14 1975 2081 2091
25. H.S. Kim, and N. Tamiya The amino acid sequence and position of the free thiol group of a short-chain neurotoxin from common-death-adder (Acanthophis antarcticus) venom Biochem J 199 1981 211 218