Modulation of the pharmacokinetic properties of PNA: Preparation of galactosyl, mannosyl, fucosyl, N-acetylgalactosaminyl, and N-acetylglucosaminyl derivatives of aminoethylglycine peptide nucleic acid monomers and their incorporation into PNA oligomers

Bioconjugate Chemistry

Volumn 14, Issue 5, 2003, Pages 941-954

  Hamzavi, Ramin ^a,b   Dolle, Frédéric ^c   Tavitian, Bertrand ^d   Dahl, Otto ^a   Nielsen, Peter E ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b Santaris Pharma AS   (Denmark)

^c DIF   (France)

^d SERVICE HOSPITALIER FRÉDÉRIC JOLIOT   (France)

Author keywords

[No Author keywords available]

Indexed keywords

MODULATION; MONOMERS; NUCLEIC ACIDS; OLIGOMERS; PEPTIDES; PHARMACOKINETICS;

AMINO-ACIDS; DECAMERS; GLYCOSYL; GLYCOSYLATED; MONOMER BEARING; NUCLEIC ACID OLIGOMERS; PEPTIDE NUCLEIC ACID; PHARMACOKINETIC PROPERTIES; SIDE-CHAINS; SYNTHESISED;

AMINO ACIDS;

ALANINE DERIVATIVE; ALPHA AMINO ACID; AMIDE; ASPARTIC ACID; CARBONYL DERIVATIVE; COMPLEMENTARY RNA; CYSTEINE; FUCOSE; GALACTOSE; GLYCINE; LYSINE; MANNOSE; N ACETYLGALACTOSAMINE; N ACETYLGLUCOSAMINE; OLIGOMER; PEPTIDE NUCLEIC ACID; SERINE; THREONINE;

AMINO TERMINAL SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG DISTRIBUTION; GLYCOSYLATION; NONHUMAN; NUCLEIC ACID SYNTHESIS; RADIOACTIVITY; RADIOCHEMISTRY; RAT; THERMOSTABILITY;

ANIMALIA;

EID: 0141681146     PISSN: 10431802     EISSN: None     Source Type: Journal    
DOI: 10.1021/bc034022x     Document Type: Article

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