An in vitro investigation of the differential cytotoxic responses of human and rat lung epithelial cell lines using TiO2 nanoparticles

International Journal of Nanotechnology

Volumn 5, Issue 1, 2008, Pages 15-29

  Sayes, Christie M ^a   Warheit, David B ^a,b,c  

^a DUPONT COMPANY   (United States)

^b DuPont Haskell Laboratory for Health and Environmental Sciences ^*

^c Nano Working Group

Author keywords

A549 cell line; In vitro cytotoxicity; In vitro in vivo comparisons; L2 cell line; TiO2 nanoparticles; Ultrafine particles

Indexed keywords

ALUMINA; BIOLOGICAL ORGANS; CELLS; COATED MATERIALS; CYTOTOXICITY; ENZYME ACTIVITY; TITANIUM DIOXIDE;

A549 CELL LINE; IN VITRO CYTOTOXICITY; IN VITRO/IN VIVO COMPARISONS; L2 CELL LINE; ULTRAFINE PARTICLES;

NANOPARTICLES;

EID: 38149004543     PISSN: 14757435     EISSN: None     Source Type: Journal    
DOI: 10.1504/IJNT.2008.016548     Document Type: Article

References (12)

1. Derfus, A.M., Chan, W.C.W. and Bhatia, S.N. (2004) 'Probing the cytotoxicity of semiconductor quantum dots', Nano Lett., Vol. 4, No. 1, pp.11-18.
2. Sayes, C.M., Fortner, J.D., Guo, W., Lyon, D.Y., Boyd, A.M., Ausman, K.D., Tao, Y.J., Sitharaman, B., Wilson, L.J., Hughes, J.B., West, J.L. and Colvin, V.L. (2004) 'The differential cytotoxicity of water-soluble fullerenes', Nano Lett., Vol. 4, No. 10, pp.1881.
3. Long, T.C., Saleh, N., Tilton, R.D., Lowry, G.V. and Veronesi, B. (2006) 'Titanium dioxide (P25) produces reactive oxygen species in immortalized brain microglia (BV2): implications for nanoparticle neurotoxicity', Environ. Sci. Technol., Vol. 40, No. 14, pp.4346.
4. 2 particulates substantially encapsulated with pyrogenically deposited, amorphous silica', Particle and Fibre Toxicology, Vol. 3, No. 3, pp.1743.
5. 2 particles: evidence for differential responses', Toxicology, Vol. 230, pp.90-104.
6. Otwinowski, Z. and Minor, W. (1997) Macromolecular Crystallography, Pt A; Academic Press Inc., San Diego, Vol. 276, pp.307-326.
7. Brunauer, S., Emmett, P.H. and Teller, E. (1938) 'Adsorption of gases in multimolecular layer', J. Am. Chem. Soc., Vol. 60, pp.309-319.
8. Mossman, T. (1983) 'Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays', J. Immunol. Methods, Vol. 65, pp.55-63.
9. Harington, J.S., Macnab, G.M., Miller, K. and King, P.C. (1971) 'Enhancement of hemolytic activity of asbestos by heat-labile factors in fresh serum', Med Lav., Vol. 62, pp.171-176.
10. Razzaboni, B.L. and Bolsaitis, P. (1990) 'Evidence of an oxidative mechanism for the hemolytic activity of silica particles', Environ. Health Perspect., Vol. 87, pp.337-341.
11. Warheit, D.B., Carakostas, M.C., Hartsky, M.A. and Hansen, J.F. (1991) 'Development of a short-term inhalation bioassay to assess pulmonary toxicity of inhaled particles: comparisons of pulmonary responses to carbonyl iron and silica', Toxicol. Appl. Pharmacol, Vol. 107, pp.350-368.
12. Worle-Knirsch, J.M., Pulskamp, K. and Krug, H.F. (2006) 'Oops they did it again! Carbon nanotubes hoax scientists in viability assays', Nano Lett., Vol. 6, No. 6, pp.1261-1268.