A screen for new trithorax group genes identified little imaginal discs, the Drosophila melanogaster homologue of human retinoblastoma binding protein 2

Genetics

Volumn 156, Issue 2, 2000, Pages 645-663

  Gildea, John J ^a,b   Lopez, Rocio ^a,c   Shearn, Allen ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

^c Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; GENE PRODUCT; LITTLE IMAGINAL DISC PROTEIN; POLYCOMB PROTEIN; RETINOBLASTOMA BINDING PROTEIN 2; RETINOBLASTOMA PROTEIN; TRITHORAX PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CHROMATIN STRUCTURE; CONTROLLED STUDY; DROSOPHILA MELANOGASTER; GENE EXPRESSION; GENETIC CONSERVATION; HOMEOBOX; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL;

ANIMALS; CARRIER PROTEINS; CHROMATIN; CROSSES, GENETIC; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; FEMALE; GENES, HOMEOBOX; GENES, LETHAL; GENOTYPE; HUMANS; INSECT PROTEINS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; REPRESSOR PROTEINS; RETINOBLASTOMA PROTEIN; SUPPRESSION, GENETIC; THORAX; TRANSCRIPTION, GENETIC; TUMOR SUPPRESSOR PROTEINS;

EID: 0033786540     PISSN: 00166731     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (106)

1. The PHD finger: Implications for chromatin mediated transcriptional regulation
2. Molecular genetic analysis of the absent, small or homeotic imaginal discs2 (ash2) gene of Drosophila melanogaster
3. Genetic interactions of the Suppressor 2 of zeste region genes
4. The molecular basis for metameric pattern in the Drosophila embryo
5. An autoregulatory enhancer element of Drosophila homeotic gene Deformed
6. Maternal expression of genes that regulate the Bithorax complex of Drosophila melanogaster
7. Maternal expression of genes that regulate the Bithorax complex of Drosophila melanogaster
8. Trithorax regulates multiple homeotic genes in the bithorax and Antennapedia complexes and exerts different tissue-specific, parasegment-specific and promoter-specific effects on each
9. Molecular characterization of the trithorax gene, a positive regulator of homeotic gene expression in Drosophila
10. Retinoblastoma protein recruits histone deacetylase to repress transcription
11. Requirements for dE2F function in proliferating cells and in post-mitotic differentiating cells
12. The Drosophila Polycomb group gene pleiohomeotic encodes a DNA binding protein with homology to the transcription factor YY1
13. Drosophila genes Posterior Sex Combx and Suppressor two of zeste encode proteins with homology to the murine bmi-1 oncogene
14. Ectopic expression of homeotic genes caused by the elimination of the Polycomb gene in Drosophila imaginal epidermis
15. A multisubunit complex containing the SWI1/ADR6, SWI2/SNF2, SWI3, SNF5, and SNF6 gene products isolated from yeast
16. Genetic interactions and dosage effects of Polycomb group genes of Drosophila
17. Genes involved in the activation of the bithorax complex of Drosophila
18. The Drosophila Enhancer of zeste gene encodes a chromosomal protein: Examination of wild-type and mutant protein distribution
19. The localization and regulation of Antennapedia protein expression in Drosophila embryos
20. Imaginal disc development
21. Osa associates with the Brahma chromatin remodeling complex and promotes the activation of some target genes
22. The trithorax group gene moira encodes a Brahma-associated putative chromatin remodeling factor in Drosophila
23. Cloning of cDNAs for cellular proteins that bind to the retinoblastoma gene product
24. The Drosophila snr1 and brm proteins are related to yeast SWI/SNF proteins and are components of a large protein complex
25. The localization and regulation of Antennapedia protein expression in Drosophila embryos
26. P transposon-induced dominant enhancer mutations of position effect variegation in Drosophila melanogaster
27. RBF, a novel RB-related gene that regulates E2F activity and interacts with cyclin E in Drosophila
28. Ectopic expression of dE2F and dDP induces cell proliferation and death in the Drosophila eye
29. The retinoblastoma protein and BRG1 form a complex and cooperate to induce cell cycle arrest
30. Polycomblike: A gene that appears to be required for the normal expression of the bithorax and Antennapedia gene complexes of Drosophila melanogaster
31. A complex genetic locus, polyhomeotic, is required for segmental specification and epidermal development in D. melanogaster
32. The amino-terminal region of the retinoblastoma gene product binds a novel nuclear matrix protein that co-localizes to centers for RNA processing
33. Genetic analysis of brahma: The Drosophila homolog of the yeast chromatin remodeling factor SWI2/SNF2
34. The trithorax-like gene encodes the Drosophila GAGA factor
35. Characterization of the retinoblastoma binding proteins RBP1 and RBP2
36. Polycomb and polyhomeotic are constituents of a multimeric protein complex in chromatin of Drosophila
37. Etude genetique et physiologique du mutant z de Drosophila melanogaster
38. The phenotype of mes-2, mes-3, mes-4 and mes-6, maternal-effect genes required for survival of the germline in Caenorhabditis elegans, is sensitive to chromosome dosage
39. Polycomb and trithorax group proteins mediate the function of a chromatin insulator
40. Novel embryonic and adult homeotic phenotypes are produced by pleiohomeotic mutations in Drosophila
41. A Polycomb-group gene regulates homeotic gene expression in Arabidopsis
42. Connectin, a target of homeotic gene control in Drosophila
43. Yeast Gcn5 functions in two multisubunit complexes to acetylate nucleosomal histones: Characterization of an Ada complex and the SAGA (Spt/Ada) complex
44. Regulation of Antennapedia transcript distribution by the bithorax complex in Drosophila
45. The immunoglobulin heavy-chain matrix-associating regions are bound by Bright: A B cell-specific trans-activator that describes a new DNA-binding protein family
46. A gene that regulates the bithorax complex differentially in larval and adult cells of Drosophila
47. Trithorax: A new homeotic mutation of Drosophila melanogaster causing transformation of abdominal and thoracic imaginal segments. I. Putative role during embryogenesis
48. Allelic pairing and gene regulation: A model for the zeste-white interaction in Drosophila melanogaster
49. Genetic analysis of the Enhancer of zeste locus and its role in gene regulation in Drosophila melanogaster
50. The Drosophila Polycombgroup gene Enhancer of zeste shares a domain of sequence similarity with trithorax
51. The Drosophila esc and E(z) proteins are direct partners in Polycomb group-mediated repression
52. A group of genes controlling the spatial expression of the bithorax complex in Drosophila
53. Changes of zeste phenotype induced by autosomal mutations in Drosophila melanogaster
54. Dosage-dependent modifiers of Polycomb and Antennapedia mutations in Drosophila
55. Trans-regulation of homeotic genes in Drosophila
56. Differential specificity for binding of retinoblastoma binding protein 2 to RB, p107, and TATA-binding protein
57. The Drosophila Polycomb group protein Psc contacts ph and Pc through specific conserved domains
58. The SAM domain of polyhomeotic, RAE28, and Scm mediates specific interactions through conserved residues
59. Trans-regulation of thoracic homeotic selector genes of the Antennapedia and bithorax complexes by the trithorax group genes: Absent, small, and homeotic discs 1 and 2
60. E(z): A polycomb group gene or a trithorax group gene?
61. The Minute genes in Drosophila and their molecular functions
62. Genetic control of developmental pathways in Drosophila melanogaster
63. A gene complex controlling segmentation in Drosophila
64. The Genome of Drosophila melanogaster
65. DNA binding within the nucleosome core
66. Rb interacts with histone deacetylase to repress transcription
67. Retinoblastoma protein represses transcription by recruiting a histone deacetylase
68. The retinoblastoma gene product is a cell cycle-dependent, nuclear matrix-associated protein
69. Genetic and molecular analysis of hyperplastic discs, a gene whose product is required for regulation of cell proliferation in Drosophila melanogaster imaginal discs and germ cells
70. The trithorax gene, a trans-acting regulator of the bithorax complex in Drosophila, encodes a protein with zinc-binding domains
71. Mapping Polycomb-repressed domains in the bithorax complex using in vivo formaldehyde crosslinked chromatin
72. The Drosophila trithorax group proteins BRM, ASH1, and ASH2 are subunits of distinct protein complexes
73. Mutations in polycombeotic, a gene of the Polycomb set of Drosophila melanogaster, cause a wide range of maternal and zygotic phenotypes
74. Cloning Drosophila genes
75. Mode of action of a homoeotic gene in Drosophila melanogaster: Localization and dosage effects of Polycomb
76. Related chromosome binding sites for zeste, suppressors of zeste and Polycomb group proteins in Drosophila and their dependence on Enhancer of zeste function
77. A proline-rich region in the Zeste protein is essential for transvection and white repression by Zeste
78. Trithorax and ASH1 interact directly and associate with the trithorax group responsive bxd region of the Ultrabithorax promoter
79. Characterization of a region of the X chromosome of Drosophila including multi sex combs (mxc), a Polycomb group gent which also functions as a rumor suppressor
80. Homeosis in Drosophila: Maternal effect of the Enhancer of Polycomb locus and its interaction with Polycomb and related loci
81. HAT3.1, a novel Arabidopsis homeodomain protein containing a conserved cysteine-rich region
82. Murine Polycomb- and trithorax-group genes regulate homeotic pathways and beyond
83. Position-effect variegation in Drosophila depends on dose of the gene encoding the E2F transcriptional activator and ceil cycle regulator
84. The Drosophila dead ringer gene is required for early embryonic patterning through regulation of argos and buttonhead expression
85. The ash1, ash2 and trithorax genes of Drosophila melanogaster are functionally related
86. Imaginal disc abnormalities in lethal mutants of Drosophila
87. Genetic studies of mutations at two loci of Drosophila melanogaster which cause a wide variety of homeotic transformations
88. Locking in stable states of gene expression: Transcriptional control during Drosophila development
89. Ten different Polycomb group genes are required for spatial control of the abdA and AbdB homeotic products
90. The Additional sex combs gene of Drosophila encodes a chromatin protein that binds to shared and unique Polycomb group sites on polytene chromosomes
91. Genetic analysis of the additional sex combs locus of Drosophila melanogaster
92. A role for retinoblastoma protein in potentiating transcriptional activation by the glucocorticoid receptor
93. The Drosophila trithorax proteins contain a novel variant of the nuclear receptor type DNA binding domain and an ancient conserved motif found in other chromosomal proteins
94. A gene product required for correct initiation of segmental determination in Drosophila
95. Role of the esc+ gene product in ensuring the selective expression of segment specific homeotic genes in Drosophila
96. The Polycomb group protein complex of Drosophila melanogaster has different compositions at different target genes
97. Co-localization of Polycomb protein and GAGA factor on regulatory elements responsible for the maintenance of homeotic gene expression
98. The Drosophila Polycomb group proteins ESC and E(Z) bind directly to each other and co-localize at multiple chromosomal sites
99. The expression of the Drosophila awd gene during normal development and in neoplastic brain tumors caused by lgl mutations
100. Molecular genetic analysis of the Drosophila melanogaster gene absent, small or homeotic discs1 (ash1)
101. The Drosophila ash1 gene gene product which is localized at specific sites on polytene chromosome contains a SET domain and a PHD finger
102. The trithorax group gene osa encodes an ARID-domain protein that genetically interacts with the brahma chromatin-remodeling factor to regulate transcription
103. Spatial regulation of Antennapedia and bithorax gene expression by the Polycomb locus of Drosophila
104. Homeosis and the interaction of zeste and white in Drosophila