Folate synthesis in higher-plant mitochondria: Coupling between the dihydropterin pyrophosphokinase and the dihydropteroate synthase activities

Biochemical Journal

Volumn 363, Issue 2, 2002, Pages 313-319

  Mouillon, Jean Marie ^a   Ravanel, Stéphane ^a   Douce, Roland ^a   Rébeillé, Fabrice ^a  

^a CNRS   (France)

Author keywords

C1 metabolism

Indexed keywords

AMINO ACIDS; BIOSYNTHESIS; ENZYMES;

BIOSYNTHETIC PATHWAY;

PROTEINS;

6 HYDROXYMETHYL 7,8 DIHYDROPTERIN PYROPHOSPHOKINASE; ADENOSINE PHOSPHATE; BACTERIAL ENZYME; DIHYDROPTEROATE SYNTHASE; FOLIC ACID; PHOSPHOTRANSFERASE; PTERIN DERIVATIVE; TETRAHYDROFOLIC ACID; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CHEMICAL REACTION; CHEMICAL REACTION KINETICS; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ESCHERICHIA COLI; HIGHER PLANT; MITOCHONDRION; NONHUMAN; POLYMERIZATION; PRIORITY JOURNAL; PROTEIN DOMAIN; REACTION ANALYSIS; SYNTHESIS;

BINDING SITES; DIHYDROPTEROATE SYNTHASE; DIPHOSPHOTRANSFERASES; ESCHERICHIA COLI; FOLIC ACID; KINETICS; MITOCHONDRIA; MODELS, BIOLOGICAL; PLANTS; PROTEIN STRUCTURE, TERTIARY; PTERINS; RECOMBINANT PROTEINS;

BACTERIA (MICROORGANISMS); EMBRYOPHYTA; ESCHERICHIA COLI;

EID: 0037090805     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3630313     Document Type: Article

References (32)

1. Folate synthesis and compartmentation in higher plants
2. Biosynthesis of folate from pterin precursors
3. Inhibition of recombinant Pneumocystis carinii dihydropteroate synthetase by sulfa drugs
4. Sulfonamide resistance in Streptococcus pneumoniae: DNA sequence of the gene encoding dihydropteroate synthase and characterization of the enzyme
5. Inhibition of Plasmodium falciparum dihydropteroate synthetase and growth in vitro by sulfa drugs
6. Sequence variation of the hydroxymethyldihydropterin pyrophosphokinase: Dihydropteroate synthase gene in lines of the human malaria parasite, Plasmodium falciparum, with differing resistance to sulfadoxine
7. Adaptation to sulfonamide resistance in Neisseria meningitidis may have required compensatory changes to retain enzyme function: Kinetic analysis of dihydropteroate synthases from N. meningitidis expressed in a knockout mutant of Escherichia coli
8. Mutations in dihydropteroate synthase are responsible for sulfone and sulfonamide resistance in Plasmodium falciparum
9. Cloning, sequencing, and enhanced expression of the dihydropteroate synthase gene of Escherichia coli MC4100
10. Functional cloning of the dihydropteroate synthase gene of Staphylococcus haemolyticus
11. Crystal structure of the anti-bacterial sulfonamide drug target dihydropteroate synthase
12. Structure and function of the dihydropteroate synthase from Staphylococcus aureus
13. Cloning, sequence analysis, and overexpression of Escherichia coli folK, the gene coding for 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase
14. A bifunctional protein in the folate biosynthetic pathway of Streptococcus pneumoniae with dihydropterin aldolase and hydroxymethyldihydropterin pyrophosphokinase activities
15. 2.0 Å X-ray structure of the ternary complex of 7,8-dihydro-6-hydroxymethylpterinpyrophosphokinase from Escherichia coli with ATP and a substrate analogue
16. Catalytic center assembly of HPPK as revealed by the crystal structure of a ternary complex at 1.25 Å resolution
17. The structure and function of the 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase from Haemophilus influenzae
18. Primary structure and expression of the dihydropteroate synthase gene of Plasmodium falciparum
19. Primary structure and expression of the dihydropteroate synthase gene of Plasmodium falciparum
20. The multifunctional folic acid synthesis fas gene of Pneumocystis carinii encodes dihydroneopterin aldolase, hydroxymethyldihydropterin pyrophosphokinase and dihydropteroate synthase
21. Mitochondria are a major site for folate and thymidylate synthesis in plants
22. Folate biosynthesis in higher plants: Purification and molecular cloning of a bifunctional 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase/7,8-dihydropteroate synthase localized in mitochondria
23. Methods for reduction, stabilization, and analyses of folates
24. Chemical and physical properties of folic acid and reduced derivatives
25. Chemistry of naturally occuring pterins
26. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
27. Dissecting the nucleotide binding properties of Escherichia coli 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase with fluorescent 3′(2)′-o-anthraniloyladenosine 5′-triphosphate
28. Equilibrium and kinetic studies of substrate binding to 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase from Escherichia coli
29. Channeling between the active sites of formiminotransferase-cyclodeaminase. Binding and kinetic studies
30. Structure of and kinetic channelling in bifunctional dihydrofolate reductase-thymidylate synthase
31. Folic acid and folates: The feasibility for nutritional enhancement in plant foods