Natural compounds from traditional medicinal herbs in the treatment of cerebral ischemia/reperfusion injury

Acta Pharmacologica Sinica

Volumn 31, Issue 12, 2010, Pages 1523-1531

  Wu, Peng Fei ^a   Zhang, Zui ^a   Wang, Fang ^a,b,c   Chen, Jian Guo ^a,b,c  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

^c HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

cerebral ischemia; natural compounds; traditional medicinal herb

Indexed keywords

BAICALEIN; BERBERINE; CARNOSIC ACID; CHOTO SAN EXTRACT; CINNAMOPHILIN; CURCUMA EXTRACT; CURCUMA LONGA EXTRACT; DEHYDROEVODIAMINE; EVODIAMINE; FLAVONOID; GINKGO BILOBA EXTRACT; GINSENOSIDE RB 1; HESPERETIN; HONOKIOL; HUPERZINE A; NATURAL PRODUCT; OXEDRINE; PAEONIFLORIN; PALMATINE; PARTHENOLIDE; PLANT EXTRACT; POLYGONUM MULTIFLORUM EXTRACT; PUERARIN; ROSMARINUS OFFICINALIS EXTRACT; RUTAECARPINE; SCUTELLARIA BAICALENSIS EXTRACT; SINOMENINE; THEAFLAVIN; UNCLASSIFIED DRUG; UNINDEXED DRUG; WOGONIN;

ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; BRAIN ISCHEMIA; DRUG MECHANISM; HERB; NEUROPROTECTION; NONHUMAN; REPERFUSION INJURY; REVIEW;

ANIMALS; BRAIN ISCHEMIA; HUMANS; MEDICINE, TRADITIONAL; NEUROPROTECTIVE AGENTS; PHYTOTHERAPY; PLANT EXTRACTS; PLANTS, MEDICINAL; REPERFUSION INJURY;

EID: 78649947576     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2010.186     Document Type: Review

References (81)

1. Stoll G, Kleinschnitz C, Nieswandt B. Molecular mechanisms of thrombus formation in ischemic stroke: novel insights and targets for treatment. Blood 2008;112:3555-62.
2. Green AR. Pharmacological approaches to acute ischaemic stroke: reperfusion certainly, neuroprotection possibly. Br J Pharmacol 2008;153: S325-38.
3. Ly JV, Zavala JA, Donnan GA. Neuroprotection and thrombolysis: combination therapy in acute ischaemic stroke. Expert Opin Pharmacother 2006;7:1571-81.
4. Mattson MP, Cheng AW. Neurohormetic phytochemicals: low-dose toxins that induce adaptive neuronal stress responses. Trends Neurosci 2006;29:632-9.
5. Doré S. Unique properties of polyphenol stilbenes in the brain: more than direct antioxidant actions; gene/protein regulatory activity. Neurosignals 2005;14:61-70.
6. van Praag H. Exercise and the brain: something to chew on. Trends Neurosci 2009;32:283-90.
7. Niizuma K, Endo H, Chan PH. Oxidative stress and mitochondrial dysfunction as determinants of ischemic neuronal death and survival. J Neurochem 2009;109:133-8.
8. Crack PJ, Taylor JM. Reactive oxygen species and the modulation of stroke. Free Radic Biol Med 2005;38:1433-44.
9. Zhang Y, Wang X, Wang X, Xu Z, Liu Z, Ni Q, et al. Protective effect of favonoids from Scutellaria baicalensis Georgi on cerebral ischemia injury. J Ethnopharmacol 2006;108:355-60.
10. Satoh T, Kosaka K, Itoh K, Kobayashi A, Yamamoto M, Shimojo Y, et al. Carnosic acid, a catechol-type electrophilic compound, protects neurons both in vitro and in vivo through activation of the Keap1/Nrf2 pathway via S-alkylation of targeted cysteines on Keap1. J Neurochem 2008;104:1116-31.
11. Rathore P, Dohare P, Varma S, Ray A, Sharma U, Jagannathan NR, et al. Curcuma oil: reduces early accumulation of oxidative product and is anti-apoptogenic in transient focal ischemia in rat brain. Neurochem Res 2008;33:1672-82.
12. Saleem S, Zhuang H, Biswal S, Christen Y, Doré S. Ginkgo biloba extract neuroprotective action is dependent on heme oxygenase 1 in ischemic reperfusion brain injury. Stroke 2008;39:3389-96.
13. Lee EJ, Chen HY, Lee MY, Chen T Y, Hsu YS, Hu YL, et al. Cinnamophilin reduces oxidative damage and protects against transient focal cerebral ischemia in mice. Free Radic Biol Med 2005;39:495-510.
14. Nimura T, Weinstein PR, Massa SM, Panter S, Sharp FR. Heme oxygenase-1 (HO-1) protein induction in rat brain following focal ischemia. Brain Res Mol Brain Res 1996;37:201-8.
15. Doré S. Decreased activity of the antioxidant heme oxygenase enzyme: implications in ischemia and in Alzheimer's disease. Free Radic Biol Med 2002;32:1276-82.
16. Li RC, Saleem S, Zhen G, Cao W, Zhuang H, Lee J, et al. Hemehemopexin complex attenuates neuronal cell death and stroke damage. J Cereb Blood Flow Metab 2009;29:953-64.
17. Endres M, Laufs U, Liao JK, Moskowitz MA. Targeting eNOS for stroke protection. Trends Neurosci; 27:283-9.
18. Ha KS, Kim KM, Kwon YG, Bai SK, Nam WD, Yoo YM, et al. Nitric oxide prevents 6-hydroxydopamine-induced apoptosis in PC12 cells through cGMP-dependent PI3 kinase/Akt activation. FASEB J 2003;17:1036-47.
19. Hua Q, Zhu X, Li P, Tang H, Cai D, Xu Y, et al. Refined Qing Kai Ling, traditional Chinese medicinal preparation, reduces ischemic stroke-induced infarct size and neurological deficits and increases expression of endothelial nitric oxide synthase. Biol Pharm Bull 2008;31:633-7.
20. Bolaños JP, Almeida A. Roles of nitric oxide in brain hypoxia-ischemia. Biochim Biophys Acta 1999;1411:415-36.
21. del Zoppo G, Ginis I, Hallenbeck JM, Iadecola C, Wang X, Feuerstein GZ. Infammation and stroke: putative role for cytokines, adhesion molecules and iNOS in brain response to ischemia. Brain Pathol 2000;10:95-112.
22. Wang T, Gu J, Wu PF, Wang F, Xiong Z, Yang YJ, et al. Protection by tetrahydroxystilbene glucoside against cerebral ischemia: involvement of JNK, SIRT1, and NF-kappaB pathways and inhibition of intracellular ROS/RNS generation. Free Radic Biol Med 2009;47:229-40.
23. Lavu S, Boss O, Elliott PJ, Lambert PD. Sirtuins - novel therapeutic targets to treat age-associated diseases. Nat Rev Drug Discov 2008;7:841-53.
24. Tang BL, Chua CE. SIRT1 and neuronal diseases. Mol Aspects Med 2008;29:187-200.
25. Howitz KT, Bitterman KJ, Cohen HY, Lamming DW, Lavu S, Wood JG, et al. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature 2003;425:191-6.
26. Waite KA, Eng C. Protean PTEN: form and function. Am J Hum Genet 2002;70:829-44.
27. Liu C, Wu J, Xu K, Cai F, Gu J, Ma L, et al. Neuroprotection by baicalein in ischemic brain injury involves PTEN/AKT pathway. J Neurochem 2010;112:1500-12.
28. Brennan AM, Suh SW, Won SJ, Narasimhan P, Kauppinen TM, Lee H, et al. NADPH oxidase is the primary source of superoxide induced by NMDA receptor activation. Nat Neurosci 2009;12:857-63.
29. Qian L, Xu Z, Zhang W, Wilson B, Hong JS, Flood PM. Sinomenine, a natural dextrorotatory morphinan analog, is anti-inflammatory and neuroprotective through inhibition of microglial NADPH oxidase. J Neuroinfammation 2007;4:23.
30. Ko HC, Wang YH, Liou KT, Chen CM, Chen CH, Wang WY, et al. Antiinflammatory effects and mechanisms of the ethanol extract of Evodia rutaecarpa and its bioactive components on neutrophils and microglial cells. Eur J Pharmacol 2007;555:211-7.
31. Dohare P, Garg P, Sharma U, Jagannathan NR, Ray M. Neuroprotective effcacy and therapeutic window of curcuma oil: in rat embolic stroke model. BMC Complement Altern Med 2008;8:55.
32. Jordán J, Segura T, Brea D, Galindo MF, Castillo J. Infammation as therapeutic objective in stroke. Curr Pharm Des 2008;14:3549-64.
33. Barone FC, Feuerstein GZ. Infammatory mediators and stroke: new opportunities for novel therapeutics. J Cereb Blood Flow Metab 1999;19:819-34.
34. Cai F, Li CR, Wu JL, Chen JG, Liu C, Min Q, et al. Theafavin ameliorates cerebral ischemia-reperfusion injury in rats through its antiinflammatory effect and modulation of STAT-1. Mediators Inflamm 2006;2006:30490.
35. Cho J, Lee HK. Wogonin inhibits ischemic brain injury in a rat model of permanent middle cerebral artery occlusion. Biol Pharm Bull 2004;27:1561-4.
36. Kao TK, Ou YC, Raung SL, Chen WY, Yen YJ, Lai CY, et al. Graptopetalum paraguayense E. Walther leaf extracts protect against brain injury in ischemic rats. Am J Chin Med 2010;38:495-516.
37. Yi JH, Park SW, Kapadia R, Vemuganti R. Role of transcription factors in mediating post-ischemic cerebral infammation and brain damage. Neurochem Int 2007;50:1014-27.
38. Lee IY, Lee JH, Yun BS. Polychlorinated compounds with PPAR-gamma agonistic effect from the medicinal fungus Phellinus ribis. Bioorg Med Chem Lett 2008;18:4566-8.
39. Genovese S, Foreman JE, Borland MG, Epifano F, Gonzalez FJ, Curini M, et al. A natural propenoic acid derivative activates peroxisome proliferator-activated receptor-β/δ (PPARβ/δ). Life Sci 2010;86:493-8.
40. Moussaieff A, Shohami E, Kashman Y, Fride E, Schmitz ML, Renner F, et al. Incensole acetate, a novel anti-infammatory compound isolated from Boswellia resin, inhibits nuclear factor-kappa B activation. Mol Pharmacol 2007;72:1657-64.
41. Kwok BH, Koh B, Ndubuisi MI, Elofsson M, Crews CM. The antiinfammatory natural product parthenolide from the medicinal herb Feverfew directly binds to and inhibits Ikappa kinase. Chem Biol 2001;8:759-766.
42. Kim JY, Jung KJ, Choi JS, Chung HY. Modulation of the age-related nuclear factor-kappaB (NF-kappaB) pathway by hesperetin. Aging Cell 2006;5:401-11.
43. Lü Q, Xu XL, He Z, Huang XJ, Guo LJ, Wang HX. Guattegaumerine protects primary cultured cortical neurons against oxidative stress injury induced by hydrogen peroxide concomitant with serum deprivation. Cell Mol Neurobiol 2009;29:355-64.
44. 2+ exchange isoforms: physiological and physiopathological relevance. J Cardiovasc Pharmacol 1993;22: S96-8.
45. Salinska E, Lazarewicz JW. NMDA receptor-mediated calcium fuxes in the hippocampus: relevance to ischemic brain pathology. Neurol Neurochir Pol 1996;30:35-42.
46. Simard JM, Tarasov KV, Gerzanich V. Non-selective cation channels, transient receptor potential channels and ischemic stroke. Biochim Biophys Acta 2007;1772:947-57.
47. 2+-permeable acid-sensing ion channels and ischemic brain injury. J Membr Biol 2006;209:59-68.
48. +-ATPase activity and mitochondrial functions. Basic Clin Pharmacol Toxicol 2007;101:108-16.
49. Wang F, Zhou HY, Cheng L, Zhao G, Zhou J, Fu LY, et al. Effects of palmatine on potassium and calcium currents in isolated rat hepatocytes. World J Gastroenterol 2003;9:329-33. (Pubitemid 36215815)
50. Wang F, Zhou HY, Zhao G, Fu LY, Cheng L, Chen JG, et al. Inhibitory effects of berberine on ion channels of rat hepatocytes. World J Gastroenterol 2004;10:2842-5. (Pubitemid 39303001)
51. Kulkarni SK, Dhir A. Berberine: a plant alkaloid with therapeutic potential for central nervous system disorders. Phytother Res 2010;24:317-24.
52. Gu L, Yang Y, Sun Y, Zheng X. Puerarin inhibits acid-sensing ion channels and protects against neuron death induced by acidosis. Planta Med 2010;76:583-8.
53. Kühn FJ, Heiner I, Lückhoff A. TRPM2: a calcium influx pathway regulated by oxidative stress and the novel second messenger ADP-ribose. Pfugers Arch 2005;451:212-9.
54. Yang KT, Chang WL, Yang PC, Chien CL, Lai MS, Su MJ, et al. Activation of the transient receptor potential M2 channel and poly (ADP-ribose) polymerase is involved in oxidative stress-induced cardiomyocyte death. Cell Death Differ 2006;13:1815-26.
55. Liu CS, Chen NH, Zhang JT. Protection of PC12 cells from hydrogen peroxide-induced cytotoxicity by salvianolic acid B, a new compound isolated from Radix Salviae miltiorrhizae. Phytomedicine 2007;14:492-7.
56. Wang H, Joseph JA. Structure-activity relationships of quercetin in antagonizing hydrogen peroxide-induced calcium dysregulation in PC12 cells. Free Radic Biol Med 1999;27:683-94.
57. Broughton BR, Reutens DC, Sobey CG. Apoptotic mechanisms after cerebral ischemia. Stroke 2009;40: e331-9.
58. Park SJ, Nam KW, Lee HJ, Cho EY, Koo U, Mar. W. Neuroprotective effects of an alkaloid-free ethyl acetate extract from the root of Sophora flavescens Ait. against focal cerebral ischemia in rats. Phytomedicine 2009;16:1042-51.
59. van Wijk SJ, Hageman GJ. Poly (ADP-ribose) polymerase-1 mediated caspase-independent cell death after ischemia/reperfusion. Free Radic Biol Med 2005;39:81-90.
60. Zhang WT, Ruan JL, Wu PF, Jiang FC, Zhang LN, Fang W, et al. Design, synthesis, and cytoprotective effect of 2-aminothiazole analogues as potent poly (adp-ribose) polymerase-1 inhibitors. J Med Chem 2009;52:718-25.
61. Ferraris D, Ficco RP, Dain D, Ginski M, Lautar S, Lee-Wisdom K, et al. Design and synthesis of poly (ADP-ribose) polymerase-1 (PARP-1) inhibitors. Part 4: Biological evaluation of imidazobenzodiazepines as potent PARP-1 inhibitors for treatment of ischemic injuries. Bioorg Med Chem 2003;11:3695-707. (Pubitemid 36952268)
62. Ye M, Fu S, Pi R, He F. Neuropharmacological and pharmacokinetic properties of berberine: a review of recent research. J Pharm Pharmacol 2009;61:831-7.
63. Rami A, Bechmann I, Stehle JH. Exploiting endogenous anti-apoptotic proteins for novel therapeutic strategies in cerebral ischemia. Prog Neurobiol 2008;85:273-96.
64. Yu SS, Zhao J, Zheng WP, Zhao Y. Neuroprotective effect of 4-hydroxybenzyl alcohol against transient focal cerebral ischemia via antiapoptosis in rats. Brain Res 2010;1308:167-75.
65. Zhang B, Hata R, Zhu P, Sato K, Wen TC, Yang L, et al. Prevention of ischemic neuronal death by intravenous infusion of a ginseng saponin, ginsenoside Rb (1), that upregulates Bcl-xL expression. J Cereb Blood Flow Metab 2006;26:708-21.
66. Teng H, Zhang ZG, Wang L, Zhang RL, Zhang L, Morris D, et al. Coupling of angiogenesis and neurogenesis in cultured endothelial cells and neural progenitor cells after stroke. J Cereb Blood Flow Metab 2008;28:764-71.
67. Sun Y, Jin K, Xie L, Childs J, Mao XO, Logvinova A, et al. VEGF-induced neuroprotection, neurogenesis, and angiogenesis after focal cerebral ischemia. J Clin Invest 2003;111:1843-51.
68. Yao RQ, Zhang L, Wang W, Li L. Cornel iridoid glycoside promotes neurogenesis and angiogenesis and improves neurological function after focal cerebral ischemia in rats. Brain Res Bull 2009;79:69-76.
69. Heurteaux C, Gandin C, Borsotto M, Widmann C, Brau F, Lhuillier M, et al. Neuroprotective and neuroproliferative activities of NeuroAid (MLC601, MLC901), a Chinese medicine, in vitro and in vivo. Neuropharmacology 2010;58:987-1001.
70. Thiels E, Klann E. Extracellular signal-regulated kinase, synaptic plasticity, and memory. Rev Neurosci 2001;12:327-45.
71. Maher P, Akaishi T, Abe K. Flavonoid fsetin promotes ERK-dependent long-term potentiation and enhances memory. Proc Natl Acad Sci USA 2006;103:16568-73.
72. Baskys A, Hou AC. Vascular dementia: pharmacological treatment approaches and perspectives. Clin Interv Aging 2007;2:327-35.
73. Chen DM, Xiao L, Cai X, Zeng R, Zhu XZ. Involvement of multitargets in paeoniforin-induced preconditioning. J Pharmacol Exp Ther 2006;319:165-80.
74. Wang Z, Du Q, Wang F, Liu Z, Li B, Wang A, et al. Microarray analysis of gene expression on herbal glycoside recipes improving deficient ability of spatial learning memory in ischemic mice. J Neurochem 2004;88:1406-15.
75. Jiang ZG, Lu XC, Nelson V, Yang X, Pan W, Chen RW, et al. A multifunctional cytoprotective agent that reduces neurodegeneration after ischemia. Proc Natl Acad Sci USA 2006;103:1581-6.
76. Youdim MB, Buccafusco JJ. Multi-functional drugs for various CNS targets in the treatment of neurodegenerative disorders. Trends Pharmacol Sci 2005;26:27-35.
77. Mantz J, Degos V, Laigle C. Recent advances in pharmacologic neuroprotection. Eur J Anaesthesiol 2010;27:6-10.
78. Cao C, He X, Wang W, Zhang L, Lin H, Du L. Kinetic distribution of paeoniflorin in cortex of normal and cerebral ischemia-reperfusion rats after intravenous administration of Paeoniae Radix extract. Biomed Chromatogr 2006;20:1283-8.
79. Wang C, Zhang D, Ma H, Liu J. Neuroprotective effects of emodin-8-O-beta-D-glucoside in vivo and in vitro. Eur J Pharmacol 2007;577:58-63. (Pubitemid 47632528)
80. Tarragó T, Kichik N, Claasen B, Prades R, Teixidó M, Giralt E. Baicalin, a prodrug able to reach the CNS, is a prolyl oligopeptidase inhibitor. Bioorg Med Chem 2008;16:7516-24.
81. Youdim KA, Dobbie MS, Kuhnle G, Proteggente AR, Abbott NJ, Rice-Evans C. Interaction between favonoids and the blood-brain barrier: in vitro studies. J Neurochem 2003;85:180-92.