Duplication of the mutant RET allele in trisomy 10 or loss of the wild-type allele in multiple endocrine neoplasia type 2-associated pheochromocytomas

Cancer Research

Volumn 60, Issue 22, 2000, Pages 6223-6226

  Huang, Steve C ^a   Koch, Christian A ^b   Vortmeyer, Alexander O ^a   Pack, Svetlana D ^a   Lichtenauer, Urs D ^a   Mannan, Poonam ^a   Lubensky, Irina A ^a   Chrousos, George P ^b   Gagel, Robert F ^c   Pacak, Karel ^b   Zhuang, Zhengping ^a,b  

^a NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^b EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^c UNIVERSITY OF TEXAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CARCINOGENESIS; CHROMOSOME 10; CLINICAL ARTICLE; GENE MUTATION; GENETIC ANALYSIS; HUMAN; PHEOCHROMOCYTOMA; PRIORITY JOURNAL; PROTO ONCOGENE; SIPPLE SYNDROME; TRISOMY;

ADRENAL GLAND NEOPLASMS; ALLELES; CHROMOSOMES, HUMAN, PAIR 10; DNA, NEOPLASM; DROSOPHILA PROTEINS; GENE EXPRESSION REGULATION, NEOPLASTIC; GERM-LINE MUTATION; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; LOSS OF HETEROZYGOSITY; MULTIPLE ENDOCRINE NEOPLASIA TYPE 2A; PHEOCHROMOCYTOMA; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-RET; RECEPTOR PROTEIN-TYROSINE KINASES; TRISOMY;

EID: 0033693018     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (11)

1. Specific mutations of the RET proto-oncogene are related to disease phenotype in MEN 2A and FMTC
2. Expression of the ret proto-oncogene product in human normal and neoplastic tissues of neural crest origin
3. The phenotypes associated with ret mutations in the multiple endocrine neoplasia type 2 syndrome
4. Trisomy 7-harbouring non-random duplication of the mutant MET allele in hereditary papillary renal carcinomas
5. Constitutional von Hippel-Lindau (VHL) gene deletions detected in VHL families by fluorescence in situ hybridization
6. The RET proto-oncogene in multiple endocrine neoplasia type 2 and Hirsch-sprung's disease
7. Nonrandom duplication of the chromosome bearing a mutated Ha-ras-l allele in mouse skin tumors
8. Genetic instability in human cancers
9. Genetic events in tumor initiation and progression in multiple endocrine neoplasia type 2
10. Genetics of human cancer
11. RET rearrangements in papillary thyroid carcinomas and adenomas detected by interphase FISH