Exposure Assessment Approaches for Engineered Nanomaterials

Risk Analysis

Volumn 30, Issue 11, 2010, Pages 1634-1644

  Abbott, Linda C ^a   Maynard, Andrew D ^b  

^a U S DEPARTMENT OF AGRICULTURE   (United States)

^b UNIVERSITY OF MICHIGAN SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

Exposure assessment; Nanomaterials; Nanoparticle

Indexed keywords

BIOLOGICAL RESPONSE; CONCEPTUAL MODEL; DETECTION TECHNIQUE; ENGINEERED NANOMATERIALS; ENVIRONMENTAL EXPOSURE; EXPOSURE ASSESSMENT; EXPOSURE METRICS; EXPOSURE MODELS; EXPOSURE PATHWAYS; FATE AND TRANSPORT; HUMAN EXPOSURES; LIFE CYCLE ANALYSIS; METRIC MATRIX; MONITORING DEVICE; NANO-MATERIALS; NANO-SCALE MATERIALS; NANOMATERIAL; NANOTECHNOLOGY PRODUCTS; PARTICLE NUMBERS; PARTICLE SHAPE; PRODUCT-LIFE-CYCLE; SURFACE AREA; SURFACE CHARACTERISTICS; TOXICITY TESTING;

MONITORING; NANOPARTICLES;

NANOSTRUCTURED MATERIALS;

NANOMATERIAL;

CONCEPTUAL FRAMEWORK; LIFE CYCLE ANALYSIS; NANOTECHNOLOGY; SIZE DISTRIBUTION; SURFACE AREA; TOXICITY TEST;

ARTICLE; ENVIRONMENTAL EXPOSURE; OCCUPATIONAL EXPOSURE;

ENVIRONMENTAL EXPOSURE; NANOSTRUCTURES; OCCUPATIONAL EXPOSURE;

EID: 78349281526     PISSN: 02724332     EISSN: 15396924     Source Type: Journal    
DOI: 10.1111/j.1539-6924.2010.01446.x     Document Type: Article

References (94)

1. Wilson Institute, Project on Emerging Nanotechnologies. Consumer Product Inventory, 2008. Available at:, Accessed on January 14, 2010.
2. European Nanotechnology Institute. Nanotechnology in Consumer Products, 2006. Available at:, Accessed on January 14, 2010.
3. Thomas T, Thomas K, Sadrich N, Savage N, Adair P, Bronaugh R. Research strategies for safety evaluation of nanomaterials, Part VII: Evaluating consumer exposure to nanoscale materials. Toxicological Sciences, 2006; 9(1):14-19.
4. Council of Canadian Academies. Small is Different: A Science Perspective on the Regulatory Challenges of the Nanoscale the Expert Panel on Nanotechnology, 2008. Available at:, Accessed on January 14, 2010.
5. Royal Society, Royal Academy of Engineering. Nanoscience and Nanotechnologies: Opportunities and Uncertainties, 2004. Available at:, Accessed on January 14, 2010.
6. Maynard AD, Kuempel ED. Airborne nanostructured particles and occupational health. Journal of Nanoparticle Research, 2005; 7(6):587-614.
7. Oberdörster G, Maynard A, Donaldson K, Catranova V, Fitzpatrick J, Ausman K, Carter J, Karn B, Kreyling W, Lai D, Olin S, Monteiro-Riviere N, Warheit D, Yang H. Principles for characterizing the potential human health effects from exposure to nanomaterials: Elements of a screening strategy. Particle and Fibre Toxicology, 2005; 2:doi:. Available at, Accessed on February 25, 2009.
8. Maynard AD, Aitken RJ. Assessing exposure to airborne nanomaterials: Current abilities and future requirements. Nanotoxicology, 2007; 1(1):26-41.
9. Oberdörster G, Oberdörster E, Oberdörster J. Nanotoxicology: An emerging discipline evolving studies of ultrafine particles. Environmental Health Perspectives, 2005; 113(7):823-839.
10. Buzea C, Blandino I, Robbie K. Nanomaterials and nanoparticles: Sources and toxicity. Biointerphases, 2007; 2(4):17-71.
11. Silva GA. Nanotechnology approaches to crossing the blood-brain barrier and drug delivery to the CNS. BMC Neuroscience, 2008; 9(Suppl 3):S4. doi: Available at, Accessed on February 25, 2009.
12. Garcia-Garcia E, Andrieux K, Gil S, Couvreur P. Colloidal carriers and blood-brain barrier (BBB) translocation: A way to deliver drugs to the brain International Journal of Pharmaceutics, 2005; 298(2005):274-292.
13. Ryman-Rasmussen JP, Riviere JE, Monteiro-Riviere NA. Penetration of intact skin by quantum dots with diverse physicochemical properties. Toxicological Sciences, 2006; 91(1):159-165.
14. Tinkle SS, Antonini JM, Rich BA, Roberts JR, Salmen R, DuPree K, Adkins EJ. Skin as a route of exposure and sensitization in chronic beryllium disease. Environmental Health Perspectives, 2003; 111(9):1202-1208.
15. Zhang LW, Monteiro-Riviere N. Assessment of quantum dot penetration into intact, tape-stripped, abraded and flexed rat skin. Skin Pharmacology and Physiology, 2008; 21:166-180.
16. Kim S, Lim YT, Soltesz EG, De Grand AM, Lee J, Nakayama A, Parker JA, Mihaljevic T, Laurence RG, Dor DM, Cohn LH, Bawendi MG, Frangioni JV. Near infra-red fluorescent type II quantum dots for sentinel lymph node mapping. Nature Biotechnology, 2004; 22(1):93-97.
17. Pflücker F, Wendel V, Hohenberg H, Gärtner E, Will T, Pfeiffer S, Wepf R, Gers-Barlag H. The human stratum corneum layer: An effective barrier against dermal uptake of different forms of topically applied micronised titanium dioxide. Skin Pharmacology and Applied Skin Physiology, 2001; 14(Suppl 1):92-97.
18. Alvarez-Román R, Naik A, Kalia YN, Guy RH, Fessi H. Skin penetration and distribution of polymeric nanoparticles. Journal of Controlled Release, 2004; 99:53-62.
19. Nohynek GJ, Dufour EK, Roberts MS. Nanotechnology, cosmetics and the skin: Is there a health risk Skin Pharmacology and Physiology, 2008; 21(3):136-149.
20. Kreyling WG, Semmler M, Erbe F, Mayer P, Takenaka S, Schulz H, Oberdörster G, Zeisenis A. Translocation of ultrafine insoluble iridium particles from lung epithelium to extrapulmonary organs is size dependent but very low. Journal of Toxicology and Environmental Health, Part A, 2002; 65(20):1513-1530.
21. Elder A, Gelein R, Silva V, Feikert T, Opanashuk L, Carter J, Potter R, Maynard A, Ito Y, Finkelstein J, Oberdörster G. Translocation of inhaled ultrafine manganese oxide particles to the central nervous system. Environmental Health Perspectives, 2006; 114(8):1172-1178.
22. Moghimi S, Hunter A, Murray J. Long-circulating and target specific nanoparticles: Theory to practice. Pharmacological Reviews, 2001; 53:283-318.
23. Maynard AD. Is Engineered Nanoparticle Exposure a Myth 2007. Available at:, Accessed on January 14, 2010.
24. Rawle A. Micron sized nano-materials. Powder Technology, 2006; 174:6-9.
25. Owen R, Handy R. Viewpoint: Formulating the problems for environmental risk assessment of nanomaterials. Environmental Science and Technology, 2007; 41(16):5582-5588.
26. Davis JM. How to assess the risks of nanotechnology: Learning from past experience. Journal of Nanoscience and Nanotechnology, 2007; 7(2):402-409.
27. Shatkin J. Nanotechnology Health and Environmental Risks. Boca Raton, FL CRC Press, 2008.
28. Environmental Defense Fund and Dupont Nano Partnership. NanoRisk Framework, 2007. Available at:, Accessed January 14, 2010.
29. Organisation for Economic Co-operation and Development. 2008. List of Manufactured Nanomaterials and List of Endpoints for Phase One of the OECD Testing Programme. Series on the Safety of Manufactured Nanomaterials, Number 6. Paris France Working Party on Manufactured Nanomaterials, ENV/JM/MON(2008)13/REV, July 7, 2008.
30. Environmental Protection Agency. 2009. Nanomaterial Case Studies: Nanoscale Titanium Dioxide in Water Treatment and Topical Sunscreen-External Review Draft. Research Triangle Park, NC National Center for Environmental Assessment, Office of Research and Development, EPA/600/R-09/057, July 2009.
31. Borm P, Robbins D, Haubold S, Kuhlbusch T, Fissan H, Donaldson K, Schins R, Stone V, Kreyling W, Lademann J, Krutmann J, Warheit D, Oberdörster E. The potential risks of nanomaterials: A review carried out for ECETOC. Particle and Fibre Toxicology, 2006; 3:doi:. Available at, Accessed on March 3, 2009.
32. Benn TM, Westeroff P. Nanosilver released into water from commercially available sock fabrics. Environmental Science and Technology, 2008; 42(11):4133-4139.
33. Rudel RA, Camaan DE, Spengler JD, Korn LR, Brody JG. Phthlates, alkylphenols, pesticides, polybrominated diphenyl esters, and other endocrine-disrupting compounds in indoor air and dust. Environmental Science and Technology, 2003; 37(20):4543-4553.
34. Taylor MR. Assuring the Safety of Nanomaterials in Food Packaging: The Regulatory Process and Key Issues. Washington, DC Woodrow Wilson International Center for Scholars, Project on Emerging Nanotechnologies Report, PEN-12, July 2008.
35. Holbrook RD, Murphy KE, Morrow JB, Cole KD. Trophic transfer of nanoparticles in a simplified invertebrate food web. Nature Nanotechnology, 2008; 3:352-355.
36. U. S. Environmental Protection Agency. Guidelines for Exposure Assessment. Washington, DC Risk Assessment Forum, EPA/600/Z-92/001, May 29, 1992.
37. Oberdörster G, Gelein RM, Ferin J, Weiss B. Association of particulate air pollution and acute mortality: Involvement of ultrafine particles Inhalation Toxicology, 1995; 7:111-124.
38. Donaldson K, Li XY, MacNee W. Ultrafine (nanometer) particle mediated lung injury. Journal of Aerosol Science, 1998; 29(5-6):553-560.
39. Donaldson K, Stone V, Gilmour PS, Brown DM, MacNee W. Ultrafine particles: Mechanisms of lung injury. Philosophical Transactions of the Royal Society A, 2000; 358(1775):2741-2749.
40. Oberdörster G. Toxicology of ultrafine particles: In vivo studies. Philosophical Transactions of the Royal Society A, 2000; 358(1775):2719-2740.
41. Tran CL, Buchanan D, Cullen RT, Searl A, Jones AD, Donaldson K. Inhalation of poorly soluble particles. II. Influence of particle surface area on inflammation and clearance. Inhalation Toxicology, 2000; 12(12):1113-1126.
42. Brown DM, Wilson MR, MacNee W, Stone V, Donaldson K. Size-dependent proinflammatory effects of ultrafine polystyrene particles: A role for surface area and oxidative stress in the enhanced activity of ultrafines. Toxicology and Applied Pharmacology, 2001; 175(3):191-199.
43. Dick CAJ, Brown DM, Donaldson K, Stone V. The role of free radicals in the toxic and inflammatory effects of four different ultrafine particle types. Inhalation Toxicology, 2003; 15(1):39-52.
44. 10 and ultrafine particles with special reference to COPD. European Respiratory Journal, 2003; 21(Suppl. 40):47S-51S.
45. Oberdörster G, Stone V, Donaldson K. Toxicology of nanoparticles: A historical perspective. Nanotoxicology, 2007; 1(1):2-25.
46. Dockery DW, Speizer FE, Stram DO, Ware JH, Spengler JD, Ferris BG. Effects of inhalable particles on respiratory health of children. American Review of Respiratory Disease, 1989; 139(3):587-594.
47. Pope CA, Dockery DW, Spengler JD, Raizenne ME. Respiratory health and PM10 pollution: A daily time series analysis. American Review of Respiratory Disease, 1991; 144(3 Pt 1):668-674.
48. Schwartz J, Spix C, Wichmann HE, Malin E. Air pollution and acute respiratory illness in five German communities. Environmental Research, 1991; 56(1):1-4.
49. Dockery DW, Pope CA, Xu X, Spengler JD, Ware JH, Fay ME, Ferris BG, Speizer FE. An association between air pollution and mortality in six U.S. cities. New England Journal of Medicine, 1993; 329(24):1753-1759.
50. Schwartz J, Slater D, Larson TV, Pierson WE, Koenig JQ. Particulate air pollution and hospital emergency room visits for asthma in Seattle. American Review of Respiratory Disease, 1993; 147:826-831.
51. Schwartz J. Short term fluctuations in air pollution and hospital admissions of the elderly for respiratory disease. Thorax, 1991; 50(5):531-538.
52. Seaton A, MacNee W, Donaldson K, Godden D. Particulate air pollution and acute health effects. Lancet, 1995; 345:176-178.
53. Romieu I, Meneses F, Ruiz S, Sienra JJ, Huerta J, White MC, Etzel RA. Effects of air pollution on the respiratory health of asthmatic children living in Mexico City. American Journal of Respiratory and Critical Care Medicine, 1996; 154(2 Pt 1):300-307.
54. Schwartz J, Dockery DW, Neas LM. Is daily mortality associated specifically with fine particles Journal of the Air and Waste Management Association, 1996; 46(10):927-939.
55. Pekkanen J, Timonen KL, Ruuskanen J, Reponen A, Mirme A. Effects of ultrafine and fine particles in urban air on peak expiratory flow among children with asthmatic symptoms. Environmental Research, 1997; 74(1):24-33.
56. Peters A, Wichmann HE, Tuch T, Heinrich J, Heyder J. Respiratory effects are associated with the number of ultrafine particles. American Journal of Respiratory and Critical Care Medicine, 1997; 155(4):1376-1383.
57. McCawley MA, Kent MS, Berakis MT. Ultrafine beryllium aerosol as a possible metric for chronic beryllium disease. Applied Occupational and Environmental Hygiene, 2001; 16:631-638.
58. Antonini JM. Health effects of welding. Critical Reviews in Toxicology, 2003; 33(1):61-103.
59. Lison D, Lardot C, Huaux F, Zanetti G, Fubini B. Influence of particle surface area on the toxicity of insoluble manganese dioxide dusts. Archives of Toxicology, 1997; 71(12):725-729.
60. 2 rods and dots in rats: Toxicity is not dependent upon particle size and surface area. Toxicological Sciences, 2006; 91(1):227-236.
61. Sayes CM, Warheit DB. An in vitro investigation of the differential cytotoxic responses of human and rat lung epithelial cell lines using TiO2 nanoparticles. International Journal of Nanotechnology, 2008; 5:15-29.
62. Oberdörster G, Sharp Z, Atudorei V, Elder A, Gelein R, Kreyling W, Cox C. Translocation of inhaled ultrafine particles to the brain. Inhalation Toxicology, 2004; 16(6-7):437-445.
63. Maynard AD. Overview of methods for analysing single ultrafine particles. Philosophical Transactions of the Royal Society A, 2000; 358(1775):2593-2609.
64. Hassellov M, Readman JW, Ranville JF, Tiede K. Nanoparticle analysis and characterization methodologies in environmental risk assessment of engineered nanoparticles. Ecotoxicology, 2008; 17:344-361.
65. Maynard AD, Aitken RJ, Butz T, Colvin V, Donaldson K, Oberdörster G, Philbert MA, Ryan J, Seaton A, Stone V, Tinkle S, Tran L, Walker NJ, Warheit DB. Safe handling of nanotechnology. Nature, 2006; 444(7117):267-269.
66. Mitchell CR, Azizova TV, Hande MP, Burak LE, Tsakok JM, Khokhryakov VF, Geard CR, Brenner DJ. Stable intrachromosomal biomarkers of past exposure to densely ionizing radiation in several chromosomes of exposed individuals. Radiation Research, 2004; 162(3):257-263.
67. Hildermann L, Cass GR, Mazurek MA, Sinoneit BRT. Mathematical modeling of urban organic aerosol: Properties measured by high-resolution gas chromatography. Environmental Science and Technology, 1993; 27:2045-2055.
68. U. S. Environmental Protection Agency. User's Guide for the Industrial Source Complex (ISC3) Dispersion Models. Volume 2. Description of Model Algorithms. Research Triangle Park, NC Office of Air Quality Planning and Standards, Emissions, Monitoring, and Analysis Division, EPA-454/B-95-003a, September 1995.
69. Cimorelli AJ, Perry SG, Venkatram A, Weil J, Paine R, Wilson RB, Lee RE, Peters ED, Brode RW. AERMOD: A dispersion model for industrial source applications. Part I: General model formulation and boundary layer characterization. Journal of Applied Meteorology, 2005; 44:682-693.
70. O'Neill NT, Campanelli M, Lupu A, Thulasiraman S, Reid JS, Aube M, Neary L, Kaminski JW, McConnell JC. Evaluation of the GEM-AQ air quality model during the Québec smoke event of 2002: Analysis of extensive and intensive optical disparities. Atmospheric Environment, 2006; 40:3737-3749.
71. Lavdas L. Program VSMOKE-Users Manual. Asheville, NC U.S. Department of Agriculture, Forest Service, Southern Research Station General Technical Report SRS-6, 1996.
72. Sassen K, Khvorostyanov VI. Cloud effects from boreal forest fire smoke: Evidence for ice nucleation from polarization lidar data and cloud model simulations. Environmental Research Letters, 2008; 3:1-12.
73. th-century transition from aboriginal to European fire management in northern Australia. Global Ecology and Biogeography, 2007; 16:246-256.
74. Vouitsis E, Ntziachristos L, Samaras Z. Modelling of diesel exhaust aerosol during laboratory sampling. Atmospheric Environment, 2005; 39(2005):1335-1345.
75. Bowker G, Baldauf R, Isakov V, Khlystov A, Petersen W. The effects of roadside structures on the transport and dispersion of ultrafine particles from highways. Atmospheric Environment, 2007; 41(2007):8128-8139.
76. Lecoanet HF, Bottero J-Y, Wiesner MR. Laboratory assessment of the mobility of nanomaterials in porous media. Environmental Science and Technology, 2004; 38(19):5164-5169.
77. Dunphy Guzman KA, Finnegan MP, Banfield JF. Influence of surface potential on aggregation and transport of titania nanoparticles. Environmental Science and Technology, 2006; 40(24):7688-7693.
78. Hyung H, Fortner JD, Hughes JB, Kim J-H. Natural organic matter stabilizes carbon nanotubes in the aqueous phase. Environmental Science and Technology, 2007; 41(1):179-184.
79. Navarro DAG, Watson DF, Aga DS, Banerjee S. Natural organic matter-mediated phase transfer of quantum dots in the aquatic environment. Environmental Science and Technology, 2009; 43(3):677-682.
80. Golpalkrishnan P, Zloczower M, Feke D. Effect of morphology and extent of infiltration on the cohesivity and dispersion mechanisms of particle agglomerates. Chemical Engineering Science, 2007; 62(2007):3740-3747.
81. Picioreanu C, Kreft J-U, Van Loosdrecht MCM. Particle-based multidimensional multispecies biofilm model. Applied and Environmental Microbiology, 2004; 70(5):3024-3040.
82. Kandlikar M, Ramachandran G, Maynard A, Murdock B, Toscano W. Health risk assessment for nanoparticles: A case for using expert judgment. Journal of Nanoparticle Research, 2007; 9(1):137-156.
83. Linkov I, Satterstrom FK, Steevens J, Ferguson E, Pleus RC. Multi-criteria decision analysis and environmental risk assessment for nanomaterials. Journal of Nanoparticle Research, 2007; 9(4):543-554.
84. Poland CA, Duffin R, Kinloch I, Maynard A, Wallace WAH, Seaton A, Stone V, Brown S, MacNee W, Donaldson K. Carbon nanotubes introduced into the abdominal cavity of mice show asbestos-like pathogenicity in a pilot study. Nature Nanotechnology, 2008; 3:423-428.
85. Risk Policy Report. Nanotechnology Exposure Data Seen as Key Gap Hampering Regulation. Washington, DC Inside Washington Publishers, December 11, 2007.
86. International Standards Organization. Workplace Atmospheres-Ultrafine, Nanoparticle and Nano-Structured Aerosols-Inhalation Exposure Characterization and Assessment. Geneva, Switzerland International Standards Organization, ISO/TR 27628, 2007.
87. Chaundry Q, Scotter M, Blackburn J, Ross B, Boxall A, Castle L, Aitken R, Watkins R. Applications and implications of nanotechnologies for the food sector. Food Additives and Contaminants: Part A, 2008; 25(3):241-258.
88. Food and Agriculture Organization of the United Nations/World Health Organization. FAO/WHO Expert Meeting on the Application of Nanotechnologies in the Food and Agriculture Sectors: Potential Food Safety Implications. Rome, Italy FAO/WHO Meeting Report, 2009.
89. Maynard AD. Nanotechnology: A Research Strategy for Addressing Risk. Washington, DC Woodrow Wilson International Center for Scholars, Project on Emerging Nanotechnologies Report, PEN 3, July 1, 2006.
90. U. S. Environmental Protection Agency. Nanomaterial Research Strategy (NRS). Washington, DC Office of Research and Development Report, EPA/620/K-09/011, June 2009.
91. U. S. Food and Drug Administration. Nanotechnology: A Report of the U. S. Food and Drug Administration Nanotechnology Task Force. Rockville, MD U.S. Food and Drug Administration, July 25, 2007.
92. U.S. Department of Agriculture. Nanoscale Science and Engineering for Agriculture and Food Systems. Washington, DC Cooperative State Research, Education and Extension Service, National Planning Workshop Report, November 18-19, 2002, Washington, DC, July 9, 2003.
93. National Science and Technology Council, Subcommittee on Nanoscale Science, Technology and Engineering. National Nanotechnology Initiative Strategy for Nanotechnology Environmental Health and Safety Research. Washington, DC National Science and Technology Council Report, February 13, 2008.
94. Maynard AD. Testimony of: Andrew D. Maynard, Ph.D., Chief Science Advisor, Project on Emerging Nanotechnologies, Woodrow Wilson International Center for Scholars, Washington, DC. Washington, DC United States House of Representatives Committee on Science & Technology Hearing on: The National Nanotechnology Initiative Amendments Act of 2008. April 16, 2008.