Neuroprotective effects of an alkaloid-free ethyl acetate extract from the root of Sophora flavescens Ait. Against focal cerebral ischemia in rats

Phytomedicine

Volumn 16, Issue 11, 2009, Pages 1042-1051

  Park, S J ^a   Nam, K W ^a,c   Lee, H J ^b   Cho, E Y ^a   Koo, U ^a   Mar, W ^a  

^a Seoul National University   (South Korea)

^b Korea Forest Research Institute   (South Korea)

^c Jung San Bio Technology   (South Korea)

Author keywords

Apoptosis; Middle cerebral artery occlusion; Neuroprotective effect; Sophora flavescens; Stroke

Indexed keywords

ACETIC ACID ETHYL ESTER; CARNOSINE; CASPASE 3; KURARINONE; NITROPRUSSIDE SODIUM; SOPHORA FLAVESCENS EXTRACT; SOPHORAFLAVONE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; CELL VIABILITY; CONTROLLED STUDY; DNA FRAGMENTATION; DOSE RESPONSE; DRUG EFFICACY; ENZYME INHIBITION; HUMAN; HUMAN CELL; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROPROTECTION; NONHUMAN; PLANT ROOT; PRIORITY JOURNAL; RAT;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CASPASE 3; CELL LINE, TUMOR; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DNA FRAGMENTATION; HUMANS; INFARCTION, MIDDLE CEREBRAL ARTERY; MALE; NEUROPROTECTIVE AGENTS; NITROPRUSSIDE; PHYTOTHERAPY; PLANT EXTRACTS; PLANT ROOTS; RATS; RATS, SPRAGUE-DAWLEY; SOPHORA;

FABACEAE; RATTUS; SOPHORA FLAVESCENS;

EID: 70349776296     PISSN: 09447113     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.phymed.2009.03.017     Document Type: Article

References (31)

1. Cheng Y.D., Al-Khoury L., and Zivin J.A. Neuroprotection for ischemic stroke: two decades of success and failure. NeuroRx 1 (2004) 36-45
2. Curin Y., Ritz M.F., and Andriantsitohaina R. Cellular mechanisms of the protective effect of polyphenols on the neurovascular unit in strokes. Cardiovasc. Hematol. Agents Med. Chem. 4 (2006) 277-288
3. Dirnagl U., Iadecola C., and Moskowitz M.A. Pathobiology of ischaemic stroke: an integrated view. Trends Neurosci. 22 (1999) 391-397
4. Earnshaw W.C., Matrins L.M., and Kaufmann S.H. Mammalian caspases: structure, activation, substrates, and functions during apoptosis. Annu. Rev. Biochem. 68 (1999) 383-424
5. Encinas M., Iglesias M., Liu Y., Wang H., Muhaisen A., Cena V., Gallego C., and Comella J.X. Sequential treatment of SH-SY5Y cells with retinoic acid and brain-derived neurotrophic factor gives rise to fully differentiated, neurotrophic factor-dependent, human neuron-like cells. J. Neurochem. 75 (2000) 991-1003
6. Gao F., Sugita M., and Nukui H. Phosphodiesterase 5 inhibitor, zaprinast, selectively increases cerebral blood flow in the ischemic penumbra in the rat brain. Neurol. Res. 27 (2005) 638-643
7. Ghatan S., Larner S., Kinoshita Y., Hetman M., Patel L., Xia Z., Youle R.J., and Morrison R.S. P38 map kinase mediates bax translocation in nitric oxide-induced apoptosis in neurons. J. Cell Biol. 150 (2000) 335-347
8. Jiang H., Hou C., Zhang S., Xie H., Zhou W., Jin Q., Cheng X., Qian R., and Zhang X. Matrine upregulates the cell cycle protein E2F-1 and triggers apoptosis via the mitochondrial pathway in K562 cells. Eur. J. Pharmacol. 559 (2007) 98-108
9. Jiang H., Meng F., Li J., and Sun X. Anti-apoptosis effects of oxymatrine protect the liver from warm ischemia reperfusion injury in rats. World J. Surg. 29 (2005) 1397-1401
10. Kato H., and Kogure K. Biochemical and molecular characteristics of the brain with developing cerebral infarction. Cell Mol. Neurobiol. 19 (1999) 93-108
11. Kim J.H., Ryu Y.B., Kang N.S., Lee B.W., Heo J.S., Jeong I.Y., and Park K.H. Glycosidase inhibitory flavonoids from Sophora flavescens. Biol. Pharm. Bull. 29 (2006) 302-325
12. Liu X.S., Jiang J., Jiao X.Y., Wu Y.E., and Lin J.H. Matrine-induced apoptosis in leukemia U937 cells: involvement of caspases activation and MAPK-independent pathways. Planta Med. 72 (2006) 501-506
13. Longa E.Z., Weinstein P.R., Carlson S., and Cumming R. Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke 20 (1989) 84-91
14. Lopez E., and Ferrer I. Staurosporine- and H-7-induced cell death in SH-SY5Y neuroblastoma cells is associated with caspase-2 and caspase-3 activation, but not with activation of the FAS/FAS-L-caspase-8 signaling pathway. Brain Res. Mol. Brain Res. 85 (2000) 61-67
15. Love S. Oxidative stress in brain ischemia. Brain Pathol. 9 (1999) 119-131
16. Ma L., Wen S., Zhan Y., He Y., Liu X., and Jiang J. Anticancer effects of the chinese medicine Matrine on murine hepatocellular carcinoma cells. Planta Med. 74 (2008) 245-251
17. Mergenthaler P., Dirnagl U., and Meisel A. Pathophysiology of stroke: lessons from animal models. Metab. Brain Dis. 19 (2004) 151-167
18. Mohammad Y.M., Divani A.A., Kirmani J.F., Harris-Lane P., and Qureshi A.I. Acute treatment for ischemic stroke in 2004. Emerg. Radiol. 11 (2004) 83-86
19. Mokudai T., Ayoub I.A., Sakakibara Y., Lee E.J., Ogilvy C.S., and Maynard K.I. Delayed treatment with nicotinamide (Vitamin B(3)) improves neurological outcome and reduces infarct volume after transient focal cerebral ischemia in Wistar rats. Stroke 31 (2000) 1679-1685
20. Moriya R., Uehara T., and Nomura Y. Mechanism of nitric oxide-induced apoptosis in human neuroblastoma SH-SY5Y cells. FEBS Lett. 484 (2000) 253-260
21. Piao X.L., Piao X.S., Kim S.W., Park J.H., Kim H.Y., and Cai S.Q. Identification and characterization of antioxidants from Sophora flavescens. Biol. Pharm. Bull. 29 (2006) 1911-1915
22. Quan W., Lee H.J., Kim C.Y., Noh C.W., Um B.H., Oak M.H., and Kim K.M. Anti-allergic prenylated flavonoids from the roots of Sophora flavescens. Planta Med. 74 (2008) 168-170
23. Rajanikant G.K., Zemke D., Senut M.C., Frenkel M.B., Chen A.F., Gupta R., and Majid A. Carnosine is neuroprotective against permanent focal cerebral ischemia in mice. Stroke 38 (2007) 3023-3031
24. Saito A., Maier C.M., Narasimhan P., Nishi T., Song Y.S., Yu F., Liu J., Lee Y.S., Nito C., Kamada H., Dodd R.L., Hsieh L.B., Hassid B., Kim E.E., Gonzalez M., and Chan P.H. Oxidative stress and neuronal death/survival signaling in cerebral ischemia. Mol. Neurobiol. 31 (2005) 105-116
25. Salvesen G.S., and Dixit V.M. Caspases: intracellular signaling by proteolysis. Cell 91 (1997) 443-446
26. Sato S., Takeo J., Aoyama C., and Kawahara H. Na+-glucose cotransporter (sglt) inhibitory flavonoids from the roots of Sophora flavescens. Bioorg. Med. Chem. 15 (2007) 3445-3449
27. Shin H.J., Kim H.J., Kwak J.H., Chun H.O., Kim J.H., Park H., Kim D.H., and Lee Y.S. A prenylated flavonol, sophoflavescenol: a potent and selective inhibitor of cGMP phosphodiesterase 5. Bioorg. Med. Chem. Lett. 12 (2002) 2313-2316
28. Swanson R.A., Morton M.T., Tsao-Wu G., Savalos R.A., Davidson C., and Sharp F.R. A semiautomated method for measuring brain infarct volume. J. Cereb. Blood Flow Metab. 10 (1990) 290-293
29. Zhang D.L., Zhang Y.T., Yin J.J., and Zhao B.L. Oral administration of Crataegus flavonoids protects against ischemia/reperfusion brain damage in gerbils. J. Neurochem. 90 (2004) 211-219
30. Zhang L., Zhang R.L., Wang Y., Zhang C., Zhang Z.G., Meng H., and Chopp M. Functional recovery in aged and young rats after embolic stroke: treatment with a phosphodiesterase type 5 inhibitor. Stroke 36 (2005) 847-852
31. Zhang L., Zhang Z., Zhang R.L., Cui Y., Lapointe M.C., Silver B., and Chopp M. Tadalafil, a long-acting type 5 phosphodiesterase isoenzyme inhibitor, improves neurological functional recovery in a rat model of embolic stroke. Brain Res. 1118 (2006) 192-198