메뉴 건너뛰기




Volumn 3, Issue 3, 2010, Pages 142-145

Minocycline, an antibiotic and a neuroprotective: Justifying role in Alzheimer's disease

Author keywords

Alzheimer's disease; CNS; Minocycline

Indexed keywords

MINOCYCLINE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; TETRACYCLINE DERIVATIVE;

EID: 77957602890     PISSN: 09742441     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (5)

References (63)
  • 1
    • 44549087765 scopus 로고    scopus 로고
    • Soluble oligomers of the amyloid β protein impair synaptic plasticity and behavior
    • Selkoe DJ. Soluble oligomers of the amyloid β protein impair synaptic plasticity and behavior. Behavioural Brain Research.2008; 192: 106-113.
    • (2008) Behavioural Brain Research. , vol.192 , pp. 106-113
    • Selkoe, D.J.1
  • 2
    • 0029896354 scopus 로고    scopus 로고
    • Mechanisms of neuronal degeneration in Alzheimer's disease
    • Yankner BA. Mechanisms of neuronal degeneration in Alzheimer's disease. Neuron.1996; 16: 921-932.
    • (1996) Neuron. , vol.16 , pp. 921-932
    • Yankner, B.A.1
  • 4
    • 0033600274 scopus 로고    scopus 로고
    • Pathophysiological basis of Alzheimer's disease
    • Selkoe D J. Pathophysiological basis of Alzheimer's disease. Nature.1999; 399: 23-31.
    • (1999) Nature. , vol.399 , pp. 23-31
    • Selkoe, D.J.1
  • 5
    • 0031829739 scopus 로고    scopus 로고
    • Cerebral Ischemia and Alzheimer's Disease: Critical Role of PET and Implications for Therapeutic Intervention
    • Abass A, Christopher C and Franz F. Cerebral Ischemia and Alzheimer's Disease: Critical Role of PET and Implications for Therapeutic Intervention. The journal of nuclear medicine.1998; 39(8):231-238.
    • (1998) The Journal of Nuclear Medicine , vol.39 , Issue.8 , pp. 231-238
    • Abass, A.1    Christopher, C.2    Franz, F.3
  • 7
    • 33847699725 scopus 로고    scopus 로고
    • Role of tau in Alzheimer's dementia and other neurodegenerative diseases
    • Quadros A, Ophelia I W, Ghania A G. Role of tau in Alzheimer's dementia and other neurodegenerative diseases. J. Appl. Biomed.2007; 1-12.
    • (2007) J. Appl. Biomed , pp. 1-12
    • Quadros, A.1    Ophelia, I.W.2    Ghania, A.G.3
  • 8
    • 0035715834 scopus 로고    scopus 로고
    • Neuropathological hallmarks ofAlzheimer's disease
    • Dubravka C, Milica S, Slobodan D. Neuropathological hallmarks ofAlzheimer's disease. Archive of Oncology. 2001;9(3):195-197.
    • (2001) Archive of Oncology , vol.9 , Issue.3 , pp. 195-197
    • Dubravka, C.1    Milica, S.2    Slobodan, D.3
  • 9
    • 16644363710 scopus 로고    scopus 로고
    • Investigation on apoptosis of neuronal cell sinduced by Amyloid beta-Protein
    • Ben-yan, Xu Z, Chen Z, Chen F,Tang M. Investigation on apoptosis of neuronal cell sinduced by Amyloid beta-Protein J Zhejiang Univ SCI. 2004; 5(8):989-994.
    • (2004) J Zhejiang Univ SCI , vol.5 , Issue.8 , pp. 989-994
    • Ben-yan, X.Z.1    Chen, Z.2    Chen, F.3    Tang, M.4
  • 10
    • 0030981585 scopus 로고    scopus 로고
    • Auguste D and Alzheimer's disease
    • Maurer K, Volk S, Gerbaldo H. Auguste D and Alzheimer's disease. Lancet. 1997; 349:1546-1549.
    • (1997) Lancet , vol.349 , pp. 1546-1549
    • Maurer, K.1    Volk, S.2    Gerbaldo, H.3
  • 11
    • 33947533977 scopus 로고    scopus 로고
    • Neuroinflammation in Alzheimer's disease; protector or promoter
    • Zilka N, Ferencik M, Hulin I. Neuroinflammation in Alzheimer's disease; protector or promoter. Bratisl Lek Listy.2006; 107(9-10): 374-381.
    • (2006) Bratisl Lek Listy. , vol.107 , Issue.9-10 , pp. 374-381
    • Zilka, N.1    Ferencik, M.2    Hulin, I.3
  • 12
  • 13
    • 5344272541 scopus 로고    scopus 로고
    • A focus on the synapse for neuroprotectionin Alzheimer disease and other dementias
    • Coleman P, Federoff H, Kurlan R. A focus on the synapse for neuroprotectionin Alzheimer disease and other dementias. Neurology.2004; 63:1155-1162.
    • (2004) Neurology , vol.63 , pp. 1155-1162
    • Coleman, P.1    Federoff, H.2    Kurlan, R.3
  • 14
    • 0344653664 scopus 로고    scopus 로고
    • Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer's disease
    • Gomez-Isla T et al. Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer's disease. Ann.Neurol.1997; 41: 17-24.
    • (1997) Ann.Neurol. , vol.41 , pp. 17-24
    • Gomez-Isla, T.1
  • 15
    • 0035863188 scopus 로고    scopus 로고
    • Decreased nuclear b-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3b conditional transgenic mice
    • Lucas JG et al. Decreased nuclear b-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3b conditional transgenic mice. The EMBO Journal.2001;20(1,2): 27-39.
    • (2001) The EMBO Journal , vol.20 , Issue.1-2 , pp. 27-39
    • Lucas, J.G.1
  • 16
    • 23844459902 scopus 로고    scopus 로고
    • Prolonged Alzheimer-like Tau Hyperphosphorylation Induced by Simultaneous Inhibition of Phosphoinositol-3 Kinase and Protein Kinase C in N2a cells
    • Guo-Gang XU, Yan-Qiu D, Shi-Jie L, Hong-Lian LI and Jian-Zhi W. Prolonged Alzheimer-like Tau Hyperphosphorylation Induced by Simultaneous Inhibition of Phosphoinositol-3 Kinase and Protein Kinase C in N2a cells. Acta Biochimica et Biophysica Sinica. 2005; 37(5): 349-354.
    • (2005) Acta Biochimica et Biophysica Sinica , vol.37 , Issue.5 , pp. 349-354
    • Guo-Gang, X.U.1    Yan-Qiu, D.2    Shi-Jie, L.3    Hong-Lian, L.I.4    Jian-Zhi, W.5
  • 17
    • 0029999787 scopus 로고    scopus 로고
    • Alzheimer's disease hyperphosphorylated tau sequesters normal tau into tangles of filaments and disassembles microtubules
    • Alonso AC, Grundke-Iqbal I, Iqbal K. Alzheimer's disease hyperphosphorylated tau sequesters normal tau into tangles of filaments and disassembles microtubules. Nat Med. 1996; 2: 783-787.
    • (1996) Nat Med. , vol.2 , pp. 783-787
    • Alonso, A.C.1    Grundke-Iqbal, I.2    Iqbal, K.3
  • 18
    • 0035066332 scopus 로고    scopus 로고
    • Alzheimer's disease: Genes, proteins, and therapy
    • Selkoe DJ. Alzheimer's disease: genes, proteins, and therapy. Physiol Rev.2001; 8:741-766.
    • (2001) Physiol Rev. , vol.8 , pp. 741-766
    • Selkoe, D.J.1
  • 20
    • 0032867538 scopus 로고    scopus 로고
    • Amyloid beta-peptide-associated free radical oxidative stress, neurotoxicity, and Alzheimer's disease
    • Butterfield DA, Yatin SM, Varadarajan S & Koppal T. Amyloid beta-peptide-associated free radical oxidative stress, neurotoxicity, and Alzheimer's disease. Methods Enzymol.1999; 309: 746-768.
    • (1999) Methods Enzymol. , vol.309 , pp. 746-768
    • Butterfield, D.A.1    Yatin, S.M.2    Varadarajan, S.3    Koppal, T.4
  • 21
    • 0032054439 scopus 로고    scopus 로고
    • Peroxide-scavenging deficit underlies oligodendrocytes susceptibility to oxidative stress
    • Juurlink BH, Thorburne SK, Hertz L. Peroxide-scavenging deficit underlies oligodendrocytes susceptibility to oxidative stress. Glia.1998; 22: 371-378.
    • (1998) Glia. , vol.22 , pp. 371-378
    • Juurlink, B.H.1    Thorburne, S.K.2    Hertz, L.3
  • 22
    • 0037312139 scopus 로고    scopus 로고
    • Cholesterol is necessary both for the toxic effect of Abeta peptides onvascular smooth muscle cells and for Abeta binding to vascular smooth muscle cell membranes
    • Subasinghe S, Unabia S, Barrow CJ, Mok SS, Agulilar MI, Small DH. Cholesterol is necessary both for the toxic effect of Abeta peptides onvascular smooth muscle cells and for Abeta binding to vascular smooth muscle cell membranes. J Neurochem.2003; 84: 471-93.
    • (2003) J Neurochem. , vol.84 , pp. 471-493
    • Subasinghe, S.1    Unabia, S.2    Barrow, C.J.3    Mok, S.S.4    Agulilar, M.I.5    Small, D.H.6
  • 23
    • 0034973583 scopus 로고    scopus 로고
    • Tetracycline Antibiotics: Mode of Action, Applications, Molecular Biology, and Epidemiology of Bacterial Resistance
    • Chopra I and Marilyn R. Tetracycline Antibiotics: Mode of Action, Applications, Molecular Biology, and Epidemiology of Bacterial Resistance. Microbiology and moleculer biology reviews. 2001;65(2): 232-260
    • (2001) Microbiology and moleculer biology reviews , vol.65 , Issue.2 , pp. 232-260
    • Chopra, I.1    Marilyn, R.2
  • 24
    • 0030450402 scopus 로고    scopus 로고
    • A novel mechanism of action of tetracyclines: Effects on nitric oxide synthases
    • Amin A R et al. A novel mechanism of action of tetracyclines: Effects on nitric oxide synthases. Proc. Natl. Acad. Sci. 1996; 93: 14014-14019.
    • (1996) Proc. Natl. Acad. Sci. , vol.93 , pp. 14014-14019
    • Amin, A.R.1
  • 28
    • 33344470866 scopus 로고    scopus 로고
    • Clinical implications of apoptosis in ischemic myocardium
    • Scarabelli TM, Kight R, Stephanou A. Clinical implications of apoptosis in ischemic myocardium. Curr Probl Cardiol. 2006; 31: 181-264.
    • (2006) Curr Probl Cardiol. , vol.31 , pp. 181-264
    • Scarabelli, T.M.1    Kight, R.2    Stephanou, A.3
  • 30
    • 0035405886 scopus 로고    scopus 로고
    • Metalloproteinases in biology and pathology of the nervous system
    • Yong VW, Power C, Forsyth P, Edwards DR. Metalloproteinases in biology and pathology of the nervous system. Nat Rev Neurosci. 2001; 2: 502-11.
    • (2001) Nat Rev Neurosci. , vol.2 , pp. 502-511
    • Yong, V.W.1    Power, C.2    Forsyth, P.3    Edwards, D.R.4
  • 31
    • 0033539522 scopus 로고    scopus 로고
    • A tetracycline derivative, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic window
    • Yrjanheikki J, Tikka T, Keinanen R, Goldsteins G, Chan PH, Koistinaho J. A tetracycline derivative, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic window. Proc Natl Acad Sci.1999; 96: 13496-500.
    • (1999) Proc Natl Acad Sci. , vol.96 , pp. 13496-500
    • Yrjanheikki, J.1    Tikka, T.2    Keinanen, R.3    Goldsteins, G.4    Chan, P.H.5    Koistinaho, J.6
  • 32
    • 0034998271 scopus 로고    scopus 로고
    • Minocycline reduces traumatic brain injury-mediated caspase-1 activation, tissue damage, and neurological dysfunction
    • Sanchez Mejia RO, Ona VO, Li M, Friendlander RM. Minocycline reduces traumatic brain injury-mediated caspase-1 activation, tissue damage, and neurological dysfunction. Neurosurgery 2001; 48: 1393-1399.
    • (2001) Neurosurgery , vol.48 , pp. 1393-1399
    • Sanchez Mejia, R.O.1    Ona, V.O.2    Li, M.3    Friendlander, R.M.4
  • 33
    • 0037007645 scopus 로고    scopus 로고
    • Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice
    • Zhu S et al. Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice. Nature. 2002; 417: 74-78.
    • (2002) Nature. , vol.417 , pp. 74-78
    • Zhu, S.1
  • 34
    • 0036522967 scopus 로고    scopus 로고
    • Blockade of microglial activation is neuroprotective in the 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine mouse model of Parkinson disease
    • Wu DC, Jackson-Lewis V, Vila M, Tieu K, Teismann P, Vadseth C et al. Blockade of microglial activation is neuroprotective in the 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine mouse model of Parkinson disease. J Neurosci. 2002; 22: 1763-1771.
    • (2002) J Neurosci. , vol.22 , pp. 1763-1771
    • Wu, D.C.1    Jackson-Lewis, V.2    Vila, M.3    Tieu, K.4    Teismann, P.5    Vadseth, C.6
  • 35
    • 33646382411 scopus 로고    scopus 로고
    • Minocycline inhibits caspase-dependent and-independent cell death pathways and is neuroprotective against hippocampal damage after treatment with kainic acid in mice
    • Heo K, Cho YJ, Cho KJ, Kim HW, Kim HJ, Shin HY et al. Minocycline inhibits caspase-dependent and-independent cell death pathways and is neuroprotective against hippocampal damage after treatment with kainic acid in mice. Neurosci Lett. 2006; 398: 195-200.
    • (2006) Neurosci Lett. , vol.398 , pp. 195-200
    • Heo, K.1    Cho, Y.J.2    Cho, K.J.3    Kim, H.W.4    Kim, H.J.5    Shin, H.Y.6
  • 36
    • 2442454612 scopus 로고    scopus 로고
    • Minocycline up-regulates Bcl-2 and protects against cell death in mitochondria
    • Wang J, Wei Q, Wang CY, Hill WD, Hess DC, Dong Z. Minocycline up-regulates Bcl-2 and protects against cell death in mitochondria J Biol Chem. 2004; 279: 19948-54.
    • (2004) J Biol Chem , vol.279 , pp. 19948-19954
    • Wang, J.1    Wei, Q.2    Wang, C.Y.3    Hill, W.D.4    Hess, D.C.5    Dong, Z.6
  • 38
    • 31844454079 scopus 로고    scopus 로고
    • Minocycline attenuates white matter damage in a rat model of chronic cerebral hypoperfusion
    • Cho KO, La HO, Cho YJ, Sung KW, Kim SW. Minocycline attenuates white matter damage in a rat model of chronic cerebral hypoperfusion. J Neurosci Res. 2006; 83: 285-291.
    • (2006) J Neurosci Res. , vol.83 , pp. 285-291
    • Cho, K.O.1    La, H.O.2    Cho, Y.J.3    Sung, K.W.4    Kim, S.W.5
  • 39
    • 33750488783 scopus 로고    scopus 로고
    • Differential effects of cyclooxygenase inhibitors on intracerebroventricular colchicineinduced dysfunction and oxidative stress in rats
    • Kumar A, Seghal N, Padi S V, Naidu P S. Differential effects of cyclooxygenase inhibitors on intracerebroventricular colchicineinduced dysfunction and oxidative stress in rats. Europ. J. Pharmacol.2006; 551: 58-66.
    • (2006) Europ. J. Pharmacol. , vol.551 , pp. 58-66
    • Kumar, A.1    Seghal, N.2    Padi, S.V.3    Naidu, P.S.4
  • 40
    • 31744450214 scopus 로고    scopus 로고
    • Degeneration and death of neurons in adult neurodegenerative diseases
    • Sarkar P K. Degeneration and death of neurons in adult neurodegenerative diseases. Curr. Sci.2005; 89:132-135.
    • (2005) Curr. Sci. , vol.89 , pp. 132-135
    • Sarkar, P.K.1
  • 41
    • 1842450678 scopus 로고    scopus 로고
    • Alzheimer's disease and acetylcholine receptors
    • Kihara T and Shimohana S.Alzheimer's disease and acetylcholine receptors. Acta. Neurobiol. Exp.2004; 64: 99-105.
    • (2004) Acta. Neurobiol. Exp. , vol.64 , pp. 99-105
    • Kihara, T.1    Shimohana, S.2
  • 42
    • 0035876916 scopus 로고    scopus 로고
    • Minocycline provides neuroprotection against N-methyl-d-aspartate neurotoxicity by inhibiting microglia
    • Tikka TM, Koistinaho JE. Minocycline provides neuroprotection against N-methyl-d-aspartate neurotoxicity by inhibiting microglia. J. Immunol.2001; 166: 7527-7533.
    • (2001) J. Immunol. , vol.166 , pp. 7527-7533
    • Tikka, T.M.1    Koistinaho, J.E.2
  • 43
    • 33947533977 scopus 로고    scopus 로고
    • Neuroinflamation in Alzheimer's disease; protector or promoter
    • Zilka N, Ferencik M, Hulin I. Neuroinflamation in Alzheimer's disease; protector or promoter. Bratisl Lek Listy.2006; 107(9-10): 374-381.
    • (2006) Bratisl Lek Listy. , vol.107 , Issue.9-10 , pp. 374-381
    • Zilka, N.1    Ferencik, M.2    Hulin, I.3
  • 45
    • 4944258716 scopus 로고    scopus 로고
    • The role of inflammation in Alzheimer's disease
    • Tuppoa E and Ariasb H R. The role of inflammation in Alzheimer's disease. Intern. J. Biochem. Cell Biol.2005; 37: 289-305.
    • (2005) Intern. J. Biochem. Cell Biol. , vol.37 , pp. 289-305
    • Tuppoa, E.1    Ariasb, H.R.2
  • 47
    • 3042845492 scopus 로고    scopus 로고
    • Microglia and Alzheimer's disease pathogenesis
    • Streit WJ. Microglia and Alzheimer's disease pathogenesis. J Neurosci Res.2004; 77:1-8.
    • (2004) J Neurosci Res. , vol.77 , pp. 1-8
    • Streit, W.J.1
  • 48
    • 33646243562 scopus 로고    scopus 로고
    • Minocycline affects microglia activation, Abeta deposition, and behavior in APP-tg mice
    • Seabrook TJ, Jiang L, Maier M, Lemere C. Minocycline affects microglia activation, Abeta deposition, and behavior in APP-tg mice. Glia.2006; 53: 776-782.
    • (2006) Glia. , vol.53 , pp. 776-782
    • Seabrook, T.J.1    Jiang, L.2    Maier, M.3    Lemere, C.4
  • 49
    • 35348819417 scopus 로고    scopus 로고
    • Minocycline Attenuates Neuronal Cell Death and Improves Cognitive Impairment in Alzheimer's Disease Models
    • Choi Y, Hye-Sun Kim, Ki YS, Eun-Mee K, Minji Kim, Hyun-Soo Kim et al. Minocycline Attenuates Neuronal Cell Death and Improves Cognitive Impairment in Alzheimer's Disease Models. Neuropsychopharmacology. 2007;32: 2393-2404.
    • (2007) Neuropsychopharmacology , vol.32 , pp. 2393-2404
    • Choi, Y.1    Kim, H.-S.2    Ki, Y.S.3    Eun-Mee, K.4    Kim, M.5    Hyun-Soo, K.6
  • 50
    • 12144290904 scopus 로고    scopus 로고
    • Minocycline inhibits contusiontriggered mitochondrial cytochrome c release and mitigates functional deficits after spinal cord injury
    • Teng YD, Choi H, Onario RC et al. Minocycline inhibits contusiontriggered mitochondrial cytochrome c release and mitigates functional deficits after spinal cord injury.Proc Natl Acad Sci. 2004; 101: 3071-76.
    • (2004) Proc Natl Acad Sci , vol.101 , pp. 3071-3076
    • Teng, Y.D.1    Choi, H.2    Onario, R.C.3
  • 51
    • 0036289498 scopus 로고    scopus 로고
    • Minocycline markedly protects the neonatal brain against hypoxic-ischemic injury
    • Arvin KL, Han BH, Du Y, Lin SZ, Paul SM, Holtzman DM. Minocycline markedly protects the neonatal brain against hypoxic-ischemic injury. Ann Neurol. 2002; 52: 54-61.
    • (2002) Ann Neurol. , vol.52 , pp. 54-61
    • Arvin, K.L.1    Han, B.H.2    Du, Y.3    Lin, S.Z.4    Paul, S.M.5    Holtzman, D.M.6
  • 52
    • 2442454612 scopus 로고    scopus 로고
    • Minocycline up-regulates Bcl-2 and protects against cell death in mitochondria
    • Wang J, Wei Q, Wang CY, Hill WD, Hess DC, Dong Z. Minocycline up-regulates Bcl-2 and protects against cell death in mitochondria J Biol Chem. 2004; 279: 19948-54.
    • (2004) J Biol Chem , vol.279 , pp. 19948-54
    • Wang, J.1    Wei, Q.2    Wang, C.Y.3    Hill, W.D.4    Hess, D.C.5    Dong, Z.6
  • 53
    • 44949091276 scopus 로고    scopus 로고
    • Accumulation of nuclear DNA damage or neuron loss: Molecular basis for a new approach to understanding selective neuronal vulnerability in neurodegenerative diseases
    • Brasnjevic I, Patrick RH, Harry WM. Accumulation of nuclear DNA damage or neuron loss: Molecular basis for a new approach to understanding selective neuronal vulnerability in neurodegenerative diseases. DNA Repair.2008; 7: 1087-1097.
    • (2008) DNA Repair. , vol.7 , pp. 1087-1097
    • Brasnjevic, I.1    Patrick, R.H.2    Harry, W.M.3
  • 54
    • 0032901904 scopus 로고    scopus 로고
    • Increased poly (ADPribosyl) ation of nuclear proteins in Alzheimer's disease
    • Love S, Barber L and Wilcock GK. Increased poly (ADPribosyl) ation of nuclear proteins in Alzheimer's disease. Brain.1999; 122: 247-253.
    • (1999) Brain. , vol.122 , pp. 247-253
    • Love, S.1    Barber, L.2    Wilcock, G.K.3
  • 55
    • 0030996538 scopus 로고    scopus 로고
    • Interaction of DNA-dependent protein kinase andpoly(ADP-ribose) polymerase with radiation-induced DNA strand breaks
    • Weinfeld M, Chaudhry MA, D'Amours D, Pelletier JD, Poirier GG, Povirk LF, et al. Interaction of DNA-dependent protein kinase andpoly(ADP-ribose) polymerase with radiation-induced DNA strand breaks. Radiat Res 1997; 148: 22-28.
    • (1997) Radiat Res , vol.148 , pp. 22-28
    • Weinfeld, M.1    Chaudhry, M.A.2    D'Amours, D.3    Pelletier, J.D.4    Poirier, G.G.5    Povirk, L.F.6
  • 56
    • 2142694340 scopus 로고    scopus 로고
    • Nuclear and mitochondrial conversations in cell death: PARP-1 and AIF signaling
    • Hong SJ, Dawson TM, Valina L.Nuclear and mitochondrial conversations in cell death: PARP-1 and AIF signaling. TRENDS in Pharmacological Sciences 2004; 25:1221-31.
    • (2004) TRENDS in Pharmacological Sciences , vol.25 , pp. 1221-1231
    • Hong, S.J.1    Dawson, T.M.2    Valina, L.3
  • 58
    • 0028294246 scopus 로고
    • Nitric oxide activationof poly (ADP-ribose) synthetase in neurotoxicity
    • Zhang J, Dawson VL, Dawson TM, Snyder SH. Nitric oxide activationof poly (ADP-ribose) synthetase in neurotoxicity. Science 1994; 263:687-689.
    • (1994) Science , vol.263 , pp. 687-689
    • Zhang, J.1    Dawson, V.L.2    Dawson, T.M.3    Snyder, S.H.4
  • 59
    • 33745457705 scopus 로고    scopus 로고
    • Minocycline inhibits poly(ADP-ribose) polymerase-1 at nanomolar concentrations
    • Alano CC, Tiina M, Kauppinen A, Viader V and Raymond AS.Minocycline inhibits poly(ADP-ribose) polymerase-1 at nanomolar concentrations.PNAS.2006;103(25)9685-9690.
    • (2006) PNAS , vol.103 , Issue.25 , pp. 9685-9690
    • Alano, C.C.1    Tiina, M.2    Kauppinen, A.3    Viader, V.4    Raymond, A.S.5
  • 60
  • 61
    • 6344269425 scopus 로고    scopus 로고
    • Minocycline protects PC12 cells from ischemic-like injury and inhibits 5-lipoxygenase activation
    • Song Y, Wei EQ, Zhang WP, Zhang WP, Zhang L, Liu JR, Chen Z. Minocycline protects PC12 cells from ischemic-like injury and inhibits 5-lipoxygenase activation. Neuroreport. 2004; 15:2181-2184.
    • (2004) Neuroreport , vol.15 , pp. 2181-2184
    • Song, Y.1    Wei, E.Q.2    Zhang, W.P.3    Zhang, W.P.4    Zhang, L.5    Liu, J.R.6    Chen, Z.7
  • 62
    • 0036753450 scopus 로고    scopus 로고
    • Cyclooxygenase and 5-lipoxygenase inhibitors protect against mononuclear phagocyte neurotoxicity
    • Klegeris A, McGeer PL. Cyclooxygenase and 5-lipoxygenase inhibitors protect against mononuclear phagocyte neurotoxicity. Neurobiol Aging. 2003; 23:787-794.
    • (2003) Neurobiol Aging , vol.23 , pp. 787-794
    • Klegeris, A.1    McGeer, P.L.2
  • 63
    • 70449507674 scopus 로고    scopus 로고
    • Therapeutic targets and limits of minocycline neuroprotection in experimental ischemic stroke
    • Matsukawa N, Takao Y, Koichi H, Lin X, Mina M et al.Therapeutic targets and limits of minocycline neuroprotection in experimental ischemic stroke.BMC Neuroscience.2009;10:126-131.
    • (2009) BMC Neuroscience , vol.10 , pp. 126-131
    • Matsukawa, N.1    Takao, Y.2    Koichi, H.3    Lin, X.4    Mina, M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.