Epidermal growth factor receptor expression correlates with poor prognosis in non-small cell lung cancer patients with p53 overexpression

Oncology Reports

Volumn 7, Issue 3, 2000, Pages 603-607

  Ohsaki, Yoshinobu ^a   Tanno, Sachie ^a   Fujita, Yuka ^a   Toyoshima, Eri ^a   Fujiuchi, Satoru ^a   Nishigaki, Yutaka ^a   Ishida, Sakae ^b   Nagase, Atsushi ^a   Miyokawa, Naoyuki ^a   Hirata, Satoshi ^a   Kikuchi, Kenjiro ^a  

^a ASAHIKAWA MEDICAL COLLEGE   (Japan)

^b HOKKAIDO MEDICAL CENTER   (Japan)

Author keywords

Epidermal growth factor receptor; Immunohistochemistry; Non small cell lung cancer; Survival time

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; PROTEIN P53;

ADENOCARCINOMA; ARTICLE; CANCER STAGING; FEMALE; FOLLOW UP; HUMAN; LARGE CELL CARCINOMA; LUNG NON SMALL CELL CANCER; LUNG TUMOR; MALE; MIDDLE AGED; MORTALITY; PATHOLOGY; PREDICTION AND FORECASTING; PROGNOSIS; RETROSPECTIVE STUDY; SQUAMOUS CELL CARCINOMA; SURVIVAL RATE; TIME; TUMOR SUPPRESSOR GENE;

ADENOCARCINOMA; CARCINOMA, LARGE CELL; CARCINOMA, NON-SMALL-CELL LUNG; CARCINOMA, SQUAMOUS CELL; FEMALE; FOLLOW-UP STUDIES; GENES, P53; HUMANS; LUNG NEOPLASMS; MALE; MIDDLE AGED; NEOPLASM STAGING; PREDICTIVE VALUE OF TESTS; PROGNOSIS; RECEPTOR, EPIDERMAL GROWTH FACTOR; RETROSPECTIVE STUDIES; SURVIVAL RATE; TIME FACTORS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 18744434862     PISSN: 1021335X     EISSN: None     Source Type: Journal    
DOI: 10.3892/or.7.3.603     Document Type: Article

References (31)

1. Takahashi T, Nau MM, Chiba I, Birrer M, Rosenberg R, Vinocour M, Levitt M, Pass H, Gazdar AF and Minna JD: p53: a frequent target for genetic abnormalities in lung cancer. Science 246: 491-494, 1989.
2. Mitsudomi T, Steinberg SM, Nau MM, Carbone D, D'Amico D, Bonder S, Oie HK, Linnoila RI, Mulshine JL, Minna JD and Gazdar AF: p53 gene mutations in non-small cell lung cancer cell lines and their correlation with the presence of ras mutations and clinical features. Oncogene 7: 171-180, 1992.
3. Horowitz JM, Park SH, Bogenmann E, Cheng JC, Yandell DW, Kaye FJ, Minna JD, Dryja TP and Weinberg RA: Frequent inactivation of the retinoblastoma anti-oncogene is restricted to subset of a human tumor cells. Proc Natl Acad Sci USA 87: 2774-2779, 1990.
4. Chang F, Syrjanen S and Syrjanen K: Implications of the p53 tumor-suppressor gene in clinical oncology. J Clin Oncol 13: 1009-1022, 1995.
5. Steinman RA, Hoffman B, Iro A, Guillout C, Liebermann DA and El-Houseini ME: Induction of p21 (WAF1/CIP1) during differentiation. Oncogene 9: 3389-3396, 1994.
6. Lowe SW, Schmitt EM, Smith SW, Osborne BA and Jacks T: p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature 362: 847-849, 1993.
7. Kastan MB, Zhan Q, El-Deiry WS, Carrier F, Jacks T, Walsh WV, Plunkett BS, Vogelstein B and Fornace AJJ: A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia. Cell 71: 587-597, 1992.
8. Carney DN, Cuttitta F, Moody TW and Minna JD: Selective stimulation of small cell lung cancer clonal growth by bombesin and gastrin-releasing peptide. Cancer Res 47: 821-825, 1987.
9. Chen SC, Chou CK, Wong FH, Chang CM and Hu CP: Overexpression of epidermal growth factor and insulin-like growth factor-I receptors and autocrine stimulation in human esophageal carcinoma cells. Cancer Res 51: 1898-1903, 1991.
10. Tateishi M, Ishida T, Mitsudomi T, Kaneko S and Sugimachi K: Immunohistochemical evidence of autocrine growth factors in adenocarcinoma of the human lung. Cancer Res 50: 7077-7080, 1990.
11. Antoniades HN, Galanopoulos T, Neville-Golden J and O'Hara CJ: Malignant epithelial cells in primary human lung carcinomas coexpress in vivo platelet-derived growth factor (PDGF) and PDGF receptor mRNAs and their protein products. Proc Natl Acad Sci USA 89: 3942-3946, 1992.
12. Forsberg K, Bergh J and Westermark B: Expression of functional PDGF β receptors in a human large-cell lung-carcinoma cell line. Int J Cancer 53: 556-560, 1993.
13. Sausville EA, Lebacq-Verheyden AM, Spindel ER, Cuttitta F, Gazdar AF and Battey JF: Expression of the gastrin-releasing peptide gene in human small cell lung cancer: evidence for alternative processing in three distinct mRNAs. J Biol Chem 261: 2451-2457, 1986.
14. Toi M, Nakamura T, Mukaida H, Wada T, Osaki A, Yamada H, Toge T, Niimoto M and Hattori T: Relationship between epidermal growth factor receptor status and various prognostic factors in human breast cancer. Cancer 65: 1980-1984, 1990.
15. Gross ME, Zorbas MA, Danels YJ, Garcia R, Gallick GE, Olive M, Brattain MG, Boman BM and Yeoman LC: Cellular growth response to epidermal growth factor in colon carcinoma cells with an amplified epidermal growth factor receptor derived from a familial adenomatous polyposis patient. Cancer Res 51: 1452-1459, 1991.
16. Hwang DL, Tay YC, Lin SS and Lev RA: Expression of epidermal growth factor receptors in human lung tumors. Cancer 58: 2260-2263, 1986.
17. Kaseda S, Ueda M, Ozawa S, Ishihara T, Abe O and Shimizu N: Expression of epidermal growth factor receptors in four histologic cell types of lung cancer. J Surg Oncol 42: 16-20, 1989.
18. Mukaida H, Toi M, Hirai T, Yamashita Y and Toge T: Clinical significance of the expression of epidermal growth factor and its receptor in esophageal cancer. Cancer 68: 142-148, 1991.
19. Sakai K, Mori S, Kawamoto T, Taniguchi S, Kobori O, Morioka Y, Kuroki T and Kano K: Expression of epidermal growth factor receptors on normal human gastric epithelia and gastric carcinomas. J Natl Cancer Inst 77: 1047-1052, 1986.
20. Reinartz JJ, George E, Lindgren BR and Niehans GA: Expression of p53, transforming growth factor alpha, epidermal growth factor receptor, and c-erbB-2 in endometrial carcinoma and correlation with survival and known predictors of survival. Hum Pathol 25: 1075-1083, 1994.
21. Kristensen GB, Holm R, Abeler VM and Trope CG: Evaluation of the prognostic significance of cathepsin D, epidermal growth factor receptor, and c-erbB-2 in early cervical squamous cell carcinoma. Cancer 78: 433-440, 1996.
22. Iihara K, Shiozaki H, Tahara H, Kobayashi K, Inoue M, Tamura S, Miyata M, Oka H, Doki Y and Mori T: Prognostic significance of transforming growth factor-α in human esophageal carcinoma. Cancer 71: 2902-2909, 1993.
23. Niikura H, Sasano H, Matsunaga G, Watanabe K, Ito K, Sato S and Yajima A: Prognostic value of epidermal growth factor receptor expression in endometrioid endometrial carcinoma. Hum Pathol 26: 892-896, 1995.
24. Thor AD, Moore DH II, Edgerton SM, Kawasaki ES, Reihsaus E, Lynch HT, Marcus JN, Schwartz L, Chen L-C, Mayall BH and Smith HS: Accumulation of p53 tumor suppressor gene protein: an independent marker of prognosis in breast cancers. J Natl Cancer Inst 84: 845-855, 1992.
25. Quinlan DC, Davidson AG, Summers CL, Warden HE and Doshi HM: Accumulation of p53 protein correlates with a poor prognosis in human lung cancer. Cancer Res 52: 4828-4831, 1992.
26. Visakorpi T, Kallioniemi O-P, Heikkinen A, Koivula T and Isalo J: Small subgroup of aggressive highly proliferative prostatic carcinomas defined by p53 accumulation. J Natl Cancer Inst 84: 883-887, 1992.
27. Nishio M, Koshikawa T, Kuroishi T, Suyama M, Uchida K, Takagi Y, Washimi O, Sugiura T, Ariyoshi Y, Takahashi T, Ueda R and Takahashi T: Prognostic significance of abnormal p53 accumulation in primary, resected non-small-cell lung cancers. J Clin Oncol 14: 497-502, 1996.
28. Ohsaki Y, Toyoshima E, Fujiuchi S, Matsui H, Hirata S, Miyokawa N, Kubo Y and Kikuchi K: bcl-2 and p53 protein expression in non-small cell lung cancers: correlation with survival time. Clin Cancer Res 2: 915-920, 1996.
29. Harris CC and Hollstein M: Clinical implication of the p53 tumor-suppressor gene. N Engl J Med 329: 1318-1327, 1993.
30. Davidoff AM, Humphrey PA, Iglehart JD and Marks JR: Genetic basis for p53 overexpression in human breast cancer. Proc Natl Acad Sci USA 88: 5006-5010, 1991.
31. Bartek J, Bartkova J, Vojtesek B, Staskova Z, Rejthar A, Kovarik J and Lane DP: Patterns of expression of the p53 tumour suppressor in human breast tissues and tumours in situ and in vitro. Int J Cancer 46: 839-844, 1990.