Frequent HIN-1 promoter methylation and lack of expression in multiple human tumor types

Molecular Cancer Research

Volumn 2, Issue 9, 2004, Pages 489-494

  Krop, Ian ^a   Player, Audrey ^b   Tablante, Ana ^a   Taylor Parker, Michele ^a   Lahti Domenici, Jaana ^a   Fukuoka, Junya ^b   Batra, Surinder K ^c   Papadopoulos, Nickolas ^d   Richards, William G ^a   Sugarbaker, David J ^a   Wright, Renée L ^a   Shim, Judy ^a   Stamey, Thomas A ^e   Sellers, William R ^a   Loda, Massimo ^a   Meyerson, Matthew ^a   Hruban, Ralph ^f   Jen, Jin ^b   Polyak, Kornelia ^a,g  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^d Och Spine at New York Presbyterian Hospitals   (United States)

^e STANFORD UNIVERSITY   (United States)

^f JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^g DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BREAST CARCINOGENESIS; BREAST CARCINOMA; CANCER GENETICS; CELL DIFFERENTIATION; CONTROLLED STUDY; CORRELATION ANALYSIS; GENE; GENE EXPRESSION; GENE FUNCTION; GENE IDENTIFICATION; GENE SILENCING; HIN 1 GENE; HUMAN; HUMAN CELL; HUMAN TISSUE; LUNG CARCINOGENESIS; LUNG CARCINOMA; LUNG LAVAGE; LUNG SMALL CELL CANCER; METHYLATION; PANCREAS CARCINOMA; PLASMA; PRIORITY JOURNAL; PROMOTER REGION; PROSTATE CARCINOMA; SALIVA; SERUM; SQUAMOUS CELL CARCINOMA;

BODY FLUIDS; CELL LINE, TUMOR; CYTOKINES; DNA METHYLATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LUNG; LUNG NEOPLASMS; MALE; NEOPLASMS; PANCREAS; PANCREATIC NEOPLASMS; PROMOTER REGIONS (GENETICS); PROSTATE; PROSTATIC NEOPLASMS; TUMOR SUPPRESSOR PROTEINS;

EID: 4644317592     PISSN: 15417786     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Krop IE, Sgroi D, Porter DA, et al. HIN-1, a putative cytokine highly expressed in normal but not cancerous mammary epithelial cells. Proc Natl Acad Sci U S A 2001;98:9796-801.
2. Wong TS, Kwong DL, Sham JS, et al. Promoter hypermethylation of high-in-normal 1 gene in primary nasopharyngeal carcinoma. Clin Cancer Res 2003;9:3042-6.
3. Porter D, Lahti-Domenici J, Torres-Arzayus M, Chin L, Polyak K. Expression of high in normal-1 (HIN-1) and uteroglobin related protein-1 (UGRP-1) in adult and developing tissues. Mech Dev 2002;114:201-4.
4. Niimi T, Keek-Waggoner CL, Popescu NC, Zhou Y, Levitt RC, Kimura S. UGRPI, a uteroglobin/Clara cell secretory protein-related protein, is a novel lung-enriched downstream target gene for the T/EBP/NKX2.1 homeodomain transcription factor. Mol Endocrinol 2001;15:2021-36.
5. Minoo P, Su G, Drum H, Bringas P, Kimura S. Defects in tracheoesophageal and lung morphogenesis in Nkx2.1(-/-) mouse embryos. Dev Biol 1999;209:60-71.
6. Niimi T, Copeland NG, Gilbert DJ, et al. Cloning, expression, and chromosomal localization of the mouse gene (Scgb3a1, alias Ugrp2) that encodes a member of the novel uteroglobin-related protein gene family. Cytogenet Genome Res 2002;97:120-7.
7. Warburton D, Schwarz M, Tefft D, Flores-Delgado G, Anderson KD, Cardoso WV. The molecular basis of lung morphogenesis. Mech Dev 2000;92:55-81.
8. Marchetti A, Barassi F, Martella C, et al. Down regulation of high in normal-1 (HIN-1) is a frequent event in stage I non-small cell lung cancer and correlates with poor clinical outcome. Clin Cancer Res 2004;10:1338-43.
9. Fujii T, Dracheva T, Player A, et al. A preliminary transcriptome map of non-small cell lung cancer. Cancer Res 2002;62:3340-6.
10. Garber ME, Troyanskaya OG, Schluens K, et al. Diversity of gene expression in adenocarcinoma of the lung. Proc Natl Acad Sci U S A 2001;98:13784-9.
11. Bhattacharjee A, Richards WG, Staunton J, et al. Classification of human lung carcinomas by mRNA expression profiling reveals distinct adenocarcinoma subclasses. Proc Natl Acad Sci U S A 2001;98:13790-5.
12. Zochbauer-Muller S, Gazdar AF, Minna JD. Molecular pathogenesis of lung cancer. Annu Rev Physiol 2002;64:681-708.
13. Edwards BK, Howe HL, Ries LA, et al. Annual report to the nation on the status of cancer, 1973-1999, featuring implications of age and aging on U.S. cancer burden. Cancer 2002;94:2766-92.
14. Ross JA, Rosen GD. The molecular biology of lung cancer. Curr Opin Pulm Med 2002;8:265-9.
15. Herman JG, Graff JR, Myohanen S, Nelkin BD, Baylin SB. Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands. Proc Natl Acad Sci U S A 1996;93:9821-6.
16. Suzuki H, Watkins DN, Jair KW, et al. Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer. Nat Genet 2004;36:417-22.
17. Fackler MJ, McVeigh M, Mehrotra J, et al. Quantitative multiplex methylation-specific PCR assay for the detection of promoter hypermethylation in multiple genes in breast cancer. Cancer Res 2004;64:4442-52.
18. Toyooka S, Toyooka KO, Maruyama R, et al. DNA methylation profiles of lung rumors. Mol Cancer Ther 2001;1:61-7.
19. Adorjan P, Distler J, Lipscher E, et al. Tumor class prediction and discovery by microarray-based DNA methylation analysis. Nucleic Acids Res 2002;30:e21.
20. St Croix B, Rago C, Velculescu V, et al. Genes expressed in human tumor endothelium. Science 2000;289:1197-202.