Dietary supplementation with carnosine improves antioxidant capacity and meat quality of finishing pigs

Journal of Animal Physiology and Animal Nutrition

Volumn 94, Issue 6, 2010, Pages

  Ma, X Y ^a,b   Jiang, Z Y ^a,b   Lin, Y C ^a,b   Zheng, C T ^a   Zhou, G L ^a  

^a INSTITUTE OF ANIMAL SCIENCE   (China)

^b Guangdong Public Laboratory of Animal Breeding and Nutrition   (China)

Author keywords

Antioxidant capacity; Carnosine; Finishing pig; Gene expression; Meat quality

Indexed keywords

ADENOSINE TRIPHOSPHATASE (CALCIUM); ANTIOXIDANT; CARNOSINE; CATALASE; GLYCOGEN; MALONALDEHYDE; SUPEROXIDE DISMUTASE;

ANIMAL; ANIMAL DISEASE; ANIMAL FOOD; ARTICLE; BODY COMPOSITION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIET; DRUG EFFECT; ENZYMOLOGY; LIVER; MALE; MEAT; METABOLISM; SKELETAL MUSCLE; STANDARD; SWINE;

ANIMAL FEED; ANIMAL NUTRITIONAL PHYSIOLOGICAL PHENOMENA; ANIMALS; ANTIOXIDANTS; BODY COMPOSITION; CALCIUM-TRANSPORTING ATPASES; CARNOSINE; CATALASE; DIET; GLYCOGEN; LIVER; MALE; MALONDIALDEHYDE; MEAT; MUSCLE, SKELETAL; SUPEROXIDE DISMUTASE; SWINE;

GLYCINE MAX; SUIDAE; ZEA MAYS;

EID: 78449235486     PISSN: 09312439     EISSN: 14390396     Source Type: Journal    
DOI: 10.1111/j.1439-0396.2010.01009.x     Document Type: Article

References (65)

1. Alaghband-Zadeh, J.; Mehdizadeh, S.; Khan, N. S.; O'Farrell, A.; Bitensky, L.; Chayen, J., 2001: The natural substrate for nitric oxide synthase activity. Cell Biochemistry Function 19, 277-280.
2. Baran, E. J., 2000: Metal complexes of carnosine. Biochemistry 65, 789-797.
3. Batrukova, M. A.; Rubtsov, A. M., 1997: Histidine-containing dipeptides as endogenous regulators of the activity of sarcoplasmic reticulum Ca-release channels. Biochimica et Biophysica Acta 1324, 142-150.
4. Begum, G.; Cunliffe, A.; Leveritt, M., 2005: Physiological role of carnosine in contracting muscle. International Journal of Sport Nutrition and Exercise Metabolism 15, 493-514.
5. Boldyrev, A. A., 1993: Does carnosine possess direct antioxidant activity? International Journal of Biochemistry 25, 1101-1107.
6. Boldyrev, A. A.; Abe, H., 1999: Metabolic transformation of neuropeptide carnosine modifies its biological activity. Cellular and Molecular Neurobiology 19, 163-175.
7. Boldyrev, A. A.; Severin, S. E., 1990: The histidine-containing dipeptides, carnosine and anserine: distribution, properties and biological significance. Advances in Enzyme Regulation 30, 175-194.
8. Boldyrev, A. A.; Dupin, A. M.; Pindel, E. V.; Severin, S. E., 1988: Anti- oxidative properties of histidine-containing dipeptides from skeletal muscles of vertebrates. Comparative Biochemistry and Physiology 89B, 245-250.
9. Carlo, C.; Giovannangelo, O.; Luigina, P.; Grazia, P.; Giancarlo, S., 1999: Influence of dietary vitamin E supplementation on 'heavy' pig carcass characteristics, meat quality, and Vitamin E status. Journal of Animal Science 77, 1755-1761.
10. Chan, W. K. M.; Decker, E. A.; Chow, C. K.; Boissonneault, G. A., 1994b: Effect of dietary carnosine on plasma and tissue antioxidant concentrations and on lipid oxidation in rat skeletal muscle. Lipids 29, 461-466.
11. Chang, L.; Geng, B.; Yu, F.; Zhao, J.; Jiang, H.; Du, J.; Tang, C., 2008: Hydrogen sulfide inhibits myocardial injury induced by homocysteine in rats. Amino Acids 34, 573-585.
12. Cornet, M.; Bousset, J., 1999: Free amino acids and dipeptides in porcine muscles: Differences between ''red'' and ''white'' muscles. Meat Science 51, 215-219.
13. Dantzer, R.; Moemede, P., 1983: Stress in farmanimals: a need for reevaluation. Journal Animal Science 57, 6-18.
14. Dunnett, M.; Harris, R. C., 1999: Influence of oral beta-alanine and L-histidine supplementation on the carnosine content of the gluteus medius. Equine Veterinary Journal Supplement 30, 499-504.
15. Faustman, C.; Cassens, R. G., 1989: Strategies for improving fresh meat colour. In: Proceedings of the 35th International Congr. Meat Science and Technology, Copenhagen, Denmark, pp. 446-453.
16. Galli, F., 2007: Amino acid and protein modification by oxygen and nitrogen species. Amino Acids 32, 497-499.
17. Gardner, M. L.; Illingworth, K. M.; Kelleher, J.; Wood, D., 1991: Intestinal absorption of the intact peptide carnosine in man, and comparison with intestinal permeability to lactulose. Journal of Physiology 439, 411-422.
18. Gilles, G., 1999: Lipids and meat quality: lipolysis, oxidation, maillard reaction and flavour. Sciences des Aliments, 19, 3-4.
19. Gulyaeva, N. V.; Dupin, A. M.; Levshina, I. P., 1989: Carnosine prevents activation of free-radical lipid oxidation during stress. Bulletin of Experimental Biology and Medicine 107, 148-152.
20. Haynes, T. E.; Li, P.; Li, X.; Shimotori, K.; Sato, H.; Flynn, N. E.; Wang, J.; Knabe, D. A.; Wu, G., 2009: L-Glutamine or L-alanyl-L-glutamine prevents oxidant- or endotoxin-induced death of neonatal enterocytes. Amino Acids 37, 131-142. doi: 10.1007/ s00726-009-0243-x.
21. Ibrahim, W.; Tatum, V.; Yeh, C. C., 2008: Effects of Dietary Carnosine and Vitamin E on Antioxidant and Oxidative Status of Rats. International Journal for Vitamin and Nutrition Research 78, 230-237.
22. Janero, D. R., 1990: Malondialdehyde and thiobarbituric acid-reactivity as diagnostic indices of lipid peroxidation and peroxidative tissue injury. Free Radical Biology and Medicine 9, 515-540.
23. Juncher, D.; Ronn, B.; Mortensen, E. T.; Henckel, P.; Karlsson, A.; Skibsted, L. H., 2001: Effect of pre-slaughter physiological conditions on the oxidative stability of colour and lipid during chill storage of pork. Meat Science 58, 347-357.
24. Kang, J. H.; Kim, K. S.; Choi, S. Y.; Kwon, H. Y.; Won, M. H.; Kang, T. C., 2002: Protective effects of carnosine, homocarnosine and anserine against peroxyl radical-mediated Cu, Zn-superoxide dismutase modification. Biochimica et Biophysica Acta 1570, 89-96.
25. Kim, H. J., 2009: Comparison of the carnosine and taurine contents of vastus lateralis of elderly Korean males, with impaired glucose tolerance, and young elite Korean swimmers. Amino Acids 36, 359-363.
26. Klebanov, G. I.; Teselkin, Y. O.; Babenkova, I. V.; Popov, I. N.; Levin, G.; Tyulina, O. V.; Boldyrev, A. A.; Vladimirov, Y. A., 1997: Evidence for a direct interaction of superoxide anion radical with carnosine. Biochemistry and Molecular Biology International 43, 99-106.
27. Kohen, R.; Yamamoto, Y.; Cundy, K. C.; Ames, B. N., 1988: Antioxidant activity of carnosine, homocarnosine, and anserine present in muscle and brain. Proceedings of the National Academy of Sciences of USA 85, 3175-3179.
28. Kuhn, G.; Hennig, U.; Kalbe, C.; Rehfeldt, C.; Ren, M. Q.; Moors, S., 2004: Growth performance, carcass characteristics and bioavailability of isoflavones in pigs fed soybean based diets. Archives of Animal Nutrition 58, 265-276.
29. Lee, B. J.; Hendricks, D. G., 1997: Antioxidant effects of L-carnosine on liposomes and beef homogenates. Journal of Food Science 62, 931-933.
30. Lee, B. J.; Deloy, G. H.; Daren, P. C., 1999: A comparison of carnosine and ascorbic acid on colour and lipid stability in a ground beef pattie model system. Meat Science 51, 245-253.
31. Lefaucheur, L.; Le Dividich, J.; Mourot, J., 1991: Influence of environ-mental temperature ongrowth, muscle andadiposetissue metabolism, and meat qualityinswine. Journal of Animal Science 69, 2844-2854.
32. Lopez, J.; Jesse, G. W.; Becker, B. A., 1991: Effects of temperature on the performance of finishing swine: II. Effects of a cold, diurnal temperature on aver-age daily gain, feed intake, and feed efficiency. Journal of Animal Science 69, 1850-1855.
33. Ma, X. Y.; Lin, Y. C.; Jiang, Z. Y.; Zheng, C. T.; Zhou, G. L.; Yu, D. Q.; Cao, T.; Wang, J.; Chen, F., 2010: Effect of dietary arginine supplementation on growth performance and meat quality of finishing pigs. Amino Acids 38, 95-102. DOI 10.1007/ s00726-008-0213-8.
34. Mason, L. M.; Hogan, S. A.; Lynch, A.; O'Sullivan, K.; Lawlor, P. G.; Kerry, J. P., 2005: Effect of restricted feeding and antioxidant supplementation on pig performance and quality characteristics of longissimus dorsi muscle from Landrace and Duroc pigs. Meat Science 70, 307-317.
35. McFarlane, B. J.; Unruh, J. A., 1996: Effect of blast chilling and postmortem calcium chloride injection on tenderness of pork longissimus muscle. Journal of Animal Science 74, 1842-1845.
36. Mikami, K.; Otaka, M.; Watanabe, D.; Goto, T.; Endoh, A.; Miura, K.; Ohshima, S.; Yoneyama, K.; Sato, M.; Shibuya, T.; Segawa, D.; Kataoka, D., 2006: Zinc L-carnosine protects against mucosal injury in portal hypertensive gastropathy through induction of heat shock protein 72. Journal of Gastroenterology and Hepatology 21, 1669-1674.
37. Miller, D. J.; O'Dowd, A., 2000: Vascular smooth muscle actions of carnosine as its zinc complex are mediated by histamine H(1) and H(2) receptors. Biochemistry 65, 798-806.
38. Mitsumoto, M.; Sasaki, K.; Otawara, K.; Sakashita, K.; Homma, N., 2002: Effect of dietary β-carotene, catechins and vitamin E supplementation on meat quality during display in pigs. In: Proceedings of the 48th International Congress of Meat Science and Technology, pp. 514-515.
39. Mora, L.; Sentandreu, M. A.; Toldra, F., 2008: Contents of creatine, creatinine and carnosine in porcine muscles of different metabolic types. Meat Science 79, 709-715.
40. Nagai, K.; Niijima, A.; Yamano, T.; Otani, H.; Okumra, N.; Tsuruoka, N.; Nakai, M.; Kiso, Y., 2003: Possible role of L-carnosine in the regulation of blood glucose through controlling autonomic nerves. Experimental Biology and Medicine 228, 1138-1145.
41. Nagasawa, T.; Yonekura, T.; Nishizawa, N., 2001: In vitro and in vivo inhibition of muscle lipid and protein oxidation by carnosine. Molecular Cell Biochemistry 225, 29-34.
42. NPPC, 1991: Procedures to evaluate market hogs. The 3rd National Pork Producers Council, Des Moines, IA.
43. Odashima, M.; Otaka, M.; Jin, M.; Konishi, N.; Kato, S.; Matsuhashi, T.; Nakamura, C.; Watanabe, S., 2002: Induction of a 72-kDa heat-shock protein in cultured rat gastric mucosal cells and rat gastric mucosa by zinc L-carnosine. Digestive Diseases and Sciences 47, 2799-2804.
44. Odashima, M.; Otaka, M.; Jin, M.; Wada, I.; Horikawa, Y.; Matsuhashi, T.; Ohba, R.; Hatakeyama, N.; Oyake, J.; Watanabe, S., 2006: Zinc L-carnosine protects colonic mucosal injury through induction of heat shock protein 72 and suppression of NF-kb activation. Life Sciences 79, 2245-2250.
45. O'Neill, L. M.; Galvin, K.; Morrissey, P. A.; Buckley, D. J., 1998: Inhibition of lipid oxidation in chicken by carnosine and dietary α- tocopherol supplementation and its determination by derivative spectrophotometry. Meat Science 50, 479-488.
46. O'Neill, L. M.; Galvin, K.; Morrissey, P. A.; Buckley, D. J., 1999: Effect of carnosine, salt and dietary vitamin E on the oxidative stability of chicken meat. Meat Science 52, 89-94.
47. Pavlov, A. R.; Revina, A. A.; Dupin, A. M.; Boldyrev, A. A.; Yaropolov, A. I., 1993: The mechanism of interaction of carnosine with superoxide radicals in water solutions. Biochimica et Biophysica Acta 1157, 304-312.
48. Peeters, E.; Driessen, B.; Geers, R., 2006: Influence of supplemental magnesium, tryptophan, vitamin C, vitamin E, and herbs on stress responses and pork quality. Journal of Animal Science 84, 1827-1838.
49. Purchas, R. W.; Morel, P. C. H.; Janz, J. A. M., 2009: Chemical composition characteristics of the longissimus and semimembranosus muscles for pigs from New Zealand and Singapore. Meat Science 81, 540-548.
50. Qiao, Y. R., 2004: Efect of cold stress on pig productive performance. Swine production 6, 25-27.
51. Sanchez, E. A.; Djenane, D.; Torrescano, G., 2003: Evaluation of the antioxidant ability of hydrazine-purified and untreated commercial carnosine in beef patties. Meat Science 64, 59-67.
52. Science and Technology ministry of China. 2006: The guiding suggestion about treating experimental animals amicablely. No.398 Document.
53. Stvolinskii, S. L.; Fedorova, T. N.; Yuneva, M. O., 2003: Protective effect of carnosine on Cu, Zn- superoxide dismutase during impaired oxidative metabolism in the brain in vivo. Bulletin of Exprimental Biology and Medicine 135, 130-132.
54. Tamba, M.; Torreggiani, A., 1999: Hydroxyl radical scavenging by carnosine and Cu (11)-carnosine complexes: a pulse-radiolysis and spectroscopic study. International Journal Radiation Biology. 75, 1177-1188.
55. Tanida, M.; Niijima, A.; Fukuda, Y.; Sawai, H.; Tsuruoka, N.; Shen, J.; Yamada, S.; Kiso, Y.; Nagai, K., 2005: Dose-dependent effects of L-carnosine on the renal sympathetic nerve and blood pressure in irethane-anes thetized rats. American Journal of Physiology-Regulatory Integrative and Comparative Physiology. 288, 447-455.
56. Temperini, C.; Scozzafava, A.; Puccetti, L.; Supuran, C., 2005: Carbonic anhydrase activators:X-ray crystal structure of the adduct of human isozyme II with histidine as a platform for the design of stronger activators. Bioorganic and Medicinal Chemistry Letters 15, 5136-5141.
57. Trostchansky, A.; Rubbo, H., 2007: Lipid nitration and formation of lipid- protein adducts: biological insights. Amino Acids 32, 517-522.
58. Vaughan-Jones, R. D.; Spitzer, K. W.; Swietach, P., 2006: Spatial aspects of intracellular pH regulation in heart muscle. Progress in Biophysics and Molecular Biology 90, 207-224.
59. Wada, I.; Otaka, M.; Jin, M.; Odashima, M.; Komatsu, K.; Konishi, N.; Matsuhashi, T.; Horikawa, Y.; Ohba, R.; Itoh, H.; Watanabe, S., 2006: Expression of HSP72 in the gastric mucosa is regulated by gastric acid in rats-Correlation of HSP72 expression with mucosal protection. Biochemical and Biophysical Research Communications 349, 611-618.
60. Warriss, P. D.; Bevis, E. A.; Ekins, P. J., 1989: The relationships between glycogen stores and muscle ultimate pH in commercially slaughtered pigs. British Veterinary Journal 145, 378-383.
61. Wen, L. Y.; Lee, W. C., 2002: Inhibition of lipid peroxidation and nonlipid oxidative damage by carnosine. Journal of the American oil Chemists' Society 79, 329-333.
62. Van De Wiel, D. F. M.; Zhang, L. W., 2007: Identification of pork quality parameters by proteomics. Meat Science 77, 46-54.
63. Wu, G., 2009: Amino acids: metabolism, functions and nutrition. Amino Acids 37, 1-17. doi:
64. Wu, G.; Meininger, C. J., 2000: Arginine nutrition and cardiovascular function. Journal of Nutrition 130, 2626-2629.
65. Zaloga, G. P.; Roberts, P. R.; Black, K. W., 1997: Carnosine is a novel peptide modulator of intracellular calcium and contractility in cardiac cells. American Journal of Physiology 272, H462-H468.