The C-terminal tail of CRTH2 is a key molecular determinant that constrains Gα i and downstream signaling cascade activation

Journal of Biological Chemistry

Volumn 284, Issue 2, 2009, Pages 1324-1336

  Schröder, Ralf ^a   Merten, Nicole ^a   Mathiesen, Jesper Mosolff ^b   Martini, Lene ^c   Kruljac Letunic, Anamarija ^d   Krop, Friederike ^d   Blaukat, Andree ^d   Fang, Ye ^e   Tran, Elizabeth ^e   Ulven, Trond ^f   Drewke, Christel ^a   Whistler, Jennifer ^c   Pardo, Leonardo ^g   Gomeza, Jesús ^a   Kostenis, Evi ^a  

^a UNIVERSITY OF BONN   (Germany)

^b Zealand Pharma AS   (Denmark)

^c UNIVERSITY OF CALIFORNIA SAN FRANCISCO   (United States)

^d Merck Serono GmbH   (Germany)

^e Corning Inc ^*  (United States)

^f UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^g UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

C TERMINUS; C-TERMINAL TAILS; CELL FUNCTIONS; CRITICAL DETERMINANTS; DYNAMIC MASS REDISTRIBUTIONS; FUNCTIONAL RESPONSE; G PROTEIN ACTIVATIONS; G PROTEINS; HETEROLOGOUS EXPRESSIONS; INFLAMMATORY DISEASE; LABEL-FREE MONITORING; MOLECULAR DETERMINANTS; PLASMA MEMBRANES; REAL TIME; RECEPTOR DOMAINS; SIGNAL ATTENUATIONS; SIGNALING CASCADES; SURFACE EXPRESSIONS; TRANSMEMBRANE RECEPTORS;

CELL MEMBRANES; PHOSPHORYLATION; PORT TERMINALS; SIGNAL PROCESSING;

SIGNALING;

BETA ARRESTIN 2; CHEMOATTRACTANT RECEPTOR; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR 44; G PROTEIN COUPLED RECEPTOR KINASE; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; RECEPTOR; UNCLASSIFIED DRUG;

AGONIST; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL MEMBRANE; CELL SPECIFICITY; CONTROLLED STUDY; DESENSITIZATION; DOWN REGULATION; DOWNSTREAM PROCESSING; EMBRYO; ENZYME ACTIVATION; ENZYME ASSAY; ENZYME INHIBITION; GENE EXPRESSION SYSTEM; GENE SILENCING; HETEROLOGOUS EXPRESSION; HUMAN; HUMAN CELL; INTERNALIZATION; MASS FRAGMENTOGRAPHY; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; MUTANT; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DETERMINATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; REAL TIME POLYMERASE CHAIN REACTION; REGULATORY MECHANISM; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; STIMULATION; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; ARRESTINS; CELL LINE; CYCLIC AMP; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GTP-BINDING PROTEIN ALPHA SUBUNITS, GI-GO; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); HUMANS; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; PROSTAGLANDIN D2; PROTEIN BINDING; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTORS, IMMUNOLOGIC; RECEPTORS, PROSTAGLANDIN; SEQUENCE ALIGNMENT; SIGNAL TRANSDUCTION; SUBSTRATE SPECIFICITY; TIME FACTORS; TRANSCRIPTIONAL ACTIVATION;

EID: 59449089513     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M806867200     Document Type: Article

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