Stable intrachromosomal biomarkers of past exposure to densely ionizing radiation in several chromosomes of exposed individuals

Radiation Research

Volumn 162, Issue 3, 2004, Pages 257-263

  Mitchell, Catherine R ^a   Azizova, Tamara V ^b   Hande, M Prakash ^a,c   Burak, Ludmilla E ^b   Tsakok, Josephine M ^a   Khokhryakov, Valentin F ^b   Geard, Charles R ^a   Brenner, David J ^a  

^a Columbia University ^*  (United States)

^b Southern Urals Biophysics Institute   (Russian Federation)

^c NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; PLUTONIUM;

ADULT; AGED; ALPHA RADIATION; ARTICLE; CHROMOSOME; CHROMOSOME ABERRATION; CLINICAL ARTICLE; CONTROLLED STUDY; FLUORESCENCE IN SITU HYBRIDIZATION; GAMMA RADIATION; HUMAN; IONIZING RADIATION; LINEAR ENERGY TRANSFER; METAPHASE; NEUTRON; OCCUPATIONAL EXPOSURE; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; RADIATION DOSE; RADIATION EXPOSURE; RUSSIAN FEDERATION;

AGED; AGED, 80 AND OVER; BODY BURDEN; CHROMOSOME ABERRATIONS; CHROMOSOME BANDING; CHROMOSOMES, HUMAN; DOSE-RESPONSE RELATIONSHIP, RADIATION; FEMALE; GAMMA RAYS; GENETIC MARKERS; HUMANS; LEUKOCYTES; MALE; MIDDLE AGED; NUCLEAR REACTORS; OCCUPATIONAL EXPOSURE; PLUTONIUM; RADIATION DOSAGE; RADIATION, IONIZING; RADIOMETRY; RISK ASSESSMENT; RISK FACTORS; RUSSIA;

EID: 4644310687     PISSN: 00337587     EISSN: None     Source Type: Journal    
DOI: 10.1667/RR3231     Document Type: Article

References (21)

1. D. J. Brenner and R. K. Sachs, Chromosomal "fingerprints" of prior exposure to densely ionizing radiation. Radiat. Res. 140, 134-142 (1994).
2. W. Deng, D. P. Morrison, K. L. Gale and J. N. Lucas, A comparative study on potential cytogenetic fingerprints for radiation LET in human lymphocytes. Int. J. Radiat. Biol. 76, 1589-1598 (2000).
3. E. Schmid, H. Braselmann and M. Bauchinger, Does the limiting F value at very low doses depend systematically on linear energy transfer? Radiat. Res. 152, 563-566 (1999).
4. R. M. Anderson, S. J. Marsden, S. J. Paice, A. E. Bristow, M. A. Kadhim, C. S. Griffin and D. T. Goodhead, Transmissible and non-transmissible complex chromosome aberrations characterized by three-color and mFISH define a biomarker of exposure to high-LET alpha particles. Radiat. Res. 159, 40-48 (2003).
5. M. Bauchinger and E. Schmid, LET dependence of yield ratios of radiation-induced intra- and interchromosomal aberrations in human lymphocytes. Int. J. Radiat. Biol. 74, 17-25 (1998).
6. M. P. Hande, T. V. Azizova, C. R. Geard, L. E. Burak, C. R. Mitchell, V. F. Khokhryakov, E. K. Vasilenko and D. J. Brenner, Past exposure to densely ionizing radiation leaves a unique permanent signature in the genome. Am. J. Hum. Genet. 72, 1162-1170 (2003).
7. T. Cremer and C. Cremer, Chromosome territories, nuclear architecture and gene regulation in mammalian cells. Nat. Rev. Genet. 2, 292-301 (2001).
8. I. Chudoba, A. Plesch, T. Lorch, J. Lemke, U. Claussen and G. Senger, High resolution multicolor-banding: A new technique for refined FISH analysis of human chromosomes. Cytogenet. Cell Genet. 84, 156-160 (1999).
9. C. Johannes, I. Chudoba and G. Obe, Analysis of X-ray-induced aberrations in human chromosome 5 using high-resolution multicolour banding FISH (mBAND). Chromosome Res. 7, 625-633 (1999).
10. L. R. Anspaugh, M. O. Degteva and E. K. Vasilenko, Mayak Production Association: Introduction. Radiat. Environ. Biophys. 41, 19-22 (2002).
11. M. R. Speicher, S. G. Ballard and D. C. Ward, Karyotyping human chromosomes by combinatorial multi-fluor FISH. Nat. Genet. 12, 368-375 (1996).
12. S. A. Romanov, E. K. Vasilenko, V. F. Khokhryakov and P. Jacob, Studies on the Mayak nuclear workers: Dosimetry. Radiat. Environ. Biophys. 41, 23-28 (2002).
13. V. F. Khokhryakov, K. G. Suslova, V. V. Vostrotin, S. A. Romanov, Z. S. Menshikh, T. I. Kudryavtseva, R. E. Filipy, S. C. Miller and M. P. Krahenbuhl, The development of the plutonium lung clearance model for exposure estimation of the Mayak Production Association, nuclear plant workers. Health Phys. 82, 425-431 (2002).
14. L. E. Burak, Y. Kodama, M. Nakano, K. Ohtaki, M. Itoh, N. D. Okladnikova, E. K. Vasilenko, J. B. Cologne and N. Nakamura, FISH examination of lymphocytes from Mayak workers for assessment of translocation induction rate under chronic radiation exposures. Int. J. Radiat. Biol. 77, 901-908 (2001).
15. J. J. Boei, S. Vermeulen, J. Moser, L. H. Mullenders and A. T. Natarajan, Intrachanges as part of complex chromosome-type exchange aberrations. Mutat. Res. 504, 47-55 (2002).
16. R. K. Sachs, D. J. Brenner, A. M. Chen, P. Hahnfeldt and L. R. Hlatky, Intra-arm and interarm chromosome intrachanges: Tools for probing the geometry and dynamics of chromatin. Radiat. Res. 148, 330-340 (1997).
17. M. N. Cornforth, K. M. Greulich-Bode, B. D. Loucas, J. Arsuaga, M. Vazquez, R. K. Sachs, M. Bruckner, M. Molls, P. Hahnfeldt and D. J. Brenner, Chromosomes are predominantly located randomly with respect to each other in interphase human cells. J. Cell Biol. 159, 237-244 (2002).
18. K. L. Johnson, D. J. Brenner, J. Nath, J. D. Tucker and C. R. Geard, Radiation-induced breakpoint misrejoining in human chromosomes: Random or non-random? Int. J. Radiat. Biol. 75, 131-141 (1999).
19. W. A. Bickmore and P. Teague, Influences of chromosome size, gene density and nuclear position on the frequency of constitutional translocations in the human population. Chromosome Res. 10, 707-715 (2002).
20. R. K. Sachs, A. Awa, Y. Kodama, M. Nakano, K. Ohtaki and J. N. Lucas, Ratios of radiation-produced chromosome aberrations as indicators of large-scale DNA geometry during interphase. Radiat. Res. 133, 345-350 (1993).
21. I. Radulescu, K. Elmroth and B. Stenerlow, Chromatin organization contributes to non-randomly distributed double-strand breaks after exposure to high-LET radiation. Radiat. Res. 161, 1-8 (2004).