Increased cardiac fatty acid uptake with dobutamine infusion in swine is accompanied by a decrease in malonyl CoA levels

Cardiovascular Research

Volumn 32, Issue 5, 1996, Pages 879-885

  Hall, Jennifer L ^a   Lopaschuk, Gary D ^b   Barr, Amy ^b   Bringas, John ^a   Pizzurro, Robert D ^a   Stanley, William C ^a,c  

^a ROCHE BIOSCIENCE   (United States)

^b UNIVERSITY OF ALBERTA   (Canada)

^c CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

dobutamine; fatty acids; pig, anesthetized; protein kinase C

Indexed keywords

DOBUTAMINE; FATTY ACID; GLUCOSE; MALONYL COENZYME A; PROTEIN KINASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; HEART MUSCLE CONTRACTILITY; HEART RATE; MALE; NONHUMAN; PRIORITY JOURNAL; SWINE;

ANIMALS; CARDIOTONIC AGENTS; DOBUTAMINE; FATTY ACIDS; FATTY ACIDS, NONESTERIFIED; GLUCOSE; HEART RATE; LACTIC ACID; MALE; MALONYL COENZYME A; MYOCARDIUM; OXYGEN; SWINE; VENTRICULAR FUNCTION, LEFT;

EID: 0030297078     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/0008-6363(96)00153-8     Document Type: Article

References (20)

1. [1] Neely JR, Whinner KM, Mochizuki S. Effects of mechanical activity and hormones on myocardial glucose and fatty acid utilization. Circ Res 1976;38(suppl 1):122-130.
2. [2] Awan MM, Saggerson ED. Malonyl-CoA metabolism in cardiac myocytes and its relevance to the control of fatty acid oxidation. Biochem J 1993;295:61-66.
3. [3] Lopaschuk GD, Belke DD, Gamble J, Itoi T, Schönekess BO. Regulation of fatty acid oxidation in the mammalian heart in health and disease. Biochim Biophys Acta 1994;1213:263-276.
4. [4] Saddik M, Gamble J, Witters LA, Lopaschuk GD. Acetyl-CoA carboxylase regulation of fatty acid oxidation in the heart. J Biol Chem 1993;268:25836-25845.
5. [5] McGarry JD, Mills SE, Long CS, Foster DW. Observations on the affinity for carnitine, and malonyl-CoA sensitivity, of camitine palmitoyltransferase 1 in animal and human tissues. Biochem J 1983;214:21-28.
6. [6] Bianchi A, Evans JL, Iverson AJ, Nordlund AC, Watts TD, Witters LA. Identification of an isozymic form of acetyl-CoA carboxylase. J Biol Chem 1990;265:1502-1509.
7. [7] Thampy KG. Formation of malonyl coenzyme A in rat heart. J Biol Chem 1989;264:17631-17634.
8. [8] Hardie DG. Regulation of fatty acid and cholesterol metabolism by the AMP-activated protein kinase. Biochim Biophys Acta 1992;1123:231-238.
9. [9] Ha JS, Daniel S, Broyles SS, Kim K. Critical phosphorylation sites for acetyl-CA carboxylase activity. J Biol Chem 1994;269:22162-22168.
10. [10] Hall JL, Van Wylen DGL, Pizzurro RD, Hamilton CD, Reiling CM, Stanley WC. Myocardial interstitial purine metabolites and lactate with increased work in swine. Cardiovasc Res 1995;30:351-355.
11. [11] Massie BM, Schwartz GG, Garcia J, Wisneski JA, Weiner MW, Owens T. Myocardial metabolism during increased work states in the porcine left ventricle in vivo. Circ Res 1994;74:64-73.
12. [12] Allard JR, Conhaim RL, Vlahakes GJ, O'Neill MJ, Huffman JI. Rapid-freezing transmural cardiac biopsy drill. Am J Physiol 1981;240:H126-H132.
13. [13] Hall JL, Hernandez LA, Henderson J, Kellerman LA, Stanley WC. Decreased interstitial glucose and transmural gradient in lactate during ischemia. Basic Res Cardiol 1994;89:468-486.
14. [14] Kudo N, Barr AJ, Barr RL, Desai S, Lopaschuk GD. High rates of fatty acid oxidation during reperfusion of ischemic hearts are associated with a decrease in malonyl CoA levels due to an increase in 5-AMP-activated protein kinase inhibition of acetyl CoA carboxylase. J Biol Chem 1995;270:17513-17520.
15. [15] Haystead TAJ, Moore F, Cohen P, Hardie DG. Roles of the AMP-activated and cyclic-AMP-dependent protein kinases in the adrenaline-induced inactivation of acetyl-CoA carboxylase in rat adipocytes. Eur J Biochem 1990;187:199-205.
16. [16] Carling D, Clarke PR, Zammit VA, Hardie DG. Purification and characterization of the AMP-activated protein kinase. Eur J Biochem 1989;186:129-136.
17. [17] Weekes J, Hawley SA, Corton J, Shugar D, Hardie DG. Activation of rat liver AMP-activated protein kinase in a purified, reconstituted system. Effects of AMP and AMP analogues. Eur J Biochem 1994;219:751-757.
18. [18] Hansford RG, Cohen L. Relative importance of pyruvate dehydrogenase interconversion and feed-back inhibition in the effect of fatty acids on pyruvate oxidation by rat heart mitochondria. Arch Biochem Biophys 1978;191:65-81.
19. [19] Stanley WC, Hernandez LA, Spires DA, Bringas J, Wallace S, McCormack JG. Pyruvate dehydrogenase activity and malonyl CoA levels in normal and ischemic swine myocardium: effects of dichloroacetate. J Mol Cell Cardiol 1996;28:905-914.
20. [20] Kim YS, Kolattukudy PE. Purification and properties of malonyl-CoA decarboxylase from rat liver mitochondria and its immunological comparison with the enzymes from rat brain, heart, and mammary gland. Arch Biochem Biophys 1978;190:234-246.