Crystal structure of the anti-bacterial sulfonamide drug target dihydropteroate synthase

Nature Structural Biology

Volumn 4, Issue 6, 1997, Pages 490-497

  Achari, Aniruddha ^a   Somers, Donald O ^a   Champness, John N ^a   Bryant, Patrick K ^a   Rosemond, Jane ^b   Stammers, David K ^c  

^a GLAXOSMITHKLINE   (United Kingdom)

^b GLAXOSMITHKLINE   (United States)

^c UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBENZOIC ACID; ANTIINFECTIVE AGENT; DIHYDROPTEROATE SYNTHASE; SULFANILAMIDE; SULFONAMIDE;

ARTICLE; CRYSTAL STRUCTURE; ENZYME INHIBITOR INTERACTION; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; ESCHERICHIA COLI; FOLATE METABOLISM; NONHUMAN; PNEUMOCYSTIS CARINII; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; BINDING SITES; CONSERVED SEQUENCE; CRYSTALLOGRAPHY, X-RAY; DIHYDROPTEROATE SYNTHASE; ESCHERICHIA COLI; MODELS, MOLECULAR; PROTEIN CONFORMATION; PROTEIN FOLDING; PTERIDINES; PTERINS; SUBSTRATE SPECIFICITY; SULFANILAMIDES; SULFONAMIDES;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; EUKARYOTA; FUNGI; PNEUMOCYSTIS CARINII; PROKARYOTA;

EID: 0030991508     PISSN: 10728368     EISSN: None     Source Type: Journal    
DOI: 10.1038/nsb0697-490     Document Type: Article

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