A comparison of noninternalizing (Herkinorin) and internalizing (DAMGO) μ-opioid agonists on cellular markers related to opioid tolerance and dependence

Synapse

Volumn 61, Issue 3, 2007, Pages 166-175

  Xu, Heng ^a   Partilla, John S ^a   Wang, Xiaoying ^a   Rutherford, John M ^a   Tidgewell, Kevin ^b   Prisinzano, Thomas E ^b   Bohn, Laura M ^c   Rothman, Richard B ^a  

^a NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

^b UNIVERSITY OF IOWA   (United States)

^c THE OHIO STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

DAMGO; Dependence; G proteins; Herkinorin; Tolerance

Indexed keywords

BETA ARRESTIN; CELL MARKER; CYCLIC AMP; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; FORSKOLIN; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); HERKINORIN; MU OPIATE RECEPTOR; MU OPIATE RECEPTOR AGONIST; NALOXONE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING ASSAY; CELL CULTURE; CHO CELL; CONTROLLED STUDY; DESENSITIZATION; DRUG RECEPTOR BINDING; GENE EXPRESSION; INTERNALIZATION; LONG TERM EXPOSURE; NONHUMAN; OPIATE ADDICTION; PRIORITY JOURNAL; WESTERN BLOTTING;

ANALGESICS, OPIOID; ANIMALS; BINDING, COMPETITIVE; CELL MEMBRANE; CHO CELLS; CRICETINAE; CRICETULUS; CYCLIC AMP; DRUG TOLERANCE; ENDOCYTOSIS; ENKEPHALIN, ALA(2)-MEPHE(4)-GLY(5)-; FORSKOLIN; FURANS; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); HUMANS; NARCOTIC ANTAGONISTS; OPIOID-RELATED DISORDERS; PYRONES; RADIOLIGAND ASSAY; RECEPTORS, OPIOID, MU;

EID: 33846251929     PISSN: 08874476     EISSN: 10982396     Source Type: Journal    
DOI: 10.1002/syn.20356     Document Type: Article

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