Polyubiquitin serves as a recognition signal, rather than a ratcheting molecule, during retrotranslocation of proteins across the endoplasmic reticulum membrane

Journal of Biological Chemistry

Volumn 278, Issue 37, 2003, Pages 34774-34782

  Flierman, Dennis ^a   Ye, Yihong ^b   Dai, Min ^c   Chau, Vincent ^c   Rapoport, Tom A ^b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^c PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOLS; BIOLOGICAL MEMBRANES; ENZYME KINETICS; HISTOLOGY; POLYPEPTIDES;

RATCHETING MECHANISM;

PROTEINS;

ADENOSINE TRIPHOSPHATASE; ADENOSINE TRIPHOSPHATE; CELL PROTEIN; GLUTATHIONE TRANSFERASE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; POLYPEPTIDE; POLYUBIQUITIN; PROTEASOME; PROTEIN NP14; PROTEIN P97; PROTEIN UFD1; PROTEIN US11; UBIQUITIN; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ARTICLE; CELL TRANSPORT; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOSOL; ENDOPLASMIC RETICULUM; ENZYME DEGRADATION; ENZYME SUBSTRATE; HUMAN; HUMAN CELL; HUMAN CYTOMEGALOVIRUS; MEMBRANE TRANSPORT; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN TRANSPORT;

ADENOSINE TRIPHOSPHATE; ADENYLYL IMIDODIPHOSPHATE; ANIMALS; ASTROCYTOMA; CATTLE; CELL MEMBRANE PERMEABILITY; CYSTEINE ENDOPEPTIDASES; ENDOPLASMIC RETICULUM; INTRACELLULAR MEMBRANES; LIVER; MULTIENZYME COMPLEXES; POLYUBIQUITIN; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN TRANSPORT; TUMOR CELLS, CULTURED;

CYTOMEGALOVIRUS; HUMAN HERPESVIRUS 5;

EID: 0041315902     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M303360200     Document Type: Article

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