Vascular endothelial growth factor (VEGF), VEGF receptors expression and microvascular density in benign and malignant thyroid diseases

International Journal of Experimental Pathology

Volumn 88, Issue 4, 2007, Pages 271-277

  Jebreel, Ala'eddin ^a   England, James ^a   Bedford, Karen ^a   Murphy, Justin ^a   Karsai, Laszlo ^a   Atkin, Stephen ^a,b  

^a HULL ROYAL INFIRMARY   (United Kingdom)

^b UNIVERSITY OF HULL   (United Kingdom)

Author keywords

MVD; Thyroid; VEGF; VEGF receptors

Indexed keywords

VASCULOTROPIN; VASCULOTROPIN RECEPTOR;

ADENOMA; CONFERENCE PAPER; CONTROLLED STUDY; DENSITY; GRAVES DISEASE; HASHIMOTO DISEASE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; NODULAR GOITER; PAPILLARY CARCINOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; THYROID DISEASE;

HUMANS; IMMUNOENZYME TECHNIQUES; NEOVASCULARIZATION, PATHOLOGIC; RECEPTORS, VASCULAR ENDOTHELIAL GROWTH FACTOR; THYROID DISEASES; THYROID GLAND; THYROID NEOPLASMS; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

EID: 34547865714     PISSN: 09599673     EISSN: 13652613     Source Type: Journal    
DOI: 10.1111/j.1365-2613.2007.00533.x     Document Type: Conference Paper

References (48)

1. Akslen L.A. Livolsi V.A. (2000) Increased angiogenesis in papillary thyroid carcinoma but lack of prognostic importance. Hum. Pathol. 31, 439 442.
2. Anan K., Morisaki T., Katano M. et al. (1996) Vascular endothelial growth factor and platelet-derived growth factor are potential angiogenic and metastatic factors in human breast cancer. Surgery 119, 333 339.
3. Bochner B.H., Cote R.J., Weidner N. et al. (1995) Angiogenesis in bladder cancer: relationship between microvessel density and tumor prognosis. J. Natl. Cancer Inst. 87, 1603 1612.
4. Brekken R.A. Thorpe P.E. (2001) Vascular endothelial growth factor and vascular targeting of solid tumors. Anticancer Res. 21, 4221 4229.
5. Bunone G., Vigneri P., Mariani L. et al. (1999) Expression of angiogenesis stimulators and inhibitors in human thyroid tumors and correlation with clinical pathological features. Am. J. Pathol. 155, 1967 1976.
6. Carlomagno F., Vitagliano D., Guida T. et al. (2002) ZD6474, an orally available inhibitor of KDR tyrosine kinase activity, efficiently blocks oncogenic RET kinases. Cancer Res. 62, 7284 7290.
7. Crew J.P. (1999) Vascular endothelial growth factor: an important angiogenic mediator in bladder cancer. Eur. J. Urol. 35, 2 8.
8. De Jong J.S., van Diest P.J., van der Valk P., Baak J.P. (1998) Expression of growth factors, growth-inhibiting factors, and their receptors in invasive breast cancer. II: Correlations with proliferation and angiogenesis. J. Pathol. 184, 53 57.
9. De la Torre N.G., Buley I., Wass J.A., Turner H.E. (2006) Angiogenesis and lymphangiogenesis in thyroid proliferative lesions: relationship to type and tumour behaviour. Endocr. Relat. Cancer 13, 931 944.
10. Dhar D.K., Kubota H., Kotoh T. et al. (1998) Tumor vascularity predicts recurrence in differentiated thyroid carcinoma. Am. J. Surg. 176, 442 447.
11. Eisma R.J., Spiro J.D., Kreutzer D.L. (1997) Vascular endothelial growth factor expression in head and neck Squamous cell carcinoma. Am. J. Surg. 174, 513 517.
12. Fenton C., Patel A., Dinauer C., Robie D.K., Tuttle R.M., Francis G.L. (2000) The expression of vascular endothelial growth factor and the type 1 vascular endothelial growth factor receptor correlate with the size of papillary thyroid carcinoma in children and young adults. Thyroid 10, 349 357.
13. Ferrara N., Houck K., Jakeman L., Leung D.W. (1992) Molecular and biological properties of the vascular endothelial growth factor family of proteins. Endocr. Rev. 13, 18 32.
14. Fontanini G., Vignati S., Pacini F., Pollina L., Basolo F. (1996) Microvessel count: an indicator of poor outcome in medullary thyroid carcinoma but not in other types of thyroid carcinoma. Mod. Pathol. 9, 636 641.
15. Gasparini G., Toi M., Gion M. et al. (1997) Prognostic significance of vascular endothelial growth factor protein in node-negative breast carcinoma. J. Natl. Cancer Inst. 89, 139 147.
16. Gerber H.P. Ferrara N. (2003) The role of VEGF in normal and neoplastic hematopoiesis. J. Mol. Med. 81, 20 31.
17. Herrmann G., Schumm-Draeger P.M., Muller C. et al. (1994) T lymphocytes, CD68-positive cells and vascularisation in thyroid carcinomas. J. Cancer Res. Clin. Oncol. 120, 651 656.
18. Horak E.R., Leek R., Klenk N. et al. (1992) Angiogenesis, assessed by platelet/endothelial cell adhesion molecule antibodies, as indicator of node metastases and survival in breast cancer. Lancet 340, 1120 1124.
19. Iitaka M., Miura S., Yamanaka K. et al. (1998) Increased serum vascular endothelial growth factor levels and intrathyroidal vascular area in patients with Graves' disease and Hashimoto's thyroiditis. J. Clin. Endocrinol. Metab. 83, 3908 3912.
20. Imoto H., Osaki T., Taga S., Ohgami A., Ichiyoshi Y., Yasumoto K. (1998) Vascular endothelial growth factor expression in non-small-cell lung cancer: prognostic significance in squamous cell carcinoma. J. Thorac. Cardiovasc. Surg. 115, 1007 1014.
21. Inoue K., Ozeki Y., Suganuma T., Sugiura Y., Tanaka S. (1997) Vascular endothelial growth factor expression in primary esophageal squamous cell carcinoma. Association with angiogenesis and tumor progression. Cancer 79, 206 213.
22. Ishiwata T., Iino Y., Takei H., Oyama T., Morishita Y. (1998) Tumor angiogenesis as an independent prognostic indicator in human papillary thyroid carcinoma. Oncol. Rep. 5, 1343 1348.
23. Katoh R., Miyagi E., Kawaoi A. et al. (1999) Expression of vascular endothelial growth factor (VEGF) in human thyroid neoplasms. Hum. Pathol. 30, 891 897.
24. Klein M., Picard E., Vignaud J.M. et al. (1999) Vascular endothelial growth factor gene and protein: strong expression in thyroiditis and thyroid carcinoma. J. Endocrinol. 161, 41 49.
25. Klein M., Vignaud J.M., Hennequin V. et al. (2001) Increased expression of the vascular endothelial growth factor is a pejorative prognosis marker in papillary thyroid carcinoma. J. Clin. Endocrinol. Metab. 86, 656 658.
26. Kliche S. Waltenberger J. (2001) VEGF receptor signalling and endothelial function. IUBMB Life 52, 61 66.
27. Maeda K., Chung Y.S., Takatsuka S. et al. (1995) Tumor angiogenesis as a predictor of recurrence in gastric carcinoma. J. Clin. Oncol. 13, 477 481.
28. Maeda K., Chung Y.S., Ogawa Y. et al. (1996) Prognostic value of vascular endothelial growth factor expression in gastric carcinoma. Cancer 77, 858 863.
29. Nagura S., Katoh R., Miyagi E., Shibuya M., Kawaoi A. (2001) Expression of vascular endothelial growth factor (VEGF) and VEGF receptor-1 (Flt-1) in Graves disease possibly correlated with increased vascular density. Hum. Pathol. 32, 10 17.
30. Poon R.T., Ng I.O., Lau C. et al. (2001) Serum vascular endothelial growth factor predicts venous invasion in hepatocellular carcinoma: a prospective study. Ann. Surg. 233, 227 235.
31. Ramsden J.D. (2000) Angiogenesis in the thyroid gland. J. Endocrinol. 166, 475 480.
32. Risau W. (1997) Mechanisms of angiogenesis. Nature 386, 671 674.
33. Salven P., Heikkila P., Joensuu H. (1997) Enhanced expression of vascular endothelial growth factor in metastatic melanoma. Br. J. Cancer 76, 930 934.
34. Sato K., Miyakawa M., Onoda N. et al. (1997) Increased concentration of vascular endothelial growth factor/vascular permeability factor in cyst fluid of enlarging and recurrent thyroid nodules. J. Clin. Endocrinol. Metab. 82, 1968 1973.
35. Segal K., Shpitzer T., Feinmesser M., Stern Y., Feinmesser R. (1996) Angiogenesis in follicular tumors of the thyroid. J. Surg. Oncol. 63, 95 98.
36. Shibuya M. (2002) Vascular endothelial growth factor receptor family genes: when did the three genes phylogenetically segregate? Biol. Chem. 383, 1573 1579.
37. Soh E.Y., Duh Q.Y., Sobhi S.A. et al. (1997) Vascular endothelial growth factor expression is higher in differentiated thyroid cancer than in normal or benign thyroid. J. Clin. Endocrinol. Metab. 82, 3741 3747.
38. Takahashi Y., Kitadai Y., Bucana C.D., Cleary K.R., Ellis L.M. (1995) Expression of vascular endothelial growth factor and its receptor, KDR,correlates with vascularity, metastasis, and proliferation of human colon cancer. Cancer Res. 55, 3964 3968.
39. Toi M., Inada K., Suzuki H., Tominaga T. (1995) Tumor angiogenesis in breast cancer: its association with vascular endothelial growth factor expression. Breast Cancer Res. Treat. 36, 193 204.
40. Viglietto G., Maglione D., Rambaldi M. et al. (1995) Upregulation of vascular endothelial growth factor (VEGF) and downregulation of placenta growth factor (PlGF) associated with malignancy in human thyroid tumors and cell lines. Oncogenesis 11, 1569 1579.
41. Wang J.F., Milosveski V., Schramek C., Fong G.H., Becks G.P., Hill D.J. (1998) Presence and possible role of vascular endothelial growth factor in thyroid cell growth and function. J. Endocrinol. 157, 5 12.
42. Weidner N., Semple J.P., Welch W.R., Folkman J. (1991) Tumor angiogenesis and metastasis: correlation in invasive breast carcinoma. N. Engl. J. Med. 324, 1 8.
43. Weidner N., Folkman J., Pozza F. et al. (1992) Tumor angiogenesis: a new significant and independent prognostic indicator in early stage breast carcinoma. J. Natl. Cancer Inst. 84, 1875 1887.
44. Weidner N., Carrol P.R., Flax J., Blumenfeld W., Folkman J. (1993) Tumor angiogenesis correlates with metastasis in invasive prostate carcinoma. Am. J. Pathol. 143, 401 409.
45. Wollman S.H., Herveg J.P., Zeligs J.D., Ericson L.E. (1978) Blood capillary enlargement during the development of thyroid hyperplasia in the rat. Endocrinology 103, 2306 2314.
46. Yamada E., Yamazaki K., Takano K., Obara T., Sato K. (2006) Iodide inhibits vascular endothelial growth factor-A expression in cultured human thyroid follicles: a microarray search for effects of thyrotropin and iodide on angiogenesis factors. Thyroid 16, 545 554.
47. Yamamoto S., Konishi I., Mandai M. et al. (1997) Expression of vascular endothelial growth factor (VEGF) in epithelial ovarian neoplasms: correlation with clinicopathology and patient survival, and analysis of serum VEGF levels. Br. J. Cancer 76, 1221 1227.
48. Ye C., Feng C., Wang S. et al. (2004) sFlt-1 gene therapy of follicular thyroid carcinoma. Endocrinology 145, 817 822.