Galantamine-induced amyloid-β clearance mediated via stimulation of microglial nicotinic acetylcholine receptors

Journal of Biological Chemistry

Volumn 285, Issue 51, 2010, Pages 40180-40191

  Takata, Kazuyuki ^a   Kitamura, Yoshihisa ^a   Saeki, Mana ^a   Terada, Maki ^a   Kagitani, Sachiko ^a   Kitamura, Risa ^a   Fujikawa, Yasuhiro ^a   Maelicke, Alfred ^b   Tomimoto, Hidekazu ^c   Taniguchi, Takashi ^a   Shimohama, Shun ^d  

^a KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

^b Galantos Pharma GmbH   (Germany)

^c MIE UNIVERSITY   (Japan)

^d SAPPORO MEDICAL UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINESTERASE; ACTIN REORGANIZATION; ALZHEIMER DISEASE; COMBINED ACTIONS; CULTURE MEDIUM; INTRACELLULAR SIGNALING; MICROGLIA; NICOTINIC ACETYLCHOLINE RECEPTORS; NICOTINIC ACETYLCHOLINE RECEPTORS (NACHRS); THERAPEUTIC TARGETS;

ANTIBODIES; ANTIGEN-ANTIBODY REACTIONS; CALCIUM; CALMODULIN; GLYCOPROTEINS;

BINDING SITES;

ACTIN; AMYLOID BETA PROTEIN; BUNGAROTOXIN RECEPTOR; CALCIUM ION; CALMODULIN; CHOLINE; GALANTAMINE;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALCIUM DEPLETION; CALCIUM SIGNALING; COMPETITIVE INHIBITION; CONTROLLED STUDY; DOSE RESPONSE; DRUG BINDING SITE; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG MECHANISM; HUMAN; HUMAN TISSUE; MICROGLIA; NERVE CELL STIMULATION; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN METABOLISM; RAT;

AGED; ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; ANTIBODIES, MONOCLONAL; BINDING SITES; CALCIUM SIGNALING; CALMODULIN; CELLS, CULTURED; CHOLINE; CHOLINESTERASE INHIBITORS; DISEASE MODELS, ANIMAL; FEMALE; GALANTAMINE; HIPPOCAMPUS; HUMANS; MALE; MICROGLIA; NOOTROPIC AGENTS; PHAGOCYTOSIS; RATS; RATS, WISTAR; RECEPTORS, NICOTINIC;

RATTUS; RODENTIA;

EID: 78650057569     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.142356     Document Type: Article

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