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Volumn 16, Issue 28, 2010, Pages 3118-3123

Gene Targeting and Expression Modulation by Peptide Nucleic Acids (PNA)

Author keywords

Antisense; Delivery; Gene targeting; PNA; Transcription

Indexed keywords

CELL PENETRATING PEPTIDE; DOUBLE STRANDED DNA; MICRORNA; OLIGOMER; PEPTIDE NUCLEIC ACID; SMALL INTERFERING RNA;

EID: 78649822317     PISSN: 13816128     EISSN: None     Source Type: Journal    
DOI: 10.2174/138161210793292546     Document Type: Article
Times cited : (65)

References (76)
  • 1
    • 0026341239 scopus 로고
    • Sequence-selective recognition of DNA by Strand displacement with a thyminesubstituted polyamide
    • Nielsen PE, Egholm M, Berg RH, Buchardt O. Sequence-selective recognition of DNA by Strand displacement with a thyminesubstituted polyamide. Science 1991; 254: 1497-500.
    • (1991) Science , vol.254 , pp. 1497-1500
    • Nielsen, P.E.1    Egholm, M.2    Berg, R.H.3    Buchardt, O.4
  • 2
    • 0027364174 scopus 로고
    • PNA hybridizes to complementary oligonucleotides obeying the watson-crick hydrogen-bonding rules
    • Egholm M, Buchardt O, Christensen L, et al. PNA hybridizes to complementary oligonucleotides obeying the watson-crick hydrogen-bonding rules. Nature 1993; 365: 566-8.
    • (1993) Nature , vol.365 , pp. 566-568
    • Egholm, M.1    Buchardt, O.2    Christensen, L.3
  • 3
    • 0032766821 scopus 로고    scopus 로고
    • Peptide nucleic acid. A molecule with two identities
    • Nielsen PE Peptide nucleic acid. A molecule with two identities. Accounts Chem Res 1999; 32: 624-30.
    • (1999) Accounts Chem Res , vol.32 , pp. 624-630
    • Nielsen, P.E.1
  • 4
    • 0028066788 scopus 로고
    • NMR Solution structure of a peptide nucleic acid complexed with RNA
    • Brown SC, Thomson SA, Veal JM, Davis DG. NMR Solution structure of a peptide nucleic acid complexed with RNA. Science 1994; 265: 777.
    • (1994) Science , vol.265 , pp. 777
    • Brown, S.C.1    Thomson, S.A.2    Veal, J.M.3    Davis, D.G.4
  • 6
    • 0030440962 scopus 로고    scopus 로고
    • PNA-nucleic acid complexes. Structure, stability and dynamics
    • Eriksson M, Nielsen PE. PNA-nucleic acid complexes. Structure, stability and dynamics. Quart Rev Biophys 1996; 29: 369-94
    • (1996) Quart Rev Biophys , vol.29 , pp. 369-394
    • Eriksson, M.1    Nielsen, P.E.2
  • 7
    • 78649861808 scopus 로고    scopus 로고
    • Modulating gene function with peptide nucleic acids (PNA)
    • In: Crooke ST, Ed., Taylor francis group, CRC Press, Chapter
    • Nielsen PE. Modulating gene function with peptide nucleic acids (PNA). In: Crooke ST, Ed. antisense drug technology. Taylor francis group, CRC Press 2008; Chapter 18.
    • (2008) Antisense Drug Technology , pp. 18
    • Nielsen, P.E.1
  • 8
    • 78649871239 scopus 로고    scopus 로고
    • RNA targeting using peptide nucleic acid
    • In: Erdmann V, Brosius J, Barciszewski J, Eds., Springer, Vol
    • Nielsen E. RNA targeting using peptide nucleic acid. In: Erdmann V, Brosius J, Barciszewski J, Eds. RNA towards medicine; Springer 2006; Vol. 173.
    • (2006) RNA Towards Medicine , pp. 173
    • Nielsen, E.1
  • 10
    • 0035477551 scopus 로고    scopus 로고
    • Nuclear antisense effects of neutral, anionic and cationic oligonucleotide analogs
    • Sazani P, Kang SH, Maier MA, et al. Nuclear antisense effects of neutral, anionic and cationic oligonucleotide analogs. Nucleic Acids Res 2001; 29: 3965-74.
    • (2001) Nucleic Acids Res , vol.29 , pp. 3965-3974
    • Sazani, P.1    Kang, S.H.2    Maier, M.A.3
  • 11
    • 23944455368 scopus 로고    scopus 로고
    • Calcium ions effectively enhance the effect of antisense peptide nucleic acids conjugated to cationic tat and oligoarginine peptides
    • Shiraishi T, Pankratova S, Nielsen PE. Calcium ions effectively enhance the effect of antisense peptide nucleic acids conjugated to cationic tat and oligoarginine peptides. Chemi Biol 2005; 12: 923-9
    • (2005) Chemi Biol , vol.12 , pp. 923-929
    • Shiraishi, T.1    Pankratova, S.2    Nielsen, P.E.3
  • 12
    • 33847020791 scopus 로고    scopus 로고
    • Peptide-based delivery of nucleic acids: Design, mechanism of uptake and applications to splice-correcting oligonucleotides
    • Abes S, Moulton H, Turner J, et al. Peptide-based delivery of nucleic acids: design, mechanism of uptake and applications to splice-correcting oligonucleotides. Biochem Soc Transact 2007; 35: 53-5
    • (2007) Biochem Soc Transact , vol.35 , pp. 53-55
    • Abes, S.1    Moulton, H.2    Turner, J.3
  • 13
    • 0141497030 scopus 로고    scopus 로고
    • Therapeutic potential of antisense oligonucleotides as modulators of alternative splicing
    • Sazani P, Kole R. Therapeutic potential of antisense oligonucleotides as modulators of alternative splicing. J Clin Invest 2003; 112: 481-6
    • (2003) J Clin Invest , vol.112 , pp. 481-486
    • Sazani, P.1    Kole, R.2
  • 14
    • 1942453441 scopus 로고    scopus 로고
    • Modification of alternative splicing by antisense therapeutics
    • Kole R, Vacek M, Williams T. Modification of alternative splicing by antisense therapeutics. Oligonucleotides 2004; 14: 65-74
    • (2004) Oligonucleotides , vol.14 , pp. 65-74
    • Kole, R.1    Vacek, M.2    Williams, T.3
  • 15
    • 56649113066 scopus 로고    scopus 로고
    • Improved cellpenetrating peptide-PNA conjugates for splicing redirection in HeLa cells and exon skipping in mdx mouse muscle
    • Ivanova GD, Arzumanov A, Abes R, et al. Improved cellpenetrating peptide-PNA conjugates for splicing redirection in HeLa cells and exon skipping in mdx mouse muscle. Nucleic Acids Res 2008; 36: 6418-28.
    • (2008) Nucleic Acids Res , vol.36 , pp. 6418-6428
    • Ivanova, G.D.1    Arzumanov, A.2    Abes, R.3
  • 16
    • 37549022222 scopus 로고    scopus 로고
    • Effective exon skipping and restoration of dystrophin expression by peptide nucleic acid antisense oligonucleotides in mdx mice
    • Yin H, Lu Q, Wood M. Effective exon skipping and restoration of dystrophin expression by peptide nucleic acid antisense oligonucleotides in mdx mice. Mol Therapy 2008; 16: 38-45
    • (2008) Mol Therapy , vol.16 , pp. 38-45
    • Yin, H.1    Lu, Q.2    Wood, M.3
  • 17
    • 32844460899 scopus 로고    scopus 로고
    • Dystrophin expression in the Mdx mouse after localised and systemic administration of a morpholino antisense oligonucleotide
    • Fletcher S, Honeyman K, Fall AM, Harding PL, Johnsen RD, Wilton SD. Dystrophin expression in the Mdx mouse after localised and systemic administration of a morpholino antisense oligonucleotide. J Gene Med 2006; 8: 207-16
    • (2006) J Gene Med , vol.8 , pp. 207-216
    • Fletcher, S.1    Honeyman, K.2    Fall, A.M.3    Harding, P.L.4    Johnsen, R.D.5    Wilton, S.D.6
  • 18
    • 58449122870 scopus 로고    scopus 로고
    • A renaissance for antisense oligonucleotide drugs in neurology: Exon skipping breaks new ground
    • Yokota T, Takeda S, Lu QL, Partridge TA, Nakamura A, Hoffman EP. A renaissance for antisense oligonucleotide drugs in neurology: exon skipping breaks new ground. Arch Neurol 2009; 66: 32-8
    • (2009) Arch Neurol , vol.66 , pp. 32-38
    • Yokota, T.1    Takeda, S.2    Lu, Q.L.3    Partridge, T.A.4    Nakamura, A.5    Hoffman, E.P.6
  • 19
    • 70349320158 scopus 로고    scopus 로고
    • Causes and consequences of microRNA dysregulation in cancer
    • Croce CM. Causes and consequences of microRNA dysregulation in cancer. Nat Rev Genet 2009; 10: 704-14
    • (2009) Nat Rev Genet , vol.10 , pp. 704-714
    • Croce, C.M.1
  • 20
    • 38649105459 scopus 로고    scopus 로고
    • miR-122 targeting with LNA/2'-Omethyl oligonucleotide mixmers, peptide nucleic acids (PNA), and PNA-peptide conjugates
    • Fabani MM. and Gait MJ. miR-122 targeting with LNA/2'-Omethyl oligonucleotide mixmers, peptide nucleic acids (PNA), and PNA-peptide conjugates. RNA 2008; 14: 336-46.
    • (2008) RNA , vol.14 , pp. 336-346
    • Fabani, M.M.1    Gait, M.J.2
  • 21
    • 72449172405 scopus 로고    scopus 로고
    • A Highly Effective and Long-Lasting Inhibition of MiRNAs With PNA-Based Antisense Oligonucleotides
    • Oh SY, Ju Y, Park H. A Highly Effective and Long-Lasting Inhibition of MiRNAs With PNA-Based Antisense Oligonucleotides. Molecules Cells 2009; 28: 341-5.
    • (2009) Molecules Cells , vol.28 , pp. 341-345
    • Oh, S.Y.1    Ju, Y.2    Park, H.3
  • 22
    • 0037837659 scopus 로고    scopus 로고
    • Superior duplex DNA strand invasion by acridine conjugated peptide nucleic acids
    • Bentin T, Nielsen PE. Superior duplex DNA strand invasion by acridine conjugated peptide nucleic acids. J Am Chem Soc 2003; 125: 6378-9.
    • (2003) J Am Chem Soc , vol.125 , pp. 6378-6379
    • Bentin, T.1    Nielsen, P.E.2
  • 23
    • 33845679853 scopus 로고    scopus 로고
    • Structural diversity of targetspecific homopyrimidine peptide nucleic acid-dsDNA complexes
    • Bentin T, Hansen GI, Nielsen PE. structural diversity of targetspecific homopyrimidine peptide nucleic acid-dsDNA complexes. Nucleic Acids Res 2006; 34: 5790-9.
    • (2006) Nucleic Acids Res , vol.34 , pp. 5790-5799
    • Bentin, T.1    Hansen, G.I.2    Nielsen, P.E.3
  • 26
    • 67949086671 scopus 로고    scopus 로고
    • High-affinity triplex targeting of double stranded DNA using chemically modified peptide nucleic acid oligomers
    • Hansen ME, Bentin T, Nielsen PE. High-affinity triplex targeting of double stranded DNA using chemically modified peptide nucleic acid oligomers. Nucleic Acids Res 2009; 37: 4498-507.
    • (2009) Nucleic Acids Res , vol.37 , pp. 4498-4507
    • Hansen, M.E.1    Bentin, T.2    Nielsen, P.E.3
  • 28
    • 0032738421 scopus 로고    scopus 로고
    • Double duplex invasion by peptide nucleic acid: A general principle for sequence-specific targeting of double-stranded DNA
    • Lohse J, Dahl O, Nielsen PE. Double duplex invasion by peptide nucleic acid: a general principle for sequence-specific targeting of double-stranded DNA. Proc Natl Acad Sci USA 1999; 96: 11804-8.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 11804-11808
    • Lohse, J.1    Dahl, O.2    Nielsen, P.E.3
  • 29
    • 0034609587 scopus 로고    scopus 로고
    • Sequence-specific protection of duplex DNA against restriction and methylation enzymes by pseudocomplementary PNAs
    • Izvolsky KI, Demidov VV, Nielsen PE, Frank-Kamenetskii MD. Sequence-specific protection of duplex DNA against restriction and methylation enzymes by pseudocomplementary PNAs. Biochemistry 2000; 39: 10908-13.
    • (2000) Biochemistry , vol.39 , pp. 10908-10913
    • Izvolsky, K.I.1    Demidov, V.V.2    Nielsen, P.E.3    Frank-Kamenetskii, M.D.4
  • 30
    • 78649868154 scopus 로고    scopus 로고
    • Site-directed gene mutation at mixed sequence targets by psoralen-conjugated pseudo-complementary peptide nucleic acids
    • Kim KH, Nielsen PE, Glazer PM. Site-directed gene mutation at mixed sequence targets by psoralen-conjugated pseudo-complementary peptide nucleic acids, Nucleic Acids Res 2007; 45: 314-23.
    • (2007) Nucleic Acids Res , vol.45 , pp. 314-323
    • Kim, K.H.1    Nielsen, P.E.2    Glazer, P.M.3
  • 31
    • 67651162092 scopus 로고    scopus 로고
    • Artificial restriction DNA cutters as new tools for gene manipulation
    • Katada H, Komiyama M. Artificial restriction DNA cutters as new tools for gene manipulation, ChemBioChem 2009; 10: 1279-88.
    • (2009) ChemBioChem , vol.10 , pp. 1279-1288
    • Katada, H.1    Komiyama, M.2
  • 32
    • 41149158074 scopus 로고    scopus 로고
    • Chiral introduction of positive charges to PNA for double-duplex invasion to versatile sequences
    • Ishizuka T, Yoshida J, Yamamoto Y, et al. Chiral introduction of positive charges to PNA for double-duplex invasion to versatile sequences, Nucleic Acids Res 2008; 36: 1464-71.
    • (2008) Nucleic Acids Res , vol.36 , pp. 1464-1471
    • Ishizuka, T.1    Yoshida, J.2    Yamamoto, Y.3
  • 33
    • 0029963160 scopus 로고    scopus 로고
    • Strand displacement binding of a duplex-forming homopurine PNA to a homopyrimidine duplex DNA target
    • Nielsen PE, Christensen L. Strand displacement binding of a duplex-forming homopurine PNA to a homopyrimidine duplex DNA target. J Am Chem Soc 1996; 118: 2287-8.
    • (1996) J Am Chem Soc , vol.118 , pp. 2287-2288
    • Nielsen, P.E.1    Christensen, L.2
  • 34
    • 37849040469 scopus 로고    scopus 로고
    • Strand invasion of mixed-sequence B-DNA by acridine-linked, gamma-peptide nucleic acid (gamma-PNA)
    • Rapireddy S, He G, Roy S, Armitage BA, Ly DH. Strand invasion of mixed-sequence B-DNA by acridine-linked, gamma-peptide nucleic acid (gamma-PNA), J Am Chem Soc 2007; 129: 15596-600.
    • (2007) J Am Chem Soc , vol.129 , pp. 15596-15600
    • Rapireddy, S.1    He, G.2    Roy, S.3    Armitage, B.A.4    Ly, D.H.5
  • 35
    • 0033616610 scopus 로고    scopus 로고
    • A cytosine analog that confers enhanced potency to antisense oligonucleotides
    • Flanagan WM, Wolf JJ, Olson P, et al. A cytosine analog that confers enhanced potency to antisense oligonucleotides. Proc Natl Acad Sci USA 1999; 96: 3513-8.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 3513-3518
    • Flanagan, W.M.1    Wolf, J.J.2    Olson, P.3
  • 36
    • 54349087593 scopus 로고    scopus 로고
    • A simple cytosine to G-clamp nucleobase substitution enables chiral G-PNAs to invade mixed-sequence double-helical B-form DNA
    • Chenna V, Rapireddy S, Sahu B, Ausin C, Pedroso E, Ly DH. A simple cytosine to G-clamp nucleobase substitution enables chiral G-PNAs to invade mixed-sequence double-helical B-form DNA, ChemBioChem 2008; 9: 2388-91.
    • (2008) ChemBioChem , vol.9 , pp. 2388-2391
    • Chenna, V.1    Rapireddy, S.2    Sahu, B.3    Ausin, C.4    Pedroso, E.5    Ly, D.H.6
  • 37
    • 34548676807 scopus 로고    scopus 로고
    • A highaffinity homologous peptide nucleic acid probes for targeting a quadruplex-forming sequence from a MYC promoter element
    • Roy S, Tanious FA, Wilson WD, Ly DH, Armitage B. A highaffinity homologous peptide nucleic acid probes for targeting a quadruplex-forming sequence from a MYC promoter element, Biochemistry 2007; 46: 10433-43.
    • (2007) Biochemistry , vol.46 , pp. 10433-43
    • Roy, S.1    Tanious, F.A.2    Wilson, W.D.3    Ly, D.H.4    Armitage, B.5
  • 38
    • 0028075767 scopus 로고
    • Sequence-specific transcription arrest by peptide nucleic acid bound to the DNA template strand
    • Nielsen PE, Egholm M, Buchardt O. Sequence-specific transcription arrest by peptide nucleic acid bound to the DNA template strand. Gene 1994; 149: 139-45.
    • (1994) Gene , vol.149 , pp. 139-145
    • Nielsen, P.E.1    Egholm, M.2    Buchardt, O.3
  • 39
    • 0027104702 scopus 로고
    • Antisense and antigen properties of peptide nucleic acids
    • Hanvey JC, Peffer NJ, Bisi JE, et al. Antisense and antigen properties of peptide nucleic acids. Science 1992; 258: 1481-5.
    • (1992) Science , vol.258 , pp. 1481-1485
    • Hanvey, J.C.1    Peffer, N.J.2    Bisi, J.E.3
  • 40
    • 0028175775 scopus 로고
    • Peptide nucleic acid-DNA strand displacement loops as artificial transcription promoters
    • Møllegaard NE, Buchardt O, Egholm M, Nielsen PE. Peptide nucleic acid-DNA strand displacement loops as artificial transcription promoters. Proc Natl Acad Sci USA 1994; 91: 3892-5.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 3892-3895
    • Møllegaard, N.E.1    Buchardt, O.2    Egholm, M.3    Nielsen, P.E.4
  • 41
    • 51649109401 scopus 로고    scopus 로고
    • Correction of a splice-site mutation in the beta-globin gene stimulated by triplex-forming peptide nucleic acids
    • Chin JY, Kuan JY, Lonkar PS, et al. Correction of a splice-site mutation in the beta-globin gene stimulated by triplex-forming peptide nucleic acids, Proc Natl Acad Sci USA 2008; 105: 13514-9.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 13514-13519
    • Chin, J.Y.1    Kuan, J.Y.2    Lonkar, P.S.3
  • 42
    • 33644832338 scopus 로고    scopus 로고
    • Inhibiting transcription of chromosomal DNA with antigene peptide nucleic acids
    • Janowski BA, Kaihatsu K, Huffman KE, et al. Inhibiting transcription of chromosomal DNA with antigene peptide nucleic acids. Nat Chem Biol 2005; 1: 210-5.
    • (2005) Nat Chem Biol , vol.1 , pp. 210-215
    • Janowski, B.A.1    Kaihatsu, K.2    Huffman, K.E.3
  • 43
    • 0034724416 scopus 로고    scopus 로고
    • An approach to genespecific transcription inhibition using oligonucleotides complementary to the template strand of the open complex
    • Milne L, Xu Y, Perrin DM, Sigman DS. An approach to genespecific transcription inhibition using oligonucleotides complementary to the template strand of the open complex. Proc Natl Acad Sci USA 2000; 97: 3136-41
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 3136-3141
    • Milne, L.1    Xu, Y.2    Perrin, D.M.3    Sigman, D.S.4
  • 44
    • 9044228030 scopus 로고    scopus 로고
    • Transcription-mediated binding of peptide nucleic acid (PNA) to double-stranded DNA: Sequence-specific suicide transcription
    • Larsen HJ, Nielsen PE. Transcription-mediated binding of peptide nucleic acid (PNA) to double-stranded DNA: sequence-specific suicide transcription. Nucleic Acids Res 1996; 24: 458-63.
    • (1996) Nucleic Acids Res , vol.24 , pp. 458-463
    • Larsen, H.J.1    Nielsen, P.E.2
  • 45
    • 33846248757 scopus 로고    scopus 로고
    • Inhibition of burkitt's lymphoma cells growth in SCID mice by a PNA specific for a regulatory sequence of the translocated C-Myc
    • Boffa LC, Cutrona G, Cilli M, et al. Inhibition of burkitt's lymphoma cells growth in SCID mice by a PNA specific for a regulatory sequence of the translocated C-Myc. Cancer Gene Therapy 2007; 14: 220-6.
    • (2007) Cancer Gene Therapy , vol.14 , pp. 220-226
    • Boffa, L.C.1    Cutrona, G.2    Cilli, M.3
  • 46
    • 67649295505 scopus 로고    scopus 로고
    • siRNA delivery systems for cancer treatment
    • Oh YK, Park TG. siRNA delivery systems for cancer treatment. Adv Drug Deliv Rev 2009; 61: 850-62.
    • (2009) Adv Drug Deliv Rev , vol.61 , pp. 850-862
    • Oh, Y.K.1    Park, T.G.2
  • 47
    • 0036903132 scopus 로고    scopus 로고
    • Systemically delivered antisense oligomers upregulate gene expression in mouse tissues
    • Sazani P, Gemignani F, Kang S.-H, et al. Systemically delivered antisense oligomers upregulate gene expression in mouse tissues. Nat Biotechnol 2002; 20: 1228-33.
    • (2002) Nat Biotechnol , vol.20 , pp. 1228-1233
    • Sazani, P.1    Gemignani, F.2    Kang, S.-H.3
  • 48
    • 38949206876 scopus 로고    scopus 로고
    • Cell penetrating peptide conjugates of steric block oligonucleotides
    • Lebleu B, Moulton HM, Abes R, et al. Cell penetrating peptide conjugates of steric block oligonucleotides. Adv Drug Deliv Rev 2008; 60: 517-29.
    • (2008) Adv Drug Deliv Rev , vol.60 , pp. 517-529
    • Lebleu, B.1    Moulton, H.M.2    Abes, R.3
  • 49
    • 34548771163 scopus 로고    scopus 로고
    • A novel cellpenetrating peptide, M918, for efficient delivery of proteins and peptide nucleic acids
    • El-Andaloussi S, Johansson HJ, Holm T, Langel Ü. A novel cellpenetrating peptide, M918, for efficient delivery of proteins and peptide nucleic acids. Mol Therapy 2007; 15: 1820-6.
    • (2007) Mol Therapy , vol.15 , pp. 1820-1826
    • El-Andaloussi, S.1    Johansson, H.J.2    Holm, T.3    Langel, Ü.4
  • 50
    • 33646950391 scopus 로고    scopus 로고
    • Evaluation of cell-penetrating peptides (CPPs) As vehicles for intracellular delivery of antisense peptide nucleic acid (PNA)
    • Bendifallah N, Rasmussen FW, Zachar V, Ebbesen P, Nielsen PE, Koppelhus U. Evaluation of cell-penetrating peptides (CPPs) As vehicles for intracellular delivery of antisense peptide nucleic acid (PNA). Bioconjug Chem 2006; 17: 750-8.
    • (2006) Bioconjug Chem , vol.17 , pp. 750-758
    • Bendifallah, N.1    Rasmussen, F.W.2    Zachar, V.3    Ebbesen, P.4    Nielsen, P.E.5    Koppelhus, U.6
  • 52
    • 0346460957 scopus 로고    scopus 로고
    • Cell-penetrating peptides. A reevaluation of the mechanism of cellular uptake
    • Richard JP, Melikov K, Vives E, et al. Cell-penetrating peptides. A reevaluation of the mechanism of cellular uptake. J Biol Chem 2003; 278: 585-90.
    • (2003) J Biol Chem , vol.278 , pp. 585-590
    • Richard, J.P.1    Melikov, K.2    Vives, E.3
  • 53
    • 32344441681 scopus 로고    scopus 로고
    • Photochemically enhanced cellular delivery of cell penetrating peptide-PNA conjugates
    • Shiraishi T, Nielsen PE. Photochemically enhanced cellular delivery of cell penetrating peptide-PNA conjugates. FEBS Lett 2006; 580: 1451-6.
    • (2006) FEBS Lett , vol.580 , pp. 1451-1456
    • Shiraishi, T.1    Nielsen, P.E.2
  • 54
    • 34250793309 scopus 로고    scopus 로고
    • Inhibiting gene expression with peptide nucleic acid (PNA)-peptide conjugates that target chromosomal DNA
    • Hu J. and Corey DR. Inhibiting gene expression with peptide nucleic acid (PNA)-peptide conjugates that target chromosomal DNA. Biochemistry 2007; 46: 7581-9.
    • (2007) Biochemistry , vol.46 , pp. 7581-7589
    • Hu, J.1    Corey, D.R.2
  • 55
    • 50249188836 scopus 로고    scopus 로고
    • Improved cellular activity of antisense peptide nucleic acids by conjugation to a cationic peptide-lipid (CatLip) domain
    • Koppelhus U, Shiraishi T, Zachar V, Pankratova S, Nielsen PE. Improved cellular activity of antisense peptide nucleic acids by conjugation to a cationic peptide-lipid (CatLip) domain. Bioconjugate Chem 2008; 19: 1526-34.
    • (2008) Bioconjugate Chem , vol.19 , pp. 1526-1534
    • Koppelhus, U.1    Shiraishi, T.2    Zachar, V.3    Pankratova, S.4    Nielsen, P.E.5
  • 56
    • 0033150534 scopus 로고    scopus 로고
    • Cellular delivery of peptide nucleic acids and inhibition of human telomerase
    • Hamilton SE, Simmons CG, Kathiriya IS, Corey DR. Cellular delivery of peptide nucleic acids and inhibition of human telomerase. Chem Biol 1999; 6: 343-51.
    • (1999) Chem Biol , vol.6 , pp. 343-351
    • Hamilton, S.E.1    Simmons, C.G.2    Kathiriya, I.S.3    Corey, D.R.4
  • 57
    • 48349109804 scopus 로고    scopus 로고
    • Subnanomolar antisense activity of phosphonate-peptide nucleic acid (PNA) conjugates delivered by cationic lipids to HeLa cells
    • Shiraishi T, Hamzavi R, Nielsen PE. Subnanomolar antisense activity of phosphonate-peptide nucleic acid (PNA) conjugates delivered by cationic lipids to HeLa cells. Nucleic Acids Res 2008; 36: 4424-32.
    • (2008) Nucleic Acids Res , vol.36 , pp. 4424-4432
    • Shiraishi, T.1    Hamzavi, R.2    Nielsen, P.E.3
  • 58
    • 0141681146 scopus 로고    scopus 로고
    • Modulation of the pharmacokinetic properties of PNA: Preparation of galactosyl, mannosyl, fucosyl, N-acetylgalactosaminyl, and N-acetylglucosaminyl derivatives of aminoethylglycine peptide nucleic acid monomers and their incorporation into PNA oligomers
    • Hamzavi R, Dolle F, Tavitian B, Dahl O, Nielsen PE. Modulation of the pharmacokinetic properties of PNA: Preparation of galactosyl, mannosyl, fucosyl, N-acetylgalactosaminyl, and N-acetylglucosaminyl derivatives of aminoethylglycine peptide nucleic acid monomers and their incorporation into PNA oligomers. Bioconjug Chem 2003; 14: 941-54.
    • (2003) Bioconjug Chem , vol.14 , pp. 941-954
    • Hamzavi, R.1    Dolle, F.2    Tavitian, B.3    Dahl, O.4    Nielsen, P.E.5
  • 60
    • 23044484982 scopus 로고    scopus 로고
    • Peptide nucleic acid antisense oligomer as a therapeutic strategy against bacterial infection: Proof of principle using mouse intraperitoneal infection
    • Tan XX, Actor JK, Chen Y. Peptide nucleic acid antisense oligomer as a therapeutic strategy against bacterial infection: proof of principle using mouse intraperitoneal infection. Antimicrob Agents Chemother 2005; 49: 3203-7.
    • (2005) Antimicrob Agents Chemother , vol.49 , pp. 3203-3207
    • Tan, X.X.1    Actor, J.K.2    Chen, Y.3
  • 61
    • 44349162361 scopus 로고    scopus 로고
    • Single acute-dose and repeatdoses toxicity of anti-HIV-1 PNA(TAR)-penetratin conjugate after intraperitoneal administration to mice
    • Chaubey B, Tripathi S, Pandey VN. Single acute-dose and repeatdoses toxicity of anti-HIV-1 PNA(TAR)-penetratin conjugate after intraperitoneal administration to mice. Oligonucleotides 2008; 18: 9-20.
    • (2008) Oligonucleotides , vol.18 , pp. 9-20
    • Chaubey, B.1    Tripathi, S.2    Pandey, V.N.3
  • 62
    • 51849096484 scopus 로고    scopus 로고
    • Pharmacokinetic analysis of polyamide nucleic-acid-cell penetrating peptide conjugates targeted against HIV-1 transactivation response element
    • Ganguly S, Chaubey B, Tripathi S, et al. Pharmacokinetic analysis of polyamide nucleic-acid-cell penetrating peptide conjugates targeted against HIV-1 transactivation response element. Oligonucleotides 2008; 18: 277-86.
    • (2008) Oligonucleotides , vol.18 , pp. 277-286
    • Ganguly, S.1    Chaubey, B.2    Tripathi, S.3
  • 63
    • 57349137502 scopus 로고    scopus 로고
    • Immunological response to peptide nucleic acid and its peptide conjugate targeted to transactivation response (TAR) region of HIV-1 RNA genome
    • Upadhyay A, Ponzio NM, Pandey VN. Immunological response to peptide nucleic acid and its peptide conjugate targeted to transactivation response (TAR) region of HIV-1 RNA genome. Oligonucleotides 2008; 18: 329-36.
    • (2008) Oligonucleotides , vol.18 , pp. 329-336
    • Upadhyay, A.1    Ponzio, N.M.2    Pandey, V.N.3
  • 64
    • 0032478330 scopus 로고    scopus 로고
    • Inhibition of translation and bacterial growth by peptide nucleic acid targeted to ribosomal RNA
    • Good L, Nielsen PE. Inhibition of translation and bacterial growth by peptide nucleic acid targeted to ribosomal RNA. Proc Natl Acad Sci USA 1998; 95: 2073-6.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 2073-2076
    • Good, L.1    Nielsen, P.E.2
  • 65
    • 0031979354 scopus 로고    scopus 로고
    • Antisense inhibition of gene expression in bacteria by PNA targeted to mRNA
    • Good L, Nielsen PE. Antisense inhibition of gene expression in bacteria by PNA targeted to mRNA. Nat Biotechnol 1998; 16: 355-8.
    • (1998) Nat Biotechnol , vol.16 , pp. 355-358
    • Good, L.1    Nielsen, P.E.2
  • 67
    • 4644226298 scopus 로고    scopus 로고
    • Inhibition of staphylococcus aureus gene expression and growth using antisense peptide nucleic acids
    • Nekhotiaeva N, Awasthi SK, Nielsen PE, Good L. Inhibition of staphylococcus aureus gene expression and growth using antisense peptide nucleic acids. Mol Therapy 2004; 10: 652-9.
    • (2004) Mol Therapy , vol.10 , pp. 652-659
    • Nekhotiaeva, N.1    Awasthi, S.K.2    Nielsen, P.E.3    Good, L.4
  • 68
    • 67650690673 scopus 로고    scopus 로고
    • Prospects for antisense peptide nucleic acid (PNA) therapies for HIV
    • Pandey VN, Upadhyay A, Chaubey B. Prospects for antisense peptide nucleic acid (PNA) therapies for HIV. Expert Opin Biol Ther 2009; 9: 975-89.
    • (2009) Expert Opin Biol Ther , vol.9 , pp. 975-989
    • Pandey, V.N.1    Upadhyay, A.2    Chaubey, B.3
  • 69
    • 23844510658 scopus 로고    scopus 로고
    • Anti-HIV-1 activity of anti-TAR polyamide nucleic acid conjugated with various membrane transducing peptides
    • Tripathi S, Chaubey B, Ganguly S, Harris D, Casale RA, Pandey VN. Anti-HIV-1 activity of anti-TAR polyamide nucleic acid conjugated with various membrane transducing peptides. Nucleic Acids Res 2005; 33: 4345-56.
    • (2005) Nucleic Acids Res , vol.33 , pp. 4345-4356
    • Tripathi, S.1    Chaubey, B.2    Ganguly, S.3    Harris, D.4    Casale, R.A.5    Pandey, V.N.6
  • 70
    • 11344260182 scopus 로고    scopus 로고
    • A PNA-transportan conjugate targeted to the TAR region of the HIV-1 genome exhibits both antiviral and virucidal properties
    • Chaubey B, Tripathi S, Ganguly S, Harris D, Casale RA, Pandey VN. A PNA-transportan conjugate targeted to the TAR region of the HIV-1 genome exhibits both antiviral and virucidal properties. Virology 2005; 331: 418-28.
    • (2005) Virology , vol.331 , pp. 418-428
    • Chaubey, B.1    Tripathi, S.2    Ganguly, S.3    Harris, D.4    Casale, R.A.5    Pandey, V.N.6
  • 71
    • 34247606647 scopus 로고    scopus 로고
    • Anti HIV-1 virucidal activity of polyamide nucleic acid-membrane transducing peptide conjugates targeted to primer binding site of HIV-1 Genome
    • Tripathi S, Chaubey B, Barton BE, Pandey VN. Anti HIV-1 virucidal activity of polyamide nucleic acid-membrane transducing peptide conjugates targeted to primer binding site of HIV-1 Genome. Virology 2007; 363: 91-103.
    • (2007) Virology , vol.363 , pp. 91-103
    • Tripathi, S.1    Chaubey, B.2    Barton, B.E.3    Pandey, V.N.4
  • 72
    • 19944433419 scopus 로고    scopus 로고
    • Sequence-specific inhibition of duck hepatitis B virus reverse transcription by peptide nucleic acids (PNA)
    • Robaczewska M, Narayan R, Seigneres B, et al. Sequence-specific inhibition of duck hepatitis B virus reverse transcription by peptide nucleic acids (PNA). J Hepatol 2005; 42: 180-7.
    • (2005) J Hepatol , vol.42 , pp. 180-187
    • Robaczewska, M.1    Narayan, R.2    Seigneres, B.3
  • 73
    • 64749087893 scopus 로고    scopus 로고
    • Inhibition of japanese encephalitis virus replication by peptide nucleic acids targeting cisacting elements on the plus- and minus-strands of viral RNA
    • Yoo JS, Kim CM, Kim JH, Kim JY, Oh JW. Inhibition of japanese encephalitis virus replication by peptide nucleic acids targeting cisacting elements on the plus- and minus-strands of viral RNA. Antiviral Res 2009; 82: 122-33.
    • (2009) Antiviral Res , vol.82 , pp. 122-133
    • Yoo, J.S.1    Kim, C.M.2    Kim, J.H.3    Kim, J.Y.4    Oh, J.W.5
  • 74
    • 0034777151 scopus 로고    scopus 로고
    • Peptide-nucleic acids (PNAs): A tool for the development of gene expression modifiers
    • Gambari R. Peptide-nucleic acids (PNAs): a tool for the development of gene expression modifiers. Curr Pharm Des 2001; 7(17): 1839-62.
    • (2001) Curr Pharm Des , vol.7 , Issue.17 , pp. 1839-1862
    • Gambari, R.1
  • 75
    • 52949113455 scopus 로고    scopus 로고
    • Peptide nucleic acids (PNAs) as diagnostic devices for genetic and cytogenetic analysis
    • Pellestor F, Paulasova P, Hamamah S. Peptide nucleic acids (PNAs) as diagnostic devices for genetic and cytogenetic analysis. Curr Pharm Des 2008; 14(24): 2439-44.
    • (2008) Curr Pharm Des , vol.14 , Issue.24 , pp. 2439-2444
    • Pellestor, F.1    Paulasova, P.2    Hamamah, S.3
  • 76
    • 1442276558 scopus 로고    scopus 로고
    • Anti-gene strategies to downregulate gene expression in mammalian cells
    • Xodo LE, Cogoi S, Rapozzi V. Anti-gene strategies to downregulate gene expression in mammalian cells. Curr Pharm Des 2004; 10(7): 805-19
    • (2004) Curr Pharm Des , vol.10 , Issue.7 , pp. 805-819
    • Xodo, L.E.1    Cogoi, S.2    Rapozzi, V.3


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