TRPM2: A calcium influx pathway regulated by oxidative stress and the novel second messenger ADP-ribose

Pflugers Archiv European Journal of Physiology

Volumn 451, Issue 1, 2005, Pages 212-219

  Kühn, Frank J P ^a   Heiner, Inka ^a   Lückhoff, Andreas ^a  

^a RWTH AACHEN UNIVERSITY   (Germany)

Author keywords

cADPR; Calcium channel; Non selective cation channel; PARP; Splice variants

Indexed keywords

ADENOSINE DIPHOSPHATE RIBOSE; ADENOSINE PHOSPHATE; CALCIUM CHANNEL; CALCIUM ION; CLOTRIMAZOLE; ECONAZOLE; FLUFENAMIC ACID; HYDROGEN PEROXIDE; IMIDAZOLE DERIVATIVE; NICOTINAMIDE ADENINE DINUCLEOTIDE; NUCLEOSIDE DIPHOSPHATASE; NUCLEOSIDE DIPHOSPHATE LINKED MOIETY X TYPE MOTIF 9; PROTEIN; TRANSIENT RECEPTOR POTENTIAL CHANNEL; TRANSIENT RECEPTOR POTENTIAL MELASTATIN 2; UNCLASSIFIED DRUG;

ARTICLE; CALCIUM TRANSPORT; CARBOXY TERMINAL SEQUENCE; CELL DEATH; CHANNEL GATING; DIABETES MELLITUS; GENE EXPRESSION; GENE LOCATION; GENETIC TRANSCRIPTION; HUMAN; LEUKOCYTE ACTIVATION; NONHUMAN; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN STRUCTURE; REPERFUSION INJURY; RNA SPLICING; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION;

ADENOSINE DIPHOSPHATE RIBOSE; ANIMALS; CALCIUM; CYCLIC ADP-RIBOSE; DRUG SYNERGISM; HUMANS; HYDROGEN PEROXIDE; OXIDATIVE STRESS; POLY(ADP-RIBOSE) POLYMERASES; SECOND MESSENGER SYSTEMS; TRPM CATION CHANNELS;

EID: 26444439972     PISSN: 00316768     EISSN: 14322013     Source Type: Journal    
DOI: 10.1007/s00424-005-1446-y     Document Type: Article

References (50)

1. Bessman MJ, Frick DN, O'Handley SF (1996) The MutT proteins or "Nudix" hydrolases, a family of versatile, widely distributed, "housecleaning" enzymes. J Biol Chem 271:25059-25062
2. Chuang HH, Neuhausser WM, Julius D (2004) The supercooling agent icilin reveals a mechanism of coincidence detection by a temperature-sensitive TRP channel. Neuron 43:859-869
3. De Murcia G, Menissier DM (1994) Poly(ADP-ribose) polymerase: a molecular nick-sensor. Trends Biochem Sci 19:172-176
4. + depletion and cell death induced by oxidative stress. J Biol Chem 278:18426-18433
5. Dunn CA, O'Handley SF, Frick DN, Bessman MJ (1999) Studies on the ADP-ribose pyrophosphatase subfamily of the nudix hydrolases and tentative identification of trgB, a gene associated with tellurite resistance. J Biol Chem 274:32318-32324
6. Fonfria E, Marshall ICB, Benham CD, Boyfield I, Brown JD, Hill K, Hughes JP, Skaper SD, McNulty S (2004) TRPM2 channel opening in response to oxidative stress is dependent on activation of poly(ADP-ribose) polymerase. Br J Pharmacol 143:186-192
7. Gabelli SB, Bianchet MA, Bessman MJ, Amzel LM (2001) The structure of ADP-ribose pyrophosphatase reveals the structural basis for the versatility of the Nudix family. Nat Struct Biol 8:467-472
8. 2+-permeable channel activated by changes in redox status confers susceptibility to cell death. Mol Cell 9:163-173
9. Harteneck C, Plant TD, Schulz G (2000) From worm to man: three subfamilies of TRP channels. Trends Neurosci 23:159-166
10. Heiner I, Eisfeld J, Halaszovich CR, Wehage E, Jüngling E, Zitt C, Lückhoff A (2003) Expression profile of the transient receptor potential (TRP) family in neutrophil granulocytes: evidence for currents through long TRP channel 2 induced by ADP-ribose and NAD. Biochem J 371:1045-1053
11. 2 in the rat insulin-secreting cell line CRI-G1. J Physiol (Lond) 501:59-66
12. Herson PS, Lee K, Pinnock RD, Hughes J, Ashford ML (1999) Hydrogen peroxide induces intracellular calcium overload by activation of a non-selective cation channel in an insulin-secreting cell line. J Biol Chem 274:833-841
13. Hill K, Benham CD, McNulty S, Randall AD (2004) Flufenamic acid is a pH-dependent antagonist of TRPM2 channels. Neuropharmacology 47:450-460
14. Hill K, McNulty S, Randall AD (2004) Inhibition of TRPM2 channels by the antifungal agents clotrimazole and econazole. Naunyn-Schmiedeberg's Arch Pharmacol 370:227-237
15. 2+-activated monovalent selective cation channel. Curr Biol 13:1153-1158
16. Inamura K, Sano S, Mochizuki H, Yokoi A, Miyake K, Nozawa C, Kitada H, Matsuhime K, Furuichi K (2003) Response to ADP-ribose by activation of TRPM2 in the CRI-G1 insulinoma cell line. J Membr Biol 191:201-207
17. + channels inhibit human pancreatic cancer cell growth in vitro. Mol Pharmacol 65:630-638
18. Jankowski A, Grinstein S (1999) A noninvasive fluorimetric procedure for measurement of membrane potential. Quantification of the NADPH oxidase-induced depolarization in activated neutrophils. J Biol Chem 274:26098-26104
19. + channel. Am J Physiol 275:C848-C856
20. - channel currents in rat ventral prostate epithelial cells. Prostate 55:118-127
21. Kolisek M, Beck A, Fleig A, Penner R (2005) Cyclic ADP-ribose and hydrogen peroxide synergize with ADP-ribose in the activation of TRPM2 channels. Mol Cell 18:61-69
22. Kraft R, Grimm C, Grosse K, Hoffmann A, Sauerbruch S, Kettenmann H, Schultz G, Harteneck C (2004) Hydrogen peroxide and ADP-ribose induce TRPM2-mediated calcium influx and cation currents in microglia. Am J Physiol 286:129-137
23. Krause KH, Campbell KP, Welsh MJ, Lew DP (1990) The calcium signal and neutrophil activation. Clin Biochem 23:159-166
24. Kühn FJP, Lückhoff A (2004) Sites of the NUDT9-H domain critical for ADP-ribose activation of the cation channel TRPM2. J Biol Chem 279:46431-46437
25. 2+-activated currents in neurons. Cell Calcium 19:431-438
26. Liu X, Zweier JL (2001) A real-time electrochemical technique for measurement of cellular hydrogen peroxide generation and consumption: evaluation in human polymorphonuclear leukocytes. Free Radic Biol Med 31:894-901
27. 2+ dependence of transient receptor potential melastatin 2 (TRPM2) cation channel activation. J Biol Chem 278:11002-11006
28. Montell C, Birnbaumer L, Flockerzi V, Bindels RJ, Bruford EA, Caterina MJ, Clapham DE, Harteneck C, Heller S, Julius D, Kojima I, Mori Y, Penner R, Prawitt D, Scharenberg AM, Schultz G, Shimizu N, Zhu MX (2002) A unified nomenclature for the superfamily of TRP cation channels. Mol Cell 9:229-231
29. 2+ channel protein (TRPC7) highly expressed in brain. Genomics 54:124-131
30. 2+-activated cation channel TRPM4. J Biol Chem 278:30813-30820
31. 2+ channel ECaC1. Br J Pharmacol 134:453-462
32. Oliver FJ, Menissier-de Murcia J, Nacci C, Decker P, Andriantsitohaina R, Muller S, de la Rubia G, Stoclet JC, de Murcia G (1999) Resistance to endotoxic shock as a consequence of defective NF-κB activation in poly (ADP-ribose) polymerase-1 deficient mice. EMBO J 18:4446-4454
33. Perraud AL, Fleig A, Dunn CA, Bagley LA, Launay P, Schmitz C, Stokes AJ, Zhu Q, Bessman MJ, Penner R, Kinet JP, Scharenberg AM (2001) ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology. Nature 411:595-599
34. Perraud AL, Knowles HM, Schmitz C (2004) Novel aspects of signaling and ion-homeostasis regulation in immunocytes. The TRPM ion channels and their potential role in modulating the immune response. Mol Immunol 41:657-673
35. 2+ permeable cation channels: from gene to biological function. Cell Calcium 33:519-531
36. Perraud AL, Shen B, Dunn CA, Rippel K, Smith MK, Bessman MJ, Stoddard BL, Scharenberg AM (2003) NUDT9 a member of the nudix hydrolase family, is an evolutionary conserved mitochondrial ADP-ribose pyrophosphatase. J Biol Chem 278:1794-1801
37. Perraud AL, Takanishi CL, Shen B, Kang S, Smith MK, Schmitz C, Knowles HM, Ferraris D, Li W, Zhang J, Stoddard BL, Scharenberg AM (2004) Accumulation of free ADP-ribose from mitochondria mediates oxidative stress-induced gating of TRPM2 cation channels. J Biol Chem 280:6138-6148
38. Qian F, Huang P, Ma L, Kuznetsov A, Tamarina N, Philipson LH (2002) TRP genes: candidates for nonselective cation channels and store-operated channels in insulin-secreting cells. Diabetes 51:183-189
39. Runnels LW, Yue L, Clapham DE (2001) TRP-PLIK, a bifunctional protein with kinase and ion channel activities. Science 291:1043-1047
40. Sano Y, Inamura K, Miyake A, Mochizuki S, Yokoi H, Matsushime H, Furuichi K (2001) Response to ADP-ribose by activation of TRPM2 in the CRI-G1 insulinoma cell line. Science 293:1327-1330
41. Shen BW, Perraud AL, Scharenberg A, Stoddard BL (2003) The crystal structure and mutational analysis of human NUDT9. J Mol Biol 332:385-398
42. Smith MA, Herson PS, Lee K, Pinnock RD, Ashford ML (2003) Hydrogen-peroxide-induced toxicity of rat striatal neurones involves activation of a non-selective cation channel. J Physiol (Lond) 547:417-425
43. Tanuma S, Yagi T, Johnson GS (1985) Endogenous ADP ribosylation of high mobility group proteins 1 and 2 and histone H1 following DNA damage in intact cells. Arch Biochem Biophys 237:38-42
44. Thelen M, Dewald B, Baggiolini M (1993) Neutrophil signal transduction and activation of the respiratory burst. Physiol Rev 73:797-821
45. Uemura T, Kudoh J, Setsuko N, Kanba S, Shimizu N (2005) Characterization of human and mouse TRPM2 genes: identification of a novel N-terminal truncated protein specifically expressed in human striatum. Biochem Biophys Res Commun 328:1232-1243
46. Virag L, Szabo C (2002) The therapeutic potential of poly(-ADP-ribose) polymerase inhibitors. Pharmacol Rev 54:375-429
47. Voets T, Droogmans G, Wissenbach U, Janssens A, Flockerzi V, Nilius B (2004) The principle of temperature-dependent gating in cold- and heat-sensitive TRP channels. Nature 430:748-754
48. Warner DS, Sheng H, Batinic-Haberle I (2004) Oxidants, antioxidants and the ischemic brain. Exp Biol 207:3221-3231
49. Wehage E, Eisfeld J, Heiner I, Jüngling E, Zitt C, Lückhoff A (2002) Activation of the cation channel long transient receptor potential channel 2 (LTRPC2) by hydrogen peroxide. A splice variant reveals a mode of activation independent of ADP-ribose. J Biol Chem 277:23150-23156
50. Zhang W, Chu X, Tong Q, Cheung JY, Conrad K, Masker K, Miller BA (2003) A novel TRPM2 isoform inhibits calcium influx and susceptibility to cell death. J Biol Chem 278:16222-16229