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Volumn 43, Issue 4, 2009, Pages 143-155

Molecular genetics of medullary thyroid carcinoma: The quest for novel therapeutic targets

Author keywords

[No Author keywords available]

Indexed keywords

ARTEMIN; BETA CATENIN; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; NEURTURIN; PERSEPHIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN P53; PROTEIN RET; PROTEIN TYROSINE PHOSPHATASE; RAS PROTEIN; RETINOBLASTOMA PROTEIN; STAT PROTEIN; TYROSINE KINASE RECEPTOR;

EID: 70450184514     PISSN: 09525041     EISSN: 14796813     Source Type: Journal    
DOI: 10.1677/JME-09-0024     Document Type: Review
Times cited : (68)

References (155)
  • 1
    • 0034702207 scopus 로고    scopus 로고
    • Multiple endocrine neoplasia type 2B mutation in human RET oncogene induces medullary thyroid carcinoma in transgenic mice
    • Acton DS, Velthuyzen D, Lips CJ & Höppener JW 2000 Multiple endocrine neoplasia type 2B mutation in human RET oncogene induces medullary thyroid carcinoma in transgenic mice. Oncogene 19 3121-3125. (Pubitemid 30438470)
    • (2000) Oncogene , vol.19 , Issue.27 , pp. 3121-3125
    • Acton, D.S.1    Velthuyzen, D.2    Lips, C.J.M.3    Hoppener, J.W.M.4
  • 2
    • 0036581222 scopus 로고    scopus 로고
    • The GDNF family: Signalling, biological functions and therapeutic value
    • DOI 10.1038/nrn812
    • Airaksinen MS & Saarma M 2002 The GDNF family: signalling, biological functions and therapeutic value. Nature Reviews. Neuroscience 3 383-394. (Pubitemid 135706635)
    • (2002) Nature Reviews Neuroscience , vol.3 , Issue.5 , pp. 383-394
    • Airaksinen, M.S.1    Saarma, M.2
  • 4
    • 33845873043 scopus 로고    scopus 로고
    • Targeted mutation of serine 697 in the Ret tyrosine kinase causes migration defect of enteric neural crest cells
    • DOI 10.1242/dev.02616
    • Asai N, Fukuda T, Wu Z, Enomoto A, Pachnis V, Takahashi M & Costantini F 2006a Targeted mutation of serine 697 in the Ret tyrosine kinase causes migration defect of enteric neural crest cells. Development 133 4507-4516. (Pubitemid 46017825)
    • (2006) Development , vol.133 , Issue.22 , pp. 4507-4516
    • Asai, N.1    Fukuda, T.2    Wu, Z.3    Enomoto, A.4    Pachnis, V.5    Takahashi, M.6    Costantini, F.7
  • 6
    • 33745051551 scopus 로고    scopus 로고
    • p18 Ink4c and Pten constrain a positive regulatory loop between cell growth and cell cycle control
    • Bai F, Pei XH, Pandolfi PP & Xiong Y 2006 p18 Ink4c and Pten constrain a positive regulatory loop between cell growth and cell cycle control. Molecular and Cellular Biology 26 4564-4576.
    • (2006) Molecular and Cellular Biology , vol.26 , pp. 4564-4576
    • Bai, F.1    Pei, X.H.2    Pandolfi, P.P.3    Xiong, Y.4
  • 8
    • 58149202128 scopus 로고    scopus 로고
    • Is NF-kB a good target for cancer therapy? Hopes and pitfalls
    • Baud V & Karin M 2009 Is NF-kB a good target for cancer therapy? Hopes and pitfalls Nature Reviews. Drug Discovery 8 33-40.
    • (2009) Nature Reviews. Drug Discovery , vol.8 , pp. 33-40
    • Baud, V.1    Karin, M.2
  • 9
    • 2342559981 scopus 로고    scopus 로고
    • The TOR pathway: A target for cancer therapy
    • Bjornsti MA & Houghton PJ 2004 The TOR pathway: a target for cancer therapy. Nature Reviews. Cancer 4 335-348. (Pubitemid 38579480)
    • (2004) Nature Reviews Cancer , vol.4 , Issue.5 , pp. 335-348
    • Bjornsti, M.-A.1    Houghton, P.J.2
  • 11
    • 0031741050 scopus 로고    scopus 로고
    • Molecular analysis of the ret and GDNF genes in a family with multiple endocrine neoplasia type 2a and Hirschsprung disease
    • DOI 10.1210/jc.83.9.3361
    • Borrego S, Eng C, Sánchez B, Sáez ME, Navarro E & Antiñolo G 1998 Molecular analysis of the ret and GDNF genes in a family with multiple endocrine neoplasia type 2A and Hirschsprung disease. Journal of Clinical Endocrinology and Metabolism 83 3361-3364. (Pubitemid 28500986)
    • (1998) Journal of Clinical Endocrinology and Metabolism , vol.83 , Issue.9 , pp. 3361-3364
    • Borrego, S.1    Eng, C.2    Sanchez, B.3    Saez, M.-E.4    Navarro, E.5    Antinolo, G.6
  • 14
    • 30644458570 scopus 로고    scopus 로고
    • Balancing cell adhesion and Wnt signaling, the key role of β-catenin
    • DOI 10.1016/j.gde.2005.12.007, PII S0959437X05002236, Oncogenes and Cell Proliferation
    • Brembeck FH, Rosário M & Birchmeier W 2006 Balancing cell adhesion and Wnt signaling, the key role of beta-catenin. Current Opinion in Genetics and Development 16 51-59. (Pubitemid 43089612)
    • (2006) Current Opinion in Genetics and Development , vol.16 , Issue.1 , pp. 51-59
    • Brembeck, F.H.1    Rosario, M.2    Birchmeier, W.3
  • 17
    • 0032560857 scopus 로고    scopus 로고
    • Post-transcriptional silencing of RET occurs, but is not required, during raf-1 mediated differentiation of medullary thyroid carcinoma cells
    • Carson-Walter EB, Smith DP, Ponder BA, Baylin SB & Nelkin BD 1998 Post-transcriptional silencing of RET occurs, but is not required, during raf-1 mediated differentiation of medullary thyroid carcinoma cells. Oncogene 17 367-376.
    • (1998) Oncogene , vol.17 , pp. 367-376
    • Carson-Walter, E.B.1    Smith, D.P.2    Ponder, B.A.3    Baylin, S.B.4    Nelkin, B.D.5
  • 19
    • 58249112736 scopus 로고    scopus 로고
    • RET/PTC1- driven neoplastic transformation and proinvasive phenotype of human thyrocytes involve Met induction and beta-catenin nuclear translocation
    • Cassinelli G, Favini E, Degl'Innocenti D, Salvi A, De Petro G, Pierotti MA, Zunino F, Borrello MG & Lanzi C 2009 RET/PTC1- driven neoplastic transformation and proinvasive phenotype of human thyrocytes involve Met induction and beta-catenin nuclear translocation. Neoplasia 11 10-21.
    • (2009) Neoplasia , vol.11 , pp. 10-21
    • Cassinelli, G.1    Favini, E.2    Degl'Innocenti, D.3    Salvi, A.4    De Petro, G.5    Pierotti, M.A.6    Zunino, F.7    Borrello, M.G.8    Lanzi, C.9
  • 24
    • 0034705479 scopus 로고    scopus 로고
    • Abrogation of nerve growth factor-induced terminal differentiation by ret oncogene involves perturbation of nuclear translocation of ERK
    • DOI 10.1074/jbc.275.25.19306
    • Colucci-D'Amato GL, D'Alessio A, CalifanoD, Cali G, Rizzo C, Nitsch L, Santelli G & de Franciscis V 2000 Abrogation of nerve growth factorinduced terminal differentiation by ret oncogene involves perturbation of nuclear translocation of ERK. Journal of Biological Chemistry 275 19306-19314. (Pubitemid 30422904)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.25 , pp. 19306-19314
    • Colucci-D'Amato, G.L.1    D'Alessio, A.2    Califano, D.3    Cali, G.4    Rizzo, C.5    Nitsch, L.6    Santelli, G.7    De Franciscis, V.8
  • 25
    • 0032563945 scopus 로고    scopus 로고
    • RET cooperates with RB/p53 inactivation in a somatic multi-step model for murine thyroid cancer
    • Coxon AB, Ward JM, Geradts J, Otterson GA, Zajac-Kaye M & Kaye FJ 1998 RET cooperates with RB/p53 inactivation in a somatic multi-step model for murine thyroid cancer. Oncogene 17 1625-1628. (Pubitemid 28472767)
    • (1998) Oncogene , vol.17 , Issue.12 , pp. 1625-1628
    • Coxon, A.B.1    Ward, J.M.2    Geradts, J.3    Otterson, G.A.4    Zajac-Kaye, M.5    Kaye, F.J.6
  • 26
    • 0041438719 scopus 로고    scopus 로고
    • Modulation of medullary thyroid carcinoma penetrance suggests the presence of modifier genes in a RET transgenic mouse model
    • Cranston AN & Ponder BA 2003 Modulation of medullary thyroid carcinoma penetrance suggests the presence of modifier genes in a RET transgenic mouse model. Cancer Research 63 4777-4780.
    • (2003) Cancer Research , vol.63 , pp. 4777-4780
    • Cranston, A.N.1    Ponder, B.A.2
  • 27
    • 49249084044 scopus 로고    scopus 로고
    • RET/PTC-induced cell growth is mediated in part by epidermal growth factor receptor (EGFR) activation: Evidence for molecular and functional interactions between RET and EGFR
    • Croyle M, Akeno N, Knauf JA, Fabbro D, Chen X, Baumgartner JE, Lane H & Fagin JA 2008 RET/PTC-induced cell growth is mediated in part by epidermal growth factor receptor (EGFR) activation: evidence for molecular and functional interactions between RET and EGFR. Cancer Research 68 4183-4191.
    • (2008) Cancer Research , vol.68 , pp. 4183-4191
    • Croyle, M.1    Akeno, N.2    Knauf, J.A.3    Fabbro, D.4    Chen, X.5    Baumgartner, J.E.6    Lane, H.7    Fagin, J.A.8
  • 34
  • 35
    • 49949106621 scopus 로고    scopus 로고
    • Analysis of Ret knockin mice reveals a critical role for IKKs, but not PI 3-K, in neurotrophic factor-induced survival of sympathetic neurons
    • Encinas M, Rozen EJ, Dolcet X, Jain S, Comella JX, Milbrandt J & Johnson EM Jr 2008 Analysis of Ret knockin mice reveals a critical role for IKKs, but not PI 3-K, in neurotrophic factor-induced survival of sympathetic neurons. Cell Death and Differentiation 15 1510-1521.
    • (2008) Cell Death and Differentiation , vol.15 , pp. 1510-1521
    • Encinas, M.1    Rozen, E.J.2    Dolcet, X.3    Jain, S.4    Comella, J.X.5    Milbrandt, J.6    Johnson Jr., E.M.7
  • 36
    • 12944284651 scopus 로고    scopus 로고
    • Dual inhibition of RET and FGFR4 restrains medullary thyroid cancer cell growth
    • Ezzat S, Huang P, Dackiw A & Asa SL 2005 Dual inhibition of RET and FGFR4 restrains medullary thyroid cancer cell growth. Clinical Cancer Research 11 1336-1341. (Pubitemid 40175788)
    • (2005) Clinical Cancer Research , vol.11 , Issue.3 , pp. 1336-1341
    • Ezzat, S.1    Huang, P.2    Dackiw, A.3    Asa, S.L.4
  • 39
    • 0033864297 scopus 로고    scopus 로고
    • Functional collaboration between different cyclin-dependent kinase inhibitors suppresses tumor growth with distinct tissue specificity
    • DOI 10.1128/MCB.20.16.6147-6158.2000
    • Franklin DS, Godfrey VL, O'Brien DA, Deng C & Xiong Y 2000 Functional collaboration between different cyclin-dependent kinase inhibitors suppresses tumor growth with distinct tissue specificity. Molecular and Cellular Biology 20 6147-6158. (Pubitemid 30613062)
    • (2000) Molecular and Cellular Biology , vol.20 , Issue.16 , pp. 6147-6158
    • Franklin, D.S.1    Godfrey, V.L.2    O'Brien, D.A.3    Deng, C.4    Xiong, Y.5
  • 40
    • 0037166286 scopus 로고    scopus 로고
    • Novel mechanism of regulation of Rac activity and lamellipodia formation by RET tyrosine kinase
    • DOI 10.1074/jbc.M200643200
    • Fukuda T, Kiuchi K & Takahashi M 2002 Novel mechanism of regulation of Rac activity and lamellipodia formation by RET tyrosine kinase. Journal of Biological Chemistry 277 19114-19121. (Pubitemid 34952477)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.21 , pp. 19114-19121
    • Fukuda, T.1    Kiuchi, K.2    Takahashi, M.3
  • 41
    • 1042284665 scopus 로고    scopus 로고
    • Multiple endocrine neoplasia
    • 10 edn, Eds PR Larsen, H Kronenberg, S Melmed & K Polonsky. Philadelphia: Saunders, Elsevier Science
    • Gagel FR & Marx SJ 2003 Multiple endocrine neoplasia. In Williams Textbook of Endocrinology, 10 edn, pp 1717-1762. Eds PR Larsen, H Kronenberg, S Melmed & K Polonsky. Philadelphia: Saunders, Elsevier Science.
    • (2003) Williams Textbook of Endocrinology , pp. 1717-1762
    • Gagel, F.R.1    Marx, S.J.2
  • 44
    • 0035912105 scopus 로고    scopus 로고
    • Over-representation of a germline variant in the gene encoding RET co-receptor GFRα-1 but not GFRα-2 or GFRα-3 in cases with sporadic medullary thyroid carcinoma
    • DOI 10.1038/sj.onc.1204289
    • Gimm O, Dziema H, Brown J, Hoang-Vu C, Hinze R, Dralle H, Mulligan LM & Eng C 2001a Over-representation of a germline variant in the gene encoding RET co-receptor GFRalpha-1 but not GFRalpha-2 or GFRalpha-3 in cases with sporadic medullary thyroid carcinoma. Oncogene 20 2161-2170. (Pubitemid 32424010)
    • (2001) Oncogene , vol.20 , Issue.17 , pp. 2161-2170
    • Gimm, O.1    Dziema, H.2    Brown, J.3    Hoang-Vu, C.4    Hinze, R.5    Dralle, H.6    Mulligan, L.M.7    Eng, C.8
  • 45
    • 0035314012 scopus 로고    scopus 로고
    • Mutation analysis of NTRK2 and NTRK3, encoding 2 tyrosine kinase receptors, in sporadic human medullary thyroid carcinoma reveals novel sequence variants
    • Gimm O, Dziema H, Brown J, de la Puente A, Hoang-Vu C, Dralle H, Plass C & Eng C 2001b Mutation analysis of NTRK2 and NTRK3, encoding 2 tyrosine kinase receptors, in sporadic human medullary thyroid carcinoma reveals novel sequence variants. International Journal of Cancer 92 70-74. (Pubitemid 32187034)
    • (2001) International Journal of Cancer , vol.92 , Issue.1 , pp. 70-74
    • Gimm, O.1    Dziema, H.2    Brown, J.3    De La Puente, A.4    Hoang-Vu, C.5    Dralle, H.6    Plass, C.7    Eng, C.8
  • 49
    • 0036561908 scopus 로고    scopus 로고
    • Modelling the molecular circuitry of cancer
    • Hahn WC & Weinberg RA 2002 Modelling the molecular circuitry of cancer. Nature Reviews. Cancer 2 331-341.
    • (2002) Nature Reviews. Cancer , vol.2 , pp. 331-341
    • Hahn, W.C.1    Weinberg, R.A.2
  • 50
    • 51449119250 scopus 로고    scopus 로고
    • Therapeutic strategies for inhibiting oncogenic BRAF signaling
    • Halilovic E & Solit DB 2008 Therapeutic strategies for inhibiting oncogenic BRAF signaling. Current Opinion in Pharmacology 8 419-426.
    • (2008) Current Opinion in Pharmacology , vol.8 , pp. 419-426
    • Halilovic, E.1    Solit, D.B.2
  • 51
    • 0028988697 scopus 로고
    • Effects of heterozygosity for the Rb-1t19neo allele in the mouse
    • Harrison DJ, Hooper ML, Armstrong JF & Clarke AR 1995 Effects of heterozygosity for the Rb-1t19neo allele in the mouse. Oncogene 10 1615-1620.
    • (1995) Oncogene , vol.10 , pp. 1615-1620
    • Harrison, D.J.1    Hooper, M.L.2    Armstrong, J.F.3    Clarke, A.R.4
  • 52
    • 0028937476 scopus 로고
    • Mice deficient in both p53 and Rb develop tumors primarily of endocrine origin
    • Harvey M, Vogel H, Lee EY, Bradley A & Donehower LA 1995 Mice deficient in both p53 and Rb develop tumors primarily of endocrine origin. Cancer Research 55 1146-1151.
    • (1995) Cancer Research , vol.55 , pp. 1146-1151
    • Harvey, M.1    Vogel, H.2    Lee, E.Y.3    Bradley, A.4    Donehower, L.A.5
  • 55
    • 0030963645 scopus 로고    scopus 로고
    • Absence of TP53 alterations in pheochromocytomas and medullary thyroid carcinomas
    • DOI 10.1002/(SICI)1098-2264(199709)20:1<24::AID-GCC4>3.0.CO;2-B
    • Herfarth KK, Wick MR, Marshall HN, Gartner E, Lum S & Moley JF 1997 Absence of TP53 alterations in pheochromocytomas and medullary thyroid carcinomas. Genes, Chromosomes and Cancer 20 24-29. (Pubitemid 27377095)
    • (1997) Genes Chromosomes and Cancer , vol.20 , Issue.1 , pp. 24-29
    • Herfarth, K.K.-F.1    Wick, M.R.2    Marshall, H.N.3    Gartner, E.4    Lum, S.5    Moley, J.F.6
  • 60
    • 2042443795 scopus 로고    scopus 로고
    • The Shp-1 and Shp-2, tyrosine phosphatases, are recruited on cell membrane in two distinct molecular complexes including Ret oncogenes
    • DOI 10.1016/j.cellsig.2004.01.002, PII S0898656804000129
    • Incoronato M, D'Alessio A, Paladino S, Zurzolo C, Carlomagno MS, Cerchia L & de Franciscis V 2004 The Shp-1 and Shp-2, tyrosine phosphatases, are recruited on cell membrane in two distinct molecular complexes including Ret oncogenes. Cellular Signalling 16 847-856. (Pubitemid 38534532)
    • (2004) Cellular Signalling , vol.16 , Issue.7 , pp. 847-856
    • Incoronato, M.1    D'Alessio, A.2    Paladino, S.3    Zurzolo, C.4    Carlomagno, M.S.5    Cerchia, L.6    De Franciscis, V.7
  • 62
    • 32044436042 scopus 로고    scopus 로고
    • Critical and distinct roles for key RET tyrosine docking sites in renal development
    • DOI 10.1101/gad.1387206
    • Jain S, Encinas M, Johnson EM Jr & Milbrandt J 2006 Critical and distinct roles for key RET tyrosine docking sites in renal development. Genes and Development 20 321-333. (Pubitemid 43200286)
    • (2006) Genes and Development , vol.20 , Issue.3 , pp. 321-333
    • Jain, S.1    Encinas, M.2    Johnson Jr., E.M.3    Milbrandt, J.4
  • 63
    • 0032518923 scopus 로고    scopus 로고
    • Expression of v-Ha-ras driven by the calcitonin/calcitonin gene-related peptide promoter: A novel transgenic murine model for medullary thyroid carcinoma
    • Johnston D, Hatzis D & Sunday ME 1998 Expression of v-Ha-ras driven by the calcitonin/calcitonin gene-related peptide promoter: a novel transgenic murine model for medullary thyroid carcinoma. Oncogene 16 167-177. (Pubitemid 28045102)
    • (1998) Oncogene , vol.16 , Issue.2 , pp. 167-177
    • Johnston, D.1    Hatzis, D.2    Sunday, M.E.3
  • 65
    • 54549113030 scopus 로고    scopus 로고
    • The von Hippel-Lindau tumour suppressor protein: O2 sensing and cancer
    • Kaelin WG Jr 2008 The von Hippel-Lindau tumour suppressor protein: O2 sensing and cancer. Nature Reviews. Cancer 8 865-873.
    • (2008) Nature Reviews. Cancer , vol.8 , pp. 865-873
    • Kaelin Jr., W.G.1
  • 66
    • 0034665364 scopus 로고    scopus 로고
    • Tissue-specific carcinogenesis in transgenic mice expressing the RET proto-oncogene with a multiple endocrine neoplasia type 2A mutation
    • Kawai K, Iwashita T, Murakami H, Hiraiwa N, Yoshiki A, Kusakabe M, Ono K, Iida K, Nakayama A & Takahashi M 2000 Tissue-specific carcinogenesis in transgenic mice expressing the RET protooncogene with a multiple endocrine neoplasia type 2A mutation. Cancer Research 60 5254-5260. (Pubitemid 30739786)
    • (2000) Cancer Research , vol.60 , Issue.18 , pp. 5254-5260
    • Kawai, K.1    Iwashita, T.2    Murakami, H.3    Hiraiwa, N.4    Yoshiki, A.5    Kusakabe, M.6    Ono, K.7    Iida, K.-I.8    Nakayama, A.9    Takahashi, M.10
  • 67
    • 24944588250 scopus 로고    scopus 로고
    • Medullary thyroid carcinoma arises in the absence of prolactin signaling
    • DOI 10.1158/0008-5472.CAN-04-3937
    • Kedzia C, Lacroix L, Ameur N, Ragot T, Kelly PA, Caillou B & Binart N 2005 Medullary thyroid carcinoma arises in the absence of prolactin signaling. Cancer Research 65 8497-8503. (Pubitemid 41330618)
    • (2005) Cancer Research , vol.65 , Issue.18 , pp. 8497-8503
    • Kedzia, C.1    Lacroix, L.2    Ameur, N.3    Ragot, T.4    Kelly, P.A.5    Caillou, B.6    Binart, N.7
  • 71
    • 17744373695 scopus 로고    scopus 로고
    • The RET proto-oncogene: A molecular therapeutic target in thyroid cancer
    • DOI 10.1111/j.1349-7006.2005.00023.x
    • Kodama Y, Asai N, Kawai K, Jijiwa M, Murakumo Y, Ichihara M & Takahashi M 2005 The RET proto-oncogene: a molecular therapeutic target in thyroid cancer. Cancer Research 96 143-148. (Pubitemid 40575914)
    • (2005) Cancer Science , vol.96 , Issue.3 , pp. 143-148
    • Kodama, Y.1    Asai, N.2    Kawai, K.3    Jijiwa, M.4    Murakumo, Y.5    Ichihara, M.6    Takahashi, M.7
  • 72
    • 33645307434 scopus 로고    scopus 로고
    • Pathogenetic mechanisms in thyroid follicular-cell neoplasia
    • Kondo T, Ezzat S & Asa SL 2006 Pathogenetic mechanisms in thyroid follicular-cell neoplasia. Nature Reviews. Cancer 6 292-306.
    • (2006) Nature Reviews. Cancer , vol.6 , pp. 292-306
    • Kondo, T.1    Ezzat, S.2    Asa, S.L.3
  • 73
    • 34547156710 scopus 로고    scopus 로고
    • Regulation of MAP kinases by MAP kinase phosphatases
    • DOI 10.1016/j.bbamcr.2006.12.002, PII S0167488906004538
    • Kondoh K & Nishida E 2007 Regulation of MAP kinases by MAP kinase phosphatases. Biochimica et Biophysica Acta 1773 1227-1237. (Pubitemid 47125976)
    • (2007) Biochimica et Biophysica Acta - Molecular Cell Research , vol.1773 , Issue.8 , pp. 1227-1237
    • Kondoh, K.1    Nishida, E.2
  • 74
    • 22244480355 scopus 로고    scopus 로고
    • RET proto-oncogene: A review and update of genotype-phenotype correlations in hereditary medullary thyroid cancer and associated endocrine tumors
    • Kouvaraki MA, Shapiro SE, Perrier ND, Cote GJ, Gagel RF, Hoff AO, Sherman SI, Lee JE & Evans DB 2005 RET proto-oncogene: a review and update of genotype-phenotype correlations in hereditary medullary thyroid cancer and associated endocrine tumors. Thyroid 15 531-544.
    • (2005) Thyroid , vol.15 , pp. 531-544
    • Kouvaraki, M.A.1    Shapiro, S.E.2    Perrier, N.D.3    Cote, G.J.4    Gagel, R.F.5    Hoff, A.O.6    Sherman, S.I.7    Lee, J.E.8    Evans, D.B.9
  • 75
    • 33645746494 scopus 로고    scopus 로고
    • Inactivation of conditional Rb by Villin-Cre leads to aggressive tumors outside the gastrointestinal tract
    • Kucherlapati MH, Nguyen AA, Bronson RT & Kucherlapati RS 2006 Inactivation of conditional Rb by Villin-Cre leads to aggressive tumors outside the gastrointestinal tract. Cancer Research 66 3576-3583.
    • (2006) Cancer Research , vol.66 , pp. 3576-3583
    • Kucherlapati, M.H.1    Nguyen, A.A.2    Bronson, R.T.3    Kucherlapati, R.S.4
  • 76
    • 33845626635 scopus 로고    scopus 로고
    • Apoptosis-mediated medullary thyroid cancer growth suppression by the PI3K inhibitor LY294002
    • Kunnimalaiyaan M, Ndiaye M & Chen H 2006a Apoptosis-mediated medullary thyroid cancer growth suppression by the PI3K inhibitor LY294002. Surgery 140 1009-1014.
    • (2006) Surgery , vol.140 , pp. 1009-1014
    • Kunnimalaiyaan, M.1    Ndiaye, M.2    Chen, H.3
  • 77
    • 33845987566 scopus 로고    scopus 로고
    • Overexpression of the NOTCH1 intracellular domain inhibits cell proliferation and alters the neuroendocrine phenotype of medullary thyroid cancer cells
    • DOI 10.1074/jbc.M603578200
    • Kunnimalaiyaan M, Vaccaro AM, Ndiaye MA & Chen H 2006b Overexpression of the NOTCH1 intracellular domain inhibits cell proliferation and alters the neuroendocrine phenotype of medullary thyroid cancer cells. Journal of Biological Chemistry 281 39819-39830. (Pubitemid 46041785)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.52 , pp. 39819-39830
    • Kunnimalaiyaan, M.1    Vaccaro, A.M.2    Ndiaye, M.A.3    Chen, H.4
  • 78
    • 0031936990 scopus 로고    scopus 로고
    • Requirement of the MASH- 1 transcription factor for neuroendocrine differentiation of thyroid C cells
    • Lanigan TM, DeRaad SK & Russo AF 1998 Requirement of the MASH- 1 transcription factor for neuroendocrine differentiation of thyroid C cells. Journal of Neurobiology 34 126-134.
    • (1998) Journal of Neurobiology , vol.34 , pp. 126-134
    • Lanigan, T.M.1    DeRaad, S.K.2    Russo, A.F.3
  • 79
    • 0001445037 scopus 로고    scopus 로고
    • E2F4 loss suppresses tumorigenesis in Rb mutant mice
    • DOI 10.1016/S1535-6108(02)00207-6
    • Lee EY, Cam H, Ziebold U, Rayman JB, Lees JA & Dynlacht BD 2002 E2F4 loss suppresses tumorigenesis in Rb mutant mice. Cancer Cell 2 463-472. (Pubitemid 41043951)
    • (2002) Cancer Cell , vol.2 , Issue.6 , pp. 463-472
    • Lee, E.Y.1    Cam, H.2    Ziebold, U.3    Rayman, J.B.4    Lees, J.A.5    Dynlacht, B.D.6
  • 81
    • 55249095625 scopus 로고    scopus 로고
    • Myeloproliferative disorders
    • Levine RL & Gilliland DG 2008 Myeloproliferative disorders. Blood 112 2190-2198.
    • (2008) Blood , vol.112 , pp. 2190-2198
    • Levine, R.L.1    Gilliland, D.G.2
  • 83
    • 0035937727 scopus 로고    scopus 로고
    • Human Glial Cell Line-derived Neurotrophic Factor Receptor α4 is the Receptor for Persephin and is Predominantly Expressed in Normal and Malignant Thyroid Medullary Cells
    • DOI 10.1074/jbc.M008279200
    • Lindahl M, Poteryaev D, Yu L, Arumae U, Timmusk T, Bongarzone I, Aiello A, Pierotti MA, Airaksinen MS & Saarma M 2001 Human glial cell line-derived neurotrophic factor receptor alpha 4 is the receptor for persephin and is predominantly expressed in normal and malignant thyroid medullary cells. Journal of Biological Chemistry 276 9344-9351. (Pubitemid 37385521)
    • (2001) Journal of Biological Chemistry , vol.276 , Issue.12 , pp. 9344-9351
    • Lindahl, M.1    Poteryaev, D.2    Yu, L.3    Arumae, U.4    Timmusk, T.5    Bongarzone, I.6    Aiello, A.7    Pierotti, M.A.8    Airaksinen, M.S.9    Saarma, M.10
  • 84
    • 33645880466 scopus 로고    scopus 로고
    • Ablation of persephin receptor glial cell line-derived neurotrophic factor family receptor alpha4 impairs thyroid calcitonin production in young mice
    • Lindfors PH, Lindahl M, Rossi J, Saarma M & Airaksinen MS 2006 Ablation of persephin receptor glial cell line-derived neurotrophic factor family receptor alpha4 impairs thyroid calcitonin production in young mice. Endocrinology 147 2237-2244.
    • (2006) Endocrinology , vol.147 , pp. 2237-2244
    • Lindfors, P.H.1    Lindahl, M.2    Rossi, J.3    Saarma, M.4    Airaksinen, M.S.5
  • 86
    • 0035354187 scopus 로고    scopus 로고
    • Nuclear factor-κB is constitutively active in C-cell carcinoma and required for RET-induced transformation
    • Ludwig L, Kessler H, Wagner M, Hoang-Vu C, Dralle H, Adler G, Böhm BO & Schmid RM 2001 Nuclear factor-kappaB is constitutively active in C-cell carcinoma and required for RET-induced transformation. Cancer Research 61 4526-4535. (Pubitemid 32685784)
    • (2001) Cancer Research , vol.61 , Issue.11 , pp. 4526-4535
    • Ludwig, L.1    Kessler, H.2    Wagner, M.3    Hoang-Vu, C.4    Dralle, H.5    Adler, G.6    Bohm, B.O.7    Schmid, R.M.8
  • 87
    • 34249743706 scopus 로고    scopus 로고
    • A Hierarchical NGF Signaling Cascade Controls Ret-Dependent and Ret-Independent Events during Development of Nonpeptidergic DRG Neurons
    • DOI 10.1016/j.neuron.2007.04.027, PII S0896627307003297
    • Luo W, Wickramasinghe SR, Savitt JM, Griffin JW, Dawson TM & Ginty DD 2007 A hierarchical NGF signaling cascade controls Ret-dependent and Ret-independent events during development of nonpeptidergic DRG neurons. Neuron 54 739-754. (Pubitemid 46843519)
    • (2007) Neuron , vol.54 , Issue.5 , pp. 739-754
    • Luo, W.1    Wickramasinghe, S.R.2    Savitt, J.M.3    Griffin, J.W.4    Dawson, T.M.5    Ginty, D.D.6
  • 88
    • 34248170296 scopus 로고    scopus 로고
    • Genotype-phenotype based surgical concept of hereditary medullary thyroid carcinoma
    • DOI 10.1007/s00268-006-0769-y
    • Machens A & Dralle H 2007 Genotype-phenotype based surgical concept of hereditary medullary thyroid carcinoma. World Journal of Surgery 31 957-968. (Pubitemid 46716774)
    • (2007) World Journal of Surgery , vol.31 , Issue.5 , pp. 957-968
    • Machens, A.1    Dralle, H.2
  • 89
    • 0036798174 scopus 로고    scopus 로고
    • The pressure rises: Update on the genetics of phaeochromocytoma
    • Maher ER & Eng C 2002 The pressure rises: update on the genetics of phaeochromocytoma. Human Molecular Genetics 11 2347-2354. (Pubitemid 35174697)
    • (2002) Human Molecular Genetics , vol.11 , Issue.20 , pp. 2347-2354
    • Maher, E.R.1    Eng, C.2
  • 92
    • 18344380647 scopus 로고    scopus 로고
    • Molecular genetics of multiple endocrine neoplasia types 1 and 2
    • DOI 10.1038/nrc1610
    • Marx SJ 2005 Molecular genetics of multiple endocrine neoplasia types 1 and 2. Nature Reviews. Cancer 5 367-375. (Pubitemid 40637828)
    • (2005) Nature Reviews Cancer , vol.5 , Issue.5 , pp. 367-375
    • Marx, S.J.1
  • 93
    • 0023228919 scopus 로고
    • Deletion of genes on chromosome 1 in endocrine neoplasia
    • DOI 10.1038/328524a0
    • Mathew CG, Smith BA, Thorpe K, Wong Z, Royle NJ, Jeffreys AJ & Ponder BA 1987 Deletion of genes on chromosome 1 in endocrine neoplasia. Nature 328 524-526. (Pubitemid 17098352)
    • (1987) Nature , vol.328 , Issue.6130 , pp. 524-526
    • Mathew, C.G.P.1    Smith, B.A.2    Thorpe, K.3
  • 100
    • 0025857633 scopus 로고
    • Low frequency of ras gene mutations in neuroblastomas, pheochromocytomas, and medullary thyroid cancers
    • Moley JF, Brother MB, Wells SA, Spengler BA, Biedler JL & Brodeur GM 1991 Low frequency of ras gene mutations in neuroblastomas, pheochromocytomas, and medullary thyroid cancers. Cancer Research 51 1596-1599.
    • (1991) Cancer Research , vol.51 , pp. 1596-1599
    • Moley, J.F.1    Brother, M.B.2    Wells, S.A.3    Spengler, B.A.4    Biedler, J.L.5    Brodeur, G.M.6
  • 101
    • 29144458355 scopus 로고    scopus 로고
    • No mutations but an increased frequency of SDHx polymorphisms in patients with sporadic and familial medullary thyroid carcinoma
    • DOI 10.1677/erc.1.00996
    • MontaniM, Schmitt AM, Schmid S, Locher T, Saremaslani P, Heitz PU, Komminoth P & Perren A 2005 No mutations but an increased frequency of SDHx polymorphisms in patients with sporadic and familial medullary thyroid carcinoma. Endocrine-Related Cancer 12 1011-1016. (Pubitemid 41815793)
    • (2005) Endocrine-Related Cancer , vol.12 , Issue.4 , pp. 1011-1016
    • Montani, M.1    Schmitt, A.M.2    Schmid, S.3    Locher, T.4    Saremaslani, P.5    Heitz, P.U.6    Komminoth, P.7    Perren, A.8
  • 106
    • 43849090932 scopus 로고    scopus 로고
    • Dysregulation of the phosphatidylinositol 3-kinase pathway in thyroid neoplasia
    • viii-ix
    • Paes JE & Ringel MD 2008 Dysregulation of the phosphatidylinositol 3-kinase pathway in thyroid neoplasia. Endocrinology and Metabolism Clinics of North America 37 375-387 (viii-ix).
    • (2008) Endocrinology and Metabolism Clinics of North America , vol.37 , pp. 375-387
    • Paes, J.E.1    Ringel, M.D.2
  • 108
    • 0033566948 scopus 로고    scopus 로고
    • Hammerhead ribozyme-mediated inactivation of mutant RET in medullary thyroid carcinoma
    • Parthasarathy R, Cote GJ & Gagel RF 1999 Hammerhead ribozymemediated inactivation of mutant RET in medullary thyroid carcinoma. Cancer Research 59 3911-3914. (Pubitemid 29393551)
    • (1999) Cancer Research , vol.59 , Issue.16 , pp. 3911-3914
    • Parthasarathy, R.1    Cote, G.J.2    Gagel, R.F.3
  • 111
    • 33846973024 scopus 로고    scopus 로고
    • NGF augments the autophosphorylation of Ret via inhibition of ubiquitin-dependent degradation
    • DOI 10.1111/j.1471-4159.2006.04292.x
    • Pierchala BA, Tsui CC, Milbrandt J & Johnson EM 2007 NGF augments the autophosphorylation of Ret via inhibition of ubiquitindependent degradation. Journal of Neurochemistry 100 1169-1176. (Pubitemid 46246395)
    • (2007) Journal of Neurochemistry , vol.100 , Issue.5 , pp. 1169-1176
    • Pierchala, B.A.1    Tsui, C.C.2    Milbrandt, J.3    Johnson, E.M.4
  • 112
    • 30144437331 scopus 로고    scopus 로고
    • Oncogenic rearrangements of the NTRK1/NGF receptor
    • Pierotti MA & Greco A 2006 Oncogenic rearrangements of the NTRK1/NGF receptor. Cancer Letters 232 90-98.
    • (2006) Cancer Letters , vol.232 , pp. 90-98
    • Pierotti, M.A.1    Greco, A.2
  • 114
    • 34250314111 scopus 로고    scopus 로고
    • 727 phosphorylation by familial medullary thyroid carcinoma-associated RET mutants induces full activation of STAT3 and is required for c-fos promoter activation, cell mitogenicity, and transformation
    • DOI 10.1074/jbc.M608952200
    • Plaza-Menacho I, van der Sluis T, Hollema H, Gimm O, Buys CH, Magee AI, Isacke CM, Hofstra RM & Eggen BJ 2007 Ras/ERK1/ 2-mediated STAT3 Ser727 phosphorylation by familial medullary thyroid carcinoma-associated RET mutants induces full activation of STAT3 and is required for c-fos promoter activation, cell mitogenicity, and transformation. Journal of Biological Chemistry 282 6415-6424. (Pubitemid 47100884)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.9 , pp. 6415-6424
    • Plaza-Menacho, I.1    Van Der Sluis, T.2    Hollema, H.3    Gimm, O.4    Buys, C.H.C.M.5    Magee, A.I.6    Isacke, C.M.7    Hofstra, R.M.W.8    Eggen, B.J.L.9
  • 115
    • 0035937777 scopus 로고    scopus 로고
    • Differential Effects of Leukocyte Common Antigen-related Protein on Biochemical and Biological Activities of RET-MEN2A and RET-MEN2B Mutant Proteins
    • DOI 10.1074/jbc.M008744200
    • Qiao S, Iwashita T, Furukawa T, Yamamoto M, Sobue G & Takahashi M 2001 Differential effects of leukocyte common antigen-related protein on biochemical and biological activities of RET-MEN2A and RET-MEN2B mutant proteins. Journal of Biological Chemistry 276 9460-9467. (Pubitemid 37385535)
    • (2001) Journal of Biological Chemistry , vol.276 , Issue.12 , pp. 9460-9467
    • Qiao, S.1    Iwashita, T.2    Furukawa, T.3    Yamamoto, M.4    Sobue, G.5    Takahashi, M.6
  • 116
    • 1342288971 scopus 로고    scopus 로고
    • Comparative biology of mouse versus human cells: Modelling human cancer in mice
    • Rangarajan A & Weinberg RA 2003 Opinion: comparative biology of mouse versus human cells: modelling human cancer in mice. Nature Reviews. Cancer 3 952-959. (Pubitemid 37500180)
    • (2003) Nature Reviews Cancer , vol.3 , Issue.12 , pp. 952-959
    • Rangarajan, A.1    Weinberg, R.A.2
  • 119
    • 43049128529 scopus 로고    scopus 로고
    • Tenets of PTEN tumor suppression
    • Salmena L, Carracedo A & Pandolfi PP 2008 Tenets of PTEN tumor suppression. Cell 133 403-414.
    • (2008) Cell , vol.133 , pp. 403-414
    • Salmena, L.1    Carracedo, A.2    Pandolfi, P.P.3
  • 120
    • 33646506360 scopus 로고    scopus 로고
    • Drug insight: Small-molecule inhibitors of protein kinases in the treatment of thyroid cancer
    • Santoro M & Carlomagno F 2006 Drug insight: small-molecule inhibitors of protein kinases in the treatment of thyroid cancer. Nature Clinical Practice. Endocrinology and Metabolism 2 42-52.
    • (2006) Nature Clinical Practice. Endocrinology and Metabolism , vol.2 , pp. 42-52
    • Santoro, M.1    Carlomagno, F.2
  • 121
    • 33747367221 scopus 로고    scopus 로고
    • CpG island methylation of tumor-related promoters occurs preferentially in undifferentiated carcinoma
    • DOI 10.1089/thy.2006.16.633
    • Schagdarsurengin U, Gimm O, Dralle H, Hoang-Vu C & Dammann R 2006 CpG island methylation of tumor-related promoters occurs preferentially in undifferentiated carcinoma. Thyroid 16 633-642. (Pubitemid 44246258)
    • (2006) Thyroid , vol.16 , Issue.7 , pp. 633-642
    • Schagdarsurengin, U.1    Gimm, O.2    Dralle, H.3    Hoang-Vu, C.4    Dammann, R.5
  • 123
    • 33947594129 scopus 로고    scopus 로고
    • Hyperactive Ras in developmental disorders and cancer
    • DOI 10.1038/nrc2109, PII NRC2109
    • Schubbert S, Shannon K & Bollag G 2007 Hyperactive Ras in developmental disorders and cancer. Nature Reviews. Cancer 7 295-308. (Pubitemid 46480970)
    • (2007) Nature Reviews Cancer , vol.7 , Issue.4 , pp. 295-308
    • Schubbert, S.1    Shannon, K.2    Bollag, G.3
  • 124
    • 0026530617 scopus 로고
    • Pheochromocytomas and C-cell thyroid neoplasms in transgenic c-mos mice: Amodel for the human multiple endocrine neoplasia type 2 syndrome
    • Schulz N, Propst F, Rosenberg MP, Linnoila RI, Paules RS, Kovatch R, Ogiso Y & Vande Woude G 1992 Pheochromocytomas and C-cell thyroid neoplasms in transgenic c-mos mice: amodel for the human multiple endocrine neoplasia type 2 syndrome. Cancer Research 52 450-455.
    • (1992) Cancer Research , vol.52 , pp. 450-455
    • Schulz, N.1    Propst, F.2    Rosenberg, M.P.3    Linnoila, R.I.4    Paules, R.S.5    Kovatch, R.6    Ogiso, Y.7    Vande Woude, G.8
  • 125
    • 0034603172 scopus 로고    scopus 로고
    • Transforming ability of MEN2A-RET requires activation of the phosphatidylinositol 3-kinase/AKT signaling pathway
    • DOI 10.1074/jbc.275.5.3568
    • Segouffin-Cariou C & Billaud M 2000 Transforming ability of MEN2A-RET requires activation of the phosphatidylinositol 3-kinase/AKT signaling pathway. Journal of Biological Chemistry 275 3568-3576. (Pubitemid 30083066)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.5 , pp. 3568-3576
    • Segouffin-Cariou, C.1    Billaud, M.2
  • 128
    • 0001251788 scopus 로고
    • The association of pheochromocytoma with carcinoma of the thyroid gland
    • Sipple JH 1961 The association of pheochromocytoma with carcinoma of the thyroid gland. American Journal of Medicine 31 163-166.
    • (1961) American Journal of Medicine , vol.31 , pp. 163-166
    • Sipple, J.H.1
  • 129
    • 36549075214 scopus 로고    scopus 로고
    • Systematic analyses of the cancer genome: Lessons learned from sequencing most of the annotated human protein-coding genes
    • DOI 10.1097/CCO.0b013e3282f31108, PII 0000162220080100000010
    • Sjöblom T 2008 Systematic analyses of the cancer genome: lessons learned from sequencing most of the annotated human proteincoding genes. Current Opinion in Oncology 20 66-71. (Pubitemid 350190983)
    • (2008) Current Opinion in Oncology , vol.20 , Issue.1 , pp. 66-71
    • Sjoblom, T.1
  • 131
    • 0034651526 scopus 로고    scopus 로고
    • C-cell hyperplasia, pheochromocytoma and sympathoadrenal malformation in
    • Smith-Hicks CL, Sizer KC, Powers JF, Tischler AS & Costantini F 2000 C-cell hyperplasia, pheochromocytoma and sympathoadrenal malformation in a mouse model of multiple endocrine neoplasia type 2B. EMBO Journal 19 612-622. (Pubitemid 30093734)
    • (2000) EMBO Journal , vol.19 , Issue.4 , pp. 612-622
    • Smith-Hicks, C.L.1    Sizer, K.C.2    Powers, J.F.3    Tischler, A.S.4    Costantini, F.5
  • 137
    • 0037122878 scopus 로고    scopus 로고
    • NGF utilizes c-Ret via a novel GFL-independent, inter-RTK signaling mechanism to maintain the trophic status of mature sympathetic neurons
    • DOI 10.1016/S0896-6273(01)00585-2
    • Tsui-Pierchala BA, Milbrandt J & Johnson EM Jr 2002 NGF utilizes c-Ret via a novel GFL-independent, inter-RTK signaling mechanism to maintain the trophic status of mature sympathetic neurons. Neuron 33 261-273. (Pubitemid 34127758)
    • (2002) Neuron , vol.33 , Issue.2 , pp. 261-273
    • Tsui-Pierchala, B.A.1    Milbrandt, J.2    Johnson Jr., E.M.3
  • 141
    • 27744515971 scopus 로고    scopus 로고
    • Editorial: Germline variants within RET: Clinical utility or scientific playtoy?
    • Weber F & Eng C 2005 Editorial: germline variants within RET: clinical utility or scientific playtoy? Journal of Clinical Endocrinology and Metabolism 90 6334-6336.
    • (2005) Journal of Clinical Endocrinology and Metabolism , vol.90 , pp. 6334-6336
    • Weber, F.1    Eng, C.2
  • 143
    • 3242736846 scopus 로고    scopus 로고
    • Evolving strategies for targeted cancer therapy - Past, present, and future
    • Wells SA & Nevins JR 2004 Evolving strategies for targeted cancer therapy - past, present, and future. Journal of the National Cancer Institute 96 980-981. (Pubitemid 39162632)
    • (2004) Journal of the National Cancer Institute , vol.96 , Issue.13 , pp. 980-981
    • Wells, S.A.1    Nevins, J.R.2
  • 147
    • 21244457181 scopus 로고    scopus 로고
    • BRAF mutation in thyroid cancer
    • XingM2005 BRAF mutation in thyroid cancer. Endocrine-Related Cancer 12 245-262.
    • (2005) Endocrine-Related Cancer , vol.12 , pp. 245-262
    • Xing, M.1
  • 148
    • 0031897273 scopus 로고    scopus 로고
    • Loss of E2F-1 reduces tumorigenesis and extends the lifespan of Rb1(+/- ) mice
    • DOI 10.1038/ng0498-360
    • Yamasaki L, Bronson R, Williams BO, Dyson NJ, Harlow E & Jacks T 1998 Loss of E2F-1 reduces tumorigenesis and extends the lifespan of Rb1(+/-) mice. Nature Genetics 18 360-364. (Pubitemid 28158165)
    • (1998) Nature Genetics , vol.18 , Issue.4 , pp. 360-364
    • Yamasaki, L.1    Bronson, R.2    Williams, B.O.3    Dyson, N.J.4    Harlow, E.5    Jacks, T.6
  • 149
    • 0027015042 scopus 로고
    • Role of insulin-like growth factor-I in the autocrine regulation of cell growth in TT human medullary thyroid carcinoma cells
    • Yang KP, Samaan NA, Liang YF & Castillo SG 1992 Role of insulin-like growth factor-I in the autocrine regulation of cell growth in TT human medullary thyroid carcinoma cells. Henry Ford Hospital Medical Journal 40 293-295.
    • (1992) Henry Ford Hospital Medical Journal , vol.40 , pp. 293-295
    • Yang, K.P.1    Samaan, N.A.2    Liang, Y.F.3    Castillo, S.G.4
  • 150
    • 57349167652 scopus 로고    scopus 로고
    • High resolution array-comparative genomic hybridization profiling reveals deoxyribonucleic acid copy number alterations associated with medullary thyroid carcinoma
    • DOI 10.1210/jc.2008-0912
    • Ye L, Santarpia L, Cote GJ, El-Naggar AK & Gagel RF 2008 High resolution array-comparative genomic hybridization profiling reveals deoxyribonucleic acid copy number alterations associated with medullary thyroid carcinoma. Journal of Clinical Endocrinology and Metabolism 93 4367-4372. (Pubitemid 352789533)
    • (2008) Journal of Clinical Endocrinology and Metabolism , vol.93 , Issue.11 , pp. 4367-4372
    • Ye, L.1    Santarpia, L.2    Cote, G.J.3    El-Naggar, A.K.4    Gagel, R.F.5
  • 151
    • 0026792908 scopus 로고
    • Role of p53 mutations in endocrine tumorigenesis: Mutation detection by polymerase chain reaction-single strand conformation polymorphism
    • Yoshimoto K, Iwahana H, Fukuda A, Sano T, Saito S & Itakura M 1992 Role of p53 mutations in endocrine tumorigenesis: mutation detection by polymerase chain reaction-single strand conformation polymorphism. Cancer Research 52 5061-5064.
    • (1992) Cancer Research , vol.52 , pp. 5061-5064
    • Yoshimoto, K.1    Iwahana, H.2    Fukuda, A.3    Sano, T.4    Saito, S.5    Itakura, M.6
  • 152
    • 51849111556 scopus 로고    scopus 로고
    • PI3K pathway alterations in cancer: Variations on a theme
    • Yuan TL & Cantley LC 2008 PI3K pathway alterations in cancer: variations on a theme. Oncogene 27 5497-5510.
    • (2008) Oncogene , vol.27 , pp. 5497-5510
    • Yuan, T.L.1    Cantley, L.C.2
  • 153
    • 18844395883 scopus 로고    scopus 로고
    • Src homology-2-containing protein tyrosine phosphatase-1 restrains cell proliferation in human medullary thyroid carcinoma
    • DOI 10.1210/en.2005-0001
    • Zatelli MC, Piccin D, Tagliati F, Bottoni A, Luchin A & degli Uberti EC 2005 SRC homology-2-containing protein tyrosine phosphatase-1 restrains cell proliferation in human medullary thyroid carcinoma. Endocrinology 146 2692-2698. (Pubitemid 40695572)
    • (2005) Endocrinology , vol.146 , Issue.6 , pp. 2692-2698
    • Zatelli, M.C.1    Piccin, D.2    Tagliati, F.3    Bottoni, A.4    Luchin, A.5    Degli Uberti, E.C.6
  • 154
    • 33845875992 scopus 로고    scopus 로고
    • Cancer phenomics: RET and PTEN as illustrative models
    • DOI 10.1038/nrc2037, PII NRC2037
    • Zbuk KM & Eng C 2007 Cancer phenomics: RET and PTEN as illustrative models. Nature Reviews. Cancer 7 35-45. (Pubitemid 46020845)
    • (2007) Nature Reviews Cancer , vol.7 , Issue.1 , pp. 35-45
    • Zbuk, K.M.1    Eng, C.2
  • 155
    • 0042190650 scopus 로고    scopus 로고
    • E2F3 loss has opposing effects on different pRB-deficient tumors, resulting in suppression of pituitary tumors but metastasis of medullary thyroid carcinomas
    • DOI 10.1128/MCB.23.18.6542-6552.2003
    • Ziebold U, Lee EY, Bronson RT & Lees JA 2003 E2F3 loss has opposing effects on different pRB-deficient tumors, resulting in suppression of pituitary tumors but metastasis of medullary thyroid carcinomas. Molecular and Cellular Biology 23 6542-6552. (Pubitemid 37075765)
    • (2003) Molecular and Cellular Biology , vol.23 , Issue.18 , pp. 6542-6552
    • Ziebold, U.1    Lee, E.Y.2    Bronson, R.T.3    Lees, J.A.4


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