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Volumn 3, Issue 10, 2006, Pages 564-574

Mechanisms of Disease: Cancer targeting and the impact of oncogenic RET for medullary thyroid carcinoma therapy

Author keywords

[No Author keywords available]

Indexed keywords

17 ALLYLAMINO 17 DEMETHOXYGELDANAMYCIN; AG 013736; AMG 706; ANTINEOPLASTIC AGENT; APTAMER; BEVACIZUMAB; CEP 701; CEP 751; CETUXIMAB; FIBROBLAST GROWTH FACTOR RECEPTOR; GEFITINIB; HEAT SHOCK PROTEIN 90 INHIBITOR; IMATINIB; IRINOTECAN; MONOCLONAL ANTIBODY; OXINDOLE DERIVATIVE; PD 173074; PEGAPTANIB; PHOSPHOPROTEIN PHOSPHATASE; PROTEIN RET; PROTEIN TYROSINE KINASE INHIBITOR; PYRAZOLOPYRIMIDINE 1; PYRAZOLOPYRIMIDINE 2; PYRAZOLOPYRIMIDINE DERIVATIVE; RECEPTOR BLOCKING AGENT; RIBOZYME; SORAFENIB; TRASTUZUMAB; UNCLASSIFIED DRUG; UNINDEXED DRUG; VANDETANIB; RET PROTEIN, HUMAN;

EID: 33750596636     PISSN: 17434254     EISSN: 17434262     Source Type: Journal    
DOI: 10.1038/ncponc0610     Document Type: Review
Times cited : (82)

References (79)
  • 1
    • 0037025173 scopus 로고    scopus 로고
    • Cancer: Addiction to oncogenes-the Achilles heal of cancer
    • Weinstein IB (2GO2) Cancer: Addiction to oncogenes-the Achilles heal of cancer. Science 297: 63-64
    • (2002) Science , vol.297 , pp. 63-64
    • Weinstein, I.B.1
  • 2
    • 0042071479 scopus 로고    scopus 로고
    • Beyond Herceptin and Gleevec
    • Fischer OM et al. (2003) Beyond Herceptin and Gleevec. Curr Opin Chem Biol 7: 490-495
    • (2003) Curr Opin Chem Biol , vol.7 , pp. 490-495
    • Fischer, O.M.1
  • 3
    • 4644245221 scopus 로고    scopus 로고
    • Targeted therapies for cancer 2004
    • Ross JS et al. (2004) Targeted therapies for cancer 2004. Am J Clin Pathol 122: 598-609
    • (2004) Am J Clin Pathol , vol.122 , pp. 598-609
    • Ross, J.S.1
  • 4
    • 0035340632 scopus 로고    scopus 로고
    • Current approaches and perspectives in the therapy of medullary thyroid carcinoma
    • Vitale G et al. (2001) Current approaches and perspectives in the therapy of medullary thyroid carcinoma. Cancer 9l: 1797-1808
    • (2001) Cancer , vol.91 , pp. 1797-1808
    • Vitale, G.1
  • 5
    • 14644446016 scopus 로고    scopus 로고
    • Medullary thyroid carcinoma: Including MEN 2A and MEN 2B syndromes
    • Quayle FJ and Moley JF (2005) Medullary thyroid carcinoma: Including MEN 2A and MEN 2B syndromes. J Surg Oncol 89: 122-129
    • (2005) J Surg Oncol , vol.89 , pp. 122-129
    • Quayle, F.J.1    Moley, J.F.2
  • 6
    • 3042749217 scopus 로고    scopus 로고
    • The RET proto-oncogene: A potential target for molecular cancer therapy
    • Pützer BM and Drosten M (2004) The RET proto-oncogene: A potential target for molecular cancer therapy. Trends Mol Med 10: 351-357
    • (2004) Trends Mol Med , vol.10 , pp. 351-357
    • Pützer, B.M.1    Drosten, M.2
  • 7
    • 22544456020 scopus 로고    scopus 로고
    • RET tyrosine kinase signaling in development and cancer
    • Arighi E et al. (2005) RET tyrosine kinase signaling in development and cancer. Cytokine Growth Factor Rev 16: 441-467
    • (2005) Cytokine Growth Factor Rev , vol.16 , pp. 441-467
    • Arighi, E.1
  • 8
    • 0036581222 scopus 로고    scopus 로고
    • The GDNF family: Signaling, biological functions and therapeutic value
    • Airaksinen MF and Saarma M (2002) The GDNF family: Signaling, biological functions and therapeutic value. Nat Rev Neurosci 3: 383-394
    • (2002) Nat Rev Neurosci , vol.3 , pp. 383-394
    • Airaksinen, M.F.1    Saarma, M.2
  • 9
    • 0037127194 scopus 로고    scopus 로고
    • Coordinated activation of autophosphorylation sites in the RET receptor tyrosine kinase: Importance of tyrosine 1062 for GDNF mediated neuronal differentiation and survival
    • Coutpier M et al. (2002) Coordinated activation of autophosphorylation sites in the RET receptor tyrosine kinase: Importance of tyrosine 1062 for GDNF mediated neuronal differentiation and survival. J Biol Chem 277: 1991-1999
    • (2002) J Biol Chem , vol.277 , pp. 1991-1999
    • Coutpier, M.1
  • 10
    • 0033964411 scopus 로고    scopus 로고
    • The GDNF family ligands and receptors-implications for neural development
    • Baloh RH et al. (2000) The GDNF family ligands and receptors-implications for neural development. Curr Opin Neurobiol 10: 103-110
    • (2000) Curr Opin Neurobiol , vol.10 , pp. 103-110
    • Baloh, R.H.1
  • 11
    • 0028174023 scopus 로고
    • Defects in the kidney and enteric nervous system in mice lacking the tyrosine kinase receptor Ret
    • Schuchardt A et al. (1994) Defects in the kidney and enteric nervous system in mice lacking the tyrosine kinase receptor Ret. Nature 367: 380-383
    • (1994) Nature , vol.367 , pp. 380-383
    • Schuchardt, A.1
  • 12
    • 0029901727 scopus 로고    scopus 로고
    • Renal agenesis and the absence of enteric neurons in mice lacking GDNF
    • Sanchez M P et al. (1996) Renal agenesis and the absence of enteric neurons in mice lacking GDNF. Nature 382: 70-73
    • (1996) Nature , vol.382 , pp. 70-73
    • Sanchez, M.P.1
  • 13
    • 0032114122 scopus 로고    scopus 로고
    • GFRα1 is an essential receptor component for GDNF in the developing nervous system and kidney
    • Cacalano G et al. (1998) GFRα1 is an essential receptor component for GDNF in the developing nervous system and kidney. Neuron 21: 53-62
    • (1998) Neuron , vol.21 , pp. 53-62
    • Cacalano, G.1
  • 14
    • 9444225531 scopus 로고    scopus 로고
    • Mice expressing a dominant-negative Ret mutation phenocopy human Hirschsprung disease and delineate a direct role of Ret in spermatogenesis
    • Jain S et al. (2 004) Mice expressing a dominant-negative Ret mutation phenocopy human Hirschsprung disease and delineate a direct role of Ret in spermatogenesis. Development 131: 5503-6513
    • (2004) Development , vol.131 , pp. 5503-6513
    • Jain, S.1
  • 15
    • 0034849573 scopus 로고    scopus 로고
    • The GDNF/RET signaling pathways and human diseases
    • Takahashi M (2001) The GDNF/RET signaling pathways and human diseases. Cytokine Growth Factor Rev 12: 361-373
    • (2001) Cytokine Growth Factor Rev , vol.12 , pp. 361-373
    • Takahashi, M.1
  • 16
    • 0035479144 scopus 로고    scopus 로고
    • The RET receptor: Function in development and dysfunction in congenital malformation
    • Manie S et al. (2001) The RET receptor: Function in development and dysfunction in congenital malformation. Trends Genet 17: 580-689
    • (2001) Trends Genet , vol.17 , pp. 580-689
    • Manie, S.1
  • 17
    • 4444324911 scopus 로고    scopus 로고
    • A targeted mutation of tyrosine 1062 in Ret causes a marked decrease of enteric neurons and renal hypoplasia
    • Jijiwa M et al. (2004) A targeted mutation of tyrosine 1062 in Ret causes a marked decrease of enteric neurons and renal hypoplasia. Mol Cell Biol 24: 8026-8036
    • (2004) Mol Cell Biol , vol.24 , pp. 8026-8036
    • Jijiwa, M.1
  • 18
    • 27144467717 scopus 로고    scopus 로고
    • Phosphotyrosine 1062 is critical for the in vivo activity of the Ret9 receptor tyrosine kinase isoform
    • Wong A et al. (2005) Phosphotyrosine 1062 is critical for the in vivo activity of the Ret9 receptor tyrosine kinase isoform. Mol Cell Biol 25: 9661-9673
    • (2005) Mol Cell Biol , vol.25 , pp. 9661-9673
    • Wong, A.1
  • 19
    • 0035974877 scopus 로고    scopus 로고
    • MEN2A-RET-induced cellular transformation by activation of STAT3
    • Schuringa JJ et al. (2001) MEN2A-RET-induced cellular transformation by activation of STAT3. Oncogene 20: 5350-5358
    • (2001) Oncogene , vol.20 , pp. 5350-5358
    • Schuringa, J.J.1
  • 20
    • 10344230447 scopus 로고    scopus 로고
    • The neuronal scaffold protein Shank3 mediates signaling and biological function of the receptor tyrosine kinase Ret in epithelial cells
    • Schuetz G et al. (2004) The neuronal scaffold protein Shank3 mediates signaling and biological function of the receptor tyrosine kinase Ret in epithelial cells. J Cell Biol 1167: 945-952
    • (2004) J Cell Biol , vol.1167 , pp. 945-952
    • Schuetz, G.1
  • 21
    • 0034671913 scopus 로고    scopus 로고
    • Signaling complexes and protein-protein interactions involved in the activation of the Ras and phosphatidylinositol 3-kinase pathways by the c-Ret receptor tyrosine kinase
    • Basset V et al. (2000) Signaling complexes and protein-protein interactions involved in the activation of the Ras and phosphatidylinositol 3-kinase pathways by the c-Ret receptor tyrosine kinase. J Biol Chem 275: 39 159-39 166
    • (2000) J Biol Chem , vol.275 , pp. 39159-39166
    • Basset, V.1
  • 22
    • 0034648718 scopus 로고    scopus 로고
    • Characterization of intracellular signals via tyrosine 1062 in RET activated by glial cell line-derived neurotrophic factor
    • Hayashi H et al. (2000) Characterization of intracellular signals via tyrosine 1062 in RET activated by glial cell line-derived neurotrophic factor. Oncogene 19: 4469-4475
    • (2000) Oncogene , vol.19 , pp. 4469-4475
    • Hayashi, H.1
  • 23
    • 2342502660 scopus 로고    scopus 로고
    • RAS and RHO GTPases in G1-phase cell-cycle regulation
    • Coleman ML et al. (2004) RAS and RHO GTPases in G1-phase cell-cycle regulation. Nat Rev Mol Cell Biol 5: 355-366
    • (2004) Nat Rev Mol Cell Biol , vol.5 , pp. 355-366
    • Coleman, M.L.1
  • 24
    • 0036632368 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-Kinase AKT pathway in human cancer
    • Vivanco I and Sawyers CL (2002) The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Nat Rev Cancer 2: 498-501
    • (2002) Nat Rev Cancer , vol.2 , pp. 498-501
    • Vivanco, I.1    Sawyers, C.L.2
  • 25
    • 6044275784 scopus 로고    scopus 로고
    • Differential requirement of Tyr1062 multidocking site by RET isoforms to promote neural cell scattering and epithelial cell branching
    • Degl'Innocenti D et al. (2004) Differential requirement of Tyr1062 multidocking site by RET isoforms to promote neural cell scattering and epithelial cell branching. Oncogene 23: 7297-7309
    • (2004) Oncogene , vol.23 , pp. 7297-7309
    • Degl'Innocenti, D.1
  • 26
    • 0034816526 scopus 로고    scopus 로고
    • Activation of BMK1 via tyrosine 1062 in RET by GDNF and MEN2A mutation
    • Hayashi Y et al. (2001) Activation of BMK1 via tyrosine 1062 in RET by GDNF and MEN2A mutation. Biochem Biophys Res Commun 281: 682-689
    • (2001) Biochem Biophys Res Commun , vol.281 , pp. 682-689
    • Hayashi, Y.1
  • 27
    • 9244251611 scopus 로고    scopus 로고
    • The full oncogenic activity of Ret/ptc2 depends on tyrosine 539, a docking site for phosphlipase Cγ
    • Borrello MG et al. (1996) The full oncogenic activity of Ret/ptc2 depends on tyrosine 539, a docking site for phosphlipase Cγ. Mol Cell Biol 16: 2151-2163
    • (1996) Mol Cell Biol , vol.16 , pp. 2151-2163
    • Borrello, M.G.1
  • 28
    • 0035952364 scopus 로고    scopus 로고
    • Thyroid cancer
    • Gimm O (2001) Thyroid cancer. Cancer Lett 163: 143-156
    • (2001) Cancer Lett , vol.163 , pp. 143-156
    • Gimm, O.1
  • 29
    • 0032535770 scopus 로고    scopus 로고
    • A National Cancer Database report on 53,856 cases of thyroid carcinoma treated in the US, 1985-1995
    • Hundahl SA et al. (1998) A National Cancer Database report on 53,856 cases of thyroid carcinoma treated in the US, 1985-1995. Cancer 83: 2638-2648
    • (1998) Cancer , vol.83 , pp. 2638-2648
    • Hundahl, S.A.1
  • 30
    • 4644327063 scopus 로고    scopus 로고
    • Medullary thyroid carcinoma
    • Leboulleux S et al. (2004) Medullary thyroid carcinoma. Clin Endocrinol 61: 299-310
    • (2004) Clin Endocrinol , vol.61 , pp. 299-310
    • Leboulleux, S.1
  • 31
    • 0038695856 scopus 로고    scopus 로고
    • Surgical treatment of medullary thyroid carcinoma
    • Cohen MS and Moley JF (2003) Surgical treatment of medullary thyroid carcinoma. J Intern Med 253: 616-626
    • (2003) J Intern Med , vol.253 , pp. 616-626
    • Cohen, M.S.1    Moley, J.F.2
  • 32
    • 85047682409 scopus 로고    scopus 로고
    • Guidelines for diagnosis and therapy of MEN type 1 and type 2
    • Brandi ML et al. (2001) Guidelines for diagnosis and therapy of MEN type 1 and type 2. J Clin Endocrinol Metab 86: 5658-5671
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 5658-5671
    • Brandi, M.L.1
  • 33
    • 0027231568 scopus 로고
    • Germ-fine mutations of the RET proto-oncogene in multiple endocrine neoplasia type 2A
    • Mulligan LM et al. (1993) Germ-fine mutations of the RET proto-oncogene in multiple endocrine neoplasia type 2A. Nature 363: 458-460
    • (1993) Nature , vol.363 , pp. 458-460
    • Mulligan, L.M.1
  • 34
    • 0028174024 scopus 로고
    • A mutation in the RET proto-oncogene associated with multiple endocrine neoplasia type 2B and sporadic medullary thyroid carcinoma
    • Hofstra RM et al. (1994) A mutation in the RET proto-oncogene associated with multiple endocrine neoplasia type 2B and sporadic medullary thyroid carcinoma. Nature 367: 375-376
    • (1994) Nature , vol.367 , pp. 375-376
    • Hofstra, R.M.1
  • 35
    • 4644256817 scopus 로고    scopus 로고
    • The relationship between specific RET proto-oncogene mutations and disease phenotype in multiple endocrine neoplasia type 2: International RET mutation consortium analysis
    • Eng C et al. (1996) The relationship between specific RET proto-oncogene mutations and disease phenotype in multiple endocrine neoplasia type 2: international RET mutation consortium analysis. JAMA 276: 1575-1579
    • (1996) JAMA , vol.276 , pp. 1575-1579
    • Eng, C.1
  • 36
    • 0028838086 scopus 로고
    • Mechanism of activation of the ret proto-oncogene by multiple endocrine neoplasia type 2 mutations
    • Asai N et al. (1995) Mechanism of activation of the ret proto-oncogene by multiple endocrine neoplasia type 2 mutations. Mol Cell Biol 15: 1613-1619
    • (1995) Mol Cell Biol , vol.15 , pp. 1613-1619
    • Asai, N.1
  • 37
    • 0028914683 scopus 로고
    • Activation of RET as a dominant-transforming gene by germline mutations of MEN2A and MEN2B
    • Santoro M et al. (1995) Activation of RET as a dominant-transforming gene by germline mutations of MEN2A and MEN2B. Science 267: 381-383
    • (1995) Science , vol.267 , pp. 381-383
    • Santoro, M.1
  • 38
    • 0030663857 scopus 로고    scopus 로고
    • The multiple endocrine neoplasia type 2B mutation switches the specificity of the Ret tyrosine kinase towards cellular substrates that are susceptible to interact with Crk and Nck
    • Bocciardi R et al. (1997) The multiple endocrine neoplasia type 2B mutation switches the specificity of the Ret tyrosine kinase towards cellular substrates that are susceptible to interact with Crk and Nck. Oncogene 115: 2257-2265
    • (1997) Oncogene , vol.115 , pp. 2257-2265
    • Bocciardi, R.1
  • 39
    • 0035866411 scopus 로고    scopus 로고
    • Increased in vivo phosphorylation of tyrosine 1062 is a potential pathogenic mechanism of multiple endocrine neoplasia type 2B
    • Salvatore D et al. (2001) Increased in vivo phosphorylation of tyrosine 1062 is a potential pathogenic mechanism of multiple endocrine neoplasia type 2B. Cancer Res 61: 1426-1431
    • (2001) Cancer Res , vol.61 , pp. 1426-1431
    • Salvatore, D.1
  • 40
    • 0028985898 scopus 로고
    • Point mutation of the RET proto-oncogene in the TT human medullary thyroid carcinoma cell line
    • Carlomagno F et al. (1995) Point mutation of the RET proto-oncogene in the TT human medullary thyroid carcinoma cell line. Biochem Biophys Res Commun 207: 1022-1028
    • (1995) Biochem Biophys Res Commun , vol.207 , pp. 1022-1028
    • Carlomagno, F.1
  • 41
    • 4344566311 scopus 로고    scopus 로고
    • Role of MEN2A-derived RET in maintenance and proliferation of medullary thyroid carcinoma
    • Drosten M et al. (2004) Role of MEN2A-derived RET in maintenance and proliferation of medullary thyroid carcinoma. J Natl Cancer Inst 96: 1231-1239
    • (2004) J Natl Cancer Inst , vol.96 , pp. 1231-1239
    • Drosten, M.1
  • 42
    • 0031749287 scopus 로고    scopus 로고
    • Bcl-2 and c-myc, but not bax and p53, are expressed during human medullary thyroid carcinoma tumorigenesis
    • Wang DG et al. (1998) Bcl-2 and c-myc, but not bax and p53, are expressed during human medullary thyroid carcinoma tumorigenesis. Am J Pathol 152: 1407-1413
    • (1998) Am J Pathol , vol.152 , pp. 1407-1413
    • Wang, D.G.1
  • 43
    • 0035811591 scopus 로고    scopus 로고
    • C-cell and thyroid epithelial tumors and altered follicular development in transgenic mice expressing the long isoform of MEN 2A RET
    • Reynolds L et al (2001) C-cell and thyroid epithelial tumors and altered follicular development in transgenic mice expressing the long isoform of MEN 2A RET. Oncogene 20: 3986-3994
    • (2001) Oncogene , vol.20 , pp. 3986-3994
    • Reynolds, L.1
  • 44
    • 0037929462 scopus 로고    scopus 로고
    • C634Y inhibits both the wild-type and the constitutively activated RET
    • C634Y inhibits both the wild-type and the constitutively activated RET. Biochem J 372: 897-903
    • (2003) Biochem J , vol.372 , pp. 897-903
    • Cerchia, L.1
  • 45
    • 22744446011 scopus 로고    scopus 로고
    • Pegaptanib: The first antiangiogenic agent approved for neovascular macular degeneration
    • Doggrell SA (2005) Pegaptanib: The first antiangiogenic agent approved for neovascular macular degeneration. Exp Opin Pharmacother 6: 1421-1423
    • (2005) Exp Opin Pharmacother , vol.6 , pp. 1421-1423
    • Doggrell, S.A.1
  • 46
    • 18344375927 scopus 로고    scopus 로고
    • Neutralizing aptamers from whole-cell SELEX inhibit the RET receptor tyrosine kinase
    • Cerchia L et al. (2005) Neutralizing aptamers from whole-cell SELEX inhibit the RET receptor tyrosine kinase. PloS Biol 3: E123
    • (2005) PloS Biol , vol.3
    • Cerchia, L.1
  • 47
    • 0031843172 scopus 로고    scopus 로고
    • Mutations in the extracellular domain cause RET loss of function by a dominant negative mechanism
    • Cosma MP et al. (1998) Mutations in the extracellular domain cause RET loss of function by a dominant negative mechanism. Mol Cell Biol 18: 3321-3329
    • (1998) Mol Cell Biol , vol.18 , pp. 3321-3329
    • Cosma, M.P.1
  • 48
    • 0036915701 scopus 로고    scopus 로고
    • A new therapeutic approach in medullary thyroid cancer treatment: Inhibition of oncogenic RET signaling by adenoviral vector-mediated expression of a dominant-negative RET mutant
    • Drosten M et al. (2002) A new therapeutic approach in medullary thyroid cancer treatment: Inhibition of oncogenic RET signaling by adenoviral vector-mediated expression of a dominant-negative RET mutant. Surgery 132: 991-997
    • (2002) Surgery , vol.132 , pp. 991-997
    • Drosten, M.1
  • 49
    • 0038235732 scopus 로고    scopus 로고
    • Antitumor capacity of a dominant-negative RET proto-oncogene mutant in a medullary thyroid carcinoma model
    • Drosten M et al. (2003) Antitumor capacity of a dominant-negative RET proto-oncogene mutant in a medullary thyroid carcinoma model. Hum Gene Ther 14: 971-982
    • (2003) Hum Gene Ther , vol.14 , pp. 971-982
    • Drosten, M.1
  • 50
    • 14844309606 scopus 로고    scopus 로고
    • Discovery of targeting peptides for selective therapy of medullary thyroid carcinoma
    • Böckmann M et al. (2004) Discovery of targeting peptides for selective therapy of medullary thyroid carcinoma. J Gene Med 7: 179-188
    • (2004) J Gene Med , vol.7 , pp. 179-188
    • Böckmann, M.1
  • 51
    • 27744531656 scopus 로고    scopus 로고
    • Novel SRESPHP peptide mediates specific binding to primary medullary thyroid carcinoma after systemic injection
    • Böckmann M et al. (2005) Novel SRESPHP peptide mediates specific binding to primary medullary thyroid carcinoma after systemic injection. Hum Gene Ther 16: 1267-1275
    • (2005) Hum Gene Ther , vol.16 , pp. 1267-1275
    • Böckmann, M.1
  • 52
    • 0033989107 scopus 로고    scopus 로고
    • Inhibition of the transforming activity of the ret/ptc1 oncoprotein by a 2-indolinone derivative
    • Lanzi C et al. (2000) Inhibition of the transforming activity of the ret/ ptc1 oncoprotein by a 2-indolinone derivative. Int J Cancer 85: 384-390
    • (2000) Int J Cancer , vol.85 , pp. 384-390
    • Lanzi, C.1
  • 53
    • 3242735120 scopus 로고    scopus 로고
    • Cellular effects and antitumor activity of the RET inhibitor RPI-1 on MEN2A-associated medullary thyroid carcinoma
    • Cuccuru G et al. (2004) Cellular effects and antitumor activity of the RET inhibitor RPI-1 on MEN2A-associated medullary thyroid carcinoma. J Natl Cancer Inst 96: 1006-1014
    • (2004) J Natl Cancer Inst , vol.96 , pp. 1006-1014
    • Cuccuru, G.1
  • 54
    • 0037392942 scopus 로고    scopus 로고
    • The specificities of protein kinase inhibitors: An update
    • Bain J et al. (2003) The specificities of protein kinase inhibitors: An update. Biochem J 371: 199-204
    • (2003) Biochem J , vol.371 , pp. 199-204
    • Bain, J.1
  • 55
    • 0036171234 scopus 로고    scopus 로고
    • The kinase inhibitor PP1 blocks tumorigenesis induced by RET oncogenes
    • Carlomagno F et al. (2002) The kinase inhibitor PP1 blocks tumorigenesis induced by RET oncogenes. Cancer Res 62: 1077-1082
    • (2002) Cancer Res , vol.62 , pp. 1077-1082
    • Carlomagno, F.1
  • 56
    • 0038697810 scopus 로고    scopus 로고
    • Efficient inhibition of RET/papillary thyroid carcinoma oncogenic kinases by 4-amino-5-(4-chloro-phenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine (PP2)
    • Carlomagno F et al. (2003) Efficient inhibition of RET/papillary thyroid carcinoma oncogenic kinases by 4-amino-5-(4-chloro-phenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine (PP2). J Clin Endocrinol Metab 88: 1897-1902
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 1897-1902
    • Carlomagno, F.1
  • 57
    • 0033104338 scopus 로고    scopus 로고
    • Ret-mediated mitogenesis requires Src kinase activity
    • Melillo RM et al. (1999) Ret-mediated mitogenesis requires Src kinase activity. Cancer Res 59: 1120-1126
    • (1999) Cancer Res , vol.59 , pp. 1120-1126
    • Melillo, R.M.1
  • 58
    • 0037699063 scopus 로고    scopus 로고
    • PP1 inhibitor induces degradation of RETMEN2A and RETMEN28 oncoproteins through proteosomal targeting
    • Carniti C et al. (2003) PP1 inhibitor induces degradation of RETMEN2A and RETMEN28 oncoproteins through proteosomal targeting. Cancer Res 63: 2234-2243
    • (2003) Cancer Res , vol.63 , pp. 2234-2243
    • Carniti, C.1
  • 59
    • 0037438513 scopus 로고    scopus 로고
    • Dual-specific Src and Abl kinase inhibitors, PP1 and CGP76030, inhibit growth and survival of cells expressing imatinib mesylate-resistant Bcr-Abl kinases
    • Warmuth M et al. (2003) Dual-specific Src and Abl kinase inhibitors, PP1 and CGP76030, inhibit growth and survival of cells expressing imatinib mesylate-resistant Bcr-Abl kinases. Blood 101: 664-672
    • (2003) Blood , vol.101 , pp. 664-672
    • Warmuth, M.1
  • 60
    • 21244488907 scopus 로고    scopus 로고
    • ZD6474-clinical experience to date
    • Heymach VJ (2005) ZD6474-clinical experience to date. Br J Cancer 92: S14-S20
    • (2005) Br J Cancer , vol.92
    • Heymach, V.J.1
  • 61
    • 0037115405 scopus 로고    scopus 로고
    • ZD6474, an orally available inhibitor of KDR tyrosine kinase activity, efficiently blocks oncogenic RET kinases
    • Carlomagno F et al. (2002) ZD6474, an orally available inhibitor of KDR tyrosine kinase activity, efficiently blocks oncogenic RET kinases. Cancer Res 62: 7284-7290
    • (2002) Cancer Res , vol.62 , pp. 7284-7290
    • Carlomagno, F.1
  • 62
    • 18144392678 scopus 로고    scopus 로고
    • ZD6474 suppresses oncogenic RET isoforms in a Drosophila model for type 2 multiple endocrine neoplasia syndromes and papillary thyroid carcinoma
    • Vidal M et al. (2005) ZD6474 suppresses oncogenic RET isoforms in a Drosophila model for type 2 multiple endocrine neoplasia syndromes and papillary thyroid carcinoma. Cancer Res 65: 3538-3541
    • (2005) Cancer Res , vol.65 , pp. 3538-3541
    • Vidal, M.1
  • 63
    • 4444273158 scopus 로고    scopus 로고
    • Disease associated mutations at valine 804 of the RET receptor tyrosine kinase confer resistance to selective tyrosine kinase inhibitors
    • Carlomagno F et al. (2004) Disease associated mutations at valine 804 of the RET receptor tyrosine kinase confer resistance to selective tyrosine kinase inhibitors. Oncogene 23: 6056-6063
    • (2004) Oncogene , vol.23 , pp. 6056-6063
    • Carlomagno, F.1
  • 64
    • 21244476799 scopus 로고    scopus 로고
    • Receptor tyrosine kinases as targets for anticancer therapeutics
    • Carlomagno F and Santoro M (2005) Receptor tyrosine kinases; as targets for anticancer therapeutics. Curr Med Chem 12: 1773-1781
    • (2005) Curr Med Chem , vol.12 , pp. 1773-1781
    • Carlomagno, F.1    Santoro, M.2
  • 65
    • 0141592764 scopus 로고    scopus 로고
    • CEP-701 and CEP-751 inhibit constitutively activated RET tyrosine kinase activity and block medullary thyroid carcinoma cell growth
    • Strock CJ et al. (2003) CEP-701 and CEP-751 inhibit constitutively activated RET tyrosine kinase activity and block medullary thyroid carcinoma cell growth. Cancer Res 63: 5559-5563
    • (2003) Cancer Res , vol.63 , pp. 5559-5563
    • Strock, C.J.1
  • 66
    • 30344439815 scopus 로고    scopus 로고
    • Activity of irinotecan and the tyrosine kinase inhibitor CEP-751 in medullary thyroid cancer
    • Strock CJ et al. (2006) Activity of irinotecan and the tyrosine kinase inhibitor CEP-751 in medullary thyroid cancer. J Clin Endocrinol Metab 91: 79-84
    • (2006) J Clin Endocrinol Metab , vol.91 , pp. 79-84
    • Strock, C.J.1
  • 67
    • 22144478699 scopus 로고    scopus 로고
    • Current therapies for advanced colorectal cancer
    • Aggarwal S and Chu E (2005) Current therapies for advanced colorectal cancer. Oncology 19: 589-595
    • (2005) Oncology , vol.19 , pp. 589-595
    • Aggarwal, S.1    Chu, E.2
  • 68
    • 0036919703 scopus 로고    scopus 로고
    • Inhibition of medullary thyroid carcinoma cell proliferation and RET phosphorylation by tyrosine kinase inhibitors
    • Cohen MS et al. (2002) Inhibition of medullary thyroid carcinoma cell proliferation and RET phosphorylation by tyrosine kinase inhibitors. Surgery 132: 960-967
    • (2002) Surgery , vol.132 , pp. 960-967
    • Cohen, M.S.1
  • 69
    • 0344442314 scopus 로고    scopus 로고
    • RET tyrosine kinase and medullary thyroid cells are unaffected by clinical doses of ST1571
    • Skinner MA et al. (2003) RET tyrosine kinase and medullary thyroid cells are unaffected by clinical doses of ST1571. Anticancer Res 23: 3601-3606
    • (2003) Anticancer Res , vol.23 , pp. 3601-3606
    • Skinner, M.A.1
  • 70
    • 12944284651 scopus 로고    scopus 로고
    • Dual inhibition of RET and FGFR4 restrains medullary thyroid cancer cell growth
    • Ezzat S et al. (2005) Dual inhibition of RET and FGFR4 restrains medullary thyroid cancer cell growth. Clin Cancer Res 11: 1336-1341
    • (2005) Clin Cancer Res , vol.11 , pp. 1336-1341
    • Ezzat, S.1
  • 72
    • 4944249117 scopus 로고    scopus 로고
    • BAY 43-9006 exhibits a broad spectrum antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis
    • Wilhem SM et al. (2004) BAY 43-9006 exhibits a broad spectrum antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res 64: 7099-7109
    • (2004) Cancer Res , vol.64 , pp. 7099-7109
    • Wilhem, S.M.1
  • 73
    • 33644747449 scopus 로고    scopus 로고
    • BAY 43-9006 inhibition of oncogenic RET mutants
    • Carlomagno et al. (2006) BAY 43-9006 inhibition of oncogenic RET mutants. J Natl Cancer Inst 98: 326-334
    • (2006) J Natl Cancer Inst , vol.98 , pp. 326-334
    • Carlomagno, F.1
  • 74
    • 0036179603 scopus 로고    scopus 로고
    • Trastuzumab: A review of its use in the treatment of metastatic breast cancer overexpressing HER2
    • McKeage K and Perry CM (2002) Trastuzumab: A review of its use in the treatment of metastatic breast cancer overexpressing HER2. Drugs 62: 209-243
    • (2002) Drugs , vol.62 , pp. 209-243
    • McKeage, K.1    Perry, C.M.2
  • 75
    • 0034192389 scopus 로고    scopus 로고
    • Improved gene transfer to neuroblastoma cells by a monoclonal antibody targeting RET, a receptor tyrosine kinase
    • Yano L et al (2000) Improved gene transfer to neuroblastoma cells by a monoclonal antibody targeting RET, a receptor tyrosine kinase. Hum Gene Ther 11: 995-1004
    • (2000) Hum Gene Ther , vol.11 , pp. 995-1004
    • Yano, L.1
  • 76
    • 0033566948 scopus 로고    scopus 로고
    • Hammerhead ribozyme-mediated inactivation of mutant RET in medullary thyroid carcinoma
    • Parthasarathy R et al. (1999) Hammerhead ribozyme-mediated inactivation of mutant RET in medullary thyroid carcinoma. Cancer Res 59: 3911-3914
    • (1999) Cancer Res , vol.59 , pp. 3911-3914
    • Parthasarathy, R.1
  • 77
    • 17944365466 scopus 로고    scopus 로고
    • Inhibition of RET oncogene activity by the protein tyrosine phosphatase SHP1
    • Hennige AM et al. (2001) Inhibition of RET oncogene activity by the protein tyrosine phosphatase SHP1. Endocrinology 142: 4441-4447
    • (2001) Endocrinology , vol.142 , pp. 4441-4447
    • Hennige, A.M.1
  • 78
    • 15944404601 scopus 로고    scopus 로고
    • The development of imatinib as a therapeutic agent for chronic myeloid leukemia
    • Deininger M et al. (2005) The development of imatinib as a therapeutic agent for chronic myeloid leukemia. Blood 105: 2640-2653
    • (2005) Blood , vol.105 , pp. 2640-2653
    • Deininger, M.1
  • 79
    • 3242736846 scopus 로고    scopus 로고
    • Evolving strategies for targeted cancer therapy - Past, present, and future
    • Wells SA and Nevins JR (2004) Evolving strategies for targeted cancer therapy - past, present, and future. J Natl Cancer Inst 96: 980-981
    • (2004) J Natl Cancer Inst , vol.96 , pp. 980-981
    • Wells, S.A.1    Nevins, J.R.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.