GATA-3 transduces survival signals in osteoblasts through upregulation of bcl-xL gene expression

Journal of Bone and Mineral Research

Volumn 25, Issue 10, 2010, Pages 2193-2204

  Chen, Ruei Ming ^a,b   Lin, Yi Ling ^b   Chou, Chih Wei ^a  

^a TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^b TAIPEI MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Apoptosis; Bcl X L; GATA 3; No preconditioning; Osteoblasts; Oxidative stress

Indexed keywords

DNA; MESSENGER RNA; NITRIC OXIDE; PROTEIN BCL XL; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR GATA 3; TRANSCRIPTION FACTOR RUNX2;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL NUCLEUS; CELL PROTECTION; CELL STRUCTURE; CELL SURVIVAL; CONTROLLED STUDY; CYTOPLASM; DNA FRAGMENTATION; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; INTRACELLULAR SIGNALING; MITOCHONDRION; NEWBORN; NONHUMAN; OSTEOBLAST; OXIDATIVE STRESS; PROMOTER REGION; PROTEIN ANALYSIS; PROTEIN DNA BINDING; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN SYNTHESIS; RAT; RNA INTERFERENCE; RNA SYNTHESIS; SKULL; UPREGULATION;

ANIMALS; BASE SEQUENCE; BCL-X PROTEIN; BLOTTING, WESTERN; CELLS, CULTURED; DNA PRIMERS; ELECTROPHORETIC MOBILITY SHIFT ASSAY; GATA3 TRANSCRIPTION FACTOR; GENE KNOCKDOWN TECHNIQUES; IMMUNOPRECIPITATION; MICROSCOPY, CONFOCAL; OSTEOBLASTS; OXIDATIVE STRESS; POLYMERASE CHAIN REACTION; RATS; RATS, WISTAR; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 77957684921     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1002/jbmr.121     Document Type: Article

References (49)

1. Eriksen EF, Eghbali-Fatourechi GZ, Khosla S. Remodeling and vascular spaces in bone. J Bone Miner Res. 2007;22:1-6.
2. Hadjidakis DJ, Androulakis II. Bone remodeling. Ann NY Acad Sci. 2006;1092:385-396.
3. Takeda S, Karsenty G. Central control of bone formation. J Bone Miner Metab. 2001;19:195-198.
4. Vanderschueren D, Vandenput L, Boonen S, Lindberg MK, Bouillon R, Ohlsson C. Androgens and bone. Endocr Rev. 2004;25:389-425.
5. Zaidi M, Alam AS, Bax BE, et al. Role of the endothelial cell in osteoclast control: new perspectives. Bone. 1993;14:97-102.
6. Bai XC, Lu D, Liu AL, et al. Reactive oxygen species stimulates receptor activator of NF-kappaB ligand expression in osteoblasts. J Biol Chem. 2005;280:17497-17506.
7. Mancini L, Moradi-Bidhendi N, Becherini L, Martineti V, MacIntyre I. The biphasic effects of nitric oxide in primary rat osteoblasts are cGMP dependent. Biochem Biophys Res Commun. 2000;274:477-481. (Pubitemid 30614343)
8. Chang CC, Liao YS, Lin YL, Chen RM. Nitric oxide protects osteoblasts from oxidative stress-induced apoptotic insults via a mitochondriadependent mechanism. J Orthop Res. 2006;24:1917-1925.
9. Damoulis PD, Hauschka PV. Nitric oxide acts in conjunction with proinflammatory cytokines to promote cell death in osteoblasts. J Bone Miner Res. 1997;12:412-422.
10. Chen RM, Liu HC, Lin YL, Jean WC, Chen JS, Wang JH. Nitric oxide induces osteoblast apoptosis through the de novo synthesis of Bax protein. J Orthop Res. 2002;20:295-302.
11. O'Shaughnessy MC, Polak JM, Afzal F, et al. Nitric oxide mediates 17β-estradiol-stimulated human and rodent osteoblast proliferation and differentiation. Biochem Biophys Res Commun. 2000;277:604-610.
12. Cottart CH, Do L, Blanc MC, et al. Hepatoprotective effect of endogenous nitric oxide during ischemia-reperfusion in the rat. Hepatology. 1999;29:809-813. (Pubitemid 29109595)
13. Tai YT, Cherng YG, Chang CC, Hwang YP, Chen JT, Chen RM. Pretreatment with low nitric oxide protects osteoblasts from high nitric oxide-induced apoptotic insults through regulation of c-Jun N-terminal kinase/c-Jun-mediated Bcl-2 gene expression and protein translocation. J Orthop Res. 2007;25:625-635.
14. Evans T, Felsenfeld G. The erythroid-specific transcription factor Eryf1: a new finger protein. Cell. 1989;58:877-885. (Pubitemid 19227897)
15. Suzuki E, Evans T, Lowry J, et al. The human GATA-6 gene: structure, chromosomal location, and regulation of expression by tissue-specific and mitogen-responsive signals. Genomics. 1996;38:283-290. (Pubitemid 27030116)
16. Burch JB. Regulation of GATA gene expression during vertebrate development. Semin Cell Dev Biol. 2005;16:71-81. (Pubitemid 40126878)
17. Barnes PJ. Role of GATA-3 in allergic diseases. Curr Mol Med. 2008; 8:330-334.
18. Ho IC, Tai TS, Pai SY. GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation. Nat Rev Immunol. 2009;9:125-135.
19. Nardelli J, Thiesson D, Fujiwara Y, Tsai FY, Orkin SH. Expression and genetic interaction of transcription factors GATA-2 and GATA-3 during development of the mouse central nervous system. Develop Biol. 1999;210:305-321.
20. van Esch H, Devriendt K. Transcription factor GATA3 and the human HDR syndrome. Cell Mol Life Sci. 2001;58:1296-1300. (Pubitemid 32844099)
21. Fiers W, Beyaert R, Declercq W, Vandenabeele P. More than one way to die: apoptosis, necrosis and reactive oxygen damage. Oncogene. 1999;18:7719-7730. (Pubitemid 30052757)
22. Hock JM, Krishnan V, Onyia JE, Bidwell JP, Milas J, Stanislaus D. Osteoblast apoptosis and bone turnover. J Bone Miner Res. 2001; 16:975-984.
23. Kang MH, Reynolds CP. Bcl-2 inhibitors: targeting mitochondrial apoptotic pathways in cancer therapy. Clin Cancer Res. 2009;15: 1126-1132.
24. Pagliari LJ, Kuwana T, Bonzon C, et al. The multidomain proapoptotic molecules Bax and Bak are directly activated by heat. Proc Natl Acad Sci USA. 2005;102:17975-17980.
25. L during apoptosis. Proc Natl Acad Sci USA. 1997;94: 3668-3672.
26. Huang J, Nakamura K, Ito Y, et al. Bcl-XL gene transfer inhibits Bax translocation and prolongs cardiac cold preservation time in rats. Circulation. 2005;112:76-83. (Pubitemid 40962572)
27. L expression and cell survival. J Biol Chem. 2005;280:29533-29542.
28. Lee ST, Wu TT, Yu PY, Chen RM. Apoptotic insults to human HepG2 cells induced by S-(+)-ketamine occurs through activation of a Baxmitochondria- caspase protease pathway. Br J Anaesth. 2009;102: 80-89.
29. Wu GJ, Chen TG, Chang HC, Chiu WT, Chang CC, Chen RM. Nitric oxide from both exogenous and endogenous sources activates mitochondria- dependent events and induces insults to human chondrocytes. J Cell Biochem. 2007;101:1520-1531.
30. Cherng YG, Chang HC, Lin YL, Kuo ML, Chiu WT, Chen RM. Apoptotic insults to human chondrocytes induced by nitric oxide are involved in sequential events, including cytoskeletal remodeling, phosphorylation of mitogen-activated protein kinase kinase kinase-1, and Baxmitochondria-mediated caspase activation. J Orthop Res. 2008;26: 1018-1026.
31. Liu HC, Chen RM, Jian WC, Lin YL. Cytotoxic and antioxidant effects of the water extract of traditional chinese herb gusuibu (Drynaria fortunei) on rat osteoblasts. J Formos Med Assoc. 2001;100:383-388.
32. Chen TG, Chen TL, Chang HC, et al. Oxidized low-density lipoprotein induces apoptotic insults to mouse cerebral endothelial cells via a Bax-mitochondria-caspase protease pathway. Toxicol Appl Pharmacol. 2007;219:42-53.
33. Ontiveros C, Irwin R, Wiseman RW, Mccabe LR. Hypoxia suppresses Runx2 independent of modeled microgravity. J Cell Physiol. 2004; 200:169-176. (Pubitemid 38880202)
34. Chang HC, Chen TL, Lin YH, Chen RM. Interruption of hepatocyte cytoskeletons by ketamine occurs through suppression of calcium mobilization and mitochondrial function. Drug Metab Dipos. 2009; 37:24-31.
35. Lee CJ, Tai YT, Lin YL, Chen RM. Molecular mechanisms of propofol-involved suppression of nitric oxide biosynthesis and inducible nitric oxide synthase gene expression in lipopolysaccharide-stimulated macrophage-like Raw 264.7 cells. Shock. 2010;33:93-100.
36. Wu GJ, Chen TL, Chang CC, Chen RM. Propofol suppresses tumor necrosis factor-α biosynthesis in lipopolysaccharide-stimulated macrophages possibly through downregulation of nuclear factorkappa B-mediated toll-like receptor 4 gene expression. Chem-Biol Interact. 2009;180:465-471.
37. Tong Q, Tsai J, Tan G, Dalgin D, Hotamisligil GS. Interaction between GATA and the C/EBP Family of Transcription Factors Is Critical in GATA-Mediated Suppression of Adipocyte Differentiation. Mol Cell Biol. 2005;25:706-715. (Pubitemid 40096591)
38. Chen TL, Chang CC, Lin YL, Ueng YF, Chen RM. Signal-transducing mechanisms of ketamine-caused inhibition of interleukin-1β gene expression in lipopolysaccharide-stimulated murine macrophagelike Raw 264.7 cells. Toxicol Appl Pharmacol. 2009;240:15-25.
39. Chang Y, Chen TL, Sheu JR, Chen RM. Suppressive effects of ketamine on macrophage functions. Toxicol Appl Pharmacol. 2005;204: 27-35. (Pubitemid 40387564)
40. Kowaluk EA, Seth P, Fung HL. Metabolic activation of sodium nitroprusside to nitric oxide in vascular smooth muscle. J Pharmacol Exp Ther. 1992;262:916-922.
41. Moncada S, Palmer RMJ, Higgs EA. Nitric oxide: physiology, pathophysiology and pharmacology. Pharmacol Rev. 1991;43:109-142.
42. Chen RM, Chen TL, Chiu WT, Chang CC. Molecular mechanism of nitric oxide-induced osteoblast apoptosis. J Orthop Res. 2005;23: 462-468. (Pubitemid 40287876)
43. Aylon Y, Oren M. Living with p53, dying of p53. Cell. 2007;130:597-600.
44. Ho WP, Chan WP, Hsieh MS, Chen RM. Runx2-mediated Bcl-2 gene expression contributes to nitric oxide protection against oxidative stress-induced osteoblast apoptosis. J Cell Biochem. 2009;108:1084-1093.
45. Yamagata T, Mitani K, Oda H, et al. Acetylation of GATA-3 affects T-cell survival and homing to secondary lymphoid organs. EMBO J. 2000; 19:4676-4687.
46. Hawse JR, Subramaniam M, Ingle JN, Oursler MJ, Rajamannan NM, Spelsberg TC. Estrogen-TGF-β cross-talk in bone and other cell types: role of TIEG, Runx2, and other transcription factors. J Cell Biochem. 2008;103:383-392. (Pubitemid 351171910)
47. Smith SS, Reyes JR, Arbon KS, Harvey WA, Hunt LM, Heggland SJ. Cadmium-induced decrease in RUNX2 mRNA expression and recovery by the antioxidant N-acetylcysteine (NAC) in the human osteoblast- like cell line, Saos-2. Toxicol Vitro. 2009;23:60-66.
48. Eliseev RA, Dong YF, Sampson E, et al. Runx2-mediated activation of the Bax gene increases osteosarcoma cell sensitivity to apoptosis. Oncogene. 2008;27:3605-3614. (Pubitemid 351793799)
49. Dobreva G, Chahrour M, Dautzenberg M, et al. SATB2 is a multifunctional determinant of craniofacial patterning and osteoblast differentiation. Cell. 2006;125:971-986. (Pubitemid 43810153)