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Volumn 8, Issue 12, 2002, Pages 1405-1413

Costimulatory molecule-targeted antibody therapy of a spontaneous autoimmune disease

Author keywords

[No Author keywords available]

Indexed keywords

FAS ANTIGEN; GAMMA INTERFERON; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY CD137; UNCLASSIFIED DRUG;

EID: 0036913169     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm1202-796     Document Type: Article
Times cited : (165)

References (43)
  • 2
    • 0025875259 scopus 로고
    • Lpr and gld: Single gene models of systemic autoimmunity and lymphoproliferative disease
    • Cohen, P.L. & Eisenberg, R.A. Lpr and gld: Single gene models of systemic autoimmunity and lymphoproliferative disease. Annu. Rev. Immunol. 9, 243-269 (1991).
    • (1991) Annu. Rev. Immunol. , vol.9 , pp. 243-269
    • Cohen, P.L.1    Eisenberg, R.A.2
  • 3
    • 0021246171 scopus 로고
    • The proliferating cells in autoimmune MRL/lpr mice lack L3T4, an antigen on "helper" T cells that is involved in the response to class II major histocompatibility antigens
    • Wofsy, D., Hardy, R.R. & Seaman, W.E. The proliferating cells in autoimmune MRL/lpr mice lack L3T4, an antigen on "helper" T cells that is involved in the response to class II major histocompatibility antigens. J. Immunol. 132, 2686-2689 (1984).
    • (1984) J. Immunol. , vol.132 , pp. 2686-2689
    • Wofsy, D.1    Hardy, R.R.2    Seaman, W.E.3
  • 4
    • 0020375486 scopus 로고
    • Abnormalities induced by the mutant gene lpr: Expansion of a unique lymphocyte subset
    • Morse, H.C. 3rd et al. Abnormalities induced by the mutant gene lpr: Expansion of a unique lymphocyte subset. J. Immunol. 129, 2612-2615 (1982).
    • (1982) J. Immunol. , vol.129 , pp. 2612-2615
    • Morse H.C. III1
  • 5
    • 0018072901 scopus 로고
    • Spontaneous murine lupus-like syndromes. Clinical and immunopathological manifestations in several strains
    • Andrews, B.S. et al. Spontaneous murine lupus-like syndromes. Clinical and immunopathological manifestations in several strains. J. Exp. Med. 148, 1198-1215 (1978).
    • (1978) J. Exp. Med. , vol.148 , pp. 1198-1215
    • Andrews, B.S.1
  • 6
    • 0033562983 scopus 로고    scopus 로고
    • Antigen-specific therapy of murine lupus nephritis using nucleosomal peptides: Tolerance spreading impairs pathogenic function of autoimmune T and B cells
    • Kaliyaperumal, A., Michaels, M.A. & Datta, S.K. Antigen-specific therapy of murine lupus nephritis using nucleosomal peptides: Tolerance spreading impairs pathogenic function of autoimmune T and B cells. J. Immunol. 162, 5775-5783 (1999).
    • (1999) J. Immunol. , vol.162 , pp. 5775-5783
    • Kaliyaperumal, A.1    Michaels, M.A.2    Datta, S.K.3
  • 7
    • 0027343886 scopus 로고
    • Treatment of murine lupus with anti-CD4 monoclonal antibodies
    • Wofsy, D. Treatment of murine lupus with anti-CD4 monoclonal antibodies. Immunol. Ser. 59, 221-236 (1993).
    • (1993) Immunol. Ser. , vol.59 , pp. 221-236
    • Wofsy, D.1
  • 8
    • 0028852328 scopus 로고
    • Interaction between CD40 and its ligand gp39 in the development of murine lupus nephritis
    • Mohan, C., Shi, Y., Laman, J.D. & Datta, S.K. Interaction between CD40 and its ligand gp39 in the development of murine lupus nephritis. J. Immunol. 154, 1470-80 (1995).
    • (1995) J. Immunol. , vol.154 , pp. 1470-1480
    • Mohan, C.1    Shi, Y.2    Laman, J.D.3    Datta, S.K.4
  • 9
    • 0028483990 scopus 로고
    • Treatment of murine lupus with CTLA4Ig
    • Finck, B.K., Linsley, P.S. & Wofsy, D. Treatment of murine lupus with CTLA4Ig. Science 265, 1225-1227 (1994).
    • (1994) Science , vol.265 , pp. 1225-1227
    • Finck, B.K.1    Linsley, P.S.2    Wofsy, D.3
  • 10
    • 0032030667 scopus 로고    scopus 로고
    • Anti-CD40 ligand antibody treatment of SNF1 mice with established nephritis: Preservation of kidney function
    • Kalled, S.L., Cutler, A.H., Datta, S.K. & Thomas, D.W. Anti-CD40 ligand antibody treatment of SNF1 mice with established nephritis: Preservation of kidney function. J. Immunol. 160, 2158-2165 (1998).
    • (1998) J. Immunol. , vol.160 , pp. 2158-2165
    • Kalled, S.L.1    Cutler, A.H.2    Datta, S.K.3    Thomas, D.W.4
  • 11
    • 0034665384 scopus 로고    scopus 로고
    • Autoantibody responses and pathology regulated by B7-1 and B7-2 costimulation in MRL/lpr lupus
    • Liang, B., Kashgarian, M.J., Sharpe, A.H. & Mamula, M.I. Autoantibody responses and pathology regulated by B7-1 and B7-2 costimulation in MRL/lpr lupus. J. Immunol. 165, 3436-3443 (2000).
    • (2000) J. Immunol. , vol.165 , pp. 3436-3443
    • Liang, B.1    Kashgarian, M.J.2    Sharpe, A.H.3    Mamula, M.I.4
  • 12
    • 0032725836 scopus 로고    scopus 로고
    • Tumour necrosis factor and other cytokines in murine lupus
    • Theofilopoulos, A.N. & Lawson, B.R. Tumour necrosis factor and other cytokines in murine lupus. Ann. Rheum. Dis. 58 Suppl. 1, 149-55 (1999).
    • (1999) Ann. Rheum. Dis. , vol.58 , Issue.SUPPL. 1 , pp. 149-155
    • Theofilopoulos, A.N.1    Lawson, B.R.2
  • 13
    • 0032936962 scopus 로고    scopus 로고
    • Cytokines in the pathogenesis of systemic lupus erythematosus
    • Kelley, V.R. & Wuthrich, R.P. Cytokines in the pathogenesis of systemic lupus erythematosus. Semin. Nephrol. 19, 57-66 (1999).
    • (1999) Semin. Nephrol. , vol.19 , pp. 57-66
    • Kelley, V.R.1    Wuthrich, R.P.2
  • 14
    • 0033942181 scopus 로고    scopus 로고
    • Treatment of murine lupus with cDNA encoding IFN-γR/Fc
    • Lawson, B.R. et al. Treatment of murine lupus with cDNA encoding IFN-γR/Fc. J. Clin. Invest. 106, 207-215 (2000).
    • (2000) J. Clin. Invest. , vol.106 , pp. 207-215
    • Lawson, B.R.1
  • 15
    • 0032374052 scopus 로고    scopus 로고
    • Role of 4-1BB in immune responses
    • Vinay, D.S. & Kwon, B.S. Role of 4-1BB in immune responses. Semin. Immunol. 10, 481-489 (1998).
    • (1998) Semin. Immunol. , vol.10 , pp. 481-489
    • Vinay, D.S.1    Kwon, B.S.2
  • 17
    • 0027285735 scopus 로고
    • Inducible T cell antigen 4-1BB. Analysis of expression and function
    • Pollok, K.E. et al. Inducible T cell antigen 4-1BB. Analysis of expression and function. J. Immunol. 150, 771-781 (1993).
    • (1993) J. Immunol. , vol.150 , pp. 771-781
    • Pollok, K.E.1
  • 18
    • 0032535119 scopus 로고    scopus 로고
    • NK1.1 cells express 4-1BB (CDw137) costimulatory molecule and are required for tumor immunity elicited by anti-4-1BB monoclonal antibodies
    • Melero, I., Johnston, J.V., Shufford, W.W., Mittler, R.S. & Chen, L. NK1.1 cells express 4-1BB (CDw137) costimulatory molecule and are required for tumor immunity elicited by anti-4-1BB monoclonal antibodies. Cell. Immunol. 190, 167-172 (1998).
    • (1998) Cell. Immunol. , vol.190 , pp. 167-172
    • Melero, I.1    Johnston, J.V.2    Shufford, W.W.3    Mittler, R.S.4    Chen, L.5
  • 19
    • 0027365746 scopus 로고
    • Molecular cloning of a ligand for the inducible T cell gene 4-1BB: A member of an emerging family of cytokines with homology to tumor necrosis factor
    • Goodwin, R.G. et al. Molecular cloning of a ligand for the inducible T cell gene 4-1BB: A member of an emerging family of cytokines with homology to tumor necrosis factor. Eur. J. Immunol. 23, 2631-2641 (1993).
    • (1993) Eur. J. Immunol. , vol.23 , pp. 2631-2641
    • Goodwin, R.G.1
  • 20
    • 0028009709 scopus 로고
    • 4-1BB T-cell antigen binds to mature B cells and macrophages, and costimulates anti-μ-primed splenic B cells
    • Pollok, K.E. et al. 4-1BB T-cell antigen binds to mature B cells and macrophages, and costimulates anti-μ-primed splenic B cells. Eur. J. Immunol. 24, 367-374 (1994).
    • (1994) Eur. J. Immunol. , vol.24 , pp. 367-374
    • Pollok, K.E.1
  • 21
    • 20244386539 scopus 로고
    • Molecular and biological characterization of human 4-1BB and its ligand
    • Alderson, M.R. et al. Molecular and biological characterization of human 4-1BB and its ligand. Eur. J. Immunol. 24, 2219-2227 (1994).
    • (1994) Eur. J. Immunol. , vol.24 , pp. 2219-2227
    • Alderson, M.R.1
  • 22
    • 0031007143 scopus 로고    scopus 로고
    • Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors
    • Melero, I. et al. Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors. Nature Med. 3, 682-685 (1997).
    • (1997) Nature Med. , vol.3 , pp. 682-685
    • Melero, I.1
  • 23
    • 0030845586 scopus 로고    scopus 로고
    • + T cell proliferation and lead to the amplification in vivo of cytotoxic T cell responses
    • + T cell proliferation and lead to the amplification in vivo of cytotoxic T cell responses. J. Exp. Med. 186, 47-55 (1997).
    • (1997) J. Exp. Med. , vol.186 , pp. 47-55
    • Shuford, W.W.1
  • 24
    • 0035284861 scopus 로고    scopus 로고
    • Ligation of 4-1BB (CDw137) regulates graft-versus-host disease, graft-versus-leukemia, and graft rejection in allogeneic bone marrow transplant recipients
    • Blazar, B.R. et al. Ligation of 4-1BB (CDw137) regulates graft-versus-host disease, graft-versus-leukemia, and graft rejection in allogeneic bone marrow transplant recipients. J. Immunol. 166, 3174-3183 (2001).
    • (2001) J. Immunol. , vol.166 , pp. 3174-3183
    • Blazar, B.R.1
  • 25
    • 0036195860 scopus 로고    scopus 로고
    • Provision of antigen and CD137 signaling breaks immunological ignorance, promoting regression of poorly immunogenic tumors
    • Wilcox, R. et al. Provision of antigen and CD137 signaling breaks immunological ignorance, promoting regression of poorly immunogenic tumors. J. Clin. Invest. 109, 651-659 (2002).
    • (2002) J. Clin. Invest. , vol.109 , pp. 651-659
    • Wilcox, R.1
  • 27
    • 0033571176 scopus 로고    scopus 로고
    • Anti-4-1BB monoclonal antibodies abrogate T cell-dependent humoral immune responses in vivo through the induction of helper T cell anergy
    • Mittler, R.S., Bailey, T.S., Klussman, K., Trailsmith, M.D. & Hoffmann, M.K. Anti-4-1BB monoclonal antibodies abrogate T cell-dependent humoral immune responses in vivo through the induction of helper T cell anergy. J. Exp. Med. 190, 1535-1540 (1999).
    • (1999) J. Exp. Med. , vol.190 , pp. 1535-1540
    • Mittler, R.S.1    Bailey, T.S.2    Klussman, K.3    Trailsmith, M.D.4    Hoffmann, M.K.5
  • 28
    • 0036467421 scopus 로고    scopus 로고
    • Administration of agonistic anti-4-1BB monoclonal antibody leads to the amelioration of experimental autoimmune encephalomyelitis
    • Sun, Y. et al. Administration of agonistic anti-4-1BB monoclonal antibody leads to the amelioration of experimental autoimmune encephalomyelitis. J. Immunol. 168, 1457-1465 (2002).
    • (2002) J. Immunol. , vol.168 , pp. 1457-1465
    • Sun, Y.1
  • 29
    • 0027477302 scopus 로고
    • Aberrant transcription caused by the insertion of an early transposable element in an intron of the Fas antigen gene of lpr mice
    • Adachi, M., Watanabe-Fukunaga, R. & Nagata, S. Aberrant transcription caused by the insertion of an early transposable element in an intron of the Fas antigen gene of lpr mice. Proc. Natl. Acad. Sci. USA 90, 1756-1760 (1993).
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 1756-1760
    • Adachi, M.1    Watanabe-Fukunaga, R.2    Nagata, S.3
  • 30
    • 0031398761 scopus 로고    scopus 로고
    • Why do defects in the Fas-Fas ligand system cause autoimmunity?
    • Suda, T. & Nagata, S. Why do defects in the Fas-Fas ligand system cause autoimmunity? J. Allergy Clin. Immunol. 100, S97-101 (1997).
    • (1997) J. Allergy Clin. Immunol. , vol.100
    • Suda, T.1    Nagata, S.2
  • 31
    • 0033151622 scopus 로고    scopus 로고
    • Reactive oxygen species regulate activation-induced T cell apoptosis
    • Hildeman, D.A. et al. Reactive oxygen species regulate activation-induced T cell apoptosis. Immunity 10, 73S-744 (1999).
    • (1999) Immunity , vol.10
    • Hildeman, D.A.1
  • 32
    • 0023706894 scopus 로고
    • Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production
    • Ding, A.H., Nathan, C.F. & Stuehr, D.J. Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production. J. Immunol. 141, 2407-2412 (1988).
    • (1988) J. Immunol. , vol.141 , pp. 2407-2412
    • Ding, A.H.1    Nathan, C.F.2    Stuehr, D.J.3
  • 33
    • 0032534664 scopus 로고    scopus 로고
    • Nitric oxide synthase plays a signaling role in TCR-triggered apoptotic death
    • Williams, M.S., Noguchi, S., Henkart, P.A. & Osawa, Y. Nitric oxide synthase plays a signaling role in TCR-triggered apoptotic death. J. Immunol. 161, 6526-6531 (1998).
    • (1998) J. Immunol. , vol.161 , pp. 6526-6531
    • Williams, M.S.1    Noguchi, S.2    Henkart, P.A.3    Osawa, Y.4
  • 35
    • 0024215452 scopus 로고
    • Local extrahepatic expression of complement genes C3, factor 8, C2, and C4 is increased in murine lupus nephritis
    • Passwell, J., Schreiner, G.F., Nonaka, M., Beuscher, H.U. & Colten, H.R. Local extrahepatic expression of complement genes C3, factor 8, C2, and C4 is increased in murine lupus nephritis. J. Clin. Invest. 82, 1676-1684 (1988).
    • (1988) J. Clin. Invest. , vol.82 , pp. 1676-1684
    • Passwell, J.1    Schreiner, G.F.2    Nonaka, M.3    Beuscher, H.U.4    Colten, H.R.5
  • 36
    • 0035487709 scopus 로고    scopus 로고
    • T cells in the pathogenesis of systemic lupus erythematosus
    • Hoffman, R.W. T cells in the pathogenesis of systemic lupus erythematosus. Front Biosci. 6, D1369-1378 (2001).
    • (2001) Front Biosci. , vol.6
    • Hoffman, R.W.1
  • 37
    • 0030944143 scopus 로고    scopus 로고
    • Unique site of IgG2a and rheumatoid factor production in MRL/lpr mice
    • Jacobson, B.A., Rothstein, T.L. & Marshak-Rothstein, A. Unique site of IgG2a and rheumatoid factor production in MRL/lpr mice. Immunol. Rev. 156, 103-110 (1997).
    • (1997) Immunol. Rev. , vol.156 , pp. 103-110
    • Jacobson, B.A.1    Rothstein, T.L.2    Marshak-Rothstein, A.3
  • 38
    • 0030953632 scopus 로고    scopus 로고
    • Roles of interferon-γ and interleukin-4 in murine lupus
    • Peng, S.L., Moslehi, J. & Craft, J. Roles of interferon-γ and interleukin-4 in murine lupus. J. Clin. Invest. 99, 1936-1946 (1997).
    • (1997) J. Clin. Invest. , vol.99 , pp. 1936-1946
    • Peng, S.L.1    Moslehi, J.2    Craft, J.3
  • 39
    • 0032518439 scopus 로고    scopus 로고
    • Interferon-γ is required for lupus-like disease and lymphoaccumulation in MRL-lpr mice
    • Balomenos, D., Rumold, R. & Theofilopoulos, A.N. Interferon-γ is required for lupus-like disease and lymphoaccumulation in MRL-lpr mice. J. Clin. Invest. 101, 364-371 (1998).
    • (1998) J. Clin. Invest. , vol.101 , pp. 364-371
    • Balomenos, D.1    Rumold, R.2    Theofilopoulos, A.N.3
  • 40
    • 0031155269 scopus 로고    scopus 로고
    • IFN-γ is essential for the development of autoimmune glomerulonephritis in MRL/lpr mice
    • Haas, C., Ryffel, B. & Le Hir, M. IFN-γ is essential for the development of autoimmune glomerulonephritis in MRL/lpr mice. J. Immunol. 158, 5484-5491 (1997).
    • (1997) J. Immunol. , vol.158 , pp. 5484-5491
    • Haas, C.1    Ryffel, B.2    Le Hir, M.3
  • 41
    • 0031831859 scopus 로고    scopus 로고
    • IFN-γ receptor signaling is essential for the initiation, acceleration, and destruction of autoimmune kidney disease in MRL-Fas(lpr) mice
    • Schwarting, A., Wada, T., Kinoshita, K., Tesch, G. & Kelley, V.R. IFN-γ receptor signaling is essential for the initiation, acceleration, and destruction of autoimmune kidney disease in MRL-Fas(lpr) mice. J. Immunol. 161, 494-503 (1998).
    • (1998) J. Immunol. , vol.161 , pp. 494-503
    • Schwarting, A.1    Wada, T.2    Kinoshita, K.3    Tesch, G.4    Kelley, V.R.5
  • 42
    • 0033976316 scopus 로고    scopus 로고
    • Dichotomic effects of IFN-γ on the development of systemic lupus erythematosus-like syndrome in MRL-lpr/lpr mice
    • Nicoletti, F. et al. Dichotomic effects of IFN-γ on the development of systemic lupus erythematosus-like syndrome in MRL-lpr/lpr mice. Eur. J. Immunol. 30, 438-447 (2000).
    • (2000) Eur. J. Immunol. , vol.30 , pp. 438-447
    • Nicoletti, F.1
  • 43
    • 0035660806 scopus 로고    scopus 로고
    • The regulation of T cell homeostasis and autoimmunity by T cell-derived LIGHT
    • Wang, J. et al. The regulation of T cell homeostasis and autoimmunity by T cell-derived LIGHT. J. Clin. Invest. 108, 1771-1780 (2001).
    • (2001) J. Clin. Invest. , vol.108 , pp. 1771-1780
    • Wang, J.1


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