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Volumn 42, Issue 10, 2010, Pages 675-683

Intervention with costimulatory pathways as a therapeutic approach for graft-versus-host disease

Author keywords

Antigens; CD86; Cell death; Graft vs host disease; Immunotherapy; Regulatory; T lymphocytes

Indexed keywords

ABATACEPT; B7 ANTIGEN; BELATACEPT; CD134 ANTIGEN; CD137 ANTIGEN; CD137 LIGAND MONOCLONAL ANTIBODY; CD2 ANTIGEN; CD28 ANTIGEN; CD30 ANTIGEN; CD30 LIGAND; CD4 ANTIGEN; CD40 ANTIGEN; CD40 LIGAND MONOCLONAL ANTIBODY; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4 ANTIBODY; GLUCOCORTICOID INDUCED TUMOR NECROSIS FACTOR RECEPTOR; GLUCOCORTICOID INDUCED TUMOR NECROSIS FACTOR RECEPTOR ANTIBODY; HERPESVIRUS ENTRY MEDIATOR LIGAND; IMMUNOGLOBULIN; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY CD137; MONOCLONAL ANTIBODY CD28; MUCIN; OX40 LIGAND; PROGRAMMED DEATH 1 RECEPTOR; T LYMPHOCYTE RECEPTOR; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR RECEPTOR; UNCLASSIFIED DRUG;

EID: 78149247315     PISSN: 12263613     EISSN: 20926413     Source Type: Journal    
DOI: 10.3858/emm.2010.42.10.071     Document Type: Review
Times cited : (9)

References (70)
  • 1
    • 12844288851 scopus 로고    scopus 로고
    • Prevention of lethal acute GVHD with an agonistic CD28 antibody and rapamycin
    • Albert MH, Yu XZ, Martin PJ, Anasetti C. Prevention of lethal acute GVHD with an agonistic CD28 antibody and rapamycin. Blood 2005;105:1355-61.
    • (2005) Blood , vol.105 , pp. 1355-1361
    • Albert, M.H.1    Yu, X.Z.2    Martin, P.J.3    Anasetti, C.4
  • 2
    • 14944370670 scopus 로고    scopus 로고
    • Distinct roles for donor- and host-derived antigen-presenting cells and costimulatory molecules in murine chronic graft-versus-host disease: Requirements depend on target organ
    • Anderson BE, McNiff JM, Jain D, Blazar BR, Shlomchik WD, Shlomchik MJ. Distinct roles for donor- and host-derived antigen-presenting cells and costimulatory molecules in murine chronic graft-versus-host disease: requirements depend on target organ. Blood 2005;105:2227-34.
    • (2005) Blood , vol.105 , pp. 2227-2234
    • Anderson, B.E.1    McNiff, J.M.2    Jain, D.3    Blazar, B.R.4    Shlomchik, W.D.5    Shlomchik, M.J.6
  • 3
    • 23744517125 scopus 로고    scopus 로고
    • Selective targeting of regulatory T cells with CD28 superagonists allows effective therapy of experimental autoimmune encephalomyelitis
    • Beyersdorf N, Gaupp S, Balbach K, Schmidt J, Toyka KV, Lin CH, Hanke T, Hünig T, Kerkau T, Gold R. Selective targeting of regulatory T cells with CD28 superagonists allows effective therapy of experimental autoimmune encephalomyelitis. J Exp Med 2005;202:445-55.
    • (2005) J Exp Med , vol.202 , pp. 445-455
    • Beyersdorf, N.1    Gaupp, S.2    Balbach, K.3    Schmidt, J.4    Toyka, K.V.5    Lin, C.H.6    Hanke, T.7    Hünig, T.8    Kerkau, T.9    Gold, R.10
  • 4
    • 0028234261 scopus 로고
    • In vivo blockade of CD28/CDTL4:B7/BB1 interaction with CTLA4 reduces lethal murine graft-versus-host disease across the major histocompatibility complex barrier in mice
    • Blazar BR, Taylor PA, Linsley PS, Vallera DA. In vivo blockade of CD28/CDTL4:B7/BB1 interaction with CTLA4 reduces lethal murine graft-versus-host disease across the major histocompatibility complex barrier in mice. Blood 1994;83:3815-25.
    • (1994) Blood , vol.83 , pp. 3815-3825
    • Blazar, B.R.1    Taylor, P.A.2    Linsley, P.S.3    Vallera, D.A.4
  • 5
    • 0030639082 scopus 로고    scopus 로고
    • Blockade of CD40 ligand-CD40 interaction impairs CD4+ T cell-mediated alloreactivity by inhibiting mature donor T cell expansion and function after bone marrow transplantation
    • Blazar BR, Taylor PA, Panoskaltsis-Mortari A, Buhlman J, Xu J, Flavell RA, Korngold R, Noelle N, Vallera DA. Blockade of CD40 ligand-CD40 interaction impairs CD4+ T cell-mediated alloreactivity by inhibiting mature donor T cell expansion and function after bone marrow transplantation. J Immunol 1997;158:29-39.
    • (1997) J Immunol , vol.158 , pp. 29-39
    • Blazar, B.R.1    Taylor, P.A.2    Panoskaltsis-Mortari, A.3    Buhlman, J.4    Xu, J.5    Flavell, R.A.6    Korngold, R.7    Noelle, N.8    Vallera, D.A.9
  • 6
    • 0032146529 scopus 로고    scopus 로고
    • CD4+ T cells tolerized ex vivo to host alloantigen by anti-CD40 ligand (CD40L:CD154) antibody lose their graft-versus-host disease lethality capacity but retain nominal antigen responses
    • Blazar BR, Taylor PA, Noelle RJ, Vallera DA. CD4+ T cells tolerized ex vivo to host alloantigen by anti-CD40 ligand (CD40L:CD154) antibody lose their graft-versus-host disease lethality capacity but retain nominal antigen responses. J Clin Invest 1998;102:473-82.
    • (1998) J Clin Invest , vol.102 , pp. 473-482
    • Blazar, B.R.1    Taylor, P.A.2    Noelle, R.J.3    Vallera, D.A.4
  • 7
    • 0035284861 scopus 로고    scopus 로고
    • Ligation of 4-1BB (CDw137) regulates graft-versus-host disease, graft-versus-leukemia, and graft rejection in allogeneic bone marrow transplant recipients
    • Blazar BR, Kwon BS, Panoskaltsis-Mortari A, Kwak KB, Peschon JJ, Taylor PA. Ligation of 4-1BB (CDw137) regulates graft-versus-host disease, graft-versus-leukemia, and graft rejection in allogeneic bone marrow transplant recipients. J Immunol 2001;166:3174-83.
    • (2001) J Immunol , vol.166 , pp. 3174-3183
    • Blazar, B.R.1    Kwon, B.S.2    Panoskaltsis-Mortari, A.3    Kwak, K.B.4    Peschon, J.J.5    Taylor, P.A.6
  • 9
    • 0037528710 scopus 로고    scopus 로고
    • Ligation of OX40 (CD134) regulates graft-versus-host disease (GVHD) and graft rejection in allogeneic bone marrow transplant recipients
    • Blazar BR, Sharpe AH, Chen AI, Panoskaltsis-Mortari A, Lees C, Akiba H, Yagita H, Killeen N, Taylor PA. Ligation of OX40 (CD134) regulates graft-versus-host disease (GVHD) and graft rejection in allogeneic bone marrow transplant recipients. Blood 2003b;101:3741-8.
    • (2003) Blood , vol.101 , pp. 3741-3748
    • Blazar, B.R.1    Sharpe, A.H.2    Chen, A.I.3    Panoskaltsis-Mortari, A.4    Lees, C.5    Akiba, H.6    Yagita, H.7    Killeen, N.8    Taylor, P.A.9
  • 12
    • 33644762845 scopus 로고    scopus 로고
    • 4-1BB stimulation inhibits allergen specific IgE, airway hyperreactivity, and eosinophilic inflammation in asthmatic mice
    • Cho YS, Kwon B, Lee TH, Moon K-A, La S, Lee J, Lee SD, Oh Y-M, Moon H-B. 4-1BB stimulation inhibits allergen specific IgE, airway hyperreactivity, and eosinophilic inflammation in asthmatic mice. Clin Exp Allergy 2006;36;377-85.
    • (2006) Clin Exp Allergy , vol.36 , pp. 377-385
    • Cho, Y.S.1    Kwon, B.2    Lee, T.H.3    Moon, K.-A.4    La, S.5    Lee, J.6    Lee, S.D.7    Oh, Y.-M.8    Moon, H.-B.9
  • 14
    • 40649125501 scopus 로고    scopus 로고
    • Murine models of chronic graftversus-host disease: Insights and unresolved issues
    • Chu YW, Gress RE. Murine models of chronic graftversus-host disease: insights and unresolved issues. Biol Blood Marrow Transpl 2008;14:365-78.
    • (2008) Biol Blood Marrow Transpl , vol.14 , pp. 365-378
    • Chu, Y.W.1    Gress, R.E.2
  • 15
    • 63149163677 scopus 로고    scopus 로고
    • The role of TNF superfamily members in T-cell function and diseases
    • Croft M. The role of TNF superfamily members in T-cell function and diseases. Nat Rev Immunol 2009;9:271-85.
    • (2009) Nat Rev Immunol , vol.9 , pp. 271-285
    • Croft, M.1
  • 16
    • 0028123024 scopus 로고
    • Antibody to the ligand of CD40, gp39, blocks the occurrence of the acute and chronic forms of graft-vs-host disease
    • Durie FH, Aruffo A, Ledbetter J, Crassi KM, Green WR, Fast LD, Noelle RJ. Antibody to the ligand of CD40, gp39, blocks the occurrence of the acute and chronic forms of graft-vs-host disease. J Clin Invest 1994;94:1333-8.
    • (1994) J Clin Invest , vol.94 , pp. 1333-1338
    • Durie, F.H.1    Aruffo, A.2    Ledbetter, J.3    Crassi, K.M.4    Green, W.R.5    Fast, L.D.6    Noelle, R.J.7
  • 17
    • 38849108168 scopus 로고    scopus 로고
    • Ex vivo expansion of CD4+CD25+FoxP3+ T regulatory cells based on synergy between IL-2 and 4-1BB signaling
    • Elpek KG, Yolcu ES, Franke DD, Lacelle C, Schabowsky RH, Shirwan H. Ex vivo expansion of CD4+CD25+FoxP3+ T regulatory cells based on synergy between IL-2 and 4-1BB signaling. J Immunol 2007;179:7295-304.
    • (2007) J Immunol , vol.179 , pp. 7295-7304
    • Elpek, K.G.1    Yolcu, E.S.2    Franke, D.D.3    Lacelle, C.4    Schabowsky, R.H.5    Shirwan, H.6
  • 19
    • 4444340010 scopus 로고    scopus 로고
    • Engagement of the CD137 (4-1BB) costimulatory molecule inhibits and reverses the autoimmune process in collagen-induced arthritis and establishes lasting disease resistance
    • Foell JL, Diez-Mendiondo BI, Diez OH, Holzer U, Ruck P, Bapat AS, Hoffmann MK, Mittler RS, Dannecker GE. Engagement of the CD137 (4-1BB) costimulatory molecule inhibits and reverses the autoimmune process in collagen-induced arthritis and establishes lasting disease resistance. Immunology 2004;113:89-98.
    • (2004) Immunology , vol.113 , pp. 89-98
    • Foell, J.L.1    Diez-Mendiondo, B.I.2    Diez, O.H.3    Holzer, U.4    Ruck, P.5    Bapat, A.S.6    Hoffmann, M.K.7    Mittler, R.S.8    Dannecker, G.E.9
  • 20
    • 26844577971 scopus 로고    scopus 로고
    • Engagement of 4-1BB inhibits the development of experimental allergic conjunctivitis in mice
    • Fukushima A, Yamaguchi T, Ishida W, Fukata K, Mittler RS, Yagita H, Ueno H. Engagement of 4-1BB inhibits the development of experimental allergic conjunctivitis in mice. J Immunol 2005;175:4897-903.
    • (2005) J Immunol , vol.175 , pp. 4897-4903
    • Fukushima, A.1    Yamaguchi, T.2    Ishida, W.3    Fukata, K.4    Mittler, R.S.5    Yagita, H.6    Ueno, H.7
  • 21
    • 35748957454 scopus 로고    scopus 로고
    • Striking dichotomy of PD-L1 and PD-L2 pathways in regulating alloreactive CD4+ and CD8+ T cells in vivo
    • Habicht A, Kewalaramani R, Vu MD, Demirci G, Blazar BR, Sayegh MH, Li XC. Striking dichotomy of PD-L1 and PD-L2 pathways in regulating alloreactive CD4+ and CD8+ T cells in vivo. Am J Transplant 2007;7:2683-92
    • (2007) Am J Transplant , vol.7 , pp. 2683-2692
    • Habicht, A.1    Kewalaramani, R.2    Vu, M.D.3    Demirci, G.4
  • 22
    • 0029125813 scopus 로고
    • Acute graft-versus-host reaction can be aborted by blockade of costiulatory molecues
    • Hakim FT, Cepeda R, Gray GS, June CH, Abe R. Acute graft-versus-host reaction can be aborted by blockade of costiulatory molecues. J Immunol 1995;155:1757-66.
    • (1995) J Immunol , vol.155 , pp. 1757-1766
    • Hakim, F.T.1    Cepeda, R.2    Gray, G.S.3    June, C.H.4    Abe, R.5
  • 25
    • 0025058266 scopus 로고
    • Inhibition of antigen-specific proliferation of type 1 murine T cell clones after stimulation with immobilized anti-CD3 monoclonal antibody
    • Jenkins MK, Chen CA, Jung G, Mueller DL, Schwartz RH. Inhibition of antigen-specific proliferation of type 1 murine T cell clones after stimulation with immobilized anti-CD3 monoclonal antibody. J Immunol 1990;144:16-22.
    • (1990) J Immunol , vol.144 , pp. 16-22
    • Jenkins, M.K.1    Chen, C.A.2    Jung, G.3    Mueller, D.L.4    Schwartz, R.H.5
  • 27
    • 14944342177 scopus 로고    scopus 로고
    • Stimulation with 4-1BB inhibits chronic graftversus-host disease by inducing activation-induced cell death of donor CD4+ T cells
    • Kim J, Choi WS, La S, Suh J-H, Kim B-S, Cho HR, Kwon BS, Kwon B. Stimulation with 4-1BB inhibits chronic graftversus-host disease by inducing activation-induced cell death of donor CD4+ T cells. Blood 2005;105:2206-13.
    • (2005) Blood , vol.105 , pp. 2206-2213
    • Kim, J.1    Choi, W.S.2    La, S.3    Suh, J.-H.4    Kim, B.-S.5    Cho, H.R.6    Kwon, B.S.7    Kwon, B.8
  • 28
    • 33645988549 scopus 로고    scopus 로고
    • Conversion of alloantigen-specific CD8+ T cell anergy to CD8+ T cell priming through in vivo ligation of glucocorticoid-induced TNF receptor
    • Kim J, Choi WS, Kang H, Kim HJ, Suh JH, Sakaguchi S, Kwon B. Conversion of alloantigen-specific CD8+ T cell anergy to CD8+ T cell priming through in vivo ligation of glucocorticoid-induced TNF receptor. J Immunol 2006;176: 5223-31.
    • (2006) J Immunol , vol.176 , pp. 5223-5231
    • Kim, J.1    Choi, W.S.2    Kang, H.3    Kim, H.J.4    Suh, J.H.5    Sakaguchi, S.6    Kwon, B.7
  • 29
    • 34547125361 scopus 로고    scopus 로고
    • Costimulatory molecule-targeted immunotherapy of chronic graft-versus-host disease
    • Kim J, Kim HJ, Park K, Kim J, Yagita H, Nam SK, Cho HR, Kwon B. Costimulatory molecule-targeted immunotherapy of chronic graft-versus-host disease. Blood 2007;110: 776-82.
    • (2007) Blood , vol.110 , pp. 776-782
    • Kim, J.1    Kim, H.J.2    Park, K.3    Kim, J.4    Yagita, H.5    Nam, S.K.6    Cho, H.R.7    Kwon, B.8
  • 30
    • 58149193839 scopus 로고    scopus 로고
    • Breaking of CD8+ T cell tolerance through in vivo ligation of CD40 results in inhibition of chronic graft-versus-host disease and complete donor cell engraftment
    • Kim J, Park K, Kim HJ, Kim J, Kim HA, Jung D, Kim HJ, Choi HJ, Choi SY, Seo KW, Cho HR, Kwon B. Breaking of CD8+ T cell tolerance through in vivo ligation of CD40 results in inhibition of chronic graft-versus-host disease and complete donor cell engraftment. J Immunol 2008;181:7380-9.
    • (2008) J Immunol , vol.181 , pp. 7380-7389
    • Kim, J.1    Park, K.2    Kim, H.J.3    Kim, J.4    Kim, H.A.5    Jung, D.6    Kim, H.J.7    Choi, H.J.8    Choi, S.Y.9    Seo, K.W.10    Cho, H.R.11    Kwon, B.12
  • 31
    • 59349103120 scopus 로고    scopus 로고
    • Induction of lethal graft-versus-host disease by anti-CD137 monoclonal antibody in mice prone to chronic graftversus- host disease
    • Kim W, Kim J, Jung D, Kim H, Cho H-J, Cho HR, Kwon B. Induction of lethal graft-versus-host disease by anti-CD137 monoclonal antibody in mice prone to chronic graftversus- host disease. Biol Blood Marrow Transplant 2009;15;306-14.
    • (2009) Biol Blood Marrow Transplant , vol.15 , pp. 306-314
    • Kim, W.1    Kim, J.2    Jung, D.3    Kim, H.4    Cho, H.-J.5    Cho, H.R.6    Kwon, B.7
  • 32
    • 34147131338 scopus 로고    scopus 로고
    • Involvement of the programmed death-1/programmed death-1 ligand pathway in CD4+ CD25+ regulatory T-cell activity to suppress alloimmune responses
    • Kitazawa Y, Fujino M, Wang Q, Kimura H, Azuma M, Kubo M, Abe R, Li XK. Involvement of the programmed death-1/programmed death-1 ligand pathway in CD4+ CD25+ regulatory T-cell activity to suppress alloimmune responses. Transplantation 2007;83:774-82.
    • (2007) Transplantation , vol.83 , pp. 774-782
    • Kitazawa, Y.1    Fujino, M.2    Wang, Q.3    Kimura, H.4    Azuma, M.5    Kubo, M.6    Abe, R.7    Li, X.K.8
  • 33
    • 78149266234 scopus 로고    scopus 로고
    • CD137-CD137 ligand interactions in inflammation
    • Kwon B. CD137-CD137 ligand interactions in inflammation. Immune Netw 2009;9:84-9.
    • (2009) Immune Netw , vol.9 , pp. 84-89
    • Kwon, B.1
  • 34
    • 65349189555 scopus 로고    scopus 로고
    • Costimulatory pathways in transplantation: Challenges and new developments
    • Li XC, Rothstein DM, Sayegh MH. Costimulatory pathways in transplantation: challenges and new developments. Immunol Rev 2009;229:271-93.
    • (2009) Immunol Rev , vol.229 , pp. 271-293
    • Li, X.C.1    Rothstein, D.M.2    Sayegh, M.H.3
  • 35
    • 0344613988 scopus 로고    scopus 로고
    • Blocking both signal 1 and signal 2 of T-cell activation prevents of apoptosis of alloreactive T cells and induction of peripheral allograft tolerance
    • Li Y, Li XC, Zheng XX, Wells AD, Turka LA, Strom TB. Blocking both signal 1 and signal 2 of T-cell activation prevents of apoptosis of alloreactive T cells and induction of peripheral allograft tolerance. Nat Med 1999;5:1298-1302.
    • (1999) Nat Med , vol.5 , pp. 1298-1302
    • Li, Y.1    Li, X.C.2    Zheng, X.X.3    Wells, A.D.4    Turka, L.A.5    Strom, T.B.6
  • 36
    • 0034097970 scopus 로고    scopus 로고
    • Therapeutic activity of agonistic monoclonal antibodies against CD40 in a chronic autoimmune inflammatory process
    • Mauri C, Mars LT, Ondei M. Therapeutic activity of agonistic monoclonal antibodies against CD40 in a chronic autoimmune inflammatory process. Nat Med 2000;6: 673-9.
    • (2000) Nat Med , vol.6 , pp. 673-679
    • Mauri, C.1    Mars, L.T.2    Ondei, M.3
  • 38
    • 0033571176 scopus 로고    scopus 로고
    • Anti-4-1BB monoclonal antibodies abrogate T celldependent humoral immune responses in vivo through the induction of helper T cell anergy
    • Mittler RS, Bailey TS, Klussman K, Trailsmith MD, Hoffmann MK. Anti-4-1BB monoclonal antibodies abrogate T celldependent humoral immune responses in vivo through the induction of helper T cell anergy. J Exp Med 1999; 190:1535-40.
    • (1999) J Exp Med , vol.190 , pp. 1535-1540
    • Mittler, R.S.1    Bailey, T.S.2    Klussman, K.3    Trailsmith, M.D.4    Hoffmann, M.K.5
  • 40
    • 77950403194 scopus 로고    scopus 로고
    • CD137 agonist antibody prevents cancer recurrence: Contribution of CD137 on both hematopoietic and nonhematopoietic cells
    • Narazaki H, Zhu Y, Luo L, Zhu G, Chen L. CD137 agonist antibody prevents cancer recurrence: contribution of CD137 on both hematopoietic and nonhematopoietic cells. Blood 2010;115:1941-8.
    • (2010) Blood , vol.115 , pp. 1941-1948
    • Narazaki, H.1    Zhu, Y.2    Luo, L.3    Zhu, G.4    Chen, L.5
  • 41
    • 0035500277 scopus 로고    scopus 로고
    • Preferential blockade of CD8+ T cell responses by administration of anti-CD137 ligand monoclonal antibody results in differential effect on development of murine acute and chronic graft-versus-host diseases
    • Nozawa K, Ohata J, Sakurai J, Hashimoto H, Miyajima H, Yagita H, Okumura K, and Azuma M. Preferential blockade of CD8+ T cell responses by administration of anti-CD137 ligand monoclonal antibody results in differential effect on development of murine acute and chronic graft-versus-host diseases. J Immunol 2001;167:4981-6.
    • (2001) J Immunol , vol.167 , pp. 4981-4986
    • Nozawa, K.1    Ohata, J.2    Sakurai, J.3    Hashimoto, H.4    Miyajima, H.5    Yagita, H.6    Okumura, K.7    Azuma, M.8
  • 42
    • 0035889922 scopus 로고    scopus 로고
    • Opposing effects of anti-activation-inducible lymphocyteimmunomodulatory molecule/inducible costimulator antibody on the development of acute versus chronic graft-versus-host disease
    • Ogawa S, Nagamatsu G, Watanabe M, Watanabe S, Hayashi T, Horita S, Nitta K, Nihei H, Tezuka K, Abe R. Opposing effects of anti-activation-inducible lymphocyteimmunomodulatory molecule/inducible costimulator antibody on the development of acute versus chronic graft-versus-host disease. J Immunol 2001;167:5741-8.
    • (2001) J Immunol , vol.167 , pp. 5741-5748
    • Ogawa, S.1    Nagamatsu, G.2    Watanabe, M.3    Watanabe, S.4    Hayashi, T.5    Horita, S.6    Nitta, K.7    Nihei, H.8    Tezuka, K.9    Abe, R.10
  • 44
    • 47949123740 scopus 로고    scopus 로고
    • CTL-promoting effects of CD40 stimulation outweigh B cell-stimulatory effects resulting in B cell elimination and disease improvement in a murine model of lupus
    • Puliaev R, Puliaeva I, Welniak LA, Ryan AE, Haas M, Murphy WJ, Via CS. CTL-promoting effects of CD40 stimulation outweigh B cell-stimulatory effects resulting in B cell elimination and disease improvement in a murine model of lupus. J Immunol 2008;181:47-61.
    • (2008) J Immunol , vol.181 , pp. 47-61
    • Puliaev, R.1    Puliaeva, I.2    Welniak, L.A.3    Ryan, A.E.4    Haas, M.5    Murphy, W.J.6    Via, C.S.7
  • 45
    • 0032080384 scopus 로고    scopus 로고
    • Involvement of CD40 ligand-CD40 and CTLA4-B7 pathways in murine acute graft-versus-host disease induced by allogeneic T cells lacking CD28
    • Saito K, Sakurai J, Ohata J, Kohsaka T, Hashimoto H, Okumura K, Abe R, Azuma M. Involvement of CD40 ligand-CD40 and CTLA4-B7 pathways in murine acute graft-versus-host disease induced by allogeneic T cells lacking CD28. J Immunol 1998;160:4225-31.
    • (1998) J Immunol , vol.160 , pp. 4225-4231
    • Saito, K.1    Sakurai, J.2    Ohata, J.3    Kohsaka, T.4    Hashimoto, H.5    Okumura, K.6    Abe, R.7    Azuma, M.8
  • 46
    • 22344434572 scopus 로고    scopus 로고
    • IFN-gamma production by alloantigen-reactive regulatory T cells is important for their regulatory function in vivo
    • Sawitzki B, Kingsley CI, Oliveira V, Karim M, Herber M, Wood KJ. IFN-gamma production by alloantigen-reactive regulatory T cells is important for their regulatory function in vivo. J Exp Med 2005;201:1925-35.
    • (2005) J Exp Med , vol.201 , pp. 1925-1935
    • Sawitzki, B.1    Kingsley, C.I.2    Oliveira, V.3    Karim, M.4    Herber, M.5    Wood, K.J.6
  • 48
    • 13944278756 scopus 로고    scopus 로고
    • Anti-CD137 mAb treatment inhibits experimental autoimmune uveitis by limiting expansion and increasing apoptotic death of uveitogenic T cells
    • Shao H, Fu Y, Liao T, Peng Y, Chen L, Kaplan HJ, Sun D. Anti-CD137 mAb treatment inhibits experimental autoimmune uveitis by limiting expansion and increasing apoptotic death of uveitogenic T cells. Invest Ophthalmol Vis Sci 2005;46:596-603.
    • (2005) Invest Ophthalmol Vis Sci , vol.46 , pp. 596-603
    • Shao, H.1    Fu, Y.2    Liao, T.3    Peng, Y.4    Chen, L.5    Kaplan, H.J.6    Sun, D.7
  • 50
    • 65349104572 scopus 로고    scopus 로고
    • Mechanisms of costimulation
    • Sharpe AH. Mechanisms of costimulation. Immunol Rev 2009;229:5-11.
    • (2009) Immunol Rev , vol.229 , pp. 5-11
    • Sharpe, A.H.1
  • 51
    • 34247573902 scopus 로고    scopus 로고
    • Graft-versus-host disease
    • Shlomchik WD. Graft-versus-host disease. Nat Rev Immunol 2007;7:340-52.
    • (2007) Nat Rev Immunol , vol.7 , pp. 340-352
    • Shlomchik, W.D.1
  • 52
    • 42949162823 scopus 로고    scopus 로고
    • A new class of reverse signaling costimulators belongs to the TNF family
    • Sun M, Fink PJ. A new class of reverse signaling costimulators belongs to the TNF family. J Immunol 2007;179:4307-12.
    • (2007) J Immunol , vol.179 , pp. 4307-4312
    • Sun, M.1    Fink, P.J.2
  • 53
    • 0036467421 scopus 로고    scopus 로고
    • Administration of agonistic anti-4-1BB monoclonal antibody leads to the amelioration of experimental autoimmune encephalomyelitis
    • Sun Y, Lin X, Chen HM, Wu Q, Subudhi SK, Chen L, Fu YX. Administration of agonistic anti-4-1BB monoclonal antibody leads to the amelioration of experimental autoimmune encephalomyelitis. J Immunol 2002a;168:1457-65.
    • (2002) J Immunol , vol.168 , pp. 1457-1465
    • Sun, Y.1    Lin, X.2    Chen, H.M.3    Wu, Q.4    Subudhi, S.K.5    Chen, L.6    Fu, Y.X.7
  • 54
    • 0036913169 scopus 로고    scopus 로고
    • Costimulatory molecule-targeted antibody therapy of a spontaneous autoimmune disease
    • Sun Y, Chen HM, Subudhi SK, Chen J, Koka R, Chen L, Fu YX. Costimulatory molecule-targeted antibody therapy of a spontaneous autoimmune disease. Nat Med 2002b;8: 1405-13.
    • (2002) Nat Med , vol.8 , pp. 1405-1413
    • Sun, Y.1    Chen, H.M.2    Subudhi, S.K.3    Chen, J.4    Koka, R.5    Chen, L.6    Fu, Y.X.7
  • 57
    • 85047686597 scopus 로고    scopus 로고
    • Blockade of LIGHT/LTbeta and CD40 signaling induces allospecific T cell anergy, preventing graft-versus-host disease
    • Tamada K, Tamura H, Flies D, Fu YX, Celis E, Pease LR, Blazar BR, Chen L. Blockade of LIGHT/LTbeta and CD40 signaling induces allospecific T cell anergy, preventing graft-versus-host disease. J Clin Invest 2002;109:549-57.
    • (2002) J Clin Invest , vol.109 , pp. 549-557
    • Tamada, K.1    Tamura, H.2    Flies, D.3    Fu, Y.X.4    Celis, E.5    Pease, L.R.6    Blazar, B.R.7    Chen, L.8
  • 58
    • 0037097593 scopus 로고    scopus 로고
    • Tolerance induction of alloreactive T cells via ex vivo blockade of the CD40:CD40L costimulatory pathway results in the generation of a potent immune regulatory cell
    • Taylor PA, Friedman TM, Korngold R, Noelle RJ, Blazar BR. Tolerance induction of alloreactive T cells via ex vivo blockade of the CD40:CD40L costimulatory pathway results in the generation of a potent immune regulatory cell. Blood 2002;99:4601-09.
    • (2002) Blood , vol.99 , pp. 4601-4609
    • Taylor, P.A.1    Friedman, T.M.2    Korngold, R.3    Noelle, R.J.4    Blazar, B.R.5
  • 59
    • 17044374080 scopus 로고    scopus 로고
    • Targeting of inducible costimulator (ICOS) expressed on alloreactive T cells down-regulates graft-versus-host disease (GVHD) and facilitates engraftment of allogeneic bone marrow (BM)
    • Taylor PA, Panoskaltsis-Mortari A, Freeman GJ, Sharpe AH, Noelle RJ, Rudensky AY, Mak TW, Serody JS, Blazar BR. Targeting of inducible costimulator (ICOS) expressed on alloreactive T cells down-regulates graft-versus-host disease (GVHD) and facilitates engraftment of allogeneic bone marrow (BM). Blood 2005;105:3372-80.
    • (2005) Blood , vol.105 , pp. 3372-3380
    • Taylor, P.A.1    Panoskaltsis-Mortari, A.2    Freeman, G.J.3    Sharpe, A.H.4    Noelle, R.J.5    Rudensky, A.Y.6    Mak, T.W.7    Serody, J.S.8    Blazar, B.R.9
  • 60
    • 0030293633 scopus 로고    scopus 로고
    • Differential effect of CTLA4Ig on murine graft-versus-host disease (GVHD): CTLA4Ig prevents both acute and chronic GVHD development but reverses only chronic GVHD
    • Via CS, Rus V, Nguyen N, Linsley P, Gause WC. Differential effect of CTLA4Ig on murine graft-versus-host disease (GVHD): CTLA4Ig prevents both acute and chronic GVHD development but reverses only chronic GVHD. J Immunol 1996;157:4258-67.
    • (1996) J Immunol , vol.157 , pp. 4258-4267
    • Via, C.S.1    Rus, V.2    Nguyen, N.3    Linsley, P.4    Gause, W.C.5
  • 61
    • 77952973583 scopus 로고    scopus 로고
    • Advances in lupus stemming from the parent-into-F1 model
    • Via CS. Advances in lupus stemming from the parent-into-F1 model. Trends Immunol 2010;31:236-45.
    • (2010) Trends Immunol , vol.31 , pp. 236-245
    • Via, C.S.1
  • 63
    • 34247867901 scopus 로고    scopus 로고
    • Immunobiology of allogeneic hematopoietic stem cell transplantation
    • Welniak LA, Blazar BR, Murphy WJ. Immunobiology of allogeneic hematopoietic stem cell transplantation. Annu Rev Immunol 2007;25:139-70.
    • (2007) Annu Rev Immunol , vol.25 , pp. 139-170
    • Welniak, L.A.1    Blazar, B.R.2    Murphy, W.J.3
  • 64
    • 0032532609 scopus 로고    scopus 로고
    • Role of CD28 in acute graft-versus-host disease
    • Yu XZ, Martin PJ, Anasetti C. Role of CD28 in acute graft-versus-host disease. Blood 1998;92:2963-70.
    • (1998) Blood , vol.92 , pp. 2963-2970
    • Yu, X.Z.1    Martin, P.J.2    Anasetti, C.3
  • 65
    • 85047693292 scopus 로고    scopus 로고
    • CD28 ligation Vinduces transplantation tolerance by IFN-gammadependent depletion of T cells that recognize alloantigens
    • Yu XZ, Albert MH, Martin PJ, Anasetti C. CD28 ligation Vinduces transplantation tolerance by IFN-gammadependent depletion of T cells that recognize alloantigens. J Clin Invest 2004;113:1624-30.
    • (2004) J Clin Invest , vol.113 , pp. 1624-1630
    • Yu, X.Z.1    Albert, M.H.2    Martin, P.J.3    Anasetti, C.4
  • 66
    • 33744913796 scopus 로고    scopus 로고
    • Opposing effects of ICOS on graft-versus-host disease mediated by CD4 and CD8 T cells
    • Yu XZ, Liang Y, Nurieva RI, Guo F, Anasetti C, Dong C. Opposing effects of ICOS on graft-versus-host disease mediated by CD4 and CD8 T cells. J Immunol 2006; 176:7394-401.
    • (2006) J Immunol , vol.176 , pp. 7394-7401
    • Yu, X.Z.1    Liang, Y.2    Nurieva, R.I.3    Guo, F.4    Anasetti, C.5    Dong, C.6
  • 68
    • 77954488978 scopus 로고    scopus 로고
    • Dendritic cells and STAT3 are essential for CD137-induced CD8 T cell activation-induced cell death
    • Zhang B, Zhang Y, Niu L, Vella AT, Mittler RS. Dendritic cells and STAT3 are essential for CD137-induced CD8 T cell activation-induced cell death. J Immunol 2010;184: 4770-8.
    • (2010) J Immunol , vol.184 , pp. 4770-4778
    • Zhang, B.1    Zhang, Y.2    Niu, L.3    Vella, A.T.4    Mittler, R.S.5
  • 69
    • 4043089873 scopus 로고    scopus 로고
    • The 4-1BB costimulation augments the proliferation of CD4+CD25+ regulatory T cells
    • Zheng G, Wang B, Chen A. The 4-1BB costimulation augments the proliferation of CD4+CD25+ regulatory T cells. J Immunol 2004;173:2428-34.
    • (2004) J Immunol , vol.173 , pp. 2428-2434
    • Zheng, G.1    Wang, B.2    Chen, A.3
  • 70
    • 34249689632 scopus 로고    scopus 로고
    • CD137 stimulation delivers an antigen-independent growth signal for T lymphocytes with memory phenotype
    • Zhu Y, Zhu G, Luo L, Flies AS, Chen L. CD137 stimulation delivers an antigen-independent growth signal for T lymphocytes with memory phenotype. Blood 2007;109: 4882-9.
    • (2007) Blood , vol.109 , pp. 4882-4889
    • Zhu, Y.1    Zhu, G.2    Luo, L.3    Flies, A.S.4    Chen, L.5


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