Thymic function in HIV-1 disease

Seminars in Immunology

Volumn 9, Issue 6, 1997, Pages 397-404

  McCune, Joseph M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Adult; HIV 1; Pathology; Rebound; Thymus

Indexed keywords

HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LYMPHOCYTE DEPLETION; PATHOPHYSIOLOGY; REVIEW; THYMUS;

EID: 0031449498     PISSN: 10445323     EISSN: None     Source Type: Journal    
DOI: 10.1006/smim.1997.0098     Document Type: Article

References (107)

1. 1. Perelson AA, Neumann AU, Markowitz M, Leonard JM, Ho DD (1996) HIV-1 dynamics in vivo: Virion clearance rate, infected cell life-span and viral generation time. Science 271:1582-1586
2. 2. Perelson AS, Essunger P, Cao Y, Vesanen M, Hurley A, Saksela K, Markowitz M, Ho D (1997) Decay characteristics of HIV-1-infected compartments during combination therapy. Nature 387:188-191
3. 3. Ho DD, Neumann AU, Perelson AS, Chen W, Leonard JM, Markowitz M (1995) Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection. Nature 373:123-126
4. 4. Wei X, Ghosh SK, Taylor ME, Johnson VA, Emini EA, Deutsch P, Lifson JD, Bonhoeffer S, Nowak MA, Hahn BA, Saag MS, Shaw GM (1995) Viral dynamics in human immunodeficiency virus type 1 infection. Nature 373:117-122
5. 5. Coffin JM (1995) HIV population dynamics in vivo: implications for genetic variation, pathogenesis, and therapy. Science 267:483-489
6. 6. McCune JM (1995) Viral latency in HIV disease. Cell 82:183-188
7. 7. Wain-Hobson S (1995) Virological mayhem. Nature 373:102
8. 8. Trepel F (1974) Number and distribution of lymphocytes in man. A critical analysis. Klin Wschr 52:511-515
9. 9. Mackall CL, Hakim FT, Gress RE (1997) T-cell regeneration: all repertoires are not created equal. Immunol Today 18:245-251
10. 10. von Gaudecker B (1991) Functional histology of the human thymus. Anat Embryol 183:1-15
11. 11. Joshi VV, Oleske JM (1985) Pathologic appraisal of the thymus gland in acquired immunodeficiency syndrome in children. Arch Pathol Lab Med 109:142-146
12. 12. Joshi W, Oleske JM, Saad S, Gadol C, Connor E, Bobila R, Minnefor AB (1986) Thymus biopsy in children with acquired immunodeficiency syndrome. Arch Pathol Lab Med 110:837-842
13. 13. Joshi VV, Oleske JM, Connor EM (1990) Morphologic findings in children with acquired immune deficiency syndrome: pathogenesis and clinical implications. Pediatr Pathol 10:155-165
14. 14. Burke AP, Anderson D, Ben son W, Turnicky R, Mann an P, Liang YH, Smialek J, Virmani R (1995) Localization of human immunodeficiency virus 1 RNA in thymic tissues from asymptomatic drug addicts. Arch Pathol Lab Med 119:3641
15. 15. Prevot S, Audouin J, Andre-Bougaran J, Griffais R, Le Tourneau A, Fournier JG, Diebold J (1992) Thymic pseudo-tumorous enlargement due to follicular hyperplasia in a human immunodeficiency virus seropositive patient. Immunohistochemical and molecular biological study of viral infected cells. Am J Clin Pathol 97:420-425
16. 16. Davis AEJ (1984) The histopathological changes in the thymus gland in the acquired immune deficiency syndrome. Annal NY Acad Sci 437:493-502
17. 17. Grody WW, Fligiel S, Naeim F (1985) Thymus involution in the acquired immunodeficiency syndrome. Am J Clin Pathol 84:85-95
18. 18. Linder J (1987) The thymus gland in secondary immunodeficiency. Arch Pathol Lab Med 111:1118-1122
19. 19. Savino W, Dardenne M, Marche C, Trophilme D, Dupuy J-M, Pekovic D, Lapointe N, Bach JF (1986) Thymic epithelium in AIDS. An immunohistologic study. Am J Pathol 122:302-307
20. 20. Schuurman HJ, Krone WJA, Broekhuizen R, van Baarlen J, van Veen P, Goldstein AL, Huber J, Goudsmit J (1989) The thymus in acquired immune deficiency syndrome: Comparison with other types of immunodeficiency disease and presence of components of human immunodeficiency virus type 1. Am J Pathol 134:1329-1334
21. 21. Seemayer TA, Laroche AC, Russo P, Malebranche R, Arnoux E, Geurin J-M, Pierre G, Dupuy J-M, Gartner JG, Lapp WS, Spira TJ, Elie R (1984) Precocious thymic involution manifest by epithelial injury in the acquired immune deficiency syndrome. Hum Pathol 15:469-474
22. 22. Pekovic DD, GornitskyM, Ajdukovic D, Dupuy J-M, Chausseau J-P, Michaud J, Lapointe N, Gilmore N, Tsoukas C, Zwadlo G, Popovic M (1987) Pathogenicity of HIV in lymphatic organs of patients with AIDS. J Pathol 152:31-35
23. 23. Jovaisas E, Koch MA, Schafer A, Stauber M, Lowenthal D (1985) LAV/ HTLV-III in 20-week fetus. Lancet 2:1129
24. 24. De Rossi A, Calabro ML, Panozzo M, Bernardi D, Caruso B, Tridente C, Chieco-Bianchi L (1990) In vitro studies of HIV-1 infection in thymic lymphocytes: A putative role of the thymus in AIDS pathogenesis. AIDS Res Hum Retroviruses 6:287-298
25. 25. Tremblay M, Numazaki K, Goldman H, Wainberg MA (1990) Infection of human thymic lymphocytes by HIV-1. AIDS 3:356-360
26. 26. Hays EF, Uittenbogaart CH, Brewer JC, Vollger LW, Zack JA (1992) In vitro studies of HIV-1 expression in thymocytes from infants and children. AIDS 6:265-272
27. 27. Calabro JL, Zanotto C, Calderazzo F, Crivellaro C, del Mistro A, de Rossi A, Chieco-Bianchi L (1995) HIV-1 infection of the thymus: evidence for a cytopathic and thymotropic viral variant in vivo. AIDS Res Hum Retro 11:11-19
28. 28. Numazaki K, Bai QX, Goldman H, Wong I, Spira B, Wainberg MA (1989) Infection of cultured human thymic epithelial cells by human immunodeficiency virus. Clin Immunol Immunopathol 51:185-195
29. 29. Stanley SK, McCune JM, Kaneshima H, Justement JS, Sullivan M, Boone E, Baselar M, Adelsberger J, Bonyhadi M, Orenstein J, Fox CH, Fauci AS (1993) Human immunodeficiency virus (HIV)-related damage to the human thymus: HIV infects thymocyte subsets and thymic epithelial cells in human thymus xenografts in the SCID-hu mouse. J Exp Med 178:1151-1163
30. 30. Autran B, Guiet P, Raphael M, Grandadam M, Agut H, Candotti D, Grenot P, Puech F, Debre P, Cesbron J-Y (1996) Thymucyte and thymic microenvironment alterations during a systemic HIV infection in a severe combined immunodeficient mouse model. AIDS 10:717-727
31. 31. Schnittman SM, Singer KH, Greenhouse JJ, Stanley SK, Whichard LP, Haynes BF, Fauci AS (1991) Thymic microenvironment induces HIV expression. Physiologic secretion of IL-6 by thymic epithelial cells up-regulates virus expression in chronically infected cells. J Immunol 147:2553-2558
32. 32. Braun J, Valentin H, Nugeyre M-T, Ohayon H, Gounon P, Barre-Sinoussi F (1996) Productive and persistent infection of human thymic epithelial cells in vitro with HIV-1. Virology 225:413-418
33. 33. Baskin GB, Murphey-Corb M, Martin LN, Davison-Fairburn B, Hu FS, Kuebler D (1991) Thymus in simian immunodeficiency virus-infected rhesus monkeys. Lab Invest 65:400-407
34. + T cells and AIDS in pig-tailed macaques. J Virol 70:3189-3197
35. 35. Li S-L, Kaaya EE, Ordonez C, Ekman E, Feichtinger H, Putkonen P, Bottiger D, Biberfeld G, Biberfeld P (1995) Thymic immunopathology and progression of SIVsm infection in cynomolgus monkeys. JAIDS 9:1-10
36. 36. Beebe AM, Dua N, Faith TG, Moore PF, Pedersen NC, Dandekar S (1994) Primary stage of feline immunodeficiency virus infection: viral dissemination and cellular targets. J Virol 68:3081-3091
37. 37. Dua N, Reubel G, Moore PF, Higgins J, Pedersen NC (1994) An experimental study of primary feline immunodeficiency virus infection in cats and a historical comparison to acute simian and human immunodeficiency virus disease. Vet Immunol Immunopathol 43:337-355
38. 38. McCune JM (1996) Development and applications of the SCID-hu mouse model. Semin Immunol 8:187-196
39. 39. Namikawa R, Weilbaecher KN, Kaneshima H, Yee EI, McCune JM (1990) Long-term human hematopoiesis in the SCID-hu mouse. J Exp Med 172:1055-1063
40. 40. McCune JM, Namikawa R, Kaneshima H, Shultz LD, Lieberman M, Weissman IL (1988) The SCID-hu mouse: Murine model for the analysis of human hematolymphoid differentiation and function. Science 241:1632-1639
41. 41. Su L, Kaneshima H, Bonyhadi M, Salimi S, Kraft D, Rabin L, McCune JM (1995) HIV-1 induced thymocyte depletion is associated with indirect cytopathicity and infection of progenitor cells in vivo. Immunity 2:25-36
42. 42. Aldrovandi GM, Feuer G, Gao L, Jamieson B, Kristeva M, Chen ISY, Zack JA (1993) The SCID-hu mouse as a model for HIV infection. Nature 363:732-736
43. 43. Bonyhadi ML, Rabin L, Salimi S, Brown DA, Kosek J, McCune JM, Kaneshima H (1993) HIV induces thymus depletion in vivo. Nature 363:728-72
44. 44. Kaneshima H, Su L, Bonyhadi M, Conner R, Ho D, McCune JM (1994) Rap id-high, syncytium-inducing isolates of HIV directly induce cytopathicity in the human thymus of the SCID-hu mouse. J Virol 68:8188-8192
45. 45. Aldrovandi GM, Zack JA (1996) Replication and pathogenicity of human immunodeficiency virus type 1 accessory gene mutants in SCID-hu mice. J Virol 70:1505-1511
46. 46. Jamieson BD, Aldrovandi GM, Planelles V, Jowett JB, Gao L, Bloch LM, Chen IS, Zack JA (1994) Requirement of human immunodeficiency virus type 1 nef for in vivo replication and pathogenicity. J Virol 68:3478-3485
47. 47. Su L, Kaneshima H, Bonyhadi ML, Lee R, Auten J, Du B, Rabin L, Hahn BH, Terwilliger E, McCune JM (1997) Identification of HIV-1 determinants for replication in vivo. Virology 227:45-52
48. 48. Boldt-Houle DM, Jamieson BD, Aldrovandi GM, Rinaldo CRJ, Ehrlich GD, Zack JA (1997) Loss of T cell receptor Vbeta repertoires in HIV type 1-infected SCID-hu mice. AIDS Res Hum Retro 13:125-134
49. 49. Komanduri KV, Salha MD, Sekaly RP, McCune JM (1997) Superantigen-mediated deletion of specific T cell receptor V beta subsets in the SCID-hu Thy/ Liv mouse is induced by staphylococcal enterotoxin B, but not HIV-1. J Immunol 158:544-549
50. 50. Moretta L, Mingari MC, Webb SR, Pearl ER, Lydyard PM, Grossi CE, Lawton AR, Cooper MD (1997) Imbalances in T cell subpopulations associated with immunodeficiency and autoimmune syndromes. Eur J Immunol 7:696-700
51. 51. Rubinstein A, Pelet B, Schweizer V (1975) Immunological decay in thymectomized infants. Helv Paediat Acta 30:425-433
52. 52. Brearley S, Gentle TA, Baynham MID, Roberts KD, Abrams LD, Thompson RA (1987) Immunodeficiency following neonatal thymectomyin man. Clin Exp Immunol 70:322-327
53. 53. McCune JM (1991) HIV-1: The infective process in vivo. Cell 64:351-363
54. 54. European Collaborative Study (1991) Children born to women with HIV-1 infection: natural history and risk of transmission. Lancet 337:353-360
55. 55. Auger I, Thomas P, DeGruttola V, Morse D, Moore D, Williams R, Truman B, Lawrence CE (1988) Incubation periods for paediatric AIDS patients. Nature 336:575-577
56. 56. Kourtis AP, Ibegbu C, Nahmias AJ, Lee FK, Clark WS, Sawyer MK, Nesheim S (1996) Early progression of disease in HIV-infected infants with thymus dysfunction. N Engl J Med 335:431-436
57. 57. Meyers A, Pepe N, Cranley W, McCarten K (1992) Decreased thymus size on chest radiography: A sign of pediatric human immunodeficiency virus infection?. Pediatrics 90:99-102
58. 58. Bratton AB, Cantab MB (1925) The normal weight of the human thymus. J Pathol Bacteriol 28:609-620
59. 59. Hammar JA (1921) The new views as to the morphology of the thymus gland and their bearing on the problem of the function of the thymus. Endocrinology 5:543-573, 731-760
60. 60. Boyd E (1932) The weight of the thymus gland in health and in disease. Am J Dis Child 43:1162-1214
61. 61. Boyd E (1927) Growth of the thymus. Its relation to status thymicolymphaticus and thymic symptoms. Am J Dis Child 33:867-879
62. 62. Greenwood M, Woods HM (1927) 'Status thymico-lymph aticus' considered in the light of recent work on the thymus. J Hyg 26:305-326
63. 63. Steinmann GG, Klaus B, Muller-Hermelink H-K (1985) The involution of the ageing human thymic epithelium is independent of puberty. Amorphometric study. Scand J Immunol 22:563-575
64. 64. Steinmann GG (1986) Changes in the human thymus during aging, in The Human Thymus -Histopathology and Pathology (Muller-Hermelink HK, ed). Springer, Newark, pp. 43-88
65. 65. Moore AV, Korobkin M, Olanow W, Heaston DK, Ram PC, Dunnick NR, Silverman PM (1983) Age-related changes in the thymus gland: CT-pathologic correlation. AJR 141:241-246
66. 66. Francis IR, Glazer GM, Bookstein FL, Gross BH (1985) The thymus: Reexamination of age-related changes in size and shape. AJR 145:249-254
67. 67. Dixon AK, Hilton CJ, Williams GT (1981) Computed tomography and histological correlation of the thymic remnant. Clin Radiol 32:255-257
68. 68. Haagensen DC, Lane N, Lattes R (1972) Neoplastic proliferation of the epithelium of the mammary lobules of adenosis, lobular neoplasia, and small cell carcinoma. Surg Clin North Am 52:497-524
69. 69. Kendall MD, Johnson HRM, Singh J (1980) The weight of the human thymus gland at necrospy. J Anat 131:485-499
70. 70. Metcalf D (1963) The autonomous behaviour of normal thymus grafts. Aust J Exp Biol 41:437-448
71. 71. Metcalf D, Sparrow N, Nakamura K, Ishidate M (1961) Thebehavior of thymus grafts in high and low leukaemia strains of mice. Austr J Exp Biol 39:441-454
72. 72. Keynes G (1954) The physiology of the thymus gland. Br Med J 1:659-663
73. 73. Muller-Hermelink HK, Steinmann GG (1984), in Age-related alterations of intrathymic microenvironment, in Lymphoid cell functions in ageing (de Weck A.L, ed) pp 75-82. Eurage
74. 74. Muller-Hermelink HK, Steinmann GG, Stein H (1982) Structural and functional alterations of the ageing human thymus. Adv Exp Med Biol 149:303-312
75. 75. Steinmann GG, Muller-Hermelink HK (1984) Immnohistological demonstration of terminal transferase (TdT) in the age-involuted human thymus. Immunobiology 126:45-52
76. 76. Steinmann GG, Muller-Hermelink HK (1984) Lymphocyte differentiation and its microenvironment in human thymus during aging. Monogr Dev Biol 17:142-155
77. 77. Steinmann GG, Klaus G, Gillis S, Muller-Hermelink HK (1984), in Thymic and splenic IL2-production and response during ageing and correlations with immunohistologic studies in Lymphoid cell functions in ageing (de Weck AL, ed) pp 161-168. Eurage
78. 78. Hirokawa K, Kubo S, Utsuyama M, Kurashima C, Sado T (1986) Age-related change in the potential of bone marrow cells to repopulate the thymus and splenic T cells in mice. Cell Immunol 100:443-451
79. 79. Hirokawa K, Utsuyama M, Kasai M (1990) Role of the thymus in ageing of the immune system ageing in Biomedical Advances in Ageing (Goldstein AL, ed) pp 375-384. Plenum Press, New York
80. 80. Hirokawa K (1992) Understanding the mechanism of the age-related decline in immune function. Nutr Rev 50:361-366
81. 81. Hirokawa K, Sato K, Makinodan T (1982) Influence of age of thymic grafts on the differentiation of T cells in nude mice. Clin Immunol Immunopath 24:251-262
82. 82. Scollay R, Shortman K (1985) Cell traffic in the adult thymus: Cell entry and exit, cell birth and death in Recognition and Regulation in Cell-mediated Immunity (Watson JD, Marbrook J, eds) pp 3-30. Marcel Dekker, New York
83. 83. Shortman K, Egerton M, Spangrude GJ, Scollay R (1990) The generation and fate of thymocytes. Semin Immunol 2:3-12
84. 84. Tough DF, Sprent J (1995) Life span of naive and memory T cells. Stem Cells 13:242-249
85. 85. Scollay RG, Butcher EC, Weissman IL (1980) Thymus cell migration. Quantitative aspects of cellular traffic from the thymus to the periphery in mice. Eur J Immunol 10:210-218
86. + T lymphocyte regeneration after intensive chemotherapy. N Engl J Med 332:143
87. 87. Storek J, Witherspoon RP, Storb R (1995) T cell reconstitution after bone marrow transplantation into adult patients does not resemble T cell development in early life. Bone Marrow Transplant 16:413-425
88. 88. Weinberg K, Annett G, Kashyap A, Lenarsky C, Forman SJ, Parkman R (1995) The effect of thymic function on immunocompetence following bone marrow transplantation. Bio Blood Marr Transpl 1:18
89. + T-cell regenerative pathways result in prolonged T-cell subset imbalance after intensive chemotherapy. Blood 89:3700-3707
90. 90. Cohen J, Hill CA, Cangir A, Sullivan MP (1980) Thymic rebound after treatment of childhood tumors. AJR 135:151-156
91. 91. Donahue DM, Leonard JC, Basmadjian GP, Nitschke RM, Hinkle GH, Ice RD, Wilson DA, Tunell WP (1981) Thymic gallium-67 localization in pediatric patients on chemotherapy. J Nucl Med 22:1043-1048
92. 92. Hibi S, Todu S, Imashuku S (1987) Thymic localization of gallium-67 in pediatric patients with lymphoid and non-lymphoid tumors. J Nucl Med 28:293-297
93. 93. Hurst R, Sabio H, Teates CD (1988) Gallium 67 uptake in thymic rebound. South Med J 81:1167-1169
94. 94. Peylan-Ramu N, Haddy TB, Jones E, Horvath K, Addle M, Magreth IT (1989) High frequency of benign mediastinal uptake of gallium-67 after completion of chemotherapy in children with high-grade non-Hodgkin's lymphoma. J Clin Oncol 7:1800-1806
95. 95. Burns DE, Schiffman FJ (1993) Beguiled by the gallium. Thymic rebound in an adult after chemotherapy for Hodgkin's disease. Chest 104:1916-1919
96. 96. Due W, Dieckmann KP, Stein H (1989) Thymic hyperplasia following chemotherapy of a testicular germ cell tumor. Immunohistological evidence for a simple rebound phenomenon. Cancer 63:446-449
97. 97. Miniero R, Busca A, Leonardo E, Mossetti C, Machado D, Vassallo E, Madon E (1993) Rebound thymic hyperplasia following high dose chemotherapy and allogeneic BMT. Bone Marrow Transplant 11:67-70
98. 98. Choyke PL, Zeman RZ, Gootenberg JE, Greenberg JN, Hoffer F, Frank JA (1987) Thymic atrophy and regrowth in response to chemotherapy: CT evaluation. AJR 149:269-272
99. 99. Small EJ, Venook AP, Damon LE (1993) Gallium-avid thymic hyperplasia in an adult after chemotherapy for Hodgkin disease. Cancer 72:905-908
100. 100. Carmossino L, Dibenedetto A, Feffer S (1985) Thymic hyperplasia following successful chemotherapy. Cancer 56:1526-1528
101. 101. Kissin CM, Husband JE, Nicholas D, Eversman W (1987) Benign thymic enlargement in adults after chemotherapy: CT demonstration. Radiology 163:67-70
102. 102. Simmonds P, Silberstein M, McKendrick J (1993) Thymic hyperplasia in adults following chemotherapy for malignancy. Aust New Zealand J Med 23:264-267
103. 103. Tait DM, Goldstraw P, Husband JE (1986) Thymic rebound in an adult following chemotherapy for testicular cancer. Eur J Surg Oncol 12:385-387
104. 104. Doppman JL, Oldfield EH, Chrousos GP, Nieman L, Udelsman R, Cutler GB, Loriaux DL (1986) Rebound thymic hyperplasia after treatment of Cushing's syndrome. AJR 147:1145-1147
105. 105. Tabarin A, Catargi B, Chanson P, Hieronimus S, Corcuff JB, Laurent F, Harter M, Drouillard J, Roger P (1995) Pseudo-tumours of the thymus after correction of hypercortisolism in patients with ectopic ACTH syndrome: a report of five cases. Clin Endocrinol 42:207-213
106. 106. Dameshek W (1951) Some speculations on the myeloproliferative syndromes. Blood 6:372-375
107. 107. Ward HP, Block MH (1971) The natural history of agnogenic myeloid metaplasia (AMM) and a critical evaluation of its relationship with the myeloproliferative syndrome. Medicine 50:357-420