-
1
-
-
0026095665
-
A retroviral oncogene, Akt, encoding a serine-threonine kinase containing an SH2-like region
-
Bellacosa A, Testa JR, Staal SP, Tsichlis PN (1991) A retroviral oncogene, Akt, encoding a serine-threonine kinase containing an SH2-like region. Science 254: 274-277
-
(1991)
Science
, vol.254
, pp. 274-277
-
-
Bellacosa, A.1
Testa, J.R.2
Staal, S.P.3
Tsichlis, P.N.4
-
2
-
-
0041338049
-
Inhibition of the phosphatidylinositol 3′-kinase-AKT pathway induces apoptosis in pancreatic carcinoma cells in vitro and in vivo
-
Bondar VM, Sweeney-Gotsch B, Andreeff M, Mills GB, McConkey DJ (2002) Inhibition of the phosphatidylinositol 3′-kinase-AKT pathway induces apoptosis in pancreatic carcinoma cells in vitro and in vivo. Mol Cancer Ther 1: 989-997
-
(2002)
Mol Cancer Ther
, vol.1
, pp. 989-997
-
-
Bondar, V.M.1
Sweeney-Gotsch, B.2
Andreeff, M.3
Mills, G.B.4
McConkey, D.J.5
-
3
-
-
0028301090
-
The oncogenic versions of the Ret and Trk tyrosine kinases bind Shc and Grb2 adaptor proteins
-
Borrello MG, Pelicci G, Arighi E, De Filippis L, Greco A, Bongarzone I, Rizzetti M, Pelicci PG, Pierotti MA (1994) The oncogenic versions of the Ret and Trk tyrosine kinases bind Shc and Grb2 adaptor proteins. Oncogene 9: 1661-1668
-
(1994)
Oncogene
, vol.9
, pp. 1661-1668
-
-
Borrello, M.G.1
Pelicci, G.2
Arighi, E.3
De Filippis, L.4
Greco, A.5
Bongarzone, I.6
Rizzetti, M.7
Pelicci, P.G.8
Pierotti, M.A.9
-
4
-
-
0035872199
-
Akt/protein kinase B is constitutively active in non-small cell lung cancer cells and promotes cellular survival and resistance to chemotherapy and radiation
-
Brognard J, Clark AS, Ni Y, Dennis PA (2001) Akt/protein kinase B is constitutively active in non-small cell lung cancer cells and promotes cellular survival and resistance to chemotherapy and radiation. Cancer Res 61: 3986-3997
-
(2001)
Cancer Res
, vol.61
, pp. 3986-3997
-
-
Brognard, J.1
Clark, A.S.2
Ni, Y.3
Dennis, P.A.4
-
5
-
-
0034214102
-
Phosphatidylinositol 3-kinase, protein kinase B and ribosomal S6 kinases in the stimulation of thyroid epithelial cell proliferation by cAMP and growth factors in the presence of insulin
-
Coulonval K, Vandeput F, Stein RC, Kozma SC, Lamy F, Dumont JE (2000) Phosphatidylinositol 3-kinase, protein kinase B and ribosomal S6 kinases in the stimulation of thyroid epithelial cell proliferation by cAMP and growth factors in the presence of insulin. Biochem J 348(Part 2): 351-358
-
(2000)
Biochem J
, vol.348
, Issue.PART 2
, pp. 351-358
-
-
Coulonval, K.1
Vandeput, F.2
Stein, R.C.3
Kozma, S.C.4
Lamy, F.5
Dumont, J.E.6
-
6
-
-
0030730905
-
Somatic deletions and mutations in the Cowden disease gene, PTEN, in sporadic thyroid tumors
-
Dahia PL, Marsh DJ, Zheng Z, Zedenius J, Komminoth P, Frisk T, Wallin G, Parsons R, Longy M, Larsson C, Eng C (1997) Somatic deletions and mutations in the Cowden disease gene, PTEN, in sporadic thyroid tumors. Cancer Res 57: 4710-4713
-
(1997)
Cancer Res
, vol.57
, pp. 4710-4713
-
-
Dahia, P.L.1
Marsh, D.J.2
Zheng, Z.3
Zedenius, J.4
Komminoth, P.5
Frisk, T.6
Wallin, G.7
Parsons, R.8
Longy, M.9
Larsson, C.10
Eng, C.11
-
7
-
-
0036256349
-
Minireview: Branded from the start - Distinct oncogenic initiating events may determine tumor fate in the thyroid
-
Fagin JA (2002) Minireview: branded from the start - distinct oncogenic initiating events may determine tumor fate in the thyroid. Mol Endocrinol 16: 903-911
-
(2002)
Mol Endocrinol
, vol.16
, pp. 903-911
-
-
Fagin, J.A.1
-
8
-
-
0034284781
-
Suppression of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD)-mediated aryl hydrocarbon receptor transformation and CYP1A1 induction by the phosphatidylinositol 3-kinase inhibitor 2-(4-morpholinyl)-8-phenyl-4H-1- benzopyran-4-one (LY294002)
-
Guo M, Joiakim A, Reiners Jr JJ (2000) Suppression of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD)-mediated aryl hydrocarbon receptor transformation and CYP1A1 induction by the phosphatidylinositol 3-kinase inhibitor 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002). Biochem Pharmacol 60: 635-642
-
(2000)
Biochem Pharmacol
, vol.60
, pp. 635-642
-
-
Guo, M.1
Joiakim, A.2
Reiners Jr., J.J.3
-
9
-
-
0034254249
-
Inhibition of c-kit receptor tyrosine kinase activity by STI 571, a selective tyrosine kinase inhibitor
-
Heinrich MC, Griffith DJ, Druker BJ, Wait CL, Ott KA, Zigler AJ (2000) Inhibition of c-kit receptor tyrosine kinase activity by STI 571, a selective tyrosine kinase inhibitor. Blood 96: 925-932
-
(2000)
Blood
, vol.96
, pp. 925-932
-
-
Heinrich, M.C.1
Griffith, D.J.2
Druker, B.J.3
Wait, C.L.4
Ott, K.A.5
Zigler, A.J.6
-
10
-
-
0036168948
-
Inhibition of phosphatidylinositol 3′-kinase increases efficacy of paclitaxel in in vitro and in vivo ovarian cancer models
-
Hu L, Hofmann J, Lu Y, Mills GB, Jaffe RB (2002) Inhibition of phosphatidylinositol 3′-kinase increases efficacy of paclitaxel in in vitro and in vivo ovarian cancer models. Cancer Res 62: 1087-1092
-
(2002)
Cancer Res
, vol.62
, pp. 1087-1092
-
-
Hu, L.1
Hofmann, J.2
Lu, Y.3
Mills, G.B.4
Jaffe, R.B.5
-
11
-
-
0034100051
-
In vivo and in vitro ovarian carcinoma growth inhibition by a phosphatidylinositol 3-kinase inhibitor (LY294002)
-
Hu L, Zaloudek C, Mills GB, Gray J, Jaffe RB (2000) In vivo and in vitro ovarian carcinoma growth inhibition by a phosphatidylinositol 3-kinase inhibitor (LY294002). Clin Cancer Res 6: 880-886
-
(2000)
Clin Cancer Res
, vol.6
, pp. 880-886
-
-
Hu, L.1
Zaloudek, C.2
Mills, G.B.3
Gray, J.4
Jaffe, R.B.5
-
12
-
-
1542348477
-
Cancer statistics, 2004
-
Jemal A, Tiwari RC, Murray T, Ghafoor A, Samuels A, Ward E, Feuer EJ, Thun MJ (2004) Cancer statistics, 2004. CA Cancer J Clin 54: 8-29
-
(2004)
CA Cancer J Clin
, vol.54
, pp. 8-29
-
-
Jemal, A.1
Tiwari, R.C.2
Murray, T.3
Ghafoor, A.4
Samuels, A.5
Ward, E.6
Feuer, E.J.7
Thun, M.J.8
-
13
-
-
0032974382
-
Insulin and TSH promote growth in size of PC Cl3 rat thyroid cells, possibly via a pathway different from DNA synthesis: Comparison with FRTL-5 cells
-
Kimura T, Dumont JE, Fusco A, Golstein J (1999) Insulin and TSH promote growth in size of PC Cl3 rat thyroid cells, possibly via a pathway different from DNA synthesis: comparison with FRTL-5 cells. Eur J Endocrinol 140: 94-103
-
(1999)
Eur J Endocrinol
, vol.140
, pp. 94-103
-
-
Kimura, T.1
Dumont, J.E.2
Fusco, A.3
Golstein, J.4
-
14
-
-
0034793849
-
Regulation of thyroid cell proliferation by TSH and other factors: A critical evaluation of in vitro models
-
Kimura T, Van Keymeulen A, Golstein J, Fusco A, Dumont JE, Roger PP (2001) Regulation of thyroid cell proliferation by TSH and other factors: a critical evaluation of in vitro models. Endocr Rev 22: 631-656
-
(2001)
Endocr Rev
, vol.22
, pp. 631-656
-
-
Kimura, T.1
Van Keymeulen, A.2
Golstein, J.3
Fusco, A.4
Dumont, J.E.5
Roger, P.P.6
-
15
-
-
0037194613
-
Phosphatidylinositol-3 kinase inhibitors enhance the anti-leukemia effect of STI571
-
Klejman A, Rushen L, Morrione A, Slupianek A, Skorski T (2002) Phosphatidylinositol-3 kinase inhibitors enhance the anti-leukemia effect of STI571. Oncogens 21: 5868-5876
-
(2002)
Oncogens
, vol.21
, pp. 5868-5876
-
-
Klejman, A.1
Rushen, L.2
Morrione, A.3
Slupianek, A.4
Skorski, T.5
-
16
-
-
0031004088
-
Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome
-
Liaw D, Marsh DJ, Li J, Dahia PL, Wang SI, Zheng Z, Bose S, Call KM, Tsou HC, Peacocke M, Eng C, Parsons R (1997) Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome. Nat Genet 16: 64-67
-
(1997)
Nat Genet
, vol.16
, pp. 64-67
-
-
Liaw, D.1
Marsh, D.J.2
Li, J.3
Dahia, P.L.4
Wang, S.I.5
Zheng, Z.6
Bose, S.7
Call, K.M.8
Tsou, H.C.9
Peacocke, M.10
Eng, C.11
Parsons, R.12
-
17
-
-
0029849215
-
Bcl-2 prevents CD95 (Fas/APO-1)-induced degradation of lamin B and poly(ADP-ribose) polymerase and restores the NF-kappaB signaling pathway
-
Mandal M, Maggirwar SB, Sharma N, Kaufmann SH, Sun SC, Kumar R (1996) Bcl-2 prevents CD95 (Fas/APO-1)-induced degradation of lamin B and poly(ADP-ribose) polymerase and restores the NF-kappaB signaling pathway. J Biol Chem 271: 30354-30359
-
(1996)
J Biol Chem
, vol.271
, pp. 30354-30359
-
-
Mandal, M.1
Maggirwar, S.B.2
Sharma, N.3
Kaufmann, S.H.4
Sun, S.C.5
Kumar, R.6
-
18
-
-
0036847703
-
Inhibition of platelet-derived growth factor-mediated proliferation of osteosarcoma cells by the novel tyrosine kinase inhibitor STI571
-
McGary EC, Weber K, Mills L, Doucet M, Lewis V, Lev DC, Fidler IJ, Bar-Eli M (2002) Inhibition of platelet-derived growth factor-mediated proliferation of osteosarcoma cells by the novel tyrosine kinase inhibitor STI571. Clin Cancer Res 8: 3584-3591
-
(2002)
Clin Cancer Res
, vol.8
, pp. 3584-3591
-
-
McGary, E.C.1
Weber, K.2
Mills, L.3
Doucet, M.4
Lewis, V.5
Lev, D.C.6
Fidler, I.J.7
Bar-Eli, M.8
-
19
-
-
0035881322
-
Overexpression and overactivation of Akt in thyroid carcinoma
-
Ringel MD, Hayre N, Saito J, Saunier B, Schuppert F, Burch H, Bernet V, Burman KD, Kohn LD, Saji M (2001) Overexpression and overactivation of Akt in thyroid carcinoma. Cancer Res 61: 6105-6111
-
(2001)
Cancer Res
, vol.61
, pp. 6105-6111
-
-
Ringel, M.D.1
Hayre, N.2
Saito, J.3
Saunier, B.4
Schuppert, F.5
Burch, H.6
Bernet, V.7
Burman, K.D.8
Kohn, L.D.9
Saji, M.10
-
20
-
-
0028074316
-
Phosphatidylinositol-3-OH kinase as a direct target of Ras
-
Rodriguez-Viciana P, Warne PH, Dhand R, Vanhaesebroeck B, Gout I, Fry MJ, Waterfield MD, Downward J (1994) Phosphatidylinositol-3-OH kinase as a direct target of Ras. Nature 370: 527-532
-
(1994)
Nature
, vol.370
, pp. 527-532
-
-
Rodriguez-Viciana, P.1
Warne, P.H.2
Dhand, R.3
Vanhaesebroeck, B.4
Gout, I.5
Fry, M.J.6
Waterfield, M.D.7
Downward, J.8
-
21
-
-
0035011548
-
Regulation of FRTL-5 thyroid cell growth by phosphatidylinositol (OH) 3 kinase-dependent Akt-mediated signaling
-
Saito J, Kohn AD, Roth RA, Noguchi Y, Tatsumo I, Hirai A, Suzuki K, Kohn LD, Saji M, Ringel MD (2001) Regulation of FRTL-5 thyroid cell growth by phosphatidylinositol (OH) 3 kinase-dependent Akt-mediated signaling. Thyroid 11: 339-351
-
(2001)
Thyroid
, vol.11
, pp. 339-351
-
-
Saito, J.1
Kohn, A.D.2
Roth, R.A.3
Noguchi, Y.4
Tatsumo, I.5
Hirai, A.6
Suzuki, K.7
Kohn, L.D.8
Saji, M.9
Ringel, M.D.10
-
22
-
-
12144288657
-
Akt activation and localisation correlate with tumour invasion and oncogene expression in thyroid cancer
-
Vasko V, Saji M, Hardy E, Kruhlak M, Larin A, Savchenko V, Miyakawa M, Isozaki O, Murakami H, Tsushima T, Burman KD, De Micco C, Ringel MD (2004) Akt activation and localisation correlate with tumour invasion and oncogene expression in thyroid cancer. J Med Genet 41: 161-170
-
(2004)
J Med Genet
, vol.41
, pp. 161-170
-
-
Vasko, V.1
Saji, M.2
Hardy, E.3
Kruhlak, M.4
Larin, A.5
Savchenko, V.6
Miyakawa, M.7
Isozaki, O.8
Murakami, H.9
Tsushima, T.10
Burman, K.D.11
De Micco, C.12
Ringel, M.D.13
-
23
-
-
0037045583
-
BCR-ABL gene mutations in relation to clinical resistance of Philadelphia-chromosome-positive leukaemia to STI571: A prospective study
-
von Bubnoff N, Schneller F, Peschel C, Duyster J (2002) BCR-ABL gene mutations in relation to clinical resistance of Philadelphia-chromosome-positive leukaemia to STI571: a prospective study. Lancet 359: 487-491
-
(2002)
Lancet
, vol.359
, pp. 487-491
-
-
Von Bubnoff, N.1
Schneller, F.2
Peschel, C.3
Duyster, J.4
-
24
-
-
0036968347
-
Activation of the PI3K/Akt pathway and chemotherapeutic resistance
-
West KA, Castillo SS, Dennis PA (2002) Activation of the PI3K/Akt pathway and chemotherapeutic resistance. Drug Resist Updat 5: 234-248
-
(2002)
Drug Resist Updat
, vol.5
, pp. 234-248
-
-
West, K.A.1
Castillo, S.S.2
Dennis, P.A.3
|