A Global In Vivo Drosophila RNAi Screen Identifies NOT3 as a Conserved Regulator of Heart Function

Cell

Volumn 141, Issue 1, 2010, Pages 142-153

  Neely, G Gregory ^a   Kuba, Keiji ^b   Cammarato, Anthony ^c   Isobe, Kazuya ^b,d   Amann, Sabine ^a   Zhang, Liyong ^e   Murata, Mitsushige ^f   Elmén, Lisa ^c   Gupta, Vaijayanti ^g   Arora, Suchir ^g   Sarangi, Rinku ^g   Dan, Debasis ^g   Fujisawa, Susumu ^b   Usami, Takako ^d   Xia, Cui ping ^a   Keene, Alex C ^h   Alayari, Nakissa N ^c   Yamakawa, Hiroyuki ^f   Elling, Ulrich ^a   Berger, Christian ^a   Novatchkova, Maria ^a   Koglgruber, Rubina ^a   Fukuda, Keiichi ^f   Nishina, Hiroshi ^d   Isobe, Mitsuaki ^d   Pospisilik, J Andrew ^a   Imai, Yumiko ^b   Pfeufer, Arne ^i,j   Hicks, Andrew A ^k   Pramstaller, Peter P ^k,l,m   Subramaniam, Sai ^g   Kimura, Akinori ^d   Ocorr, Karen ^c   Bodmer, Rolf ^c   Penninger, Josef M ^a   more..

^a INSTITUTE OF MOLECULAR BIOTECHNOLOGY   (Austria)

^b AKITA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c BURNHAM INSTITUTE   (United States)

^d TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^e TORONTO GENERAL HOSPITAL   (Canada)

^f KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^g Strand Life Sciences ^*  (India)

^h NEW YORK UNIVERSITY   (United States)

ⁱ TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^j INSTITUTE OF EPIDEMIOLOGY   (Germany)

^k INSTITUTE FOR RENEWABLE ENERGY   (Italy)

^l General Central Hospital   (Italy)

^m UNIVERSITY OF LÜBECK   (Germany)

more..

Author keywords

Humdisease; RNA

Indexed keywords

CHEMOKINE RECEPTOR CCR4; HISTONE DEACETYLASE; PROTEIN HSP83; PROTEIN NOT1; PROTEIN NOT3; PROTEIN NOT4; PROTEIN UBC4; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARDIOVASCULAR SYSTEM; CHROMATIN ASSEMBLY AND DISASSEMBLY; CONGESTIVE CARDIOMYOPATHY; CONTROLLED STUDY; DNA SCREENING; DROSOPHILA; ENZYME INHIBITION; EPIGENETICS; FUNCTIONAL ASSESSMENT; GENETIC CONSERVATION; GENETIC IDENTIFICATION; GENETIC SUSCEPTIBILITY; GENOME ANALYSIS; GENOME WIDE SCREENING; HEART FAILURE; HEART FUNCTION; HEART MUSCLE CONTRACTILITY; HEART STRESS; HEART VENTRICLE TACHYCARDIA; HETEROZYGOSITY; HIGH THROUGHPUT SCREENING; HUMAN; IN VIVO STUDY; KNOCKOUT MOUSE; LETHALITY; MOUSE; NONHUMAN; POSTTRANSCRIPTIONAL GENE SILENCING; PRIORITY JOURNAL; QT INTERVAL; REPOLARIZATION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; TRANSCRIPTION REGULATION;

MAMMALIA; MUS;

EID: 77950946233     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cell.2010.02.023     Document Type: Article

References (40)

1. A.H.A. (2005). http://www.americanheart.org/.
2. Alayari N.N., Vogler G., Taghli-Lamallem O., Ocorr K., Bodmer R., Cammarato A. Fluorescent Labeling of Drosophila Heart Structures. J. Vis. Exp. 2009, 10.3791/1423.
3. Albert T.K., Lemaire M., van Berkum N.L., Gentz R., Collart M.A., Timmers H.T. Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits. Nucleic Acids Res. 2000, 28:809-817.
4. Behm-Ansmant I., Rehwinkel J., Doerks T., Stark A., Bork P., Izaurralde E. mRNA degradation by miRNAs and GW182 requires both CCR4:NOT deadenylase and DCP1:DCP2 decapping complexes. Genes Dev. 2006, 20:1885-1898.
5. Bodmer R. Heart development in Drosophila and its relationship to vertebrates. Trends Cardiovasc. Med. 1995, 5:21-28.
6. Cripps R.M., Olson E.N. Control of cardiac development by an evolutionarily conserved transcriptional network. Dev. Biol. 2002, 246:14-28.
7. Denis C.L. Identification of new genes involved in the regulation of yeast alcohol dehydrogenase II. Genetics 1984, 108:833-844.
8. Dietzl G., Chen D., Schnorrer F., Su K.C., Barinova Y., Fellner M., Gasser B., Kinsey K., Oppel S., Scheiblauer S., et al. A genome-wide transgenic RNAi library for conditional gene inactivation in Drosophila. Nature 2007, 448:151-156.
9. Dudbridge F., Gusnanto A. Estimation of significance thresholds for genomewide association scans. Genet. Epidemiol. 2008, 32:227-234.
10. Fink M., Callol-Massot C., Chu A., Ruiz-Lozano P., Izpisua Belmonte J.C., Giles W., Bodmer R., Ocorr K. A new method for detection and quantification of heartbeat parameters in Drosophila, zebrafish, and embryonic mouse hearts. Biotechniques 2009, 46:101-113.
11. Gordon T., Castelli W.P., Hjortland M.C., Kannel W.B., Dawber T.R. Predicting coronary heart disease in middle-aged and older persons. The Framington study. JAMA 1977, 238:497-499.
12. Han Z., Olson E.N. Hand is a direct target of Tinman and GATA factors during Drosophila cardiogenesis and hematopoiesis. Development 2005, 132:3525-3536.
13. Hu G., Kim J., Xu Q., Leng Y., Orkin S.H., Elledge S.J. A genome-wide RNAi screen identifies a new transcriptional module required for self-renewal. Genes Dev. 2009, 23:837-848.
14. Jayne S., Zwartjes C.G., van Schaik F.M., Timmers H.T. Involvement of the SMRT/NCoR-HDAC3 complex in transcriptional repression by the CNOT2 subunit of the human Ccr4-Not complex. Biochem. J. 2006, 398:461-467.
15. Joza N., Oudit G.Y., Brown D., Bénit P., Kassiri Z., Vahsen N., Benoit L., Patel M.M., Nowikovsky K., Vassault A., et al. Muscle-specific loss of apoptosis-inducing factor leads to mitochondrial dysfunction, skeletal muscle atrophy, and dilated cardiomyopathy. Mol. Cell. Biol. 2005, 25:10261-10272.
16. Kuba K., Zhang L., Imai Y., Arab S., Chen M., Maekawa Y., Leschnik M., Leibbrandt A., Markovic M., Makovic M., et al. Impaired heart contractility in Apelin gene-deficient mice associated with aging and pressure overload. Circ. Res. 2007, 101:e32-e42.
17. Lakatta E.G., Levy D. Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: Part II: the aging heart in health: links to heart disease. Circulation 2003, 107:346-354.
18. Laribee R.N., Shibata Y., Mersman D.P., Collins S.R., Kemmeren P., Roguev A., Weissman J.S., Briggs S.D., Krogan N.J., Strahl B.D. CCR4/NOT complex associates with the proteasome and regulates histone methylation. Proc. Natl. Acad. Sci. USA 2007, 104:5836-5841.
19. Lloyd-Jones D., Adams R., Carnethon M., De Simone G., Ferguson T.B., Flegal K., Ford E., Furie K., Go A., Greenlund K., et al. Heart disease and stroke statistics-2009 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation 2009, 119:e21-e181. American Heart Association Statistics Committee and Stroke Statistics Subcommittee.
20. Lo P.C., Frasch M. A role for the COUP-TF-related gene seven-up in the diversification of cardioblast identities in the dorsal vessel of Drosophila. Mech. Dev. 2001, 104:49-60.
21. Morita H., Seidman J., Seidman C.E. Genetic causes of human heart failure. J. Clin. Invest. 2005, 115:518-526.
22. Moss A.J., Kass R.S. Long QT syndrome: from channels to cardiac arrhythmias. J. Clin. Invest. 2005, 115:2018-2024.
23. Mudd J.O., Kass D.A. Tackling heart failure in the twenty-first century. Nature 2008, 451:919-928.
24. Nabel E.G. Cardiovascular disease. N. Engl. J. Med. 2003, 349:60-72.
25. Nerbonne J.M. Studying cardiac arrhythmias in the mouse-a reasonable model for probing mechanisms?. Trends Cardiovasc. Med. 2004, 14:83-93.
26. Newton-Cheh C., Eijgelsheim M., Rice K.M., de Bakker P.I., Yin X., Estrada K., Bis J.C., Marciante K., Rivadeneira F., Noseworthy P.A., et al. Common variants at ten loci influence QT interval duration in the QTGEN Study. Nature genetics 2009, 41:399-406.
27. Ocorr K., Perrin L., Lim H.Y., Qian L., Wu X., Bodmer R. Genetic control of heart function and aging in Drosophila. Trends Cardiovasc. Med. 2007, 17:177-182.
28. Ocorr K., Reeves N.L., Wessells R.J., Fink M., Chen H.S., Akasaka T., Yasuda S., Metzger J.M., Giles W., Posakony J.W., Bodmer R. KCNQ potassium channel mutations cause cardiac arrhythmias in Drosophila that mimic the effects of aging. Proc. Natl. Acad. Sci. USA 2007, 104:3943-3948.
29. Paternostro G., Vignola C., Bartsch D.U., Omens J.H., McCulloch A.D., Reed J.C. Age-associated cardiac dysfunction in Drosophila melanogaster. Circ. Res. 2001, 88:1053-1058.
30. Peng W., Togawa C., Zhang K., Kurdistani S.K. Regulators of cellular levels of histone acetylation in Saccharomyces cerevisiae. Genetics 2008, 179:277-289.
31. Pfeufer A., Sanna S., Arking D.E., Müller M., Gateva V., Fuchsberger C., Ehret G.B., Orrú M., Pattaro C., Köttgen A., et al. Common variants at ten loci modulate the QT interval duration in the QTSCD Study. Nat. Genet. 2009, 41:407-414.
32. Qian L., Bodmer R. Partial loss of GATA factor Pannier impairs adult heart function in Drosophila. Hum. Mol. Genet. 2009, 18:3153-3163.
33. Qian L., Mohapatra B., Akasaka T., Liu J., Ocorr K., Towbin J.A., Bodmer R. Transcription factor neuromancer/TBX20 is required for cardiac function in Drosophila with implications for human heart disease. Proc. Natl. Acad. Sci. USA 2008, 105:19833-19838.
34. Ray V.M., Dowse H.B. Mutations in and deletions of the Ca2+ channel-encoding gene cacophony, which affect courtship song in Drosophila, have novel effects on heartbeating. J. Neurogenet. 2005, 19:39-56.
35. Rusconi J.C., Challa U. Drosophila Mrityu encodes a BTB/POZ domain-containing protein and is expressed dynamically during development. Int. J. Dev. Biol. 2007, 51:259-263.
36. Sanguinetti M.C., Tristani-Firouzi M. hERG potassium channels and cardiac arrhythmia. Nature 2006, 440:463-469.
37. Sanyal S., Jennings T., Dowse H., Ramaswami M. Conditional mutations in SERCA, the Sarco-endoplasmic reticulum Ca2+-ATPase, alter heart rate and rhythmicity in Drosophila. J. Comp. Physiol. [B] 2006, 176:253-263.
38. Tucker M., Valencia-Sanchez M.A., Staples R.R., Chen J., Denis C.L., Parker R. The transcription factor associated Ccr4 and Caf1 proteins are components of the major cytoplasmic mRNA deadenylase in Saccharomyces cerevisiae. Cell 2001, 104:377-386.
39. Wang Q., Curran M.E., Splawski I., Burn T.C., Millholland J.M., VanRaay T.J., Shen J., Timothy K.W., Vincent G.M., de Jager T., et al. Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias. Nat. Genet. 1996, 12:17-23.
40. Yusuf S., Reddy S., Ounpuu S., Anand S. Global burden of cardiovascular diseases: part I: general considerations, the epidemiologic transition, risk factors, and impact of urbanization. Circulation 2001, 104:2746-2753.