Control of cardiac development by an evolutionarily conserved transcriptional network

Developmental Biology

Volumn 246, Issue 1, 2002, Pages 14-28

  Cripps, Richard M ^a   Olson, Eric N ^b  

^a UNIVERSITY OF NEW MEXICO   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Cardiogenesis; Dorsal vessel; Drosophila; Gene network; Heart; Review; Transcription factor; Transcription network

Indexed keywords

MYOCARDIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

CELL DIFFERENTIATION; CELL FATE; CELL LINEAGE; CELL STRUCTURE; DROSOPHILA; EMBRYOLOGY; HEART DEVELOPMENT; HEART MUSCLE CELL; MOLECULAR DYNAMICS; MOLECULAR EVOLUTION; MORPHOGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

DROSOPHILA MELANOGASTER; MAMMALIA;

EID: 0036608009     PISSN: 00121606     EISSN: None     Source Type: Journal    
DOI: 10.1006/dbio.2002.0666     Document Type: Review

References (130)

1. The genome sequence of Drosophila melanogaster
2. BMP-2 induces ectopic expression of cardiac lineage markers and interferes with somite formation in chicken embryos
3. tinman and bagpipe: Two homeobox genes that determine cell fates in the dorsal mesoderm of Drosophila
4. Regulation of chamber-specific gene expression in the developing heart by Irx4
5. Heartless, a Drosophila FGF receptor homolog, is essential for cell migration and establishment of several mesodermal lineages
6. Transcriptional control of muscle development by myocyte enhancer factor-2 (MEF2) proteins
7. The gene tinman is required for specification of the heart and visceral muscles in Drosophila
8. Heart development in Drosophila and its relationship to vertebrate systems
9. Genetic determination of Drosophila heart development
10. Drosophila MEF2, a transcription factor that is essential for myogenesis
11. A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and disease
12. Functional redundancy: The respective roles of the two sloppy paired genes in Drosophila segmentation
13. Combinatorial signaling codes for the progressive determination of cell fates in the Drosophila embryonic mesoderm
14. inscuteable and numb mediate asymmetric muscle progenitor cell divisions during Drosophila myogenesis
15. Identification of novel DNA binding targets and regulatory domains of a murine Tinman homeodomain factor nkx-2.5
16. The homeodomain transcription factor NK-4 acts as either a transcriptional activator or repressor and interacts with the p300 coactivator and the Groucho repressor
17. The myogenic regulatory gene Mef2 is a direct target for transcriptional activation by Twist during Drosophila myogenesis
18. Transcription of the myogenic regulatory gene Mef2 in cardiac, somatic and visceral muscle cell lineages is regulated by a Tinman-dependent core enhancer
19. The cardiac transcription factors Nkx2.5 and GATA-4 are mutual cofactors
20. The atrial natriuretic factor promoter is a downstream target for Nkx2.5 in the myocardium
21. Parsing the heart: Genetic modules for organ assembly
22. The multitype zinc-finger protein U-shaped functions in heart cell specification in the Drosophila embryo
23. Conserved cardiogenic functions of the multitype zinc-finger proteins: U-shaped and FOG-2
24. Induction of visceral and cardiac mesoderm by ectodermal Dpp in the early Drosophila embryo
25. Intersecting signalling and transcriptional pathways in Drosophila heart specification
26. The heterotrimeric protein G0 is required for the formation of heart epithelium in Drosophila
27. Genetically distinct cardial cells within the Drosophila heart
28. The zinc finger proteins Pannier and GATA4 function as cardiogenic factors in Drosophila
29. Combinatorial control of Drosophila Mef2 gene expression in cardiac and somatic muscle cell lineages
30. D-Mef2 is a target for tinman activation during Drosophila heart development
31. Pannier is a transcriptional target and partner of Tinman during Drosophila cardiogenesis
32. heartless encodes a fibroblast growth factor receptor (DFR1/DFGF-R2) involved in the directional migration of early mesodermal cells in the Drosophila embryo
33. A conserved role for H15-related T-box transcription factors in zebrafish and Drosophila heart formation
34. The Drosophila sloppy paired locus encodes two proteins involved in segmentation that show homology to mammalian transcription factors
35. The pruned gene encodes the Drosophila serum response factor and regulates cytoplasmic outgrowth during terminal branching of the tracheal system
36. The role of cell adhesion molecules in Drosophila heart morphogenesis: faint sausage, shotgun/DE-cadherin, and laminin A are required for discrete stages in heart development
37. Ras pathway specificity is determined by the integration of multiple signal-activated and tissue-restricted transcription factors
38. The chicken GATA-6 locus contains multiple control regions that confer distinct patterns of heart region-specific expression in transgenic mouse embryos
39. Dorsal-twist interactions establish snail expression in the presumptive mesoderm of the Drosophila embryo
40. ladybird, a new component of the cardiogenic pathway in Drosophila required for diversification of heart precursors
41. Cross-repressive interactions of identity genes are essential for proper specification of cardiac and muscular fates in Drosophila
42. The dorsal morphogen gradient regulates the mesoderm determinant twist in early Drosophila embryos
43. The Xenopus GATA-4/5/6 genes are associated with cardiac specification and can regulate cardiac-specific transcription during embryogenesis
44. Drosophila MEF2 is a direct regulator of Actin57B transcription in cardiac, skeletal and visceral muscle lineages
45. Csx: A murine homeobox-containing gene specifically expressed in the developing heart
46. Tinman regulates the transcription of the beta-3 tubulin gene (βTub60D) in the dorsal vessel of Drosophila
47. The embryonic expression patterns of zfh-1 and zfh-2, two Drosophila genes encoding novel zinc-finger homeodomain proteins
48. Postembryonic hematopoiesis in Drosophila
49. GATA 4/5/6, a subfamily of three transcription factors transcribed in developing heart and gut
50. Segmental patterning of heart precursors in Drosophila
51. Wingless effects mesoderm patterning and ectoderm segmentation events via induction of its downstream target sloppy paired
52. Twist-mediated activation of the NK-4 homeobox gene in the visceral mesoderm of Drosophila requires two distinct dusters of E-box regulatory elements
53. The cardiac tissue-restricted homeobox protein Csx/Nkx2.5 physically associates with the zinc finger protein GATA4 and cooperatively activates atrial natriuretic factor gene expression
54. Twist and snail as positive and negative regulators during Drosophila mesoderm development
55. Nkx-2.5 induction in mice is mediated by a Smad consensus regulatory region
56. Control of early cardiac-specific transcription of Nkx2-5 by a GATA-dependent enhancer
57. Cardiac-specific activity of an Nkx2.5 enhancer requires an evolutionarily conserved Smad binding site
58. Requirement of the MADS domain transcription factor D-MEF2 for muscle formation in Drosophila
59. Myocyte-specific enhancer factor 2 acts cooperatively with a muscle activator region to regulate Drosophila tropomyosin gene muscle expression
60. Control of mouse cardiac morphogenesis and myogenesis by transcription factor MEF2C
61. Requirement of the MADS-box transcription factor MEF2C for vascular development
62. Heparan sulfate proteoglycans are essential for FGF receptor signaling during Drosophila embryonic development
63. Nkx-2.5: A novel murine homeobox gene expressed in early heart progenitor cells and their myogenic descendants
64. A role for the COUP-TF-related gene seven-up in the diversification of cardioblast identities in the dorsal vessel of Drosophila
65. FOG-2, a heart- and brain-enriched cofactor for GATA transcription factors
66. Myogenic and morphogenetic defects in the heart tubes of murine embryos lacking the homeobox gene Nkx2.5
67. Inhibition of Wnt activity induces heart formation from posterior mesoderm
68. A GATA-dependent right ventricular enhancer controls dHAND transcription in the developing heart
69. Heart development: Learning from mistakes
70. The internal anatomy and histology of the imago
71. Ostia, the inflow tracts of the Drosophila heart, develop from a genetically distinct subset of cardial cells
72. Direct activation of a GATA6 cardiac enhancer by Nkx2.5: Evidence for a reinforcing regulatory network of Nkx2.5 and GATA transcription factors in the developing heart
73. A genome-wide survey of basic helix-loop-helix factors in Drosophila
74. A novel sulfonylurea receptor family member expressed in the embryonic Drosophila dorsal vessel and tracheal system
75. Drosophila Mef2 expression during mesoderm development is controlled by a complex array of cis-acting regulatory modules
76. Functional analysis of the Drosophila twist promoter reveals a Dorsal-binding ventral activator region
77. Dual roles for the zeste-white3/shaggy-encoded kinase in mesoderm and heart development of Drosophila
78. Mesodermal cell fate decisions in Drosophila are under the control of the lineage genes numb, Notch, and sanpodo
79. Differential rescue of visceral and cardiac defects in Drosophila by vertebrate tinman-related genes
80. The wingless signaling pathway is directly involved in Drosophila heart development
81. The orphan nuclear receptor COUP-TFII is required for angiogenesis and heart development
82. zfh-1, the Drosophila homolog of ZEB, is a transcriptional repressor that regulates somatic myogenesis
83. TGF-beta family signal transduction in Drosophila development: From Mad to Smads
84. Divergent roles for NK-2 class homeobox genes in cardiogenesis in flies and mice
85. A series of mutations in the D-MEF2 transcription factor reveal multiple functions in larval and adult myogenesis in Drosophila
86. Identification of upstream regulatory regions in the heart-expressed homeobox gene Nkx2-5
87. Induction and differentiation of the zebrafish heart requires fibroblast growth factor 8 (fgf8/acerebellar)
88. Control of cell fates and segmentation in the Drosophila mesoderm
89. The circulatory system and associated cells and tissues
90. Identification of immune system and response genes, and novel mutations causing melanotic tumor formation in Drosophila melanogaster
91. A gradient of nuclear localization of the dorsal protein determines dorsoventral pattern in the Drosophila embryo
92. Embryonic origin and differentiation of the Drosophila heart
93. The graded distribution of the dorsal morphogen is initiated by selective nuclear transport in Drosophila
94. Wnt antagonism initiates cardiogenesis in Xenopus laevis
95. A role for bone morphogenetic proteins in the induction of cardiac myogenesis
96. Induction of avian cardiac myogenesis by anterior endoderm
97. Building the heart piece by piece: Modularity of cis-elements regulation Nkx2-5 transcription
98. A GATA-dependent Nkx-2.5 regulatory dement activates early cardiac gene expression in transgenic mice
99. GATA-4 and Nkx-2.5 coactivate Nkx-2 DNA binding targets: Role for regulating early cardiac gene expression
100. BMP signaling is required for heart formation in vertebrate
101. Requirements of DFR1/Heartless, a mesoderm-specific Drosophila FGF-receptor, for the formation of heart, visceral and somatic muscles, and ensheathing of longitudinal axon tracts in CNS
102. A genetic blueprint for cardiac development
103. A subclass of bHLH proteins required for cardiac morphogenesis
104. Regulation of cardiac mesodermal and neural crest development by the bHLH transcription factor, dHAND
105. Relocalization of the dorsal protein from the cytoplasm to the nucleus correlates with its function
106. The Drosophila homeobox genes zfh-1 and even-skipped are required for cardiac-specific differentiation of a numb-dependent lineage
107. The pioneer gene apontic is required for morphogenesis and function of the Drosophila heart
108. Molecular cloning of FOG-2: A modulator of transcription factor GATA-4 in cardiomyocytes
109. A syndrome of tricuspid atresia in mice with a targeted mutation of the gene encoding Fog-2
110. Complex modular cis-acting elements regulate expression of the cardiac specifying homeobox gene Csx/Nkx2.5
111. Drosophila MEF2 is regulated by twist and is expressed in both the primordial and differentiated cells of the embryonic somatic, visceral, and heart musculature
112. FOG-2: A novel GATA-family cofactor related to multitype zinc-finger proteins Friend of GATA-1 and U-shaped
113. FOG-2, a cofactor for GATA transcription factors, is essential for heart morphogenesis and development of the coronary vessels from epicardium
114. Sequence-specific transactivation of the Drosophila twist gene by the dorsal gene product
115. Wnt signals from the neural tube block ectopic cardiogenesis
116. Cardiac enhancer activity of the homeobox gene tinman depends on CREB consensus binding sites in Drosophila
117. The Drosophila protein Dof is specifically required for FGF signaling
118. Irx4 forms an inhibitory complex with the vitamin D and retinoic X receptors to regulate cardiac chamber-specific slow MyHC3 expression
119. Activation of cardiac gene expression by myocardin, a transcriptional cofactor for serum response factor
120. odd-skipped is expressed in multiple tissues during Drosophila embryogenesis
121. Characterization of a novel subset of cardiac cells and their progenitors in the Drosophila embryo
122. "Insect Physiology," 4th Ed.
123. Heart development in Drosophila requires the segment polarity gene wingless
124. Smad proteins act in combination with synergistic and antagonistic regulators to target Dpp responses to the Drosophila mesoderm
125. Laminin is required for heart, somatic muscles, and gut development in the Drosophila embryo
126. Patterning during organogenesis: Genetic analysis of cardiac chamber formation
127. The bHLH transcription factor hand2 plays parallel roles in zebrafish heart and pectoral fin development
128. Regulation and function of tinman during dorsal mesoderm induction and heart specification in Drosophila
129. Regulation of the Twist target gene tinman by modular cis-regulatory elements during early mesoderm development