TCR activation of ZAP70 is impaired in CD4+CD8+ thymocytes as a consequence of intrathymic interactions that diminish available P56(lck)

Immunity

Volumn 4, Issue 5, 1996, Pages 495-504

  Wiest, David L ^a,d   Ashe, Jennifer M ^a   Ryo, Abe ^b,e   Bolen, Joseph B ^c   Singer, Alfred ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b NAVAL MEDICAL RESEARCH INSTITUTE   (United States)

^c MERCK RESEARCH LABORATORIES   (United States)

^d FOX CHASE CANCER CENTER   (United States)

^e TOKYO UNIVERSITY OF SCIENCE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; PROTEIN TYROSINE KINASE; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ARTICLE; CALCIUM MOBILIZATION; CELL MATURATION; CONTROLLED STUDY; LYMPHOCYTE DIFFERENTIATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; T LYMPHOCYTE SUBPOPULATION; THYMOCYTE;

EID: 0030152354     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(00)80415-X     Document Type: Article

References (56)

1. fyn. Cell 70, 751-763.
2. + thymic selection in humans lacking ZAP-70. Cell 76, 947-958.
3. Bolen, J.B., Thompson, P.A., Eiseman, E., and Horak, I.D. (1991). Expression and interactions of the Src family of tyrosine kinases. Adv. Cancer Res. 57, 103-149.
4. Borgulya, P., Kishi, H., Muller, U., Kirberg, J., and von Boehmer, H. (1991). Development of the CD4 and CD8 lineage of T cells: instruction versus selection. EMBO J. 10, 913-918.
5. Burkhardt, A., Stealey, B., Rowley, R.B., Mahajan, S., Prendergast, M., Fargnoli, J., and Bolen, J.B. (1994). Temporal regulation of non-transmembrane protein tyrosine kinase enzyme activity following T cell antigen receptor engagement. J. Biol. Chem. 269, 23642-23647.
6. Chan, A.C., Irving, B.A., Fraser, J.D., and Weiss, A. (1991). The zeta chain is associated with a tyrosine kinase and upon T-cell antigen receptor stimulation associates with ZAP-70, a 70-kDa tyrosine phosphoprotein. Proc. Natl. Acad. Sci. USA 88, 9166-9170.
7. Chan, A.C., Iwashima, M., Turck, C.W., and Weiss, A. (1992). ZAP-70, a 70kD protein-tyrosine kinase that associates with the TCR zeta chain. Cell 71, 649-662.
8. Chan, A.C., Desai, D.M., and Weiss, A. (1994). The role of protein-tyrosine kinases and protein-tyrosine phosphatases in T cell antigen receptor signal transduction. Annu. Rev. Immunol. 12, 555-592.
9. Chan, A.C., Dalton, M., Johnson, R., Kong, G.H., Wang, T., Thoma, R., and Kurasaki, T. (1995). Activation of ZAP-70 kinase activity by phosphorylation of tyrosine 493 is required for lymphocyte antigen receptro function. EMBO J. 14, 2499-2508.
10. Chan, S.H., Cosgrove, D., Waltzinger, C., Benoist, C., and Mathis, D. (1993). Another view of the selective model of thymocyte selection. Cell 73, 225-236.
11. Cosgrove, D., Gray, D., Dierich, A., Kaufman, J., Lemeur, M., Benoist, C., and Mathis, D. (1991). Mice lacking MHC class II molecules. Cell 66, 1051-1066.
12. Coulie, P.G., Uyttenhove, C., Wauters, P., Manolios, N., Klausner, R.D., Samelson, L.E., and Van Snick, J. (1991). Identification of a murine monoclonal antibody specific for an allotypic determinant on mouse CD3. Eur. J. Immunol. 21, 1703-1709.
13. Davis, C.B., Killeen, N., Crooks, M.E.C., Raulet, D., and Littman, D.R. (1993). Evidence for a stochastic mechanism in the differentiation of mature subsets of T lymphocytes. Cell 73, 237-247.
14. Dialynas, D.P., Wilde, D.B., Marrack, P., Peirres, A., Wall, K.A., Havran, W., Otten, G., Loken, M.R., Pierres, M., Kappler, J., and Fitch, F.W. (1983). Characterization of the murine antigenic determinant, designated L3T4a, recognized by monoclonal antibody GK1.5, expression of L3T4a by functional T cell clones appears to correlate primarily with class II MHC antigen-reactivity, Immunol. Rev. 74, 29-56.
15. Elder, M.E., Lin, D., Clever, J., Chan, A.C., Hope, T.J., Weiss, A., and Parslow, T.G. (1994). Human severe combined immunodeficiency due to a defect in ZAP-70, a T cell tyrosine kinase. Science 264, 1596-1599.
16. 2+ in response to antigen receptor cross-linking. Nature 330, 179-181.
17. + T cells in major histocompatibility complex class II-deficient mice. Science 253, 1417-1420.
18. + thymocytes. Nature 330, 170-173.
19. Iwashima, M., Irving, B.A., Oers, N.S.C., Chan, A.C., and Weiss, A. (1994). Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases. Science 263, 1136-1139.
20. + thymocytes. Proc. Natl. Acad. Sci. USA 90, 2438-2442.
21. Kolanus, W., Romeo, C., and Seed, B. (1993). T cell activation by clustered tyrosine kinases. Cell 74, 171-183.
22. Kubo, R.T., Born, W., Kappler, J.W., Marrack, P., and Pigeon, M. (1989). Characterization of a monoclonal antibody which detects all murine αβ T cell receptors. J. Immunol. 142, 2736-2742.
23. Ledbetter, J.A., and Herzenberg, L.A. (1979). Xenogeneic monoclonal antibodies to mouse lymphoid differentiation antigens, Immunol. Rev. 47, 63-90.
24. Leo, O., Foo, M., Sachs, D.H., Samelson, L.E., and Bluestone, J.A. (1987). Identification of a monoclonal antibody specific for a murine T3 polypeptide. Proc. Natl. Acad. Sci. USA 84, 1374-1378.
25. Luo, K., and Sefton, B. (1990). Cross-linking of T-cell surface molecules CD4 and CD8 stimulates phosphorylation of the lck tyrosine protein kinase at the autophosphorylation site. Mol. Cell. Biol. 10, 5305-5313.
26. Madrenas, J., Wange, R.L., Wang, J.L., Isakov, N., Samelson, L.E., and Germain, R. (1995). Zeta phosphorylation without ZAP-70 activation induced by TCR antagonists or partial agonists. Science 267, 515-518.
27. Marth, J.D., Peet, R., Krebs, E.G., and Perlmutter, R.M. (1985). A lymphocyte-specific protein tyrosine kinase gene is rearranged and overexpressed in the murine T cell lymphoma LSTRA. Cell 43, 393-404.
28. McCarthy, S.A., Kruisbeek, A.M., Uppenkamp, I.K., Sharrow, S.O., and Singer, A. (1988). Engagement of the CD4 molecule influences cell surface expression of the T-cell receptor on thymocytes. Nature 336, 76-79.
29. lck. Nature 357, 161-164.
30. + thymocytes results in tyrosine phosphorylation of the T cell receptor ζ chain. Nature 341, 651-654.
31. + cells by CD4. Science 249, 1558-1561.
32. Negishi, I., Motoyama, N., Nakayama, K., Nakayama, K., Senju, S., Hatakeyama, S., Zhang, Q., Chan, A.C., and Loh, D.Y. (1995). Essential role for ZAP-70 in both positive and negative selection of thymocytes. Nature 376, 435-438.
33. Neumeister, E.N., Zhu, Y., Richard, S., Terhorst, C., Chan, A.C., and Shaw, A.S. (1995). Binding of ZAP-70 to phosphorylated T-cell receptor zeta and eta enhances its autophosphorylation and generates specific binding sites for SH2 domain-containing proteins. Mol. Cell Biol. 15, 3171-3178.
34. O'Shea, J.J., McVicar, D.W., Bailey, T.L., Burns, C., and Smyth, M.J. (1992). Activation of human peripheral blood T lymphocytes by pharmacological induction of protein-tyrosine phosphorylation. Proc. Natl. Acad. Sci. USA 89, 10306-10310.
35. + cells but markedly decreased helper cell activity in mice lacking CD4. Nature 353, 180-182.
36. Robey, E., and Fowlkes, B.J. (1994). Selective events in T cell development. Annu. Rev. Immunol. 12, 675-705.
37. Robey, E., Fowlkes, B.J., Gordon, J.W., Kioussis, D., von Boehmer, H., Ramsdel, F., and Axel, R. (1991). Thymic selection in CD8 transgenic mice supports an instructive model for commitment to a CD4 or CD8 lineage. Cell 64, 99-107.
38. Samelson, L.E., Harford, J.B., and Klausner, R.D. (1985). Identification of the components of the murine T cell antigen receptor complex. Cell 43, 223-231.
39. Samelson, L.E., Phillips, A.F., Luong, E.T., and Klausner, R.D. (1990). Association of fyn protein-tyrosine kinase with the T-cell antigen receptor. Proc. Natl. Acad. Sci. USA 87, 4358-4362.
40. Shaw, A.S., Amrein, K.E., Hammond, C., Stern, D.F., Sefton, B.M., and Rose, J.K. (1989). The lck tyrosine protein kinase interacts with the cytoplasmic tail of the CD4 glycoprotein through its unique amino-terminal domain. Cell 59, 627-636.
41. Sloan-Lancaster, J., Shaw, A.S., Rothbard, J.B., and Allen, P.M. (1994). Partial T cell signaling, altered phospho-zeta and lack of ZAP70 recruitment in APL-induced T cell anergy. Cell 79, 913-922.
42. Stefanova, I., Horejsi, V., Ansotegui, I.J., Knapp, W., and Stockinger, H. (1991). GPI-anchored cell-surface molecules complexed to protein tyrosine kinases. Science 254, 1016-1019.
43. fyn mutant mice display differential signaling in thymocytes and peripheral T cells. Cell 70, 741-750.
44. + T cell lineages: a new perspective on thymic commitment and selection. Immunity 2, 413-425.
45. van Ewijk, W., Rouse, R.V., and Weissman, I.L. (1980). Distribution of H-2 microenvironments in the mouse thymus. J. Histochem. Cytochem. 28, 1089-1099.
46. van Oers, N.S.C., Killeen, N., and Weiss, A. (1994). ZAP-70 is constitutively associated with tyrosine-phosphorylated TCR zeta in murine thymocytes and lymph node T cells. Immunity 1, 675-685.
47. lck. Cell 55, 301-308.
48. lck. Nature 338, 257-259.
49. Veillette, A., Zuniga-Pflucker, J.C., Bolen, J.B., and Kruisbeek, A. (1989b). Engagement of CD4 and CD8 expressed on immature thymocytes induced activation of intracellular tyrosine phosphorylation pathways. J. Exp. Med. 270, 1671-1680.
50. Wange, R.L., Isakov, N., Burke, T.R., Otaka, A., Roller, P.P., Watts, J.D., Aebersold, R., and Samelson, L.E. (1995a). F2(Pmp)2-TAM zeta 3, a novel competitive inhibitor of the binding of ZAP-70 to the T cell antigen receptor, blocks early T cell signaling. J. Biol. Chem. 270, 944-948.
51. Wange, R.L., Guitian, R., Isakov, N., Watts, J.D., Aebersold, R., and Samelson, L.E. (1995b). Activating and inhibitory mutations in adjacent tyrosines in the kinase domain of ZAP-70. J. Biol. Chem. 270, 18730-18733.
52. Watts, J.D., Affolter, M., Krebs, D.L., Wange, R.L., Samelson, L.E., and Aebersold, R. (1994). Identification by electrospray ionization mass spectrometry of the sites of tyrosine phosphorylation induced in activated Jurkat T cells on the protein tyrosine kinase ZAP-70. J. Biol. Chem. 269, 29520-29529.
53. Weil, R., Cloutier, J.-F., Fournel, M., and Veillette, A. (1995). Regulation of ZAP-70 by src family tyrosine protein kinases in an antigen-specific T-cell line. J. Biol. Chem. 270, 2791-2799.
54. lck tyrosine kinase: basis for differential signaling by CD4 and CD8 in immature thymocytes expressing both coreceptor molecules. J. Exp. Med. 178, 1701-1712.
55. Wiest, D.L., Kearse, K.P., Shores, E.W., and Singer, A. (1994). Developmentally regulated expression of CD3 components independent of clonotypic T cell antigen receptor complexes on immature thymocytes. J. Exp. Med. 180, 1375-1382.
56. Wiest, D.L., Burgess, W., McKean, D., Kearse, K.P., and Singer, A. (1995). The molecular chaperone calnexin is expressed on the surface of immature thymocytes in association with clonotype-independent CD3 complexes. EMBO J. 14, 3425-3433.