Zinc L-carnosine protects against mucosal injury in portal hypertensive gastropathy through induction of heat shock protein 72

Journal of Gastroenterology and Hepatology (Australia)

Volumn 21, Issue 11, 2006, Pages 1669-1674

  Mikami, Ken Ichiro ^a   Otaka, Michiro ^a   Watanabe, Daisuke ^a   Goto, Takashi ^a   Endoh, Ayako ^a   Miura, Kouichi ^a   Ohshima, Shigetoshi ^a   Yoneyama, Kazuo ^a   Sato, Michiko ^a   Shibuya, Tomomi ^a   Segawa, Daisuke ^a   Kataoka, Ei ^a   Yoshino, Ryutaro ^a   Takeuchi, Satoko ^a   Sato, Wataru ^a   Odashima, Masaru ^a   Watanabe, Sumio ^a  

^a AKITA UNIVERSITY   (Japan)

Author keywords

Heat shock protein; Portal hypertensive gastropathy; Zinc

Indexed keywords

ANTIULCER AGENT; CARNOSINE; HEAT SHOCK PROTEIN 72; HYDROCHLORIC ACID; POLAPREZINC; ZINC; ZINC SULFATE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILE DUCT LIGATION; BLOOD SAMPLING; CELL PROTECTION; DISEASE MODEL; DRUG EFFECT; LIVER CIRRHOSIS; MALE; NONHUMAN; PORTAL HYPERTENSION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; RAT; STOMACH DISEASE; STOMACH MUCOSA; STOMACH MUCOSA INJURY; STOMACH PROTECTION; WESTERN BLOTTING; ZINC BLOOD LEVEL;

EID: 33748786772     PISSN: 08159319     EISSN: 14401746     Source Type: Journal    
DOI: 10.1111/j.1440-1746.2006.04328.x     Document Type: Article

References (45)

1. Primignani M, Carpinelli L, Preatoni P et al. Natural history of portal hypertensive gastropathy in cirrhosis. Gastroenterology 2000; 119: 181-7.
2. D'Amico G, Montalbano L, Traina M et al. The Liver Study Group of V. Cervello Hospital. Natural history of congestive gastropathy in cirrhosis. Gastroenterology 1990; 99: 1558-64.
3. Sarfeh IJ, Soliman H, Waxman K et al. Impaired oxygenation of gastric mucosa in portal hypertension. The basis for increased susceptibility to injury. Dig. Dis. Sci. 1989; 34: 225-8.
4. Ferraz JG, McKnight GW, Sharkey A, Wallace JL. Impaired vasodilatory responses in the gastric microcirculation of anesthetized rats with secondary biliary cirrhosis. Gastroenterology 1995; 108: 1183-91.
5. Sarfeh IJ, Juler GL, Stemmer EA, Mason GR. Results of surgical management of hemorrhagic gastritis in patients with gastroesophageal varices. Surg. Gynecol. Obstet 1982; 155: 167-70.
6. Beck PL, Lee SS, McKnight GW, Wallace JL. Characterization of spontaneous and ethanol-induced gastric damage in cirrhotic rats. Gastroenterology 1992; 103: 1048-55.
7. Kawanaka H, TomikawaM, Jones MK et al. Defective mitogen-activated protein kinase (ERK2) signaling in gastric mucosa of portal hypertensive rats: potential therapeutic implications. Hepatology 2001; 34: 990-9.
8. Hightower LE. Cultured animal cells exposed to amino acid analogues or puromycin rapidly synthesize several polypeptides. J. Cell Physiol. 1980; 102: 407-27.
9. Itoh H, Tashima Y. The stress (heat shock) proteins. Int. J. Biochem. 1991; 23: 1185-91.
10. Kiang JG, Tsokos GC. Heat shock protein 70 kDa: molecular biology, biochemistry, and physiology. Pharmacol. Ther. 1998; 80: 183-201.
11. Rajdev S, Hara K, Kokubo Y et al. Mice overexpressing rat heat shock protein 70 are protected against cerebral infarction. Ann. Neurol. 2000; 47: 782-91.
12. Lubbers NL, Polakowski JS, Wegner CD et al. Oral bimoclomol elevates heat shock protein 70 and reduces myocardial infarct size in rats. Eur. J. Pharmacol. 2002; 435: 79-83.
13. Fujimori S, Otaka M, Itoh H et al. Induction of a 72-kDa heat shock protein and cytoprotection against thioacetamide-induced liver injury in rats. Dig. Dis. Sci. 1997; 42: 1987-94.
14. Nakamura K, Rokutan K, Marui N, Aoike A, Kawai K. Induction of heat shock proteins and their implication in protection against ethanol-induced damage in cultured guinea pig gastric mucosal cells. Gastroenterology 1991; 101: 161-6.
15. Otaka M, Zeniya A, Fujimori S et al. Preinduction of a 72-kDa heat shock protein prevents HCl-induced gastric mucosal lesion. Gastroenterology 1996; 110: A219.
16. Hatayama T, Asai Y, Wakatsuki T, Kitamura T, Imahara H. Regulation of hsp70 synthesis induced by cupric sulfate and zinc sulfate in thermotolerant HeLa cells. J. Biochem. 1993; 114: 592-7.
17. Tons C, Klasterhalfen B, Klein HM et al. Induction of heat shock protein 70 by zinc bis (DL-hydrogen aspartate) reduces ischemic small-bowel tissue damage in rats. Langenbecks Arch. Chir. 1997; 382: 43-8.
18. Seiki M, Ueki S, Tanaka Y et al. Studies on anti-ulcer effects of a new compound, zinc 1-carnosine. Folia Pharmacol. Jpn. 1990; 95: 257-69.
19. Arakawa T, Satoh H, Nakamura A et al. Effects of zinc 1-carnosine on gastric mucosal and cell damage caused by ethanol in rats. Dig. Dis. Sci. 1990; 35: 559-66.
20. Yoshikawa T, Naito Y, Tanigawa T, Yoneta T, Kondo M. The antioxidant properties of a novel zinc-carnosine chelate compound, N-(3-aminopropionyl)-L- histidinato zinc. Biochim. Biophys. Acta 1991; 1115: 15-22.
21. Cho CH, Hui WM, Chen BW, Luk CT, Lam SK. The cytoprotective effect of zinc 1-carnosine on ethanol-induced gastric gland damage in rabbits. J. Pharm. Pharmacol. 1992; 44: 364-5.
22. Nishiwaki H, Kato S, Sugamoto S et al. Ulcerogenic and healing impairing actions of monochloramine in rat stomachs: effects of zinc 1-carnosine, polaprezinc. J. Physiol. Pharmacol. 1999; 50: 183-95.
23. Odashima M, Otaka M, Jin M et al. Induction of a 72-kDa heat shock protein in cultured rat gastric mucosal cells and rat gastric mucosa by zinc 1-carnosine. Dig. Dis. Sci. 2002; 47: 2799-804.
24. Lebrec D. Animal models of portal hypertension. In: Okuda K, Benhamou JP, eds. Portal Hypertension: Clinical and Physiological Aspects. Tokyo: Springer-Verlag, 1991; 101-13.
25. Ohno T, Ohtsuki H, Okabe S. Effect of 16,16-dimethyl prostaglandin E2 on ethanol-induced and aspirin-induced gastric damage in the rat. Gastroenterology 1988; 88: 353-61.
26. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 1976; 72: 248-54.
27. Otaka M, Itoh H, Kuwabara T et al. Induction of a 60-kDa heat shock protein in rat pancreas by water-immersion stress. Int. J. Biochem. 1993; 25: 1769-73.
28. Towbin H, Staehelin T, Gordon J. Electrophoreic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc. Natl Acad. Sci. USA 1979; 76: 4350-3.
29. Watanabe D, Otaka M, Mikami K et al. Expression of a 72-kDa heat shock protein and protection in gastric mucosa in cirrhotic rats. J. Gastroenterol. 2004; 39: 724-33.
30. Gething MJ, Sambrook J. Protein folding in the cell. Nature 1992; 355: 33-45.
31. Rothman JE. Polypeptide chain binding proteins: Catalysts of protein folding and related processes in the cells. Cell 1989; 59: 591-601.
32. Kiang JG, Wang XD, Ding XZ, Gist I, Smallridge RC. Heat shock inhibits the hypoxia-induced effects in rat thyroid FRTL-5 cells. Thyroid 1996; 6: 475-83.
33. Mestril R, Chi SH, Sayen MR, Dillmann WH. Isolation of a novel inducible rat heat shock protein (HSP70) gene and its expression during ischemia/hypoxia and heat shock. Biochem. J. 1994; 298: 561-9.
34. Jin M, Otaka M, Okuyama A et al. Association of 72-kDa heat shock protein expression with adaptation to aspirin in rat gastric mucosa. Dig. Dis. Sci. 1999; 44: 1401-7.
35. Aggett PJ. Severe zinc deficiency. In: Millis CF, ed. Zinc in Human Biology. New York: Springer-Verlag, 1989; 259-79.
36. Loguercio C, De Girolamo V, Federico A et al. Relationship of blood trace elements to liver damage, nutritional status, and oxidative stress in chronic nonalcoholic liver disease. Biol. Trace Elem. Res. 2001; 81: 245-54.
37. Camps J, Bargallo T, Gimenez A et al. Relationship between hepatic lipid peroxidation and fibrogenesis in carbon tetrachloride-treated rats: effect of zinc administration. Clin. Sci. 1992; 83: 695-700.
38. Miyoshi A, Matsuo H, Miwa G, Nakajima M. Clinical evaluation of Z-103 in the treatment of gastric ulcer. Jpn Pharmacol. Ther. 1992; 20: 181-97.
39. Dupuy D, Szabo S. Protection by metals against ethanol-induced gastric mucosal injury in the rat. Comparative biochemical and pharmacologic studies implicate protein sulfhydryls. Gastroenterology 1986; 91: 966-74.
40. Seiki M, Aita H, Mera Y et al. The gastric mucosal adhesiveness of Z-103 in rats with chronic ulcer. Folia Pharmacol. Jpn. 1992; 99: 255-63.
41. Westin G, Schaffner W. A zinc-responsive factor interacts with a metal-regulated enhancer element (MRE) of the mouse metallothionein-I gene. EMBO J. 1988; 7: 3763-70.
42. Wu BJ, Kingston RE, Morimoto RI. Human HSP70 promoter contains at least two distinct regulatory domains. Proc. Natl Acad. Sci. USA 1986; 83: 629-33.
43. Krones CJ, Klosterhalfen B, Butz N et al. Effect of zinc pretreatment on pulmonary endothelial cells in vitro and pulmonary function in a porcine model of endotoxemia. J. Surg. Res. 2005; 123: 251-6.
44. Lebrec D, Poynard T, Hillon P, Benhamou JP. Propranolol for prevention of recurrent gastrointestinal bleeding in patients with cirrhosis: a controlled study. N. Engl. J. Med. 1981; 305: 1371-4.
45. Takagi H, Nagamine T, Abe T et al. Zinc supplementation enhances the response to interferon therapy in patients with chronic hepatitis C. J. Viral Hepat. 2001; 8: 367-71.