Pharmacokinetics and tissue distribution of a peptide nucleic acid after intravenous administration

Antisense and Nucleic Acid Drug Development

Volumn 12, Issue 2, 2002, Pages 65-70

  McMahon, Beth M ^a   Mays, Dennis ^b   Lipsky, James ^b   Stewart, Jennifer A ^a   Fauq, Abdul ^a   Richelson, Elliott ^a  

^a MAYO CLINIC   (United States)

^b MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; NEUROTENSIN; NEUROTENSIN RECEPTOR; PEPTIDE NUCLEIC ACID; ANTISENSE OLIGODEOXYNUCLEOTIDE; NEUROTENSIN TYPE 1 RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DISTRIBUTION VOLUME; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG HALF LIFE; DRUG LIVER LEVEL; DRUG TISSUE LEVEL; HEART; KIDNEY; MALE; NONHUMAN; PLASMA CLEARANCE; PRIORITY JOURNAL; RAT; SPLEEN; ANIMAL; GENETICS; INTRAVENOUS DRUG ADMINISTRATION; NUCLEOTIDE SEQUENCE; SPRAGUE DAWLEY RAT; TISSUE DISTRIBUTION;

ANIMALIA;

ANIMALS; BASE SEQUENCE; INJECTIONS, INTRAVENOUS; MALE; OLIGODEOXYRIBONUCLEOTIDES, ANTISENSE; PEPTIDE NUCLEIC ACIDS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, NEUROTENSIN; RNA, MESSENGER; TISSUE DISTRIBUTION;

EID: 0035989848     PISSN: 10872906     EISSN: None     Source Type: Journal    
DOI: 10.1089/108729002760070803     Document Type: Article

References (26)

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2. Contrasting effects of PNA invasion of the chimeric DMMYC gene on transcriotion of its myc and PVT domains
3. Dihydrotestosterone as a selective cellular/nuclear localization vector for anti-gene peptide nucleic acid in prostatic carcinoma cells
4. Peptide nucleic acid delivery to human mitochondria
5. Peptide nucleic acids: Expanding the scope of nucleic acid recognition
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7. Stability of peptide nucleic acids in human serum and cellular extracts
8. Peptide nucleic acid targeted mutagenesis of a chromosomal gene in mouse cells
9. Antisense inhibition of delta-opioid receptor gene function in vivo by peptide nucleic acids
10. Physiologically based pharmacokinetic modeling: Principles and applications
11. Inhibition of translation and bacterial growth by peptide nucleic acid targeted to ribosomal RNA
12. Anti-sense and antigene properties of peptide nucleic acids
13. Detection of peptide nucleic acids in tissue extracts of treated animals by gel shift assay
14. Efficient in vitro inhibition of HIV-1 gag reverse transcription by peptide nucleic acid (PNA) at minimal ratios of PNA/RNA
15. Inhibition of the bovine papillomavirus E2 protein activity by peptide nucleic acid
16. In vitro hybridization of technetium-99m-labeled peptide nucleic acid (PNA)
17. Peptide nucleic acids (PNAs): Potential antisense and anti-gene agents
18. Vectormediated delivery of a polyamide ("peptide") nucleic acid analogue through the blood-brain barrier in vivo
19. Cell penetrating PNA constructs regulate galanin receptor levels and modify pain transmissions in vivo
20. Intrathecal administration of Pna targeting galanin receptor reduces galanin-mediated inhibitory effect in the rat spinal cord
21. Probenecid protects against in vivo acetaminophen-induced nephrotoxicity in male Wistar rats
22. Peptide nucleic acids targeted to the neurotensin receptor and administered intraperitoneally cross the blood-brain barrier and specifically reduce gene expression
23. Specific gene blockade shows that peptide nucleic acids readily enter neuronal cells in vivo
24. Altering behavioral responses and dopamine transporter protein with anti-sense peptide nucleic acids
25. Inhibition of telomerase activity by a cell-penatrating peptide nucleic acid construct in human melanoma cells
26. Phospholipid membrane permeability of peptide nucleic acid