Biological application of microelectrode arrays in drug discovery and basic research

Analytical and Bioanalytical Chemistry

Volumn 377, Issue 3, 2003, Pages 486-495

  Stett, Alfred ^a   Egert, Ulrich ^b   Guenther, Elke ^a   Hofmann, Frank ^a   Meyer, Thomas ^c   Nisch, Wilfried ^a   Haemmerle, Hugo ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b UNIVERSITY OF FREIBURG   (Germany)

^c MULTI CHANNEL SYSTEMS MCS GMBH   (Germany)

Author keywords

Cell culture; Drug discovery; Electrophysiology; Field potential; Ion channel; Microelectrode array; Organotypic tissue culture; Safety pharmacology

Indexed keywords

BIOSENSORS; CELL CULTURE; CELL MEMBRANES; DRUG PRODUCTS; ELECTROPHYSIOLOGY; NEUROLOGY; OPTICAL RECORDING; TISSUE; TOXIC MATERIALS;

DRUG DISCOVERY; FIELD POTENTIAL; ION CHANNELS; MICROELECTRODE ARRAYS (MEA); ORGANOTYPIC TISSUE CULTURE; SAFETY PHARMACOLOGY;

MICROELECTRODES;

ACTION POTENTIAL; ANIMAL; CELL CULTURE; CYTOLOGY; DRUG EFFECT; DRUG SCREENING; ELECTROPHYSIOLOGY; GENETIC PROCEDURES; HEART; HEART MUSCLE; HUMAN; INSTRUMENTATION; METHODOLOGY; MICROELECTRODE; NERVE CELL; ORGAN CULTURE TECHNIQUE; PHYSIOLOGY; REVIEW;

ACTION POTENTIALS; ANIMALS; BIOSENSING TECHNIQUES; CELLS, CULTURED; DRUG EVALUATION, PRECLINICAL; ELECTROPHYSIOLOGY; HEART; HUMANS; MICROELECTRODES; MYOCARDIUM; NEURONS; ORGAN CULTURE TECHNIQUES;

EID: 0347598249     PISSN: 16182642     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00216-003-2149-x     Document Type: Review

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