메뉴 건너뛰기




Volumn 10, Issue 7, 2010, Pages 608-625

Medullary thyroid cancer: A promising model for targeted therapy

Author keywords

Medullary thyroid carcinoma; Multiple endocrine neoplasia; RET; Sorafenib; Sunitinib; Targeted therapy; Tyrosine kinase inhibitors; Vandetanib

Indexed keywords

FIBROBLAST GROWTH FACTOR RECEPTOR; HEAT SHOCK PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; NERVE GROWTH FACTOR RECEPTOR; PROTEASOME INHIBITOR; PROTEIN RET; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; RAF PROTEIN; SOMATOMEDIN RECEPTOR;

EID: 77957977657     PISSN: 15665240     EISSN: None     Source Type: Journal    
DOI: 10.2174/156652410792630607     Document Type: Article
Times cited : (19)

References (145)
  • 1
    • 33750596636 scopus 로고    scopus 로고
    • Mechanisms of Disease: Cancer targeting and the impact of oncogenic RET for medullary thyroid carcinoma therapy
    • Drosten M, Pützer BM. Mechanisms of Disease: cancer targeting and the impact of oncogenic RET for medullary thyroid carcinoma therapy. Nat Clin Pract Oncol 2006; 3: 564-74.
    • (2006) Nat Clin Pract Oncol , vol.3 , pp. 564-574
    • Drosten, M.1    Pützer, B.M.2
  • 4
    • 0032535770 scopus 로고    scopus 로고
    • A National Cancer Data Base report on 53,856 cases of thyroid carcinoma treated in the U.S., 1985-1995
    • Hundahl SA, Fleming ID, Fremgen AM, Menck HR. A National Cancer Data Base report on 53,856 cases of thyroid carcinoma treated in the U.S., 1985-1995. Cancer 1998; 83: 2638-48.
    • (1998) Cancer , vol.83 , pp. 2638-2648
    • Hundahl, S.A.1    Fleming, I.D.2    Fremgen, A.M.3    Menck, H.R.4
  • 5
    • 33746264000 scopus 로고    scopus 로고
    • Molecular advances in medullary thyroid cancer diagnostics
    • Hubner RA, Houlston RS. Molecular advances in medullary thyroid cancer diagnostics. Clin Chim Acta 2006; 370: 2-8.
    • (2006) Clin Chim Acta , vol.370 , pp. 2-8
    • Hubner, R.A.1    Houlston, R.S.2
  • 6
    • 35748944138 scopus 로고    scopus 로고
    • Molecular mechanisms of medullary thyroid carcinoma: Current approaches in diagnosis and treatment
    • Boikos SA, Stratakis CA. Molecular mechanisms of medullary thyroid carcinoma: current approaches in diagnosis and treatment. Histol Histopathol 2008; 23: 109-16.
    • (2008) Histol Histopathol , vol.23 , pp. 109-116
    • Boikos, S.A.1    Stratakis, C.A.2
  • 7
    • 0018844676 scopus 로고
    • Clinical characteristics distinguishing hereditary from sporadic medullary thyroid carcinoma. Treatment implications
    • Block MA, Jackson CE, Greenawald KA, Yott JB, Tashjian AH Jr. Clinical characteristics distinguishing hereditary from sporadic medullary thyroid carcinoma. Treatment implications. Arch Surg 1980; 115: 142-8.
    • (1980) Arch Surg , vol.115 , pp. 142-148
    • Block, M.A.1    Jackson, C.E.2    Greenawald, K.A.3    Yott, J.B.4    Tashjian Jr., A.H.5
  • 8
    • 4644256817 scopus 로고    scopus 로고
    • The relationship between specific RET proto-oncogene mutations and disease phenotype in multiple endocrine neoplasia type 2. International RET mutation consortium analysis
    • Eng C, Clayton D, Schuffenecker I, et al. The relationship between specific RET proto-oncogene mutations and disease phenotype in multiple endocrine neoplasia type 2. International RET mutation consortium analysis. JAMA, 1996; 276: 1575-9.
    • (1996) JAMA , vol.276 , pp. 1575-1579
    • Eng, C.1    Clayton, D.2    Schuffenecker, I.3
  • 9
    • 33747080744 scopus 로고    scopus 로고
    • RET as a diagnostic and therapeutic target in sporadic and hereditary endocrine tumors
    • De Groot JW, Links TP, Plukker JT, Lips CJ, Hofstra RM. RET as a diagnostic and therapeutic target in sporadic and hereditary endocrine tumors. Endocr Rev 2006; 27: 535-60.
    • (2006) Endocr Rev , vol.27 , pp. 535-560
    • de Groot, J.W.1    Links, T.P.2    Plukker, J.T.3    Lips, C.J.4    Hofstra, R.M.5
  • 12
    • 0036581222 scopus 로고    scopus 로고
    • The GDNF family: Signalling, biological functions and therapeutic value
    • Airaksinen MS, Saarma M. The GDNF family: signalling, biological functions and therapeutic value. Nat Rev Neurosci 2002; 3: 383-94.
    • (2002) Nat Rev Neurosci , vol.3 , pp. 383-394
    • Airaksinen, M.S.1    Saarma, M.2
  • 13
    • 33645290520 scopus 로고    scopus 로고
    • RET receptor signaling: Dysfunction in thyroid cancer and Hirschsprung's disease
    • Asai N, Jijiwa M, Enomoto A, et al. RET receptor signaling: dysfunction in thyroid cancer and Hirschsprung's disease. Pathol Int 2006; 56: 164-72.
    • (2006) Pathol Int , vol.56 , pp. 164-172
    • Asai, N.1    Jijiwa, M.2    Enomoto, A.3
  • 14
    • 40449086887 scopus 로고    scopus 로고
    • A novel RET kinase-beta-catenin signaling pathway contributes to tumorigenesis in thyroid carcinoma
    • Gujral TS, van Veelen W, Richardson DS, et al. A novel RET kinase-beta-catenin signaling pathway contributes to tumorigenesis in thyroid carcinoma. Cancer Res 2008; 68: 1338-46.
    • (2008) Cancer Res , vol.68 , pp. 1338-1346
    • Gujral, T.S.1    van Veelen, W.2    Richardson, D.S.3
  • 15
    • 58249112736 scopus 로고    scopus 로고
    • RET/PTC1- driven neoplastic transformation and proinvasive phenotype of human thyrocytes involve Met induction and beta-catenin nuclear translocation
    • Cassinelli G, Favini E, Degl'Innocenti D, et al. RET/PTC1- driven neoplastic transformation and proinvasive phenotype of human thyrocytes involve Met induction and beta-catenin nuclear translocation. Neoplasia 2009; 11: 10-21.
    • (2009) Neoplasia , vol.11 , pp. 10-21
    • Cassinelli, G.1    Favini, E.2    Degl'Innocenti, D.3
  • 16
    • 22244480355 scopus 로고    scopus 로고
    • RET proto-oncogene: A review and update of genotype-phenotype correlations in hereditary medullary thyroid cancer and associated endocrine tumors
    • Kouvaraki MA, Shapiro SE, Perrier ND, et al. RET proto-oncogene: a review and update of genotype-phenotype correlations in hereditary medullary thyroid cancer and associated endocrine tumors. Thyroid 2005; 15: 531-44.
    • (2005) Thyroid , vol.15 , pp. 531-544
    • Kouvaraki, M.A.1    Shapiro, S.E.2    Perrier, N.D.3
  • 17
    • 63049118581 scopus 로고    scopus 로고
    • Genotype-phenotype relationship in multiple endocrine neoplasia type 2. Implications for clinical management
    • Raue F, Frank-Raue K. Genotype-phenotype relationship in multiple endocrine neoplasia type 2. Implications for clinical management. Hormones 2009; 8: 23-8.
    • (2009) Hormones , vol.8 , pp. 23-28
    • Raue, F.1    Frank-Raue, K.2
  • 18
    • 0034173477 scopus 로고    scopus 로고
    • Diagnostic approach, genetic screening and prognostic factors of medullary thyroid carcinoma
    • Corsello SM, Lovicu RM, Migneco MG, Rufini V, Summaria V. Diagnostic approach, genetic screening and prognostic factors of medullary thyroid carcinoma. Rays 2000; 25: 257-66
    • (2000) Rays , vol.25 , pp. 257-266
    • Corsello, S.M.1    Lovicu, R.M.2    Migneco, M.G.3    Rufini, V.4    Summaria, V.5
  • 19
    • 12344335450 scopus 로고    scopus 로고
    • Advances in the management of hereditary medullary thyroid cancer
    • Machens A, Ukkat J, Brauckhoff M, Gimm O, Dralle, H. Advances in the management of hereditary medullary thyroid cancer. J Intern Med 2005; 257: 50-9.
    • (2005) J Intern Med , vol.257 , pp. 50-59
    • Machens, A.1    Ukkat, J.2    Brauckhoff, M.3    Gimm, O.4    Dralle, H.5
  • 20
    • 58249095068 scopus 로고    scopus 로고
    • The genetic basis of hereditary medullary thyroid cancer: Clinical implications for the surgeon, with a particular emphasis on the role of prophylactic thyroidectomy
    • Sakorafas GH, Friess H, Peros G. The genetic basis of hereditary medullary thyroid cancer: clinical implications for the surgeon, with a particular emphasis on the role of prophylactic thyroidectomy. Endocr Relat Cancer 2008; 15: 871-84.
    • (2008) Endocr Relat Cancer , vol.15 , pp. 871-884
    • Sakorafas, G.H.1    Friess, H.2    Peros, G.3
  • 21
    • 0028838086 scopus 로고
    • Mechanism of activation of the ret proto-oncogene by multiple endocrine neoplasia 2A mutations
    • Asai N, Iwashita T, Matsuyama M, Takahashi M. Mechanism of activation of the ret proto-oncogene by multiple endocrine neoplasia 2A mutations. Mol Cell Biol 1995; 15: 1613-9
    • (1995) Mol Cell Biol , vol.15 , pp. 1613-1619
    • Asai, N.1    Iwashita, T.2    Matsuyama, M.3    Takahashi, M.4
  • 22
    • 0028914683 scopus 로고
    • Activation of RET as a dominant transforming gene by germline mutations of MEN2A and MEN2B
    • Santoro M, Carlomagno F, Romano A, et al. Activation of RET as a dominant transforming gene by germline mutations of MEN2A and MEN2B. Science 1995; 267: 381-3.
    • (1995) Science , vol.267 , pp. 381-383
    • Santoro, M.1    Carlomagno, F.2    Romano, A.3
  • 23
    • 0030663857 scopus 로고    scopus 로고
    • The multiple endocrine neoplasia type 2B point mutation switches the specificity of the Ret tyrosine kinase towards cellular substrates that are susceptible to interact with Crk and Nck
    • Bocciardi R, Mograbi B, Pasini B, et al. The multiple endocrine neoplasia type 2B point mutation switches the specificity of the Ret tyrosine kinase towards cellular substrates that are susceptible to interact with Crk and Nck. Oncogene 1997; 15: 2257-65.
    • (1997) Oncogene , vol.15 , pp. 2257-2265
    • Bocciardi, R.1    Mograbi, B.2    Pasini, B.3
  • 24
    • 0035866411 scopus 로고    scopus 로고
    • Increased in vivo phosphorylation of ret tyrosine 1062 is a potential pathogenetic mechanism of multiple endocrine neoplasia type 2B
    • Salvatore D, Melillo RM, Monaco C, et al. Increased in vivo phosphorylation of ret tyrosine 1062 is a potential pathogenetic mechanism of multiple endocrine neoplasia type 2B. Cancer Res 2001; 61: 1426-31.
    • (2001) Cancer Res , vol.61 , pp. 1426-1431
    • Salvatore, D.1    Melillo, R.M.2    Monaco, C.3
  • 25
    • 0035479144 scopus 로고    scopus 로고
    • The RET receptor: Function in development and dysfunction in congenital malformation
    • Manié S, Santoro M, Fusco A, Billaud M. The RET receptor: function in development and dysfunction in congenital malformation. Trends Genet 2001; 17: 580-9.
    • (2001) Trends Genet , vol.17 , pp. 580-589
    • Manié, S.1    Santoro, M.2    Fusco, A.3    Billaud, M.4
  • 26
    • 0031984945 scopus 로고    scopus 로고
    • A GTG to ATG novel point mutation at codon 804 in exon 14 of the RET proto-oncogene in two families affected by familial medullary thyroid carcinoma
    • Fattorusso O, Quadro L, Libroia A, et al. A GTG to ATG novel point mutation at codon 804 in exon 14 of the RET proto-oncogene in two families affected by familial medullary thyroid carcinoma. Hum Mut 1998; 1: S167-71
    • (1998) Hum Mut , vol.1
    • Fattorusso, O.1    Quadro, L.2    Libroia, A.3
  • 27
    • 17944370976 scopus 로고    scopus 로고
    • Familial medullary thyroid carcinoma with noncysteine ret mutations: Phenotype-genotype relationship in a large series of patients
    • Niccoli-Sire P, Murat A, Rohmer V, et al. Familial medullary thyroid carcinoma with noncysteine ret mutations: phenotype-genotype relationship in a large series of patients. J Clin Endocrinol Metab 2001; 86: 3746-53
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 3746-3753
    • Niccoli-Sire, P.1    Murat, A.2    Rohmer, V.3
  • 28
    • 0029944584 scopus 로고    scopus 로고
    • Heterogeneous mutation of the RET proto-oncogene in subpopulations of medullary thyroid carcinoma
    • Eng C, Mulligan LM, Healey CS, et al. Heterogeneous mutation of the RET proto-oncogene in subpopulations of medullary thyroid carcinoma. Cancer Res 1996; 56: 2167-70.
    • (1996) Cancer Res , vol.56 , pp. 2167-2170
    • Eng, C.1    Mulligan, L.M.2    Healey, C.S.3
  • 29
    • 40849094269 scopus 로고    scopus 로고
    • Prognostic significance of somatic RET oncogene mutations in sporadic medullary thyroid cancer: A 10-year follow-up study
    • Elisei R, Cosci B, Romei C, et al. Prognostic significance of somatic RET oncogene mutations in sporadic medullary thyroid cancer: a 10-year follow-up study. J Clin Endocrinol Metab 2008; 93: 682-7.
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 682-687
    • Elisei, R.1    Cosci, B.2    Romei, C.3
  • 30
    • 67349168712 scopus 로고    scopus 로고
    • Correlation of RET somatic mutations with clinicopathological features in sporadic medullary thyroid carcinomas
    • Moura MM, Cavaco BM, Pinto AE, et al. Correlation of RET somatic mutations with clinicopathological features in sporadic medullary thyroid carcinomas. Br J Cancer 2009; 100: 1777-83.
    • (2009) Br J Cancer , vol.100 , pp. 1777-1783
    • Moura, M.M.1    Cavaco, B.M.2    Pinto, A.E.3
  • 31
    • 72549114451 scopus 로고    scopus 로고
    • Aggressive inherited and sporadic medullary thyroid carcinomas display similar oncogenic pathways
    • Ameur N, Lacroix L, Roucan S, et al. Aggressive inherited and sporadic medullary thyroid carcinomas display similar oncogenic pathways. Endocr Relat Cancer 2009; 16: 1261-72.
    • (2009) Endocr Relat Cancer , vol.16 , pp. 1261-1272
    • Ameur, N.1    Lacroix, L.2    Roucan, S.3
  • 32
    • 0025857633 scopus 로고
    • Low frequency of ras gene mutations in neuroblastomas, pheochromocytomas, and medullary thyroid cancers
    • Moley JF, Brother MB, Wells SA, Spengler BA, Biedler JL, Brodeur GM. Low frequency of ras gene mutations in neuroblastomas, pheochromocytomas, and medullary thyroid cancers. Cancer Res 1991; 51: 1596-99.
    • (1991) Cancer Res , vol.51 , pp. 1596-1599
    • Moley, J.F.1    Brother, M.B.2    Wells, S.A.3    Spengler, B.A.4    Biedler, J.L.5    Brodeur, G.M.6
  • 33
    • 0029097741 scopus 로고
    • Point mutations of ras and Gs alpha subunit genes in thyroid tumors
    • Horie H, Yokogoshi Y, Tsuyuguchi M, Saito S. Point mutations of ras and Gs alpha subunit genes in thyroid tumors. Jpn J Cancer Res 1995; 86: 737-42.
    • (1995) Jpn J Cancer Res , vol.86 , pp. 737-742
    • Horie, H.1    Yokogoshi, Y.2    Tsuyuguchi, M.3    Saito, S.4
  • 35
    • 21244457181 scopus 로고    scopus 로고
    • BRAF mutation in thyroid cancer
    • Xing M. BRAF mutation in thyroid cancer. Endocr Relat Cancer 2005; 12: 245-62.
    • (2005) Endocr Relat Cancer , vol.12 , pp. 245-262
    • Xing, M.1
  • 37
    • 70450184514 scopus 로고    scopus 로고
    • Molecular genetics of medullary thyroid carcinoma: The quest for novel therapeutic targets
    • Cerrato A, De Falco V, Santoro M. Molecular genetics of medullary thyroid carcinoma: the quest for novel therapeutic targets. J Mol Endocrinol 2009; 43: 143-55.
    • (2009) J Mol Endocrinol , vol.43 , pp. 143-155
    • Cerrato, A.1    de Falco, V.2    Santoro, M.3
  • 38
    • 33745660346 scopus 로고    scopus 로고
    • Somatic VHL gene alterations in MEN2-associated medullary thyroid carcinoma
    • Koch CA, Brouwers FM, Vortmeyer AO, et al. Somatic VHL gene alterations in MEN2-associated medullary thyroid carcinoma. BMC Cancer 2006; 6: 131.
    • (2006) BMC Cancer , vol.6 , pp. 131
    • Koch, C.A.1    Brouwers, F.M.2    Vortmeyer, A.O.3
  • 39
    • 0033693018 scopus 로고    scopus 로고
    • Duplication of the mutant RET allele in trisomy 10 or loss of the wild-type allele in multiple endocrine neoplasia type 2-associated pheochromocytomas
    • Huang SC, Koch CA, Vortmeyer AO, et al. Duplication of the mutant RET allele in trisomy 10 or loss of the wild-type allele in multiple endocrine neoplasia type 2-associated pheochromocytomas. Cancer Res 2000; 60: 6223-6.
    • (2000) Cancer Res , vol.60 , pp. 6223-6226
    • Huang, S.C.1    Koch, C.A.2    Vortmeyer, A.O.3
  • 40
    • 0024588674 scopus 로고
    • The molecular biology of medullary thyroid carcinoma. A model for cancer development and progression
    • Nelkin BD, de Bustros AC, Mabry M, Baylin SB. The molecular biology of medullary thyroid carcinoma. A model for cancer development and progression. JAMA 1989; 261: 3130-5.
    • (1989) JAMA , vol.261 , pp. 3130-3135
    • Nelkin, B.D.1    de Bustros, A.C.2    Mabry, M.3    Baylin, S.B.4
  • 41
    • 54549114194 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-kinase/akt signaling pathway in medullary thyroid cancer
    • Pitt SC, Chen H. The phosphatidylinositol 3-kinase/akt signaling pathway in medullary thyroid cancer. Surgery 2008; 144: 721-4.
    • (2008) Surgery , vol.144 , pp. 721-724
    • Pitt, S.C.1    Chen, H.2
  • 42
    • 0034603172 scopus 로고    scopus 로고
    • Transforming ability of MEN2A-RET requires activation of the phosphatidylinositol 3- kinase/AKT signaling pathway
    • Segouffin-Cariou C, Billaud M. Transforming ability of MEN2A-RET requires activation of the phosphatidylinositol 3- kinase/AKT signaling pathway. J Biol Chem 2000; 275; 3568-76.
    • (2000) J Biol Chem , vol.275 , pp. 3568-3576
    • Segouffin-Cariou, C.1    Billaud, M.2
  • 43
    • 33845987566 scopus 로고    scopus 로고
    • Overexpression of the NOTCH1 intracellular domain inhibits cell proliferation and alters the neuroendocrine phenotype of medullary thyroid cancer cells
    • Kunnimalaiyaan M, Vaccaro AM, Ndiaye MA, Chen H. Overexpression of the NOTCH1 intracellular domain inhibits cell proliferation and alters the neuroendocrine phenotype of medullary thyroid cancer cells. J Biol Chem 2006; 281: 39819-30.
    • (2006) J Biol Chem , vol.281 , pp. 39819-39830
    • Kunnimalaiyaan, M.1    Vaccaro, A.M.2    Ndiaye, M.A.3    Chen, H.4
  • 44
    • 34147168760 scopus 로고    scopus 로고
    • Inactivation of glycogen synthase kinase-3beta, a downstream target of the raf-1 pathway, is associated with growth suppression in medullary thyroid cancer cells
    • Kunnimalaiyaan M, Vaccaro AM, Ndiaye MA, Chen H. Inactivation of glycogen synthase kinase-3beta, a downstream target of the raf-1 pathway, is associated with growth suppression in medullary thyroid cancer cells. Mol Cancer Ther 2007; 6: 1151-8.
    • (2007) Mol Cancer Ther , vol.6 , pp. 1151-1158
    • Kunnimalaiyaan, M.1    Vaccaro, A.M.2    Ndiaye, M.A.3    Chen, H.4
  • 45
    • 41849093688 scopus 로고    scopus 로고
    • Low telomerase activity: Possible role in the progression of human medullary thyroid carcinoma
    • Stadler G, Wieser M, Streubel B, et al. Low telomerase activity: possible role in the progression of human medullary thyroid carcinoma. Eur J Cancer 2008; 44: 866-75.
    • (2008) Eur J Cancer , vol.44 , pp. 866-875
    • Stadler, G.1    Wieser, M.2    Streubel, B.3
  • 46
    • 58249093583 scopus 로고    scopus 로고
    • P18 is a tumor suppressor gene involved in human medullary thyroid carcinoma and pheochromocytoma development
    • van Veelen W, Klompmaker R, Gloerich M, et al. P18 is a tumor suppressor gene involved in human medullary thyroid carcinoma and pheochromocytoma development. Int J Cancer 2009; 124: 339-45.
    • (2009) Int J Cancer , vol.124 , pp. 339-345
    • van Veelen, W.1    Klompmaker, R.2    Gloerich, M.3
  • 47
    • 50649112589 scopus 로고    scopus 로고
    • Expression of matrix metalloproteinase 2 (MMP-2) and tissue inhibitor of metalloproteinase 2 (TIMP-2) in medullary thyroid carcinoma: Prognostic implications
    • Cavalheiro BG, Junqueira CR, Brandão LG. Expression of matrix metalloproteinase 2 (MMP-2) and tissue inhibitor of metalloproteinase 2 (TIMP-2) in medullary thyroid carcinoma: prognostic implications. Thyroid 2008; 18: 865-71.
    • (2008) Thyroid , vol.18 , pp. 865-871
    • Cavalheiro, B.G.1    Junqueira, C.R.2    Brandão, L.G.3
  • 48
    • 15744385035 scopus 로고    scopus 로고
    • Gene expression profiles reveal that DCN, DIO1, and DIO2 are underexpressed in benign and malignant thyroid tumors
    • Arnaldi LA, Borra RC, Maciel RM, Cerutti JM. Gene expression profiles reveal that DCN, DIO1, and DIO2 are underexpressed in benign and malignant thyroid tumors. Thyroid 2005; 15: 210-21.
    • (2005) Thyroid , vol.15 , pp. 210-221
    • Arnaldi, L.A.1    Borra, R.C.2    Maciel, R.M.3    Cerutti, J.M.4
  • 49
    • 20444495684 scopus 로고    scopus 로고
    • Decreased type 1 iodothyronine deiodinase expression might be an early and discrete event in thyroid cell dedifferentation towards papillary carcinoma
    • Souza Meyer EL, Dora JM, Wagner MS, Maia AL. Decreased type 1 iodothyronine deiodinase expression might be an early and discrete event in thyroid cell dedifferentation towards papillary carcinoma. Clin Endocrinol 2005; 62: 672-8.
    • (2005) Clin Endocrinol , vol.62 , pp. 672-678
    • Souza Meyer, E.L.1    Dora, J.M.2    Wagner, M.S.3    Maia, A.L.4
  • 51
    • 33745939304 scopus 로고    scopus 로고
    • Apoptotic cell death induction and angiogenesis inhibition in large established medullary thyroid carcinoma xenografts by Ret inhibitor RPI-1
    • Petrangolini G, Cuccuru G, Lanzi C, et al. Apoptotic cell death induction and angiogenesis inhibition in large established medullary thyroid carcinoma xenografts by Ret inhibitor RPI-1. Biochem Pharmacol 2006; 72: 405-14.
    • (2006) Biochem Pharmacol , vol.72 , pp. 405-414
    • Petrangolini, G.1    Cuccuru, G.2    Lanzi, C.3
  • 52
    • 0032778530 scopus 로고    scopus 로고
    • Expression of angiogenesis stimulators and inhibitors in human thyroid tumors and correlation with clinical pathological features
    • Bunone G, Vigneri P, Mariani L, et al. Expression of angiogenesis stimulators and inhibitors in human thyroid tumors and correlation with clinical pathological features. Am J Pathol 1999; 155: 1967-76.
    • (1999) Am J Pathol , vol.155 , pp. 1967-1976
    • Bunone, G.1    Vigneri, P.2    Mariani, L.3
  • 53
    • 23644436667 scopus 로고    scopus 로고
    • Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: Developmental culling and cancer
    • Lee S, Nakamura E, Yang H, et al. Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: developmental culling and cancer. Cancer Cell 2005; 8: 155-67.
    • (2005) Cancer Cell , vol.8 , pp. 155-167
    • Lee, S.1    Nakamura, E.2    Yang, H.3
  • 54
    • 34547865714 scopus 로고    scopus 로고
    • Vascular endothelial growth factor (VEGF), VEGF receptors expression and microvascular density in benign and malignant thyroid diseases
    • Jebreel A, England J, Bedford K, Murphy J, Karsai L, Atkin S. Vascular endothelial growth factor (VEGF), VEGF receptors expression and microvascular density in benign and malignant thyroid diseases. Int J Exp Pathol 2007; 88, 271-7.
    • (2007) Int J Exp Pathol , vol.88 , pp. 271-277
    • Jebreel, A.1    England, J.2    Bedford, K.3    Murphy, J.4    Karsai, L.5    Atkin, S.6
  • 55
    • 37249003928 scopus 로고    scopus 로고
    • Oncogene addiction: Setting the stage for molecularly targeted cancer therapy
    • Sharma SV, Settleman, J. Oncogene addiction: setting the stage for molecularly targeted cancer therapy. Gene Dev 2007; 21: 3214-31.
    • (2007) Gene Dev , vol.21 , pp. 3214-3231
    • Sharma, S.V.1    Settleman, J.2
  • 56
    • 17744373695 scopus 로고    scopus 로고
    • The RET proto-oncogene: A molecular therapeutic target in thyroid cancer
    • Kodama Y, Asai N, Kawai K, et al. The RET proto-oncogene: a molecular therapeutic target in thyroid cancer. Cancer Sci 2005; 96: 143-8.
    • (2005) Cancer Sci , vol.96 , pp. 143-148
    • Kodama, Y.1    Asai, N.2    Kawai, K.3
  • 57
    • 33646828701 scopus 로고    scopus 로고
    • Genetics of papillary thyroid cancer initiation: Implications for therapy
    • Fagin JA. Genetics of papillary thyroid cancer initiation: implications for therapy. Trans Am Clin Climatol Assoc 2005; 116: 259-69.
    • (2005) Trans Am Clin Climatol Assoc , vol.116 , pp. 259-269
    • Fagin, J.A.1
  • 58
    • 38149036597 scopus 로고    scopus 로고
    • Molecular genetics of thyroid cancer: Implications for diagnosis, treatment and prognosis
    • Nikiforova MN, Nikiforov YE. Molecular genetics of thyroid cancer: implications for diagnosis, treatment and prognosis. Expert Rev Mol Diagn 2008; 8: 83-5.
    • (2008) Expert Rev Mol Diagn , vol.8 , pp. 83-85
    • Nikiforova, M.N.1    Nikiforov, Y.E.2
  • 61
    • 0034092056 scopus 로고    scopus 로고
    • Clavilactones, a novel class of tyrosine kinase inhibitors of fungal origin
    • Cassinelli G, Lanzi C, Pensa T, et al. Clavilactones, a novel class of tyrosine kinase inhibitors of fungal origin. Biochem Pharmacol 2000; 59: 1539-47.
    • (2000) Biochem Pharmacol , vol.59 , pp. 1539-1547
    • Cassinelli, G.1    Lanzi, C.2    Pensa, T.3
  • 62
    • 10644242812 scopus 로고    scopus 로고
    • RET signals through focal adhesion kinase in medullary thyroid cancer cells
    • Panta GR, Nwariaku F, Kim LT. RET signals through focal adhesion kinase in medullary thyroid cancer cells. Surgery 2004; 136: 1212-7.
    • (2004) Surgery , vol.136 , pp. 1212-1217
    • Panta, G.R.1    Nwariaku, F.2    Kim, L.T.3
  • 63
    • 38349125637 scopus 로고    scopus 로고
    • Fusco A, et al. siRNA nanoformulation against the ret/PTC1 junction oncogene is efficient in an in vivo model of papillary thyroid carcinoma
    • De Martimprey H, Bertrand JR, Fusco A, et al. siRNA nanoformulation against the ret/PTC1 junction oncogene is efficient in an in vivo model of papillary thyroid carcinoma. Nucleic Acids Res 2008; 36: e2.
    • (2008) Nucleic Acids Res , vol.e2 , pp. 36
    • de Martimprey, H.1    Bertrand, J.R.2
  • 64
  • 65
    • 0036171234 scopus 로고    scopus 로고
    • The kinase inhibitor PP1 blocks tumorigenesis induced by RET oncogenes
    • Carlomagno F, Vitagliano D, Guida T, et al. The kinase inhibitor PP1 blocks tumorigenesis induced by RET oncogenes. Cancer Res 2002; 62: 1077-82.
    • (2002) Cancer Res , vol.62 , pp. 1077-1082
    • Carlomagno, F.1    Vitagliano, D.2    Guida, T.3
  • 66
    • 0038697810 scopus 로고    scopus 로고
    • Efficient inhibition of RET/papillary thyroid carcinoma oncogenic kinases by 4-amino-5-(4-chloro-phenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine (PP2)
    • Carlomagno F, Vitagliano D, Guida T, et al. Efficient inhibition of RET/papillary thyroid carcinoma oncogenic kinases by 4-amino-5-(4-chloro-phenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine (PP2). J Clin Endocrinol Metab 2003; 88: 1897-902.
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 1897-1902
    • Carlomagno, F.1    Vitagliano, D.2    Guida, T.3
  • 67
    • 0037699063 scopus 로고    scopus 로고
    • PP1 inhibitor induces degradation of RETMEN2A and RETMEN2B oncoproteins through proteosomal targeting
    • Carniti C, Perego C, Mondellini P, Pierotti MA, Bongarzone I. PP1 inhibitor induces degradation of RETMEN2A and RETMEN2B oncoproteins through proteosomal targeting. Cancer Res 2003; 63: 2234-43.
    • (2003) Cancer Res , vol.63 , pp. 2234-2243
    • Carniti, C.1    Perego, C.2    Mondellini, P.3    Pierotti, M.A.4    Bongarzone, I.5
  • 68
    • 4444273158 scopus 로고    scopus 로고
    • Disease associated mutations at valine 804 in the RET receptor tyrosine kinase confer resistance to selective kinase inhibitors
    • Carlomagno F, Guida T, Anaganti S, et al. Disease associated mutations at valine 804 in the RET receptor tyrosine kinase confer resistance to selective kinase inhibitors. Oncogene 2004; 23: 6056-63.
    • (2004) Oncogene , vol.23 , pp. 6056-6063
    • Carlomagno, F.1    Guida, T.2    Anaganti, S.3
  • 69
    • 0033104338 scopus 로고    scopus 로고
    • Ret-mediated mitogenesis requires Src kinase activity
    • Melillo RM, Barone MV, Lupoli G, et al. Ret-mediated mitogenesis requires Src kinase activity. Cancer Res 1999; 59: 1120-6.
    • (1999) Cancer Res , vol.59 , pp. 1120-1126
    • Melillo, R.M.1    Barone, M.V.2    Lupoli, G.3
  • 70
    • 0141592764 scopus 로고    scopus 로고
    • CEP-701 and CEP-751 inhibit constitutively activated RET tyrosine kinase activity and block medullary thyroid carcinoma cell growth
    • Strock CJ, Park JI, Rosen M, et al. CEP-701 and CEP-751 inhibit constitutively activated RET tyrosine kinase activity and block medullary thyroid carcinoma cell growth. Cancer Res 2003, 63: 5559-63.
    • (2003) Cancer Res , vol.63 , pp. 5559-5563
    • Strock, C.J.1    Park, J.I.2    Rosen, M.3
  • 71
    • 30344439815 scopus 로고    scopus 로고
    • Activity of irinotecan and the tyrosine kinase inhibitor CEP-751 in medullary thyroid cancer
    • Strock CJ, Park JI, Rosen DM, et al. Activity of irinotecan and the tyrosine kinase inhibitor CEP-751 in medullary thyroid cancer. J Clin Endocrinol Metab 2006; 91: 79-84.
    • (2006) J Clin Endocrinol Metab , vol.91 , pp. 79-84
    • Strock, C.J.1    Park, J.I.2    Rosen, D.M.3
  • 72
    • 0033989107 scopus 로고    scopus 로고
    • Inhibition of transforming activity of the ret/ptc1 oncoprotein by a 2- indolinone derivative
    • Lanzi C, Cassinelli G, Pensa T, et al. Inhibition of transforming activity of the ret/ptc1 oncoprotein by a 2- indolinone derivative. Int J Cancer 2000; 85: 384-90
    • (2000) Int J Cancer , vol.85 , pp. 384-390
    • Lanzi, C.1    Cassinelli, G.2    Pensa, T.3
  • 73
    • 3242735120 scopus 로고    scopus 로고
    • Cellular effects and antitumor activity of RET inhibitor RPI-1 on MEN2A- associated medullary thyroid carcinoma
    • Cuccuru G, Lanzi C, Cassinelli G, et al. Cellular effects and antitumor activity of RET inhibitor RPI-1 on MEN2A- associated medullary thyroid carcinoma. J Natl Cancer Inst 2004; 96: 1006-14.
    • (2004) J Natl Cancer Inst , vol.96 , pp. 1006-1014
    • Cuccuru, G.1    Lanzi, C.2    Cassinelli, G.3
  • 74
    • 33846850223 scopus 로고    scopus 로고
    • Vandetanib (ZD6474): An orally available receptor tyrosine kinase inhibitor that selectively targets pathways critical for tumor growth and angiogenesis
    • Herbst RS, Heymach JV, O'Reilly MS, Onn A, Ryan, AJ. Vandetanib (ZD6474): an orally available receptor tyrosine kinase inhibitor that selectively targets pathways critical for tumor growth and angiogenesis. Expert Opin Investig Drugs 2007; 16: 239-49.
    • (2007) Expert Opin Investig Drugs , vol.16 , pp. 239-249
    • Herbst, R.S.1    Heymach, J.V.2    O'Reilly, M.S.3    Onn, A.4    Ryan, A.J.5
  • 75
    • 0037115405 scopus 로고    scopus 로고
    • ZD6474, an orally available inhibitor of KDR tyrosine kinase activity, efficiently blocks oncogenic RET kinases
    • Carlomagno F, Vitagliano D, Guida T, et al. ZD6474, an orally available inhibitor of KDR tyrosine kinase activity, efficiently blocks oncogenic RET kinases. Cancer Res 2002; 15: 7284-90.
    • (2002) Cancer Res , vol.15 , pp. 7284-7290
    • Carlomagno, F.1    Vitagliano, D.2    Guida, T.3
  • 76
    • 33845963343 scopus 로고    scopus 로고
    • Structure and chemical inhibition of the RET tyrosine kinase domain
    • Knowles PP, Murray-Rust J, Kjaer S, et al. Structure and chemical inhibition of the RET tyrosine kinase domain. J Biol Chem 2006; 281: 33577-87.
    • (2006) J Biol Chem , vol.281 , pp. 33577-33587
    • Knowles, P.P.1    Murray-Rust, J.2    Kjaer, S.3
  • 77
    • 23844544081 scopus 로고    scopus 로고
    • Clinical evaluation of ZD6474, an orally active inhibitor of VEGF and EGF receptor signaling, in patients with solid, malignant tumors
    • Holden SN, Eckhardt SG, Basser R, et al. Clinical evaluation of ZD6474, an orally active inhibitor of VEGF and EGF receptor signaling, in patients with solid, malignant tumors. Ann Oncol 2005; 16: 1391-7.
    • (2005) Ann Oncol , vol.16 , pp. 1391-1397
    • Holden, S.N.1    Eckhardt, S.G.2    Basser, R.3
  • 79
    • 33745153723 scopus 로고    scopus 로고
    • Cellular effects of imatinib on medullary thyroid cancer cells harboring multiple endocrine neoplasia Type 2A and 2B associated RET mutations
    • de Groot JW, Plaza Menacho I, Schepers H, et al. Cellular effects of imatinib on medullary thyroid cancer cells harboring multiple endocrine neoplasia Type 2A and 2B associated RET mutations. Surgery 2006; 139: 806-14.
    • (2006) Surgery , vol.139 , pp. 806-814
    • de Groot, J.W.1    Plaza Menacho, I.2    Schepers, H.3
  • 82
    • 33644747449 scopus 로고    scopus 로고
    • BAY 43-9006 inhibition of oncogenic RET mutants
    • Carlomagno F, Anaganti S, Guida T, et al. BAY 43-9006 inhibition of oncogenic RET mutants. J Natl Cancer Inst 2006; 98: 326-34.
    • (2006) J Natl Cancer Inst , vol.98 , pp. 326-334
    • Carlomagno, F.1    Anaganti, S.2    Guida, T.3
  • 83
    • 33749000911 scopus 로고    scopus 로고
    • AMG 706, an oral, multikinase inhibitor that selectively targets vascular endothelial growth factor, platelet-derived growth factor, and kit receptors, potently inhibits angiogenesis and induces regression in tumor xenografts
    • Polverino A, Coxon A, Starnes C, et al. AMG 706, an oral, multikinase inhibitor that selectively targets vascular endothelial growth factor, platelet-derived growth factor, and kit receptors, potently inhibits angiogenesis and induces regression in tumor xenografts. Cancer Res 2006; 66: 8715-21.
    • (2006) Cancer Res , vol.66 , pp. 8715-8721
    • Polverino, A.1    Coxon, A.2    Starnes, C.3
  • 84
    • 68949108390 scopus 로고    scopus 로고
    • Phase II study of safety and efficacy of motesanib in patients with progressive or symptomatic, advanced or metastatic medullary thyroid cancer
    • Schlumberger MJ, Elisei R, Bastholt L, et al. Phase II study of safety and efficacy of motesanib in patients with progressive or symptomatic, advanced or metastatic medullary thyroid cancer. J Clin Oncol 2009; 27: 3794-801.
    • (2009) J Clin Oncol , vol.27 , pp. 3794-3801
    • Schlumberger, M.J.1    Elisei, R.2    Bastholt, L.3
  • 85
    • 46449117698 scopus 로고    scopus 로고
    • Motesanib diphosphate in progressive differentiated thyroid cancer
    • Sherman SI, Wirth LJ, Droz JP, et al. Motesanib diphosphate in progressive differentiated thyroid cancer. N Engl J Med 2008; 359, 31-42.
    • (2008) N Engl J Med , vol.359 , pp. 31-42
    • Sherman, S.I.1    Wirth, L.J.2    Droz, J.P.3
  • 86
    • 36549021634 scopus 로고    scopus 로고
    • A phase I dose - escalation study of the safety and pharmacokinetics (PK) of XL184, a VEGFR and MET kinase inhibitor, administered orally to patients (pts) with advanced malignancies
    • Salgia R, Hong DS, Camacho LH, et al. A phase I dose - escalation study of the safety and pharmacokinetics (PK) of XL184, a VEGFR and MET kinase inhibitor, administered orally to patients (pts) with advanced malignancies. J Clin Oncol 2007; 25 (18 Suppl): 14031.
    • (2007) J Clin Oncol , vol.25 , Issue.18 SUPPL. , pp. 14031
    • Salgia, R.1    Hong, D.S.2    Camacho, L.H.3
  • 87
    • 0034192389 scopus 로고    scopus 로고
    • Improved gene transfer to neuroblastoma cells by a monoclonal antibody targeting RET, a receptor tyrosine kinase
    • Yano L, Shimura M, Taniguchi M, et al. Improved gene transfer to neuroblastoma cells by a monoclonal antibody targeting RET, a receptor tyrosine kinase. Hum Gene Ther 2000; 11: 995-1004.
    • (2000) Hum Gene Ther , vol.11 , pp. 995-1004
    • Yano, L.1    Shimura, M.2    Taniguchi, M.3
  • 88
    • 3042724865 scopus 로고    scopus 로고
    • Transmembrane peptides as inhibitors of ErbB receptor signaling
    • Bennasroune A, Fickova M, Gardin A, et al. Transmembrane peptides as inhibitors of ErbB receptor signaling. Mol Biol Cell 2004;15: 3464-74.
    • (2004) Mol Biol Cell , vol.15 , pp. 3464-3474
    • Bennasroune, A.1    Fickova, M.2    Gardin, A.3
  • 89
    • 67650672206 scopus 로고    scopus 로고
    • The development and testing of aptamers for cancer
    • Barbas AS, White RR. The development and testing of aptamers for cancer. Curr Opin Investig Drugs 2009; 10: 572-8.
    • (2009) Curr Opin Investig Drugs , vol.10 , pp. 572-578
    • Barbas, A.S.1    White, R.R.2
  • 90
    • 18344375927 scopus 로고    scopus 로고
    • Neutralizing aptamers from whole-cell SELEX inhibit the RET receptor tyrosine kinase
    • Cerchia L, Duconge F, Pestourie C, et al. Neutralizing aptamers from whole-cell SELEX inhibit the RET receptor tyrosine kinase. PLoS Biol 2005; 3, e123.
    • (2005) PLoS Biol , vol.e123 , pp. 3
    • Cerchia, L.1    Duconge, F.2    Pestourie, C.3
  • 91
    • 0036915701 scopus 로고    scopus 로고
    • A new therapeutic approach in medullary thyroid cancer treatment: Inhibition of oncogenic RET signaling by adenoviral vector-mediated expression of a dominant-negative RET mutant
    • Drosten M, Frilling A, Stiewe T, Putzer BM. A new therapeutic approach in medullary thyroid cancer treatment: inhibition of oncogenic RET signaling by adenoviral vector-mediated expression of a dominant-negative RET mutant. Surgery 2002; 132: 991-7.
    • (2002) Surgery , vol.132 , pp. 991-997
    • Drosten, M.1    Frilling, A.2    Stiewe, T.3    Putzer, B.M.4
  • 92
    • 0038235732 scopus 로고    scopus 로고
    • Antitumor capacity of a dominant-negative RET proto-oncogene mutant in a medullary thyroid carcinoma model
    • Drosten M, Stiewe T, Putzer BM. Antitumor capacity of a dominant-negative RET proto-oncogene mutant in a medullary thyroid carcinoma model. Hum Gene Ther 2003; 14: 971-82.
    • (2003) Hum Gene Ther , vol.14 , pp. 971-982
    • Drosten, M.1    Stiewe, T.2    Putzer, B.M.3
  • 93
    • 0033566948 scopus 로고    scopus 로고
    • Hammerhead ribozyme-mediated inactivation of mutant RET in medullary thyroid carcinoma
    • Parthasarathy R, Cote GJ, Gagel RF. Hammerhead ribozyme-mediated inactivation of mutant RET in medullary thyroid carcinoma. Cancer Res 1999; 59: 3911-4.
    • (1999) Cancer Res , vol.59 , pp. 3911-3914
    • Parthasarathy, R.1    Cote, G.J.2    Gagel, R.F.3
  • 94
    • 17944365466 scopus 로고    scopus 로고
    • Inhibition of Ret oncogene activity by the protein tyrosine phosphatase SHP1
    • Hennige AM, Lammers R, Höppner W, et al. Inhibition of Ret oncogene activity by the protein tyrosine phosphatase SHP1. Endocrinology 2001; 142: 4441-7.
    • (2001) Endocrinology , vol.142 , pp. 4441-4447
    • Hennige, A.M.1    Lammers, R.2    Höppner, W.3
  • 95
    • 14644440555 scopus 로고    scopus 로고
    • Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis
    • Hicklin DJ, Ellis LM. Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. J Clin Oncol 2005; 23: 1001-27.
    • (2005) J Clin Oncol , vol.23 , pp. 1001-1027
    • Hicklin, D.J.1    Ellis, L.M.2
  • 96
    • 63849261238 scopus 로고    scopus 로고
    • Tumor angiogenesis and molecular targets for therapy
    • Cao Y. Tumor angiogenesis and molecular targets for therapy. Front Biosci 2009; 14: 3962-73.
    • (2009) Front Biosci , vol.14 , pp. 3962-3973
    • Cao, Y.1
  • 97
    • 65949102289 scopus 로고    scopus 로고
    • Immunotherapy of metastatic renal cell carcinoma
    • McDermott, D.F. Immunotherapy of metastatic renal cell carcinoma. Cancer 2009; 115 (10 Suppl): 2298-305.
    • (2009) Cancer , vol.115 , Issue.10 SUPPL. , pp. 2298-2305
    • McDermott, D.F.1
  • 98
    • 0033671622 scopus 로고    scopus 로고
    • Neutralizing vascular endothelial growth factor activity inhibits thyroid cancer growth in vivo
    • Soh EY, Eigelberger MS, Kim KJ, et al. Neutralizing vascular endothelial growth factor activity inhibits thyroid cancer growth in vivo. Surgery 2000; 128: 1059-65.
    • (2000) Surgery , vol.128 , pp. 1059-1065
    • Soh, E.Y.1    Eigelberger, M.S.2    Kim, K.J.3
  • 99
    • 50649095801 scopus 로고    scopus 로고
    • Axitinib is an active treatment for all histologic subtypes of advanced thyroid cancer: Results from a phase II study
    • Cohen EE, Rosen LS, Vokes EE, et al. Axitinib is an active treatment for all histologic subtypes of advanced thyroid cancer: results from a phase II study. J Clin Oncol 2008; 26: 4708-13.
    • (2008) J Clin Oncol , vol.26 , pp. 4708-4713
    • Cohen, E.E.1    Rosen, L.S.2    Vokes, E.E.3
  • 100
    • 21144442649 scopus 로고    scopus 로고
    • Antivascular therapy of human follicular thyroid cancer experimental bone metastasis by blockade of epidermal growth factor receptor and vascular growth factor receptor phosphorylation
    • Younes MN, Yigitbasi OG, Park YW, et al. Antivascular therapy of human follicular thyroid cancer experimental bone metastasis by blockade of epidermal growth factor receptor and vascular growth factor receptor phosphorylation. Cancer Res 2005; 65: 4716-27.
    • (2005) Cancer Res , vol.65 , pp. 4716-4727
    • Younes, M.N.1    Yigitbasi, O.G.2    Park, Y.W.3
  • 101
    • 35348816177 scopus 로고    scopus 로고
    • Differential effects of cetuximab and AEE 788 on epidermal growth factor receptor (EGF-R) and vascular endothelial growth factor receptor (VEGF-R) in thyroid cancer cell lines
    • Hoffmann S, Burchert A, Wunderlich A, et al. Differential effects of cetuximab and AEE 788 on epidermal growth factor receptor (EGF-R) and vascular endothelial growth factor receptor (VEGF-R) in thyroid cancer cell lines. Endocrine 2007; 31: 105-13.
    • (2007) Endocrine , vol.31 , pp. 105-113
    • Hoffmann, S.1    Burchert, A.2    Wunderlich, A.3
  • 102
    • 1442299164 scopus 로고    scopus 로고
    • Effects of PTK787/ZK222584, a tyrosine kinase inhibitor, on the growth of a poorly differentiated thyroid carcinoma: An animal study
    • Schoenberger J, Grimm D, Kossmehl P, Infanger M, Kurth E, Eilles C. Effects of PTK787/ZK222584, a tyrosine kinase inhibitor, on the growth of a poorly differentiated thyroid carcinoma: an animal study. Endocrinology 2004; 145: 1031-8.
    • (2004) Endocrinology , vol.145 , pp. 1031-1038
    • Schoenberger, J.1    Grimm, D.2    Kossmehl, P.3    Infanger, M.4    Kurth, E.5    Eilles, C.6
  • 103
    • 34547666982 scopus 로고    scopus 로고
    • The tyrosine kinase inhibitor, AZD2171, inhibits vascular endothelial growth factor receptor signaling and growth of anaplastic thyroid cancer in an orthotopic nude mouse model
    • Gomez-Rivera F, Santillan-Gomez AA, Younes MN, et al. The tyrosine kinase inhibitor, AZD2171, inhibits vascular endothelial growth factor receptor signaling and growth of anaplastic thyroid cancer in an orthotopic nude mouse model. Clin Cancer Res 2007; 13: 4519-27.
    • (2007) Clin Cancer Res , vol.13 , pp. 4519-4527
    • Gomez-Rivera, F.1    Santillan-Gomez, A.A.2    Younes, M.N.3
  • 104
    • 18844395883 scopus 로고    scopus 로고
    • SRC homology-2-containing protein tyrosine phosphatase-1 restrains cell proliferation in human medullary thyroid carcinoma
    • Zatelli MC, Piccin D, Tagliati F, Bottoni A, Luchin A, Degli Uberti E. SRC homology-2-containing protein tyrosine phosphatase-1 restrains cell proliferation in human medullary thyroid carcinoma. Endocrinology 2005; 146; 2692-8.
    • (2005) Endocrinology , vol.146 , pp. 2692-2698
    • Zatelli, M.C.1    Piccin, D.2    Tagliati, F.3    Bottoni, A.4    Luchin, A.5    Degli Uberti, E.6
  • 105
    • 33845626635 scopus 로고    scopus 로고
    • Apoptosis-mediated medullary thyroid cancer growth suppression by the PI3K inhibitor LY294002
    • Kunnimalaiyaan M, Ndiaye M, Chen, H. Apoptosis-mediated medullary thyroid cancer growth suppression by the PI3K inhibitor LY294002. Surgery 2006; 140: 1009-15.
    • (2006) Surgery , vol.140 , pp. 1009-1015
    • Kunnimalaiyaan, M.1    Ndiaye, M.2    Chen, H.3
  • 106
    • 0035354187 scopus 로고    scopus 로고
    • Nuclear factor-kappaB is constitutively active in C-cell carcinoma and required for RET-induced transformation
    • Ludwig L, Kessler H, Wagner M, et al. Nuclear factor-kappaB is constitutively active in C-cell carcinoma and required for RET-induced transformation. Cancer Res 2001; 61: 4526-35.
    • (2001) Cancer Res , vol.61 , pp. 4526-4535
    • Ludwig, L.1    Kessler, H.2    Wagner, M.3
  • 107
    • 0346887056 scopus 로고    scopus 로고
    • The role of human achaete-scute homolog-1 in medullary thyroid cancer cells
    • Sippel RS, Carpenter JE, Kunnimalaiyaan M, Chen H. The role of human achaete-scute homolog-1 in medullary thyroid cancer cells. Surgery 2003; 34: 866-71.
    • (2003) Surgery , vol.34 , pp. 866-871
    • Sippel, R.S.1    Carpenter, J.E.2    Kunnimalaiyaan, M.3    Chen, H.4
  • 108
    • 12944284651 scopus 로고    scopus 로고
    • Dual inhibition of RET and FGFR4 restrains medullary thyroid cancer cell growth
    • Ezzat S, Huang P, Dackiw A, Asa SL. Dual inhibition of RET and FGFR4 restrains medullary thyroid cancer cell growth. Clin Cancer Res 2005; 11: 1336-41.
    • (2005) Clin Cancer Res , vol.11 , pp. 1336-1341
    • Ezzat, S.1    Huang, P.2    Dackiw, A.3    Asa, S.L.4
  • 109
    • 12144290914 scopus 로고    scopus 로고
    • Inhibition of the insulin-like growth factor receptor-1 tyrosine kinase activity as a therapeutic strategy for multiple myeloma, other hematologic malignancies, and solid tumors
    • Mitsiades CS, Mitsiades NS, McMullan CJ, et al. Inhibition of the insulin-like growth factor receptor-1 tyrosine kinase activity as a therapeutic strategy for multiple myeloma, other hematologic malignancies, and solid tumors. Cancer Cell 2004; 5: 221-30.
    • (2004) Cancer Cell , vol.5 , pp. 221-230
    • Mitsiades, C.S.1    Mitsiades, N.S.2    McMullan, C.J.3
  • 110
    • 34248363673 scopus 로고    scopus 로고
    • A multicenter phase 2 study of the farnesyltransferase inhibitor tipifarnib in intermediate- to high-risk myelodysplastic syndrome
    • Fenaux P, Raza A, Mufti GJ, et al. A multicenter phase 2 study of the farnesyltransferase inhibitor tipifarnib in intermediate- to high-risk myelodysplastic syndrome. Blood 2007; 109: 4158-63.
    • (2007) Blood , vol.109 , pp. 4158-4163
    • Fenaux, P.1    Raza, A.2    Mufti, G.J.3
  • 111
    • 10744227474 scopus 로고    scopus 로고
    • Farnesyltransferase inhibitor R115777 in myelodysplastic syndrome: Clinical and biologic activities in the phase 1 setting
    • Kurzrock R, Kantarjian HM, Cortes JE, et al. Farnesyltransferase inhibitor R115777 in myelodysplastic syndrome: clinical and biologic activities in the phase 1 setting. Blood 2003; 102: 4527-34.
    • (2003) Blood , vol.102 , pp. 4527-4534
    • Kurzrock, R.1    Kantarjian, H.M.2    Cortes, J.E.3
  • 112
    • 49849083911 scopus 로고    scopus 로고
    • Medullary thyroid cancer: Targeting the RET kinase pathway with sorafenib/tipifarnib
    • Hong D, Ye L, Gagel R, et al. Medullary thyroid cancer: targeting the RET kinase pathway with sorafenib/tipifarnib. Mol Cancer Ther 2008; 7: 1001-6.
    • (2008) Mol Cancer Ther , vol.7 , pp. 1001-1006
    • Hong, D.1    Ye, L.2    Gagel, R.3
  • 113
    • 0037221065 scopus 로고    scopus 로고
    • The Ras/Raf/MEK/extracellular signal-regulated kinase pathway induces autocrine-paracrine growth inhibition via the leukemia inhibitory factor/JAK/STAT pathway
    • Park JI, Strock CJ, Ball DW, Nelkin BD. The Ras/Raf/MEK/extracellular signal-regulated kinase pathway induces autocrine-paracrine growth inhibition via the leukemia inhibitory factor/JAK/STAT pathway. Mol Cell Biol 2003; 23: 543-54.
    • (2003) Mol Cell Biol , vol.23 , pp. 543-554
    • Park, J.I.1    Strock, C.J.2    Ball, D.W.3    Nelkin, B.D.4
  • 114
    • 0028870305 scopus 로고
    • Glycogen synthase kinase 3 regulates cell fate in Dictyostelium
    • Harwood AJ, Plyte SE, Woodgett J, Strutt H, Kay RR. Glycogen synthase kinase 3 regulates cell fate in Dictyostelium. Cell 1995; 80: 139-48.
    • (1995) Cell , vol.80 , pp. 139-148
    • Harwood, A.J.1    Plyte, S.E.2    Woodgett, J.3    Strutt, H.4    Kay, R.R.5
  • 116
    • 33750054677 scopus 로고    scopus 로고
    • Differential roles of glycogen synthase kinase-3 isoforms in the regulation of transcriptional activation
    • Liang MH, Chuang DM. Differential roles of glycogen synthase kinase-3 isoforms in the regulation of transcriptional activation. J Biol Chem 2006; 281: 30479-84.
    • (2006) J Biol Chem , vol.281 , pp. 30479-30484
    • Liang, M.H.1    Chuang, D.M.2
  • 117
    • 33947519417 scopus 로고    scopus 로고
    • Regulation and function of glycogen synthase kinase-3 isoforms in neuronal survival
    • Liang MH, Chuang DM. Regulation and function of glycogen synthase kinase-3 isoforms in neuronal survival. J Biol Chem 2007; 282: 3904-17.
    • (2007) J Biol Chem , vol.282 , pp. 3904-3917
    • Liang, M.H.1    Chuang, D.M.2
  • 118
    • 19644387196 scopus 로고    scopus 로고
    • The Akt inhibitor KP372-1 suppresses Akt activity and cell proliferation and induces apoptosis in thyroid cancer cells
    • Mandal M, Kim S, Younes MN, et al. The Akt inhibitor KP372-1 suppresses Akt activity and cell proliferation and induces apoptosis in thyroid cancer cells. Br J Cancer 2005; 92: 1899-905.
    • (2005) Br J Cancer , vol.92 , pp. 1899-1905
    • Mandal, M.1    Kim, S.2    Younes, M.N.3
  • 119
    • 30144437331 scopus 로고    scopus 로고
    • Oncogenic rearrangements of the NTRK1/NGF receptor
    • Pierotti MA, Greco A. Oncogenic rearrangements of the NTRK1/NGF receptor. Cancer Lett 2006; 232: 90-8.
    • (2006) Cancer Lett , vol.232 , pp. 90-98
    • Pierotti, M.A.1    Greco, A.2
  • 120
    • 0035314012 scopus 로고    scopus 로고
    • Mutation analysis of NTRK2 and NTRK3, encoding 2 tyrosine kinase receptors, in sporadic human medullary thyroid carcinoma reveals novel sequence variants
    • Gimm O, Dziema H, Brown J, et al. Mutation analysis of NTRK2 and NTRK3, encoding 2 tyrosine kinase receptors, in sporadic human medullary thyroid carcinoma reveals novel sequence variants. Int J Cancer 2001; 92: 70-4.
    • (2001) Int J Cancer , vol.92 , pp. 70-74
    • Gimm, O.1    Dziema, H.2    Brown, J.3
  • 121
    • 0033551229 scopus 로고    scopus 로고
    • Roles of trk family neurotrophin receptors in medullary thyroid carcinoma development and progression
    • McGregor LM, McCune BK, Graff JR, et al. Roles of trk family neurotrophin receptors in medullary thyroid carcinoma development and progression. Proc Natl Acad Sci USA 1999; 96: 4540-5.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 4540-4545
    • McGregor, L.M.1    McCune, B.K.2    Graff, J.R.3
  • 122
    • 0242624594 scopus 로고    scopus 로고
    • Growth factor receptors as therapeutic targets: Strategies to inhibit the insulin-like growth factor I receptor
    • Surmacz E. Growth factor receptors as therapeutic targets: strategies to inhibit the insulin-like growth factor I receptor. Oncogene 2003; 22: 6589-97.
    • (2003) Oncogene , vol.22 , pp. 6589-6597
    • Surmacz, E.1
  • 123
    • 0023198222 scopus 로고
    • Expression of insulin-like growth factor-I and -II genes in rat medullary thyroid carcinoma
    • Höppener JW, Steenbergh PH, Slebos RJ, et al. Expression of insulin-like growth factor-I and -II genes in rat medullary thyroid carcinoma. FEBS Lett 1987; 215: 122-6.
    • (1987) FEBS Lett , vol.215 , pp. 122-126
    • Höppener, J.W.1    Steenbergh, P.H.2    Slebos, R.J.3
  • 124
    • 33748083676 scopus 로고    scopus 로고
    • Growth-inhibitory effects of human anti-insulin-like growth factor-I receptor antibody (A12) in an orthotopic nude mouse model of anaplastic thyroid carcinoma
    • Wang Z, Chakravarty G, Kim S, et al. Growth-inhibitory effects of human anti-insulin-like growth factor-I receptor antibody (A12) in an orthotopic nude mouse model of anaplastic thyroid carcinoma. Clin Cancer Res 2006; 12: 4755-65.
    • (2006) Clin Cancer Res , vol.12 , pp. 4755-4765
    • Wang, Z.1    Chakravarty, G.2    Kim, S.3
  • 126
    • 33645307434 scopus 로고    scopus 로고
    • Pathogenetic mechanisms in thyroid follicular-cell neoplasia
    • Kondo T, Ezzat S, Asa SL. Pathogenetic mechanisms in thyroid follicular-cell neoplasia. Nat Rev Cancer 2006; 6: 292-306.
    • (2006) Nat Rev Cancer , vol.6 , pp. 292-306
    • Kondo, T.1    Ezzat, S.2    Asa, S.L.3
  • 127
    • 0038030643 scopus 로고    scopus 로고
    • Pituitary tumor transforming gene and fibroblast growth factor-2 expression: Potential prognostic indicators in differentiated thyroid cancer
    • Boelaert K, McCabe CJ, Tannahill LA, et al. Pituitary tumor transforming gene and fibroblast growth factor-2 expression: potential prognostic indicators in differentiated thyroid cancer. J Clin Endocrinol Metab 2003; 88: 2341-7.
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 2341-2347
    • Boelaert, K.1    McCabe, C.J.2    Tannahill, L.A.3
  • 129
    • 33751095944 scopus 로고    scopus 로고
    • Angiogenesis and lymphangiogenesis in thyroid proliferative lesions: Relationship to type and tumour behaviour
    • de la Torre NJ, Buley I, Wass JA, Turner HE. Angiogenesis and lymphangiogenesis in thyroid proliferative lesions: relationship to type and tumour behaviour. Endocr Relat Cancer 2006; 13: 931-44
    • (2006) Endocr Relat Cancer , vol.13 , pp. 931-944
    • de la Torre, N.J.1    Buley, I.2    Wass, J.A.3    Turner, H.E.4
  • 130
    • 14244249958 scopus 로고    scopus 로고
    • Fibroblast growth factor receptors as molecular targets in thyroid carcinoma
    • St Bernard R, Zheng L, Liu W, Winer D, Asa SL, Ezzat S. Fibroblast growth factor receptors as molecular targets in thyroid carcinoma. Endocrinology 2005; 146: 1145-53.
    • (2005) Endocrinology , vol.146 , pp. 1145-1153
    • St Bernard, R.1    Zheng, L.2    Liu, W.3    Winer, D.4    Asa, S.L.5    Ezzat, S.6
  • 131
    • 34347258170 scopus 로고    scopus 로고
    • Epigenetically controlled fibroblast growth factor receptor 2 signaling imposes on the RAS/BRAF/mitogen-activated protein kinase pathway to modulate thyroid cancer progression
    • Kondo T, Zheng L, Liu W, Kurebayashi J, Asa SL, Ezzat S. Epigenetically controlled fibroblast growth factor receptor 2 signaling imposes on the RAS/BRAF/mitogen-activated protein kinase pathway to modulate thyroid cancer progression. Cancer Res 2007; 67: 5461-70.
    • (2007) Cancer Res , vol.67 , pp. 5461-5470
    • Kondo, T.1    Zheng, L.2    Liu, W.3    Kurebayashi, J.4    Asa, S.L.5    Ezzat, S.6
  • 133
    • 2342613652 scopus 로고    scopus 로고
    • The proteasome: A suitable antineoplastic target
    • Adams J. The proteasome: a suitable antineoplastic target. Nat Rev Cancer 2004; 4: 349-60.
    • (2004) Nat Rev Cancer , vol.4 , pp. 349-360
    • Adams, J.1
  • 134
    • 45249108658 scopus 로고    scopus 로고
    • Nuclear factor-kappaB activation is associated with somatic and germ line RET mutations in medullary thyroid carcinoma
    • Gallel P, Pallares J, Dolcet X, et al. Nuclear factor-kappaB activation is associated with somatic and germ line RET mutations in medullary thyroid carcinoma. Hum Pathol 2008; 39: 994-1001.
    • (2008) Hum Pathol , vol.39 , pp. 994-1001
    • Gallel, P.1    Pallares, J.2    Dolcet, X.3
  • 135
    • 19944426112 scopus 로고    scopus 로고
    • Oncogenic and anti-apoptotic activity of NF-kappa B in human thyroid carcinomas
    • Pacifico F, Mauro C, Barone C, et al. Oncogenic and anti-apoptotic activity of NF-kappa B in human thyroid carcinomas. J Biol Chem 2004; 279: 54610-9.
    • (2004) J Biol Chem , vol.279 , pp. 54610-54619
    • Pacifico, F.1    Mauro, C.2    Barone, C.3
  • 136
    • 0037973279 scopus 로고    scopus 로고
    • A phase 2 study of bortezomib in relapsed, refractory myeloma
    • Richardson PG, Barlogie B, Berenson J, et al. A phase 2 study of bortezomib in relapsed, refractory myeloma. N Engl J Med 2003; 348: 2609-17.
    • (2003) N Engl J Med , vol.348 , pp. 2609-2617
    • Richardson, P.G.1    Barlogie, B.2    Berenson, J.3
  • 137
    • 41549133200 scopus 로고    scopus 로고
    • Proteasome inhibitors in cancer therapy: Lessons from the first decade
    • Orlowski RZ, Kuhn DJ. Proteasome inhibitors in cancer therapy: lessons from the first decade. Clin Cancer Res 2008; 14: 1649-57.
    • (2008) Clin Cancer Res , vol.14 , pp. 1649-1657
    • Orlowski, R.Z.1    Kuhn, D.J.2
  • 138
    • 33748744702 scopus 로고    scopus 로고
    • Antitumor effects of the proteasome inhibitor bortezomib in medullary and anaplastic thyroid carcinoma cells in vitro
    • Mitsiades CS, McMillin D, Kotoula V, et al. Antitumor effects of the proteasome inhibitor bortezomib in medullary and anaplastic thyroid carcinoma cells in vitro. J Clin Endocrinol Metab 2006; 91: 4013-21.
    • (2006) J Clin Endocrinol Metab , vol.91 , pp. 4013-4021
    • Mitsiades, C.S.1    McMillin, D.2    Kotoula, V.3
  • 139
    • 44449130087 scopus 로고    scopus 로고
    • Valproic acid activates Notch1 signaling and induces apoptosis in medullary thyroid cancer cells
    • Greenblatt DY, Cayo MA, Adler JT, et al. Valproic acid activates Notch1 signaling and induces apoptosis in medullary thyroid cancer cells. (2008) Ann Surg., 247, 1036-1040
    • (2008) Ann Surg , vol.247 , pp. 1036-1040
    • Greenblatt, D.Y.1    Cayo, M.A.2    Adler, J.T.3
  • 140
    • 40349091384 scopus 로고    scopus 로고
    • Suberoyl bis-hydroxamic acid activates Notch-1 signaling and induces apoptosis in medullary thyroid carcinoma cells
    • Ning L, Greenblatt DY, Kunnimalaiyaan M, Chen H. Suberoyl bis-hydroxamic acid activates Notch-1 signaling and induces apoptosis in medullary thyroid carcinoma cells. Oncologist 2008; 13: 98-104.
    • (2008) Oncologist , vol.13 , pp. 98-104
    • Ning, L.1    Greenblatt, D.Y.2    Kunnimalaiyaan, M.3    Chen, H.4
  • 141
    • 50049117726 scopus 로고    scopus 로고
    • Suberoyl bishydroxamic acid activates notch1 signaling and suppresses tumor progression in an animal model of medullary thyroid carcinoma
    • Ning L, Jaskula-Sztul R, Kunnimalaiyaan M, Chen H. Suberoyl bishydroxamic acid activates notch1 signaling and suppresses tumor progression in an animal model of medullary thyroid carcinoma. Am Surg Oncol 2008; 15: 2600-5.
    • (2008) Am Surg Oncol , vol.15 , pp. 2600-2605
    • Ning, L.1    Jaskula-Sztul, R.2    Kunnimalaiyaan, M.3    Chen, H.4
  • 142
    • 0036919703 scopus 로고    scopus 로고
    • Inhibition of medullary thyroid carcinoma cell proliferation and RET phosphorylation by tyrosine kinase inhibitors
    • Cohen MS, Hussain HB, Moley JF. Inhibition of medullary thyroid carcinoma cell proliferation and RET phosphorylation by tyrosine kinase inhibitors. Surgery 2002; 132: 960-7.
    • (2002) Surgery , vol.132 , pp. 960-967
    • Cohen, M.S.1    Hussain, H.B.2    Moley, J.F.3
  • 145
    • 71849111319 scopus 로고    scopus 로고
    • Medullary thyroid cancer: Molecular biology and novel molecular therapies
    • Cakir M, Grossman AB. Medullary thyroid cancer: molecular biology and novel molecular therapies. Neuroendocrinology 2009; 90: 323-48.
    • (2009) Neuroendocrinology , vol.90 , pp. 323-348
    • Cakir, M.1    Grossman, A.B.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.